LOCUS       NM_001033895            2614 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus CREB regulated transcription coactivator 2
            (Crtc2), mRNA.
ACCESSION   NM_001033895 XM_227389
VERSION     NM_001033895.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2614)
  AUTHORS   Fang,W.L., Lai,S.Y., Lai,W.A., Lee,M.T., Liao,C.F., Ke,F.C. and
            Hwang,J.J.
  TITLE     CRTC2 and Nedd4 ligase involvement in FSH and TGFbeta1 upregulation
            of connexin43 gap junction
  JOURNAL   J Mol Endocrinol 55 (3), 263-275 (2015)
   PUBMED   26508620
  REMARK    GeneRIF: CRTC2 and Nedd4 ligase involvement in FSH and TGFbeta1
            upregulation of connexin43 gap junction
REFERENCE   2  (bases 1 to 2614)
  AUTHORS   McTague,J., Ferguson,M., Chik,C.L. and Ho,A.K.
  TITLE     The adrenergic-regulated CRTC1 and CRTC2 phosphorylation and
            cellular distribution is independent of endogenous SIK1 in the male
            rat pinealocyte
  JOURNAL   Mol Cell Endocrinol 414, 156-167 (2015)
   PUBMED   26210066
  REMARK    GeneRIF: Results indicate that overexpressing SIK1 can
            phosphorylate CRTC1 and CRTC2 in the norepinephrine (NE)-stimulated
            pinealocytes. Howeve, the endogenous SIK1 does not appear to be the
            main regulator of their phosphorylation and intracellular
            localization.
REFERENCE   3  (bases 1 to 2614)
  AUTHORS   Jiang,S.J., Dong,H., Li,J.B., Xu,L.J., Zou,X., Wang,K.F., Lu,F.E.
            and Yi,P.
  TITLE     Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2
            signaling pathway in streptozotocin-induced diabetic rats
  JOURNAL   World J Gastroenterol 21 (25), 7777-7785 (2015)
   PUBMED   26167077
  REMARK    GeneRIF: Berberine inhibited hepatic gluconeogenesis via the
            regulation of the LKB1-AMPK-TORC2 signaling pathway.
REFERENCE   4  (bases 1 to 2614)
  AUTHORS   Highland,J.A., Weiser,M.J., Hinds,L.R. and Spencer,R.L.
  TITLE     CRTC2 activation in the suprachiasmatic nucleus, but not
            paraventricular nucleus, varies in a diurnal fashion and increases
            with nighttime light exposure
  JOURNAL   Am J Physiol Cell Physiol 307 (7), C611-C621 (2014)
   PUBMED   25080490
  REMARK    GeneRIF: Suggest that CRTC2 participates in CREB-dependent photic
            entrainment of suprachiasmatic nucleus function.
REFERENCE   5  (bases 1 to 2614)
  AUTHORS   Zhou,Y., Wang,D., Gao,X., Lew,K., Richards,A.M. and Wang,P.
  TITLE     mTORC2 phosphorylation of Akt1: a possible mechanism for hydrogen
            sulfide-induced cardioprotection
  JOURNAL   PLoS One 9 (6), e99665 (2014)
   PUBMED   24949720
  REMARK    GeneRIF: These data suggest mTORC2 phosphorylation of Akt is a key
            mediator of H2S-induced cardioprotection in I/R.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2614)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 2614)
  AUTHORS   Kim,S.J., Nian,C., Widenmaier,S. and McIntosh,C.H.
  TITLE     Glucose-dependent insulinotropic polypeptide-mediated up-regulation
            of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by
            cyclic AMP (cAMP) response element binding protein (CREB) and
            cAMP-responsive CREB coactivator 2
  JOURNAL   Mol Cell Biol 28 (5), 1644-1656 (2008)
   PUBMED   18086876
  REMARK    GeneRIF: Gastric inhibitory polypeptide-mediated up-regulation of
            beta-cell antiapoptotic Bcl-2 gene expression is coordinated by
            CREB and TORC2.
REFERENCE   8  (bases 1 to 2614)
  AUTHORS   Ohmae,S., Takemoto-Kimura,S., Okamura,M., Adachi-Morishima,A.,
            Nonaka,M., Fuse,T., Kida,S., Tanji,M., Furuyashiki,T., Arakawa,Y.,
            Narumiya,S., Okuno,H. and Bito,H.
