LOCUS       NM_175757               1416 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus crystallin, lambda 1 (Cryl1), mRNA.
ACCESSION   NM_175757
VERSION     NM_175757.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1416)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 1416)
  AUTHORS   Ishikura,S., Usami,N., Araki,M. and Hara,A.
  TITLE     Structural and functional characterization of rabbit and human
            L-gulonate 3-dehydrogenase
  JOURNAL   J Biochem 137 (3), 303-314 (2005)
   PUBMED   15809331
REFERENCE   3  (bases 1 to 1416)
  AUTHORS   Chen,J., Yu,L., Li,D., Gao,Q., Wang,J., Huang,X., Bi,G., Wu,H. and
            Zhao,S.
  TITLE     Human CRYL1, a novel enzyme-crystallin overexpressed in liver and
            kidney and downregulated in 58% of liver cancer tissues from 60
            Chinese patients, and four new homologs from other mammalians
  JOURNAL   Gene 302 (1-2), 103-113 (2003)
   PUBMED   12527201
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Nov 27, 2020 this sequence version replaced NM_175757.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY040223.1, BC078685.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               JAXUCZ010000015.1  35661460-35661563   c
            105-212             JAXUCZ010000015.1  35645837-35645944   c
            213-339             JAXUCZ010000015.1  35623436-35623562   c
            340-501             JAXUCZ010000015.1  35576811-35576972   c
            502-696             JAXUCZ010000015.1  35567931-35568125   c
            697-802             JAXUCZ010000015.1  35552095-35552200   c
            803-909             JAXUCZ010000015.1  35543612-35543718   c
            910-1416            JAXUCZ010000015.1  35542628-35543134   c
FEATURES             Location/Qualifiers
     source          1..1416
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..1416
                     /gene="Cryl1"
                     /note="crystallin, lambda 1"
                     /db_xref="GeneID:290277"
                     /db_xref="RGD:631427"
     exon            1..104
                     /gene="Cryl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1023
                     /gene="Cryl1"
                     /EC_number="1.1.1.45"
                     /note="gul3DH; L-gulonate 3-dehydrogenase; crystallin,
                     lamda 1"
                     /codon_start=1
                     /product="lambda-crystallin homolog"
                     /protein_id="NP_786933.1"
                     /db_xref="GeneID:290277"
                     /db_xref="RGD:631427"
                     /translation="MASPAAGGVVIIGSGLIGRSWAMLFASGGFKVKLYDIEQQQITN
                     ALESIRKEMKSLEQSGSLKGSLGAEQQLSLISGCGNLAEAVEGAMHIQECVPENLELK
                     KKIFAQLDRIVDDQVILSSSSSCLLPSKLFTGLAHVKQCIVAHPVNPPYYVPLVELVP
                     HPETAPATMDRTYALMKKIRQTPVRVLKEIDGFVLNRLQYAIISEAWRLVEEGIVSPN
                     DLDLVMSDGLGMRYAFIGPLETMHLNAEGMVSYCDRYSEGMKRVLKTFGPVPEFSGDT
                     VEKVNQDMCMKVPDDPEHLAARRHWRDDCLMQLSKLKHQMQPQ"
     exon            105..212
                     /gene="Cryl1"
                     /inference="alignment:Splign:2.1.0"
     exon            213..339
                     /gene="Cryl1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..501
                     /gene="Cryl1"
                     /inference="alignment:Splign:2.1.0"
     exon            502..696
                     /gene="Cryl1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..802
                     /gene="Cryl1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..909
                     /gene="Cryl1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1416
                     /gene="Cryl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacccgctca gctttgctgg ctccctccgc tagcgcagct gtacggccag gcccggatct
       61 gccatggcgt ccccagcagc gggcggggtg gtgatcatag gcagtggact cattggccgg
      121 agctgggcta tgctgtttgc cagtggaggc ttcaaggtga aactctatga cattgagcaa
      181 cagcagataa cgaacgccct ggaaagcatc aggaaggaga tgaaatcgct ggagcagtct
      241 ggttctctca aaggctccct gggcgcagag cagcagctct ctctcatcag tggctgcggt
      301 aacctcgccg aagcagtaga gggcgccatg cacattcagg agtgcgttcc ggagaaccta
      361 gaactgaaga agaagatttt tgcccagctg gaccgcattg tggacgacca ggtcatcctc
      421 agcagctcta gctcatgcct gctgccttcc aagctgttca cgggcttggc acatgtgaag
      481 cagtgcatcg tggctcatcc tgtcaatcca ccatattatg tcccgctggt tgagctagtc
      541 cctcacccag agacagctcc agccacaatg gacagaacct atgccttgat gaagaagatt
      601 agacagaccc cagtgagagt cctgaaggag atcgatggct ttgtcctgaa ccgcttgcag
      661 tacgcgatca tcagtgaggc ctggagactg gtggaggaag gaatagtgtc tcctaacgac
      721 ctggacctgg tcatgtcaga tgggctgggt atgcggtatg cgttcattgg acccttggag
      781 accatgcacc tcaatgcgga aggtatggtg agctactgtg acagatacag tgaaggaatg
      841 aagcgtgtcc tcaagacttt tgggcctgtt cccgagttct caggggacac agtggagaaa
      901 gttaaccagg acatgtgcat gaaggttcca gatgatccag agcacttagc tgccaggagg
      961 cattggaggg acgactgtct catgcaactc tccaaactga agcaccagat gcagccccag
     1021 tgaatttcct gtaatgcccc tgctccttct gggcagagct gttagggaga tgagaagctc
     1081 ttgaaccaat ccctgtgcag catcaagaag cccaggtctg ctcccctgtg tttcactgtg
     1141 ggcagctata gaggccaagt gtcttctggt cactcctgcc aagccctgca ctgggtatgg
     1201 aagcactgct taggttctga ggtggcttcc tgccaccttg ggcaaacagg ctgaagagtc
     1261 caccttttct ttccagtgtg attacacatg catttccagg tgatgatgtt cagtttcctg
     1321 ttaccttaat ccacttcaaa tgtgtttttt gtaaccattt tctaacccct ttctgagtgt
     1381 cctgtaacct tcacaataaa gcaatcactt tcagtt
//
