LOCUS       NM_021855               1325 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cone-rod homeobox (Crx), mRNA.
ACCESSION   NM_021855
VERSION     NM_021855.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1325)
  AUTHORS   Rohde,K., Hertz,H. and Rath,M.F.
  TITLE     Homeobox genes in melatonin-producing pinealocytes: Otx2 and Crx
            act to promote hormone synthesis in the mature rat pineal gland
  JOURNAL   J Pineal Res 66 (4), e12567 (2019)
   PUBMED   30803008
  REMARK    GeneRIF: The results suggest that Otx2 and Crx, both alone and in
            combination, act to control pineal melatonin synthesis.
REFERENCE   2  (bases 1 to 1325)
  AUTHORS   Rohde,K., Rovsing,L., Ho,A.K., Moller,M. and Rath,M.F.
  TITLE     Circadian dynamics of the cone-rod homeobox (CRX) transcription
            factor in the rat pineal gland and its role in regulation of
            arylalkylamine N-acetyltransferase (AANAT)
  JOURNAL   Endocrinology 155 (8), 2966-2975 (2014)
   PUBMED   24877634
  REMARK    GeneRIF: The rhythmic nature of pineal CRX protein may directly
            modulate the daily profile of Aanat expression by inducing
            nighttime expression of this enzyme, facilitating nocturnal
            melatonin synthesis
REFERENCE   3  (bases 1 to 1325)
  AUTHORS   Daiger,S.P., Sullivan,L.S. and Bowne,S.J.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   4  (bases 1 to 1325)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   5  (bases 1 to 1325)
  AUTHORS   Sanuki,R., Omori,Y., Koike,C., Sato,S. and Furukawa,T.
  TITLE     Panky, a novel photoreceptor-specific ankyrin repeat protein, is a
            transcriptional cofactor that suppresses CRX-regulated
            photoreceptor genes
  JOURNAL   FEBS Lett 584 (4), 753-758 (2010)
   PUBMED   20026326
REFERENCE   6  (bases 1 to 1325)
  AUTHORS   Mitton,K.P., Swain,P.K., Chen,S., Xu,S., Zack,D.J. and Swaroop,A.
  TITLE     The leucine zipper of NRL interacts with the CRX homeodomain. A
            possible mechanism of transcriptional synergy in rhodopsin
            regulation
  JOURNAL   J Biol Chem 275 (38), 29794-29799 (2000)
   PUBMED   10887186
REFERENCE   7  (bases 1 to 1325)
  AUTHORS   Kimura,A., Singh,D., Wawrousek,E.F., Kikuchi,M., Nakamura,M. and
            Shinohara,T.
  TITLE     Both PCE-1/RX and OTX/CRX interactions are necessary for
            photoreceptor-specific gene expression
  JOURNAL   J Biol Chem 275 (2), 1152-1160 (2000)
   PUBMED   10625658
REFERENCE   8  (bases 1 to 1325)
  AUTHORS   Sakamoto,K., Oishi,K., Okada,T., Onuma,Y., Yokoyama,K., Sugimoto,K.
            and Ishida,N.
  TITLE     Molecular cloning of the cone-rod homeobox gene (Crx) from the rat
            and its temporal expression pattern in the retina under a daily
            light-dark cycle
  JOURNAL   Neurosci Lett 261 (1-2), 101-104 (1999)
   PUBMED   10081937
REFERENCE   9  (bases 1 to 1325)
  AUTHORS   Freund,C.L., Wang,Q.L., Chen,S., Muskat,B.L., Wiles,C.D.,
            Sheffield,V.C., Jacobson,S.G., McInnes,R.R., Zack,D.J. and
            Stone,E.M.
  TITLE     De novo mutations in the CRX homeobox gene associated with Leber
            congenital amaurosis
  JOURNAL   Nat Genet 18 (4), 311-312 (1998)
   PUBMED   9537410
REFERENCE   10 (bases 1 to 1325)
  AUTHORS   Li,X., Chen,S., Wang,Q., Zack,D.J., Snyder,S.H. and Borjigin,J.
