LOCUS       NM_013056                782 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus crystallin, beta A1 (Cryba1), mRNA.
ACCESSION   NM_013056 XM_001080813 XM_340846
VERSION     NM_013056.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 782)
  AUTHORS   Yamada,T., Nanashima,N., Shimizu,T., Nakazawa,Y., Nakazawa,M. and
            Tsuchida,S.
  TITLE     Establishment of a recessive mutant small-eye rat with lens
            involution and retinal detachment associated with partial deletion
            and rearrangement of the Cryba1 gene
  JOURNAL   Biochem J 471 (2), 293-305 (2015)
   PUBMED   26303524
  REMARK    GeneRIF: These results suggest that the disappearance of the
            betaA3/A1-crystallin protein and, in addition, down-regulation of
            the Nufip2 gene as a consequence of gene rearrangement causes the
            HiSER phenotype.
REFERENCE   2  (bases 1 to 782)
  AUTHORS   Valapala,M., Edwards,M., Hose,S., Hu,J., Wawrousek,E., Lutty,G.A.,
            Zigler,J.S. Jr., Qian,J. and Sinha,D.
  TITLE     betaA3/A1-crystallin is a critical mediator of STAT3 signaling in
            optic nerve astrocytes
  JOURNAL   Sci Rep 5, 8755 (2015)
   PUBMED   25736717
  REMARK    GeneRIF: Data show that strocytes deficient in betaA3/A1-crystallin
            protein exhibit altered levels of total and activated signal
            transducer and activator of transcription 3 (STAT3).
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 782)
  AUTHORS   Zhu,J., Shao,J., Yao,Y., Chu,Z.D., Yu,Q.Q., Zhao,W., Lin,Q. and
            Zhang,Z.Y.
  TITLE     Differential proteomics analysis of proteins from human diabetic
            and age-related cataractous lenses
  JOURNAL   J Res Med Sci 18 (11), 984-989 (2013)
   PUBMED   24520233
REFERENCE   4  (bases 1 to 782)
  AUTHORS   Yu,Y., Li,J., Xu,J., Wang,Q., Yu,Y. and Yao,K.
  TITLE     Congenital polymorphic cataract associated with a G to A splice
            site mutation in the human beta-crystallin gene CRYbetaA3/A1
  JOURNAL   Mol Vis 18, 2213-2220 (2012)
   PUBMED   22919269
REFERENCE   5  (bases 1 to 782)
  AUTHORS   Yang,Z., Su,D., Li,Q., Yang,F., Ma,Z., Zhu,S. and Ma,X.
  TITLE     A novel T-->G splice site mutation of CRYBA1/A3 associated with
            autosomal dominant nuclear cataracts in a Chinese family
  JOURNAL   Mol Vis 18, 1283-1288 (2012)
   PUBMED   22665976
REFERENCE   6  (bases 1 to 782)
  AUTHORS   Lampi,K.J., Shih,M., Ueda,Y., Shearer,T.R. and David,L.L.
  TITLE     Lens proteomics: analysis of rat crystallin sequences and
            two-dimensional electrophoresis map
  JOURNAL   Invest Ophthalmol Vis Sci 43 (1), 216-224 (2002)
   PUBMED   11773034
REFERENCE   7  (bases 1 to 782)
  AUTHORS   Graw,J., Jung,M., Loster,J., Klopp,N., Soewarto,D., Fella,C.,
            Fuchs,H., Reis,A., Wolf,E., Balling,R. and Hrabe de Angelis,M.
  TITLE     Mutation in the betaA3/A1-crystallin encoding gene Cryba1 causes a
            dominant cataract in the mouse
  JOURNAL   Genomics 62 (1), 67-73 (1999)
   PUBMED   10585769
REFERENCE   8  (bases 1 to 782)
  AUTHORS   Litt,M., Carrero-Valenzuela,R., LaMorticella,D.M., Schultz,D.W.,
            Mitchell,T.N., Kramer,P. and Maumenee,I.H.
  TITLE     Autosomal dominant cerulean cataract is associated with a chain
            termination mutation in the human beta-crystallin gene CRYBB2
  JOURNAL   Hum Mol Genet 6 (5), 665-668 (1997)
   PUBMED   9158139
REFERENCE   9  (bases 1 to 782)
  AUTHORS   Aarts,H.J., Lubsen,N.H. and Schoenmakers,J.G.
