LOCUS       NM_198750               2938 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus cryptochrome circadian regulator 1 (Cry1), mRNA.
ACCESSION   NM_198750 XM_216868
VERSION     NM_198750.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2938)
  AUTHORS   Peng,J., Zhao,J., Tang,Q., Wang,J., Song,W., Lu,X., Huang,X.,
            Chen,G., Zheng,W., Zhang,L., Han,Y., Yan,C., Wan,Q. and Chen,L.
  TITLE     Low intensity near-infrared light promotes bone regeneration via
            circadian clock protein cryptochrome 1
  JOURNAL   Int J Oral Sci 14 (1), 53 (2022)
   PUBMED   36376275
  REMARK    GeneRIF: Low intensity near-infrared light promotes bone
            regeneration via circadian clock protein cryptochrome 1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2938)
  AUTHORS   Toledo,M., Batista-Gonzalez,A., Merheb,E., Aoun,M.L., Tarabra,E.,
            Feng,D., Sarparanta,J., Merlo,P., Botre,F., Schwartz,G.J.,
            Pessin,J.E. and Singh,R.
  TITLE     Autophagy Regulates the Liver Clock and Glucose Metabolism by
            Degrading CRY1
  JOURNAL   Cell Metab 28 (2), 268-281 (2018)
   PUBMED   29937374
REFERENCE   3  (bases 1 to 2938)
  AUTHORS   Wong,J.C.Y., Smyllie,N.J., Banks,G.T., Pothecary,C.A.,
            Barnard,A.R., Maywood,E.S., Jagannath,A., Hughes,S., van der
            Horst,G.T.J., MacLaren,R.E., Hankins,M.W., Hastings,M.H.,
            Nolan,P.M., Foster,R.G. and Peirson,S.N.
  TITLE     Differential roles for cryptochromes in the mammalian retinal clock
  JOURNAL   FASEB J 32 (8), 4302-4314 (2018)
   PUBMED   29561690
REFERENCE   4  (bases 1 to 2938)
  AUTHORS   Mavroudis,P.D., DuBois,D.C., Almon,R.R. and Jusko,W.J.
  TITLE     Modeling circadian variability of core-clock and clock-controlled
            genes in four tissues of the rat
  JOURNAL   PLoS One 13 (6), e0197534 (2018)
   PUBMED   29894471
  REMARK    GeneRIF: The model efficiently described the synchronous
            rhythmicity of core-clock genes and further predicted that their
            phases are mainly regulated by Per2 and Cry1 transcriptional delays
            and Rev-Erba and Cry1 degradation rates.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2938)
  AUTHORS   Tong,X., Zhang,D., Charney,N., Jin,E., VanDommelen,K., Stamper,K.,
            Gupta,N., Saldate,J. and Yin,L.
  TITLE     DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven
            Gluconeogenesis in Liver
  JOURNAL   Diabetes 66 (10), 2571-2582 (2017)
   PUBMED   28790135
  REMARK    Erratum:[Diabetes. 2017 Dec;66(12):3144. doi: 10.2337/db17-er12e..
            PMID: 28993340]
REFERENCE   6  (bases 1 to 2938)
  AUTHORS   Kume,K., Zylka,M.J., Sriram,S., Shearman,L.P., Weaver,D.R., Jin,X.,
            Maywood,E.S., Hastings,M.H. and Reppert,S.M.
  TITLE     mCRY1 and mCRY2 are essential components of the negative limb of
            the circadian clock feedback loop
  JOURNAL   Cell 98 (2), 193-205 (1999)
   PUBMED   10428031
REFERENCE   7  (bases 1 to 2938)
  AUTHORS   van der Horst,G.T., Muijtjens,M., Kobayashi,K., Takano,R.,
            Kanno,S., Takao,M., de Wit,J., Verkerk,A., Eker,A.P., van
            Leenen,D., Buijs,R., Bootsma,D., Hoeijmakers,J.H. and Yasui,A.
  TITLE     Mammalian Cry1 and Cry2 are essential for maintenance of circadian
            rhythms
  JOURNAL   Nature 398 (6728), 627-630 (1999)
   PUBMED   10217146
REFERENCE   8  (bases 1 to 2938)
  AUTHORS   Kobayashi,K., Kanno,S., Smit,B., van der Horst,G.T., Takao,M. and
            Yasui,A.
  TITLE     Characterization of photolyase/blue-light receptor homologs in
            mouse and human cells
  JOURNAL   Nucleic Acids Res 26 (22), 5086-5092 (1998)
   PUBMED   9801304
REFERENCE   9  (bases 1 to 2938)
  AUTHORS   Zhao,S. and Sancar,A.