  TITLE     A pineal regulatory element (PIRE) mediates transactivation by the
            pineal/retina-specific transcription factor CRX
  JOURNAL   Proc Natl Acad Sci U S A 95 (4), 1876-1881 (1998)
   PUBMED   9465110
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 13, 2022 this sequence version replaced NM_021855.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB021129.1, AF135838.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMN13663598,
                                    SAMN13663604 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                JAXUCZ010000001.1  85681789-85681852   c
            65-196              JAXUCZ010000001.1  85673878-85674009   c
            197-348             JAXUCZ010000001.1  85671290-85671441   c
            349-1325            JAXUCZ010000001.1  85667971-85668947   c
FEATURES             Location/Qualifiers
     source          1..1325
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1325
                     /gene="Crx"
                     /note="cone-rod homeobox"
                     /db_xref="GeneID:60446"
                     /db_xref="RGD:620511"
     exon            1..64
                     /gene="Crx"
                     /inference="alignment:Splign:2.1.0"
     exon            65..196
                     /gene="Crx"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..996
                     /gene="Crx"
                     /note="cone-rod homeobox containing"
                     /codon_start=1
                     /product="cone-rod homeobox protein"
                     /protein_id="NP_068627.2"
                     /db_xref="GeneID:60446"
                     /db_xref="RGD:620511"
                     /translation="MMTYMNPGPHYSVNALALSGPSVDLMHQAVPYSSAPRKQRRERT
                     TFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQK
                     QQQQPPGVQAKARPAKRKAGTSPRPSTDVCTDPLGISDSYSPSLPGPSGSPTTAVATV
                     SIWSPASESPLPEAQRAGLVASGSSLTSAPYAMTYAPASAFCSSPSAYASPSSYFSGL
                     DPYLSPMVPQLGGPALSPLSGPSVGPSLAQSPTSLSGQSYSTYSPVDSLEFKDPTGTW
                     KFTYNPMDPLDYKDQSAWKFQIL"
     exon            197..348
                     /gene="Crx"
                     /inference="alignment:Splign:2.1.0"
     exon            349..1325
                     /gene="Crx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtctgat gacaccatcc aggacctggg catccaggag agcccccatt tcttctttcc
       61 aaaggcaccc aatctgggcc ctagtctctg aagatcatga tgacgtatat gaacccggga
      121 cctcactatt cggtcaatgc cttggccctg agtggcccca gtgtggacct gatgcaccag
      181 gctgtcccat actcaagtgc ccctaggaag cagaggcggg agcggaccac gttcaccagg
      241 agccagctgg aggagctgga ggccctgttt gccaagaccc agtacccgga tgtgtatgca
      301 cgtgaggagg ttgctctcaa gatcaacctg cctgagtcca gggtccaggt ctggttcaag
      361 aatcgcaggg cgaaatgcag acagcagagg cagcagcaga aacagcagca gcagccccca
      421 ggggtacaag ccaaggctcg tcctgcgaag aggaaggcag gcacatcccc gagaccctct
      481 acagatgttt gtacagatcc tttgggcatc tcagattcct acagcccatc tctgcctggt
      541 ccctcaggtt cacctaccac agcagtggcc accgtatcca tctggagtcc ggcctcagag
      601 tctcctttgc ctgaggccca gagagctggc ctagtggctt cagggtcctc tctcacctca
      661 gccccttatg ccatgaccta tgcccctgct tctgctttct gttcttcacc ttcagcttat
      721 gcatctccaa gctcctattt cagtgggttg gatccatacc tttctcccat ggtgccccag
      781 ctagggggtc cggctctcag ccccctctcg ggcccctctg tggggccatc cttggcccag
      841 tcccccacct ccttgtcagg ccagagctat agcacctaca gccccgtgga cagcctggaa
      901 ttcaaggacc ctacaggcac ctggaaattc acctacaatc ccatggaccc tctggactac
      961 aaagatcaga gtgcctggaa gtttcagatc ttgtagaaga ggcttcatat tctcccttcc
     1021 agcggaatca ccctctctgg actccggctg ccacctcctg cttagattcc aggagagtag
     1081 ctctcagcaa gcatcagcaa gtagcaatcc tgccaaaggc tgtgaaaaat tcagccccag
     1141 gtgtaggcca ccctcagctc cattagagtt taaccccttt accacctacc ccaagcaatg
     1201 aaagggactt cctctcccaa gacagtccag cagcaaccag tagatagcat gaccgatgtg
     1261 tatatctgat gctttcccca gtcttcagta aaggtgctga gaacttgctc tggagagaaa
     1321 gaaaa
//