  TITLE     Crystallin gene expression during rat lens development
  JOURNAL   Eur J Biochem 183 (1), 31-36 (1989)
   PUBMED   2753045
REFERENCE   10 (bases 1 to 782)
  AUTHORS   Aarts,H.J., Jacobs,E.H., van Willigen,G., Lubsen,N.H. and
            Schoenmakers,J.G.
  TITLE     Different evolution rates within the lens-specific beta-crystallin
            gene family
  JOURNAL   J Mol Evol 28 (4), 313-321 (1989)
   PUBMED   2499686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Sep 1, 2012 this sequence version replaced
            XM_001080813.3, XM_340846.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA997738.1, DV214089.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                JAXUCZ010000010.1  63112782-63112817   c
            37-101              JAXUCZ010000010.1  63111021-63111085   c
            102-220             JAXUCZ010000010.1  63110033-63110151   c
            221-362             JAXUCZ010000010.1  63108696-63108837   c
            363-505             JAXUCZ010000010.1  63107225-63107367   c
            506-782             JAXUCZ010000010.1  63106465-63106741   c
FEATURES             Location/Qualifiers
     source          1..782
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..782
                     /gene="Cryba1"
                     /gene_synonym="BA3A1C; beta-A3"
                     /note="crystallin, beta A1"
                     /db_xref="GeneID:25583"
                     /db_xref="RGD:2415"
     exon            1..36
                     /gene="Cryba1"
                     /gene_synonym="BA3A1C; beta-A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..653
                     /gene="Cryba1"
                     /gene_synonym="BA3A1C; beta-A3"
                     /note="beta-A3 crystallin"
                     /codon_start=1
                     /product="beta-crystallin A3"
                     /protein_id="NP_037188.1"
                     /db_xref="GeneID:25583"
                     /db_xref="RGD:2415"
                     /translation="METQTVQRELETLPTTKMAQTNPMPGSMGPWKITIYDQENFQGK
                     RMEFTSSCPNVSERSFDNVRSLKVECGAWIGYEHTSFCGQQFILERGEYPRWDAWSGS
                     NAYHIERLMSFRPICSANHKESKITIFEKENFIGRQWEICDDYPSLQAMGWFNNEVGS
                     MKIQCGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGTHAQTSQIQSIRRIQQ"
     exon            37..101
                     /gene="Cryba1"
                     /gene_synonym="BA3A1C; beta-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            102..220
                     /gene="Cryba1"
                     /gene_synonym="BA3A1C; beta-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            221..362
                     /gene="Cryba1"
                     /gene_synonym="BA3A1C; beta-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            363..505
                     /gene="Cryba1"
                     /gene_synonym="BA3A1C; beta-A3"
                     /inference="alignment:Splign:2.1.0"
     exon            506..782
                     /gene="Cryba1"
                     /gene_synonym="BA3A1C; beta-A3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accagatgga gacccagact gtgcagcggg agctggaaac tcttccaacc accaagatgg
       61 ctcagaccaa ccctatgcca gggtccatgg ggccatggaa gataaccatc tatgatcagg
      121 agaacttcca gggcaagagg atggagttca ccagctcctg cccaaatgtc tctgaacgta
      181 gttttgataa tgtccggtca cttaaggtgg agtgtggcgc ctggattggt tatgagcaca
      241 ccagcttctg tgggcaacag ttcatcctgg agagaggaga ataccctcga tgggatgcct
      301 ggagtgggag caatgcctat catattgagc gtctcatgtc cttccgaccc atctgttctg
      361 ctaatcataa agagtctaag atcaccatct ttgagaaaga gaactttatt ggacgccagt
      421 gggagatctg tgatgactac ccttccttac aagccatggg ttggttcaac aatgaagtgg
      481 gttccatgaa gatacagtgt ggagcttggg tttgctacca gtatcctgga tatcgtggtt
      541 atcagtatat cttggaatgt gaccatcacg gaggagacta caaacactgg agagagtggg
      601 gaactcatgc tcagacttct cagatccaat caattcgccg aatacaacaa tagtagagtc
      661 aaagattcaa aattcctcaa gcatgcaaac ttactaagca ttatagaatt ttatgttctg
      721 cccagacact gcatccaaat gttagcacta aaatccacaa taaatgtcat ttaaaaaaaa
      781 aa
//