  TITLE     Human blue-light photoreceptor hCRY2 specifically interacts with
            protein serine/threonine phosphatase 5 and modulates its activity
  JOURNAL   Photochem Photobiol 66 (5), 727-731 (1997)
   PUBMED   9383998
REFERENCE   10 (bases 1 to 2938)
  AUTHORS   Hsu,D.S., Zhao,X., Zhao,S., Kazantsev,A., Wang,R.P., Todo,T.,
            Wei,Y.F. and Sancar,A.
  TITLE     Putative human blue-light photoreceptors hCRY1 and hCRY2 are
            flavoproteins
  JOURNAL   Biochemistry 35 (44), 13871-13877 (1996)
   PUBMED   8909283
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC107677.1.
            
            On Nov 6, 2005 this sequence version replaced NM_198750.1.
            
            Summary: This gene encodes a flavin adenine dinucleotide-binding
            protein that is a key component of the circadian core oscillator
            complex, which regulates the circadian clock. This gene is
            upregulated by Clock/Arntl heterodimers but then represses this
            upregulation in a feedback loop using Per/Cry heterodimers to
            interact with Clock/Arntl. Polymorphisms in this gene have been
            associated with altered sleep patterns. The encoded protein is
            widely conserved across plants and animals. Loss of the related
            gene in mouse results in a shortened circadian cycle in complete
            darkness. [provided by RefSeq, Feb 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107677.1, AF545855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2938
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..2938
                     /gene="Cry1"
                     /note="cryptochrome circadian regulator 1"
                     /db_xref="GeneID:299691"
                     /db_xref="RGD:735083"
     exon            1..694
                     /gene="Cry1"
                     /inference="alignment:Splign:2.1.0"
     CDS             537..2303
                     /gene="Cry1"
                     /note="cryptochrome 1 (photolyase-like); cryptochrome
                     circadian clock 1"
                     /codon_start=1
                     /product="cryptochrome-1"
                     /protein_id="NP_942045.2"
                     /db_xref="GeneID:299691"
                     /db_xref="RGD:735083"
                     /translation="MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGS
                     SNVGINRWRFLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFKEWNITKLSIEYDS
                     EPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDKIIELNGGQPPLTYKRFQTLVSKM
                     EPLEMPADTITSDVIGKCTTPLSDDHDEKYGVPSLEELGFDTDGLSSAVWPGGETEAL
                     TRLERHLERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKKV
                     KKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGR
                     TGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELLLDADWSI
                     NAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVLRGFPAKYIYDPWNA
                     PEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGLGLLASVPSNPN
                     GNGGLMGYAPGENVPSGGSGGGNCSQGSGILHYAHGDSQQTNPLKQGRSSMGTGLSSG
                     KRPSQEEDAQSVGPKVQRQSSN"
     exon            695..803
                     /gene="Cry1"
                     /inference="alignment:Splign:2.1.0"
     exon            804..946
                     /gene="Cry1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1131
                     /gene="Cry1"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1220
                     /gene="Cry1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1361
                     /gene="Cry1"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1673
                     /gene="Cry1"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1825
                     /gene="Cry1"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..2028
                     /gene="Cry1"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2127
