LOCUS       NM_173140                700 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus crystallin, beta A2 (Cryba2), mRNA.
ACCESSION   NM_173140
VERSION     NM_173140.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 700)
  AUTHORS   Puk,O., Ahmad,N., Wagner,S., Hrabe de Angelis,M. and Graw,J.
  TITLE     First mutation in the betaA2-crystallin encoding gene is associated
            with small lenses and age-related cataracts
  JOURNAL   Invest Ophthalmol Vis Sci 52 (5), 2571-2576 (2011)
   PUBMED   21212184
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 700)
  AUTHORS   Sergeev,Y.V., Hejtmancik,J.F. and Wingfield,P.T.
  TITLE     Energetics of domain-domain interactions and entropy driven
            association of beta-crystallins
  JOURNAL   Biochemistry 43 (2), 415-424 (2004)
   PUBMED   14717595
  REMARK    Erratum:[Biochemistry. 2007 Feb 6;46(5):1456]
REFERENCE   3  (bases 1 to 700)
  AUTHORS   Hulsebos,T.J., Cerosaletti,K.M., Fournier,R.E., Sinke,R.J.,
            Rocchi,M., Marzella,R., Jenkins,N.A., Gilbert,D.J. and
            Copeland,N.G.
  TITLE     Identification of the human beta A2 crystallin gene (CRYBA2):
            localization of the gene on human chromosome 2 and of the
            homologous gene on mouse chromosome 1
  JOURNAL   Genomics 28 (3), 543-548 (1995)
   PUBMED   7490092
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY158891.1.
            
            [WARNING] On Jul 22, 2024 this sequence was replaced by
            NM_173140.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY158891.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..700
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..700
                     /gene="Cryba2"
                     /note="crystallin, beta A2"
                     /db_xref="GeneID:286925"
                     /db_xref="RGD:628768"
     exon            1..32
                     /gene="Cryba2"
                     /inference="alignment:Splign:2.1.0"
     exon            33..197
                     /gene="Cryba2"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..630
                     /gene="Cryba2"
                     /note="betaA2-crystallin"
                     /codon_start=1
                     /product="beta-crystallin A2"
                     /protein_id="NP_775163.1"
                     /db_xref="GeneID:286925"
                     /db_xref="RGD:628768"
                     /translation="MSSAPAPGPAPACLTLWDEEDFQGRRCRLLSDCANVCERGALRR
                     VRSVKVENGAWVAFEYPDFQGQQFILEKGDYPCWSAWSGSSGHHSNQLLSFRPVLCAN
                     HSDSRVTLFEGENFQGCKFELSDDYPSLPSMGWTSKDVGSLKVSSGAWVAYQYPGYRG
                     YQYVLERDRHSGEFRTYNDFGTQAHTGQLQSIRRVQH"
     exon            198..339
                     /gene="Cryba2"
                     /inference="alignment:Splign:2.1.0"
     exon            340..482
                     /gene="Cryba2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..685
                     /gene="Cryba2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cattttccgt aggtgcggtg ctcactcact tgcgacatga gcagcgcccc ggcaccgggc
       61 ccggcacccg cttgcctcac gctctgggac gaggaggact tccagggtcg tcgctgccgg
      121 ctactgagcg actgtgccaa cgtctgtgag cggggagccc tgcggagggt gcgctcagtc
      181 aaggtggaaa acggcgcatg ggtggccttt gagtaccccg acttccaggg acagcagttc
      241 attctagaga agggagacta tccttgctgg agtgcctgga gcggtagcag cggccaccac
      301 agcaaccaat tgctgtcctt caggccagtg ctctgtgcga accacagtga cagccgtgtg
      361 accctgtttg agggggaaaa cttccagggc tgcaagtttg aactcagtga tgactaccca
      421 tcactgcctt ccatgggctg gaccagcaaa gatgtgggtt ccctcaaagt cagctctgga
      481 gcgtgggtgg cctaccaata ccctggctac cgaggctacc agtatgtctt agaacgggac
      541 cggcacagtg gggagttccg tacctacaat gactttggca cacaggccca tactggacag
      601 ctgcagtcca ttcgaagagt ccagcattag gctccacatt cccagacatc acccataaga
      661 ttctcaataa aagctctaga acctaaaaaa aaaaaaaaaa
//
