LOCUS       NM_033095                634 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus crystallin, gamma D (Crygd), mRNA.
ACCESSION   NM_033095
VERSION     NM_033095.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 634)
  AUTHORS   Johnson,A.C., Lee,J.W., Harmon,A.C., Morris,Z., Wang,X.,
            Fratkin,J., Rapp,J.P., Gomez-Sanchez,E. and Garrett,M.R.
  TITLE     A mutation in the start codon of gamma-crystallin D leads to
            nuclear cataracts in the Dahl SS/Jr-Ctr strain
  JOURNAL   Mamm Genome 24 (3-4), 95-104 (2013)
   PUBMED   23404175
  REMARK    GeneRIF: The Met1Val substitution in CrygD is almost certainly the
            cause of cataracts in the SS/Jr-Ctr rat strain.
REFERENCE   2  (bases 1 to 634)
  AUTHORS   Wang,K., Cheng,C., Li,L., Liu,H., Huang,Q., Xia,C.H., Yao,K.,
            Sun,P., Horwitz,J. and Gong,X.
  TITLE     GammaD-crystallin associated protein aggregation and lens fiber
            cell denucleation
  JOURNAL   Invest Ophthalmol Vis Sci 48 (8), 3719-3728 (2007)
   PUBMED   17652744
REFERENCE   3  (bases 1 to 634)
  AUTHORS   Graw,J., Neuhauser-Klaus,A., Klopp,N., Selby,P.B., Loster,J. and
            Favor,J.
  TITLE     Genetic and allelic heterogeneity of Cryg mutations in eight
            distinct forms of dominant cataract in the mouse
  JOURNAL   Invest Ophthalmol Vis Sci 45 (4), 1202-1213 (2004)
   PUBMED   15037589
REFERENCE   4  (bases 1 to 634)
  AUTHORS   Nandrot,E., Slingsby,C., Basak,A., Cherif-Chefchaouni,M.,
            Benazzouz,B., Hajaji,Y., Boutayeb,S., Gribouval,O., Arbogast,L.,
            Berraho,A., Abitbol,M. and Hilal,L.
  TITLE     Gamma-D crystallin gene (CRYGD) mutation causes autosomal dominant
            congenital cerulean cataracts
  JOURNAL   J Med Genet 40 (4), 262-267 (2003)
   PUBMED   12676897
REFERENCE   5  (bases 1 to 634)
  AUTHORS   Santhiya,S.T., Shyam Manohar,M., Rawlley,D., Vijayalakshmi,P.,
            Namperumalsamy,P., Gopinath,P.M., Loster,J. and Graw,J.
  TITLE     Novel mutations in the gamma-crystallin genes cause autosomal
            dominant congenital cataracts
  JOURNAL   J Med Genet 39 (5), 352-358 (2002)
   PUBMED   12011157
REFERENCE   6  (bases 1 to 634)
  AUTHORS   Dirks,R.P., Klok,E.J., van Genesen,S.T., Schoenmakers,J.G. and
            Lubsen,N.H.
  TITLE     The sequence of regulatory events controlling the expression of the
            gamma D-crystallin gene during fibroblast growth factor-mediated
            rat lens fiber cell differentiation
  JOURNAL   Dev Biol 173 (1), 14-25 (1996)
   PUBMED   8575616
REFERENCE   7  (bases 1 to 634)
  AUTHORS   Ooki,K., Amuro,N., Shimizu,Y. and Okazaki,T.
  TITLE     High level expression of rat gamma-D-crystallin in Escherichia coli
  JOURNAL   Biochimie 76 (5), 398-403 (1994)
   PUBMED   7849105
REFERENCE   8  (bases 1 to 634)
  AUTHORS   Voorter,C.E., De Haard-Hoekman,W.A., Hermans,M.M., Bloemendal,H.
            and De Jong,W.W.
  TITLE     Differential synthesis of crystallins in the developing rat eye
            lens
  JOURNAL   Exp Eye Res 50 (4), 429-437 (1990)
   PUBMED   2338125
REFERENCE   9  (bases 1 to 634)
  AUTHORS   den Dunnen,J.T., van Neck,J.W., Cremers,F.P., Lubsen,N.H. and
            Schoenmakers,J.G.
  TITLE     Nucleotide sequence of the rat gamma-crystallin gene region and
            comparison with an orthologous human region
  JOURNAL   Gene 78 (2), 201-213 (1989)
   PUBMED   2777080
REFERENCE   10 (bases 1 to 634)
  AUTHORS   den Dunnen,J.T., Moormann,R.J., Lubsen,N.H. and Schoenmakers,J.G.
  TITLE     Concerted and divergent evolution within the rat gamma-crystallin
            gene family
  JOURNAL   J Mol Biol 189 (1), 37-46 (1986)
   PUBMED   3783678
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Oct 31, 2022 this sequence version replaced NM_033095.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X57169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000009.1  73937359-73937409   c
            52-294              JAXUCZ010000009.1  73937029-73937271   c
            295-634             JAXUCZ010000009.1  73935798-73936137   c
FEATURES             Location/Qualifiers
     source          1..634
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..634
                     /gene="Crygd"
                     /gene_synonym="Cryg4; Len"
                     /note="crystallin, gamma D"
                     /db_xref="GeneID:24278"
                     /db_xref="RGD:2422"
     exon            1..51
                     /gene="Crygd"
                     /gene_synonym="Cryg4; Len"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..567
                     /gene="Crygd"
                     /gene_synonym="Cryg4; Len"
                     /note="gamma-D-crystallin; gamma-crystallin 2-2;
                     Crystallin, gamma polypeptide 4"
                     /codon_start=1
                     /product="gamma-crystallin D"
                     /protein_id="NP_149086.1"
                     /db_xref="GeneID:24278"
                     /db_xref="RGD:2422"
                     /translation="MGKITFYEDRGFQGRHYECSTDHSNLQPYFSRCNSVRVDSGCWM
                     LYEQPNFTGCQYFLRRGDYPDYQQWMGFSDSVRSCRLIPHAGSHRIRLYEREDYRGQM
                     VEFTEDCPSLQDRFHFNEIYSLNVLEGCWVLYEMTNYRGRQYLLRPGEYRRYHDWGAM
                     NARVGSLRRVMDFY"
     exon            52..294
                     /gene="Crygd"
                     /gene_synonym="Cryg4; Len"
                     /inference="alignment:Splign:2.1.0"
     exon            295..634
                     /gene="Crygd"
                     /gene_synonym="Cryg4; Len"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acactcaact gaaacctccc atccgacccg caaacaacag ccatggggaa gatcaccttc
       61 tatgaggacc gcggcttcca gggccgccac tatgagtgca gcacagacca ctccaacctg
      121 cagccctact tcagccgctg caactctgtg cgcgtggaca gtggctgctg gatgctctat
      181 gagcagccca acttcacagg ctgccagtac ttccttcgtc gcggggacta ccctgactac
      241 cagcagtgga tgggtttcag cgactctgtc cgctcctgcc gcctcatccc ccacgccggc
      301 tcccacagga tcagactgta cgagagggaa gattacagag gccagatggt agagttcact
      361 gaggactgcc cctctctcca ggaccgattc cacttcaatg agatctactc cctcaatgtg
      421 ctggagggct gctgggtcct ctatgagatg accaactaca gggggcgaca gtacctgctg
      481 aggcccgggg agtataggcg ctaccacgac tggggcgcca tgaatgccag ggttggctct
      541 ctgaggagag tcatggattt ctattaaatt ggttttttac tctacccttt ctccatctgg
      601 aagctaataa agtattttct gtgtgttccc ggca
//
