LOCUS       NM_012937                732 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus crystallin, beta B2 (Crybb2), mRNA.
ACCESSION   NM_012937
VERSION     NM_012937.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 732)
  AUTHORS   Liu,B.F. and Liang,J.J.
  TITLE     Protein-protein interactions among human lens acidic and basic
            beta-crystallins
  JOURNAL   FEBS Lett 581 (21), 3936-3942 (2007)
   PUBMED   17662718
REFERENCE   2  (bases 1 to 732)
  AUTHORS   Liedtke,T., Schwamborn,J.C., Schroer,U. and Thanos,S.
  TITLE     Elongation of axons during regeneration involves retinal crystallin
            beta b2 (crybb2)
  JOURNAL   Mol Cell Proteomics 6 (5), 895-907 (2007)
   PUBMED   17264069
  REMARK    GeneRIF: These data are the first to show that axonal regeneration
            is related to crybb2 movement.
REFERENCE   3  (bases 1 to 732)
  AUTHORS   Liu,B.F. and Liang,J.J.
  TITLE     Domain interaction sites of human lens betaB2-crystallin
  JOURNAL   J Biol Chem 281 (5), 2624-2630 (2006)
   PUBMED   16319073
REFERENCE   4  (bases 1 to 732)
  AUTHORS   Sergeev,Y.V., Hejtmancik,J.F. and Wingfield,P.T.
  TITLE     Energetics of domain-domain interactions and entropy driven
            association of beta-crystallins
  JOURNAL   Biochemistry 43 (2), 415-424 (2004)
   PUBMED   14717595
  REMARK    Erratum:[Biochemistry. 2007 Feb 6;46(5):1456]
REFERENCE   5  (bases 1 to 732)
  AUTHORS   Lampi,K.J., Shih,M., Ueda,Y., Shearer,T.R. and David,L.L.
  TITLE     Lens proteomics: analysis of rat crystallin sequences and
            two-dimensional electrophoresis map
  JOURNAL   Invest Ophthalmol Vis Sci 43 (1), 216-224 (2002)
   PUBMED   11773034
REFERENCE   6  (bases 1 to 732)
  AUTHORS   Dirks,R.P., Kraft,H.J., Van Genesen,S.T., Klok,E.J., Pfundt,R.,
            Schoenmakers,J.G. and Lubsen,N.H.
  TITLE     The cooperation between two silencers creates an enhancer element
            that controls both the lens-preferred and the differentiation
            stage-specific expression of the rat beta B2-crystallin gene
  JOURNAL   Eur J Biochem 239 (1), 23-32 (1996)
   PUBMED   8706714
REFERENCE   7  (bases 1 to 732)
  AUTHORS   David,L.L. and Shearer,T.R.
  TITLE     Beta-crystallins insolubilized by calpain II in vitro contain
            cleavage sites similar to beta-crystallins insolubilized during
            cataract
  JOURNAL   FEBS Lett 324 (3), 265-270 (1993)
   PUBMED   8405363
REFERENCE   8  (bases 1 to 732)
  AUTHORS   Aarts,H.J., Lubsen,N.H. and Schoenmakers,J.G.
  TITLE     Crystallin gene expression during rat lens development
  JOURNAL   Eur J Biochem 183 (1), 31-36 (1989)
   PUBMED   2753045
REFERENCE   9  (bases 1 to 732)
  AUTHORS   Carper,D., Smith-Gill,S.J. and Kinoshita,J.H.
  TITLE     Immunocytochemical localization of the 27K beta-crystallin
            polypeptide in the mouse lens during development using a specific
            monoclonal antibody: implications for cataract formation in the
            Philly mouse
  JOURNAL   Dev Biol 113 (1), 104-109 (1986)
   PUBMED   3943659
REFERENCE   10 (bases 1 to 732)
  AUTHORS   Kador,P.F., Fukui,H.N., Fukushi,S., Jernigan,H.M. Jr. and
            Kinoshita,J.H.
  TITLE     Philly mouse: a new model of hereditary cataract
  JOURNAL   Exp Eye Res 30 (1), 59-68 (1980)
   PUBMED   7363969
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012937.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X16072.1, CA997770.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680452, SAMN13663604
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                JAXUCZ010000012.1  49230192-49230271
            81-199              JAXUCZ010000012.1  49233085-49233203
            200-332             JAXUCZ010000012.1  49236241-49236373
            333-475             JAXUCZ010000012.1  49237362-49237504
            476-732             JAXUCZ010000012.1  49239860-49240116
FEATURES             Location/Qualifiers
     source          1..732
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..732
                     /gene="Crybb2"
                     /note="crystallin, beta B2"
                     /db_xref="GeneID:25422"
                     /db_xref="RGD:2417"
     exon            1..80
                     /gene="Crybb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..644
                     /gene="Crybb2"
                     /note="beta-B2 crystallin; beta-crystallin Bp;
                     R.norvegicus CRYBB2 gene (crystallin, beta B2)"
                     /codon_start=1
                     /product="beta-crystallin B2"
                     /protein_id="NP_037069.1"
                     /db_xref="GeneID:25422"
                     /db_xref="RGD:2417"
                     /translation="MASDHQTQAGKPQPLNPKIIIFEQENFQGHSHELSGPCPNLKET
                     GMEKAGSVLVQAGPWVGYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSSLRPIKV
                     DSQEHKIILYENPNFTGKKMEIVDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYR
                     GLQYLLEKGDYKDNSDFGAPHPQVQSVRRIRDMQWHQRGAFHPSS"
     exon            81..199
                     /gene="Crybb2"
                     /inference="alignment:Splign:2.1.0"
     exon            200..332
                     /gene="Crybb2"
                     /inference="alignment:Splign:2.1.0"
     exon            333..475
                     /gene="Crybb2"
                     /inference="alignment:Splign:2.1.0"
     exon            476..732
                     /gene="Crybb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcacctcga caccagagag tccaccatgg cctcagacca ccagacacag gcgggcaagc
       61 cccagcccct taaccctaag atcatcatct tcgaacagga gaacttccag ggccattccc
      121 atgagctcag cgggccctgc cccaacctga aggagactgg gatggagaag gcgggctccg
      181 tcctggtgca ggctggaccc tgggtgggct acgagcaggc taattgcaag ggagagcagt
      241 ttgtgtttga gaagggcgag tacccacgct gggactcctg gaccagcagc cggaggacgg
      301 actccctcag ttctctgaga cccatcaaag tggacagcca agagcacaag atcatcttat
      361 atgagaaccc caactttacg ggcaagaaga tggagattgt cgatgatgac gtacccagct
      421 ttcacgctca cggataccaa gaaaaagtgt cttccgtgcg cgtgcagagc ggcacgtggg
      481 ttgggtatca gtaccctggc taccgtgggc tgcagtatct gctggagaag ggggattaca
      541 aggacaacag cgacttcggg gcccctcacc cccaggtgca atctgtgcgt cgcatccgtg
      601 acatgcagtg gcaccagcgg ggcgccttcc acccctccag ctaaagccct gaccctcccg
      661 tccccagggt ccaggcctgc caccccgggg cctcctgaca cccagagtga ataaagtgtg
      721 gcttgcaact tg
//
