LOCUS       NM_133405               3988 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cryptochrome circadian regulator 2 (Cry2), mRNA.
ACCESSION   NM_133405 XM_006234547
VERSION     NM_133405.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3988)
  AUTHORS   Sokolowska,E., Viitanen,R., Misiewicz,Z., Mennesson,M., Saarnio,S.,
            Kulesskaya,N., Kangsep,S., Liljenback,H., Marjamaki,P., Autio,A.,
            Callan,S.A., Nuutila,P., Roivainen,A., Partonen,T. and Hovatta,I.
  TITLE     The circadian gene Cryptochrome 2 influences stress-induced brain
            activity and depressive-like behavior in mice
  JOURNAL   Genes Brain Behav 20 (4), e12708 (2021)
   PUBMED   33070440
  REMARK    GeneRIF: The circadian gene Cryptochrome 2 influences
            stress-induced brain activity and depressive-like behavior in mice.
REFERENCE   2  (bases 1 to 3988)
  AUTHORS   Wong,J.C.Y., Smyllie,N.J., Banks,G.T., Pothecary,C.A.,
            Barnard,A.R., Maywood,E.S., Jagannath,A., Hughes,S., van der
            Horst,G.T.J., MacLaren,R.E., Hankins,M.W., Hastings,M.H.,
            Nolan,P.M., Foster,R.G. and Peirson,S.N.
  TITLE     Differential roles for cryptochromes in the mammalian retinal clock
  JOURNAL   FASEB J 32 (8), 4302-4314 (2018)
   PUBMED   29561690
REFERENCE   3  (bases 1 to 3988)
  AUTHORS   Kriebs,A., Jordan,S.D., Soto,E., Henriksson,E., Sandate,C.R.,
            Vaughan,M.E., Chan,A.B., Duglan,D., Papp,S.J., Huber,A.L.,
            Afetian,M.E., Yu,R.T., Zhao,X., Downes,M., Evans,R.M. and
            Lamia,K.A.
  TITLE     Circadian repressors CRY1 and CRY2 broadly interact with nuclear
            receptors and modulate transcriptional activity
  JOURNAL   Proc Natl Acad Sci U S A 114 (33), 8776-8781 (2017)
   PUBMED   28751364
REFERENCE   4  (bases 1 to 3988)
  AUTHORS   Jordan,S.D., Kriebs,A., Vaughan,M., Duglan,D., Fan,W.,
            Henriksson,E., Huber,A.L., Papp,S.J., Nguyen,M., Afetian,M.,
            Downes,M., Yu,R.T., Kralli,A., Evans,R.M. and Lamia,K.A.
  TITLE     CRY1/2 Selectively Repress PPARdelta and Limit Exercise Capacity
  JOURNAL   Cell Metab 26 (1), 243-255 (2017)
   PUBMED   28683290
REFERENCE   5  (bases 1 to 3988)
  AUTHORS   Goriki,A., Hatanaka,F., Myung,J., Kim,J.K., Yoritaka,T., Tanoue,S.,
            Abe,T., Kiyonari,H., Fujimoto,K., Kato,Y., Todo,T., Matsubara,A.,
            Forger,D. and Takumi,T.
  TITLE     A novel protein, CHRONO, functions as a core component of the
            mammalian circadian clock
  JOURNAL   PLoS Biol 12 (4), e1001839 (2014)
   PUBMED   24736997
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3988)
  AUTHORS   van der Horst,G.T., Muijtjens,M., Kobayashi,K., Takano,R.,
            Kanno,S., Takao,M., de Wit,J., Verkerk,A., Eker,A.P., van
            Leenen,D., Buijs,R., Bootsma,D., Hoeijmakers,J.H. and Yasui,A.
  TITLE     Mammalian Cry1 and Cry2 are essential for maintenance of circadian
            rhythms
  JOURNAL   Nature 398 (6728), 627-630 (1999)
   PUBMED   10217146
REFERENCE   7  (bases 1 to 3988)
  AUTHORS   Kobayashi,K., Kanno,S., Smit,B., van der Horst,G.T., Takao,M. and
            Yasui,A.
