LOCUS       NM_001081660             618 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus crystallin, gamma C (Crygc), transcript variant
            2, mRNA.
ACCESSION   NM_001081660
VERSION     NM_001081660.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 618)
  AUTHORS   Yao,K., Jin,C., Zhu,N., Wang,W., Wu,R., Jiang,J. and Shentu,X.
  TITLE     A nonsense mutation in CRYGC associated with autosomal dominant
            congenital nuclear cataract in a Chinese family
  JOURNAL   Mol Vis 14, 1272-1276 (2008)
   PUBMED   18618005
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 618)
  AUTHORS   Muller,C., Wohlke,A. and Distl,O.
  TITLE     Evaluation of three canine gamma-crystallins (CRYGB, CRYGC, and
            CRYGS) as candidates for hereditary cataracts in the dachshund
  JOURNAL   Mol Vis 13, 125-132 (2007)
   PUBMED   17327821
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 618)
  AUTHORS   Organisciak,D., Darrow,R., Gu,X., Barsalou,L. and Crabb,J.W.
  TITLE     Genetic, age and light mediated effects on crystallin protein
            expression in the retina
  JOURNAL   Photochem Photobiol 82 (4), 1088-1096 (2006)
   PUBMED   16602829
REFERENCE   4  (bases 1 to 618)
  AUTHORS   Pigaga,V. and Quinlan,R.A.
  TITLE     Lenticular chaperones suppress the aggregation of the
            cataract-causing mutant T5P gamma C-crystallin
  JOURNAL   Exp Cell Res 312 (1), 51-62 (2006)
   PUBMED   16303126
REFERENCE   5  (bases 1 to 618)
  AUTHORS   Graw,J., Neuhauser-Klaus,A., Klopp,N., Selby,P.B., Loster,J. and
            Favor,J.
  TITLE     Genetic and allelic heterogeneity of Cryg mutations in eight
            distinct forms of dominant cataract in the mouse
  JOURNAL   Invest Ophthalmol Vis Sci 45 (4), 1202-1213 (2004)
   PUBMED   15037589
REFERENCE   6  (bases 1 to 618)
  AUTHORS   Szpirer,C., Szpirer,J., Van Vooren,P., Tissir,F., Simon,J.S.,
            Koike,G., Jacob,H.J., Lander,E.S., Helou,K., Klinga-Levan,K. and
            Levan,G.
  TITLE     Gene-based anchoring of the rat genetic linkage and cytogenetic
            maps: new regional localizations, orientation of the linkage
            groups, and insights into mammalian chromosome evolution
  JOURNAL   Mamm Genome 9 (9), 721-734 (1998)
   PUBMED   9716657
REFERENCE   7  (bases 1 to 618)
  AUTHORS   Voorter,C.E., De Haard-Hoekman,W.A., Hermans,M.M., Bloemendal,H.
            and De Jong,W.W.
  TITLE     Differential synthesis of crystallins in the developing rat eye
            lens
  JOURNAL   Exp Eye Res 50 (4), 429-437 (1990)
   PUBMED   2338125
REFERENCE   8  (bases 1 to 618)
  AUTHORS   den Dunnen,J.T., van Neck,J.W., Cremers,F.P., Lubsen,N.H. and
            Schoenmakers,J.G.
  TITLE     Nucleotide sequence of the rat gamma-crystallin gene region and
            comparison with an orthologous human region
  JOURNAL   Gene 78 (2), 201-213 (1989)
   PUBMED   2777080
REFERENCE   9  (bases 1 to 618)
  AUTHORS   den Dunnen,J.T., Moormann,R.J., Lubsen,N.H. and Schoenmakers,J.G.
  TITLE     Concerted and divergent evolution within the rat gamma-crystallin
            gene family
  JOURNAL   J Mol Biol 189 (1), 37-46 (1986)
   PUBMED   3783678
REFERENCE   10 (bases 1 to 618)
  AUTHORS   Moormann,R.J., den Dunnen,J.T., Bloemendal,H. and Schoenmakers,J.G.
  TITLE     Extensive intragenic sequence homology in two distinct rat lens
            gamma-crystallin cDNAs suggests duplications of a primordial gene
  JOURNAL   Proc Natl Acad Sci U S A 79 (22), 6876-6880 (1982)
   PUBMED   6294661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M19359.1.
            
            On or before Feb 24, 2007 this sequence version replaced
            XM_217421.4, XM_001072315.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the coding region compared to variant 1. The resulting protein
            (isoform 2) is shorter but has the same N- and C-termini compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..618
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..618
                     /gene="Crygc"
                     /gene_synonym="Cryg; Cryg3; Len"
                     /note="crystallin, gamma C"
                     /db_xref="GeneID:24277"
                     /db_xref="RGD:2421"
     exon            1..36
                     /gene="Crygc"
                     /gene_synonym="Cryg; Cryg3; Len"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..552
                     /gene="Crygc"
                     /gene_synonym="Cryg; Cryg3; Len"
                     /note="isoform 2 is encoded by transcript variant 2;
                     gamma-crystallin C; gamma-C-crystallin; gamma-crystallin
                     2-1; crystallin, gamma polypeptide 3"
                     /codon_start=1
                     /product="gamma-crystallin C isoform 2"
                     /protein_id="NP_001075129.1"
                     /db_xref="GeneID:24277"
                     /db_xref="RGD:2421"
                     /translation="MGKITFYEDRGFQGRCYECSSDCPNLQTYFSRCNSIRVDSGCWM
                     LYERPNYQGHQYFLRRGDYPDYQQWMGFSDSIRSCRLIPHTGSHRMRLYEKEDHKGVM
                     MELSEDCSCIQDRFHLSEVRSLHVLEGCWVLYEMPNYRGRQYLLRPQEYRRYHDWGAV
                     DAKAGSLRRVVDLY"
     exon            37..279
                     /gene="Crygc"
                     /gene_synonym="Cryg; Cryg3; Len"
                     /inference="alignment:Splign:2.1.0"
     exon            280..618
                     /gene="Crygc"
                     /gene_synonym="Cryg; Cryg3; Len"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgaactca ccacgggtca gccagccatg gggaagatca ccttctacga ggaccgaggc
       61 ttccagggcc gctgctatga gtgcagcagc gactgcccca acctgcagac ctacttcagc
      121 cgctgcaact ccatccgcgt ggacagtggc tgctggatgc tctatgagcg ccccaactac
      181 cagggccacc agtacttcct gcgacgcggg gactaccctg actaccagca gtggatgggt
      241 ttcagcgact ccattcgctc ctgccgcctc atcccccata caggttccca caggatgcgt
      301 ctgtatgaga aagaagatca caaaggcgtc atgatggagc tgagtgaaga ctgctcctgc
      361 atccaggacc gcttccacct cagtgaggtg cgctcgctgc acgtgctaga gggctgctgg
      421 gtcctctatg agatgcctaa ctaccgaggc cggcagtatc tgctgaggcc tcaagagtac
      481 cggcgctacc acgactgggg cgctgtagat gctaaggcag gctctttgcg gagggtggta
      541 gatttatact aaaataggtg aacgctacca ttttctcatt ttggaaccta ataaagtatt
      601 tagtctgtat tgttggca
//