                     /gene="Cry1"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2199
                     /gene="Cry1"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2307
                     /gene="Cry1"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2923
                     /gene="Cry1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgcggcct ggagctctag cccgcgctat ccgagctcgc tgcccactct ggggcgcaca
       61 ggccgcgtcg cgcggaggcc gcggaagctc gtgtcggtcc gtggaggccg cctggggcgc
      121 gccaccgtct cctcgcgggc cgcctcggtt gggcgagctt tccgtgacga gcctcccggg
      181 gctgctgcgg ccagctcggg ccgtcgtggc ggctcgagcc ccgcgcgctc gcttgtactc
      241 cgggggtccc aggccctgga aggtatgcgt gtcctccgga cgctgggcgc gggctcctga
      301 aggacgtcgc gcgtggatcc cggagcctcg gcagcctcca ttcatctgcc agctgcgcgc
      361 tcgccgcctc cgcgccccgc ctcggcgtcg cctcctcccg tcccctctct gccgcccttt
      421 ccccactcct cgcgtgagga ggttctcctg gaagcgcagg tgtcggttat gagcccgact
      481 tccctcgctt gaagctctcg gtagaagaag tcggggtgac ccgccgcgcc ccgagcatgg
      541 gggtgaacgc cgtgcattgg ttccgaaagg gactccggct gcacgacaac cccgccctga
      601 aggagtgcat ccagggcgcc gacaccatcc gctgcgtgta catcctcgac ccctggttcg
      661 ccggctcttc caacgtgggc atcaacaggt ggcgattttt gcttcagtgt cttgaggacc
      721 ttgatgccaa tctacgaaag ttaaattctc gcctgtttgt gatccgggga cagccagctg
      781 acgtgtttcc gaggcttttc aaggaatgga atattactaa actttcaatt gagtacgatt
      841 ctgagccttt tgggaaggaa cgagatgcgg ccatcaagaa gctggccact gaggctggtg
      901 tggaagtcat cgtgcgcatt tcacacacac tgtatgacct agacaagatc atagaactca
      961 atggtgggca gccaccccta acatacaaaa ggtttcagac tctcgtcagc aaaatggagc
     1021 ccctggagat gccagcagac accatcacat cagacgtgat agggaagtgc acaacccctc
     1081 tgtccgacga ccatgatgag aagtacggag ttccttccct ggaggagctc ggttttgata
     1141 ccgatggctt gtcctctgcg gtgtggccag gaggagaaac tgaggcactt acacgtttgg
     1201 aaaggcattt ggaaagaaag gcctgggtgg caaactttga aagacctcga atgaatgcaa
     1261 actccctgct cgcaagccca actggactga gtccttatct ccgcttcggt tgtttgtcat
     1321 gtcggctatt ttatttcaaa ctaacagatc tctacaaaaa ggtaaagaaa aatagttccc
     1381 ctcccctttc tctttatggg caactcctgt ggcgtgaatt tttttataca gcagccacaa
     1441 acaacccacg ctttgacaaa atggaaggga accccatctg tgttcaaatc ccttgggaca
     1501 agaatcccga ggctctggcc aaatgggcag aaggccggac aggctttccg tggattgacg
     1561 ccatcatgac acagcttcgt caggagggct ggatccacca tctagcccga catgcagttg
     1621 cctgtttcct gacccgcggc gacctatgga tcagttggga agaagggatg aaggtctttg
     1681 aagaattact gcttgacgcc gactggagca tcaatgctgg gagttggatg tggctgtcct
     1741 gcagttcctt tttccaacag tttttccact gctactgccc tgttggtttt ggtaggagga
     1801 cagaccccaa tggagactat attaggcgtt atttgcctgt cctaagaggc ttccctgcaa
     1861 aatatatcta cgatccttgg aatgcaccag aaggtatcca gaaggtagcc aaatgtttga
     1921 taggcgttaa ttatcccaaa ccaatggtga accatgccga ggcaagtcga ctgaatattg
     1981 aaagaatgaa gcagatctat cagcagctct cccgctacag agggctaggc ctccttgcct
     2041 cagtcccttc taatcctaat gggaacggag ggctcatggg ctatgctcct ggagagaatg
     2101 tccccagcgg tggcagtggt ggcggaaact gctctcaagg aagtggtatt ttacactatg
     2161 ctcacggaga cagtcagcaa actaacccac taaagcaagg aagaagctcc atgggcactg
     2221 gcctcagcag cgggaagcgc ccaagtcagg aagaggacgc acagagtgtt ggccccaaag
     2281 tccagcgaca gagcagtaac tgatacgaaa gcatgcggga ggagtcctcg cagctgaagt
     2341 tggtgggaga gtcagtactt ctcatttaaa ttatttaaaa atgtcattca ttcatggaaa
     2401 acagttatat ttcgaacata ttatttctaa tatttctgtg gtttttaact ttttaatgaa
     2461 tgtcacatag gacaagtggt aatttgtata taaagaactt ggtaaaaaat ttgcttaatg
     2521 taaatatagc cacagttaga atagactcat cagtatattt ttgataattt ttcatgtatg
     2581 gtaaaagtta aagttaacag atattctgat ataaatctca agagttttga gagtcattgt
     2641 gggaaaatgg gaagttttta gactttctta aaaagacttt gttaaaattt taggacacat
     2701 ttttccagac atcattgttt gacctaattt tgcagtcttt gataatactg ctttagaagc
     2761 tccgtggaat cagtgcgaac gctcctgtct gcgtggacag tctgtgttac agcccgtgca
     2821 gctgctctga ctcgcactgt gcactgtgcc cagccccttt gtctccctcc ttgttcattt
     2881 ccagctaccg tgactttgtt attaaagtat atgcaaatat ggaaaaaaaa aaaaaaaa
//