  TITLE     Characterization of photolyase/blue-light receptor homologs in
            mouse and human cells
  JOURNAL   Nucleic Acids Res 26 (22), 5086-5092 (1998)
   PUBMED   9801304
REFERENCE   8  (bases 1 to 3988)
  AUTHORS   Ishibashi,K., Miyamoto,K., Taketani,Y., Morita,K., Takeda,E.,
            Sasaki,S. and Imai,M.
  TITLE     Molecular cloning of a second human stanniocalcin homologue (STC2)
  JOURNAL   Biochem Biophys Res Commun 250 (2), 252-258 (1998)
   PUBMED   9753616
REFERENCE   9  (bases 1 to 3988)
  AUTHORS   Zhao,S. and Sancar,A.
  TITLE     Human blue-light photoreceptor hCRY2 specifically interacts with
            protein serine/threonine phosphatase 5 and modulates its activity
  JOURNAL   Photochem Photobiol 66 (5), 727-731 (1997)
   PUBMED   9383998
REFERENCE   10 (bases 1 to 3988)
  AUTHORS   Hsu,D.S., Zhao,X., Zhao,S., Kazantsev,A., Wang,R.P., Todo,T.,
            Wei,Y.F. and Sancar,A.
  TITLE     Putative human blue-light photoreceptors hCRY1 and hCRY2 are
            flavoproteins
  JOURNAL   Biochemistry 35 (44), 13871-13877 (1996)
   PUBMED   8909283
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166416.1.
            
            On or before Feb 5, 2014 this sequence version replaced
            XM_006234547.1, NM_133405.1.
            
            Summary: This gene encodes a flavin adenine dinucleotide-binding
            protein that is a key component of the circadian core oscillator
            complex, which regulates the circadian clock. This gene is
            upregulated by Clock/Arntl heterodimers but then represses this
            upregulation in a feedback loop using Per/Cry heterodimers to
            interact with Clock/Arntl. Polymorphisms in this gene have been
            associated with altered sleep patterns. The encoded protein is
            widely conserved across plants and animals. [provided by RefSeq,
            Feb 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166416.1, FQ211347.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3988
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..3988
                     /gene="Cry2"
                     /note="cryptochrome circadian regulator 2"
                     /db_xref="GeneID:170917"
                     /db_xref="RGD:620935"
     exon            1..214
                     /gene="Cry2"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..1787
                     /gene="Cry2"
                     /note="cryptochrome 2 (photolyase-like); cryptochrome
                     circadian clock 2"
                     /codon_start=1
                     /product="cryptochrome-2"
                     /protein_id="NP_596896.2"
                     /db_xref="GeneID:170917"
                     /db_xref="RGD:620935"
                     /translation="MAAAAVVAATVPAQSMGADGASSVHWFRKGLRLHDNPALLAAVR
                     GARCVRCVYILDPWFAASSSVGINRWRFLLQSLEDLDTSLRKLNSRLFVVRGQPADVF
                     PRLFKEWGVTRLTFEYDSEPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDRIIELN
                     GQKPPLTYKRFQALISRMELPKKPVGAVSSQHMENCRAEIQENHDDTYGVPSLEELGF
                     PTEGLGPAVWQGGETEALARLDKHLERKAWVANYERPRMNANSLLASPTGLSPYLRFG
                     CLSCRLFYYRLWDLYRKVKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICI
                     QIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWVSW
                     ESGVRVFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPVGFGRRTDPSGDYIRRY
                     LPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQ
                     LSRYRGLCLLASVPSCVEDLSHPVAEPGSSQAGSISNTGPRPLSSGPASPKRKLEAAE
                     EPPGEELSKRARVTVTQMPAQEPPSKDS"
     exon            215..323
                     /gene="Cry2"
                     /inference="alignment:Splign:2.1.0"
     exon            324..466
                     /gene="Cry2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..651
                     /gene="Cry2"
                     /inference="alignment:Splign:2.1.0"
     exon            652..740
                     /gene="Cry2"
                     /inference="alignment:Splign:2.1.0"
     exon            741..881
                     /gene="Cry2"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1193
                     /gene="Cry2"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1345
                     /gene="Cry2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1548
                     /gene="Cry2"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1641
                     /gene="Cry2"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1789
                     /gene="Cry2"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..3967
                     /gene="Cry2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgatggcggc ggctgctgtg gtggcagcga cggtccccgc gcagtcgatg ggcgcggacg
       61 gcgcgtcctc cgtgcactgg ttccgcaaag gactacggct ccacgacaac cccgcgctgt
      121 tagctgccgt gcgcggggcg cgctgtgtgc gctgcgtcta catcctcgac ccgtggttcg
      181 cggcctcctc gtcagtgggc atcaaccgat ggaggttcct actgcagtct ctagaagatc
      241 tggacacaag cttaagaaag ctgaattccc gtctgtttgt agtccggggt cagccagctg
      301 atgtgttccc aaggcttttc aaggaatggg gggtgacccg cttgaccttt gaatatgact
      361 ccgaaccctt tgggaaagaa cgggatgcag ccattatgaa gatggccaag gaggcgggtg
      421 tggaggtggt gactgagaac tctcacaccc tttatgactt agacagaatc atcgaactga
      481 atgggcagaa accacccctt acctacaagc gctttcaggc tctcatcagc cgtatggagc
      541 tgcccaagaa gccagtgggg gctgtgagca gccagcatat ggagaactgc agagctgaga
      601 tccaggagaa ccatgatgac acctatggcg tgccttcctt agaggaactg ggattcccca
      661 cagaaggact tggcccagct gtttggcaag gaggagagac agaagctctg gcccgcctgg
      721 ataagcactt ggaacggaag gcctgggttg ccaactatga gagacctcgg atgaatgcca
      781 attccttgct ggccagcccc acaggcctca gcccctacct gcgctttggc tgcctctcct
      841 gccgcctctt ctactaccgc ctgtgggact tgtacagaaa ggtgaagagg aacagcacac
      901 cccccctctc cttatttgga caactcctat ggcgagaatt cttctataca gcggccacca
      961 acaaccccag gtttgaccga atggagggga accccatctg catccagatc ccctgggacc
     1021 gcaaccccga agccctggcc aagtgggccg agggcaagac aggcttccct tggattgacg
     1081 ccatcatgac ccaactgagg caggagggct ggatccacca cctggcccgg cacgctgtgg
     1141 cctgcttcct cacccgaggg gacctctggg tcagctggga gagcggggtc cgggtatttg
     1201 atgagttgct cctggatgca gatttcagcg tgaatgcagg cagctggatg tggctgtcct
     1261 gcagtgcttt cttccaacag ttcttccact gctactgccc tgtgggcttt ggccgacgca
     1321 cggaccccag tggggactac atccggcgat acctgcccaa actgaaaggc ttcccctctc
     1381 gatatatcta tgagccctgg aatgctcccg agtcggttca gaaggccgct aagtgcatca
