LOCUS       NM_012936                980 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus crystallin, beta B1 (Crybb1), mRNA.
ACCESSION   NM_012936
VERSION     NM_012936.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 980)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   2  (bases 1 to 980)
  AUTHORS   Mackay,D.S., Boskovska,O.B., Knopf,H.L., Lampi,K.J. and Shiels,A.
  TITLE     A nonsense mutation in CRYBB1 associated with autosomal dominant
            cataract linked to human chromosome 22q
  JOURNAL   Am J Hum Genet 71 (5), 1216-1221 (2002)
   PUBMED   12360425
REFERENCE   3  (bases 1 to 980)
  AUTHORS   Lampi,K.J., Shih,M., Ueda,Y., Shearer,T.R. and David,L.L.
  TITLE     Lens proteomics: analysis of rat crystallin sequences and
            two-dimensional electrophoresis map
  JOURNAL   Invest Ophthalmol Vis Sci 43 (1), 216-224 (2002)
   PUBMED   11773034
REFERENCE   4  (bases 1 to 980)
  AUTHORS   David,L.L. and Shearer,T.R.
  TITLE     Beta-crystallins insolubilized by calpain II in vitro contain
            cleavage sites similar to beta-crystallins insolubilized during
            cataract
  JOURNAL   FEBS Lett 324 (3), 265-270 (1993)
   PUBMED   8405363
REFERENCE   5  (bases 1 to 980)
  AUTHORS   den Dunnen,J.T., Moormann,R.J., Lubsen,N.H. and Schoenmakers,J.G.
  TITLE     Intron insertions and deletions in the beta/gamma-crystallin gene
            family: the rat beta B1 gene
  JOURNAL   Proc Natl Acad Sci U S A 83 (9), 2855-2859 (1986)
   PUBMED   3458246
REFERENCE   6  (bases 1 to 980)
  AUTHORS   den Dunnen,J.T., Moormann,R.J. and Schoenmakers,J.G.
  TITLE     Rat lens beta-crystallins are internally duplicated and homologous
            to gamma-crystallins
  JOURNAL   Biochim Biophys Acta 824 (4), 295-303 (1985)
   PUBMED   3879970
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012936.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2380127.1,
                                           SRR26360194.1621467.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               JAXUCZ010000012.1  50043628-50043756   c
            130-314             JAXUCZ010000012.1  50042084-50042268   c
            315-433             JAXUCZ010000012.1  50039853-50039971   c
            434-566             JAXUCZ010000012.1  50036176-50036308   c
            567-709             JAXUCZ010000012.1  50032234-50032376   c
            710-980             JAXUCZ010000012.1  50030146-50030416   c
FEATURES             Location/Qualifiers
     source          1..980
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..980
                     /gene="Crybb1"
                     /gene_synonym="CRYB1; CRYB11"
                     /note="crystallin, beta B1"
                     /db_xref="GeneID:25421"
                     /db_xref="RGD:2416"
     exon            1..129
                     /gene="Crybb1"
                     /gene_synonym="CRYB1; CRYB11"
                     /inference="alignment:Splign:2.1.0"
     exon            130..314
                     /gene="Crybb1"
                     /gene_synonym="CRYB1; CRYB11"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..893
                     /gene="Crybb1"
                     /gene_synonym="CRYB1; CRYB11"
                     /note="beta-B1 crystallin"
                     /codon_start=1
                     /product="beta-crystallin B1"
                     /protein_id="NP_037068.2"
                     /db_xref="GeneID:25421"
                     /db_xref="RGD:2416"
                     /translation="MSQVAKAAATTAVNPGPDGKGKGTPSTGTAPAPGPTPVPASVPR
                     PAAKVGELPPGSYRLVVFEQENFQGRRVEFSGECLNLGDRGFDRVRSLIVLSGPWVAF
                     EQSAFRGEMFVLEKGEYPRWDTWTSSYRSDRLMSFRPIRMDSQEHKICLFEGANFKGN
                     TMEIQEDDVPSLWVYGFCDRVGSITVSSGTWVGYQYPGYRGYQYLLEPGDFRHWNEWG
                     AFQPQMQAVRRLRDRQWHQEGCFPVLTAEPPK"
     exon            315..433
                     /gene="Crybb1"
                     /gene_synonym="CRYB1; CRYB11"
                     /inference="alignment:Splign:2.1.0"
     exon            434..566
                     /gene="Crybb1"
                     /gene_synonym="CRYB1; CRYB11"
                     /inference="alignment:Splign:2.1.0"
     exon            567..709
                     /gene="Crybb1"
                     /gene_synonym="CRYB1; CRYB11"
                     /inference="alignment:Splign:2.1.0"
     exon            710..980
                     /gene="Crybb1"
                     /gene_synonym="CRYB1; CRYB11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggccccat ccaggtttgc tgagccagct gcctctttgt gctacactat agaccctggt
       61 gcctgccagg ttataaaatg gggggttggc cctgagggac ccataacacc agcctgtcca
      121 ccaacacagc atcagaaacc atgtctcagg ttgccaaggc tgcagccacc actgcggtga
      181 acccagggcc tgatggcaaa gggaagggaa ccccatccac agggacagcc ccagcccctg
      241 gccctactcc tgtcccagct tctgtgccca ggcctgctgc caaagtaggg gaactgcctc
      301 ctggaagcta caggctggtc gtctttgagc aggaaaactt ccagggccgc cgggtggaat
      361 tctcggggga gtgcctgaac ctgggggacc gtggcttcga cagagtgcgc agtctgatcg
      421 tcctctccgg accctgggtg gcctttgagc aatctgcctt ccgtggggag atgtttgtcc
      481 tggagaaggg tgagtaccca cgatgggaca cctggaccag cagttaccgc agtgaccggc
      541 tcatgtcctt ccggcccatc aggatggatt cccaggagca taagatctgc ctgtttgaag
      601 gggccaactt caagggcaac accatggaga tccaagagga tgacgtgccc agcctctggg
      661 tttatggctt ctgtgaccgt gtgggcagta taaccgtctc cagtggcaca tgggtcggct
      721 atcagtaccc aggctaccgt ggctaccagt atctgctgga gcccggagac ttccggcact
      781 ggaacgagtg gggtgccttc cagccgcaga tgcaggctgt gcggcgcttg cgggaccgtc
      841 agtggcacca agagggctgc ttcccggtgc taaccgctga gccccccaag tgagccaaac
      901 tcctggcctc acttctacag cccgccctgc ctcaggtccc atcccccctc ccagtcccct
      961 aataaagttc ctacagccga
//