     1441 ttggcgtgga ctacccacgg cccatcgtca accacgcaga gactagtcgg ctcaacattg
     1501 agcggatgaa gcagatctac caacagctgt cacgataccg ggggctctgt ctgttggcat
     1561 ctgtcccttc ctgtgtagaa gacctcagtc accctgtggc agagcctggt tctagccagg
     1621 ctgggagcat cagcaacaca ggccccagac cactgtccag tggcccagcc tcccccaaac
     1681 gcaagctgga agcagctgag gaacctccag gtgaagaact gagcaagcgg gctagagtga
     1741 cagtgactca gatgcctgcc caggagccac caagcaagga ctcctgagac tggagagcca
     1801 ttgctccgtg agcaaagccc aggtgcctga gctgccatgg ccacagagaa gacatggaac
     1861 ctacagagaa gacagtcacc aacagacaga gcgagcgact gtgtgtgtgc agagggaggt
     1921 gtggtgtgcc gtttgcgtgt gcatgcatct gtttacactc tcatgatcct gaatgttgcc
     1981 tgtgctggag gagcccctag atcatgcctt cttaccaggg ctgtttcttg acttccagac
     2041 ataagactag aacccgcagc agtaaccgtc agcccaaatc tgcccctggg agccccaata
     2101 gggtggtaag accctagctt gaattctggt ctctgcctcc ccagactctt cttcctccct
     2161 ccttttaaca aggagctgga gggccacatt tttgactctc atctaaagca tggagtttca
     2221 gaggcagtca gagtcctgct gacttagttc ccacttttct gacactagaa cctgagcagg
     2281 ctggaataga tgtgtcctgt tgatcttaaa cagcctggcc agtcttctta taaaatcctg
     2341 tgccattaac aggcttccct gatgtctaag gctacagact agtgtgttgt gtgcccagta
     2401 ctgcttatgt cagcctcaga cataatatca gtctttgtag aaccttctaa aaaaaaccac
     2461 atggggaata gactcccagt cttctgtccc ttccctagca gctaaggtcc agtctcgacc
     2521 ttctagaagc tgtggacagg ctagggtctg aactggtgaa agaaacccag gtcccacagc
     2581 tgcagggccc ctggttcctc tggctgtact cctgacacca catgctccag ccagtactgc
     2641 tgatatccag ccaggcaagc tggacagcct ggctggtcag cacctgccct gcagtgtcag
     2701 ctgcccagga ctgagcttcc ggagactcag acagacttag gggtggagca ctgcctctgg
     2761 cagttggcga gaggtcagag accatgcctg gcacatcaac atcttcgcag agcagcagtg
     2821 aaggattgac atagagaagt caagccttgc tttccagggg agccaactct ccctcccact
     2881 gttgggtcat atggagaaag aagttatgaa aggatctggg ggtacctgag caagtcttcc
     2941 ttccaccccg tggcctgcat ttgagccaca gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3001 gtgtgtgtgt gtgtgtgtgt gtgtgtgttt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3061 gtgtgtgtgt ggagagagag agagagagag agagagtgag tgagtttgtt tctgtttgga
     3121 tttttgttct cacatgtaac attaagctgg cctctgggcc ttttcctctc tacctcccct
     3181 gtgacctttc ctagcctcag agttgttaat gcccttggcc ctggcctttt tttgtgtcag
     3241 accagaaccc tggggtcagg ctcccccctc cagctgtcta gcacatctga caggcttctt
     3301 tttgagatgg cctcaggttt tctcagcaga gagctgcctt tagtccaact gtttatgttc
     3361 atcatcctga ctagaagcat cctacgattg tgtgaagaaa cggcatctgt gatgccatgt
     3421 tcagagtcat ggggtgtggc ctccctgtcc ctagccccag gccaagagga aagggccaaa
     3481 ggctcttgct ggagggacag tagaatgcgt ctggagaact ggtcccagag gagcaaaggc
     3541 ttattctggg gccagtattt attttgcaac atcttcagct atggggacaa tggccttctc
     3601 tgcttttttg atgatggctc tctcctcaag gtacaagttg gcaaggtcat ctgtccttcc
     3661 acctccttga catgttggcc catttccagg acagccttcc agtgaatgga gcagactatt
     3721 ccacagctgt gggatagagt gtcttggagc cctggaatga cttcatgcct ccttttgcct
     3781 agcctgagtg gccctgagga ctgtcacaga acagtgcccc atgtcctgct cctgggcccg
     3841 agcatgggga agagatggtt gcaggcaaga gcactttaca gcattcccca ttgctgggaa
     3901 ggttgtttct cctacagtgt gtgaatactt acctgtttta taaatgtctg atcctgtctg
     3961 agtaaaaaaa aaaaaaaaaa aaaaaaaa
//