  TITLE     Molecular identification and characterization of a family of
            kinases with homology to Ca2+/calmodulin-dependent protein kinases
            I/IV
  JOURNAL   J Biol Chem 281 (29), 20427-20439 (2006)
   PUBMED   16684769
REFERENCE   9  (bases 1 to 2614)
  AUTHORS   Shaw,R.J., Lamia,K.A., Vasquez,D., Koo,S.H., Bardeesy,N.,
            Depinho,R.A., Montminy,M. and Cantley,L.C.
  TITLE     The kinase LKB1 mediates glucose homeostasis in liver and
            therapeutic effects of metformin
  JOURNAL   Science 310 (5754), 1642-1646 (2005)
   PUBMED   16308421
REFERENCE   10 (bases 1 to 2614)
  AUTHORS   Koo,S.H., Flechner,L., Qi,L., Zhang,X., Screaton,R.A., Jeffries,S.,
            Hedrick,S., Xu,W., Boussouar,F., Brindle,P., Takemori,H. and
            Montminy,M.
  TITLE     The CREB coactivator TORC2 is a key regulator of fasting glucose
            metabolism
  JOURNAL   Nature 437 (7062), 1109-1111 (2005)
   PUBMED   16148943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 5, 2022 this sequence version replaced NM_001033895.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168242.1, DQ185515.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               JAXUCZ010000002.1  178007274-178007535
            263-364             JAXUCZ010000002.1  178010411-178010512
            365-481             JAXUCZ010000002.1  178010586-178010702
            482-543             JAXUCZ010000002.1  178011714-178011775
            544-612             JAXUCZ010000002.1  178012408-178012476
            613-716             JAXUCZ010000002.1  178012643-178012746
            717-746             JAXUCZ010000002.1  178012837-178012866
            747-811             JAXUCZ010000002.1  178013021-178013085
            812-861             JAXUCZ010000002.1  178013209-178013258
            862-1106            JAXUCZ010000002.1  178013378-178013622
            1107-1513           JAXUCZ010000002.1  178013975-178014381
            1514-1777           JAXUCZ010000002.1  178015714-178015977
            1778-1964           JAXUCZ010000002.1  178016437-178016623
            1965-2614           JAXUCZ010000002.1  178016748-178017397
FEATURES             Location/Qualifiers
     source          1..2614
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2614
                     /gene="Crtc2"
                     /gene_synonym="RGD1308903; Torc2"
                     /note="CREB regulated transcription coactivator 2"
                     /db_xref="GeneID:310615"
                     /db_xref="RGD:1308903"
     exon            1..262
                     /gene="Crtc2"
                     /gene_synonym="RGD1308903; Torc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2185
                     /gene="Crtc2"
                     /gene_synonym="RGD1308903; Torc2"
                     /note="TORC-2; transducer of CREB protein 2; transducer of
                     regulated cAMP response element-binding protein 2"
                     /codon_start=1
                     /product="CREB-regulated transcription coactivator 2"
                     /protein_id="NP_001029067.1"
                     /db_xref="GeneID:310615"
                     /db_xref="RGD:1308903"
                     /translation="MATSGANGPGSATASASNPRKFSEKIALQKQRQAEETAAFEEVM
                     MDIGSTRLQAQKLRLAYTRSSHYGGSLPNVNQIGCGLAEFQSPLHSPLDSSRSTRHHG
                     LVERVQRDPRRMVSPLRRYPRHIDSSPYSPAYLSPPPESGWRRMMPWGNLPAEKGQLF
                     RLPSALNRTSSDSALHTSVMNPNPQDTYPGPTPPSVLPSRRGGFLDGEMDAKVPAIEE
                     NLVDDKHLLKPWDAKKLSSSSSRPRSCEVPGINIFPSPDQPANVPVLPPAMSTGGSLP
                     DLTNLHFPPPLPTPLDPEETVYPSLSGGNSTTNLTHTMTHLGISGGLGLGPSYDVPGL
                     HSPLSHPSLQSSLSNPNLQASLSSPQPQLQGSHSHPSLPASSLAHHALPTTSLGHPSL
                     SAPALSSSSSSSSTSSPVLSAPPYPASTPGASPRHRRVPLSPLSLPAGPADARRSQQQ
                     LPKQFSPTMSPTLSSITQGVPLDTSKLPTDQRLPPYPYSPPSLVIPSHPPTPKSLQQL
                     PSQACLVQPSGGQPPGRQPHYGTLYPPGSSGHGQQPYHRPINDFSLGNLEQFNMESPS
                     TSLVLDPPAFSEGPGFLGSEGSVSGPQDSHVLNHQNLTHCSRHGSGPNIILTGDSSPG
                     FSKEIAAALAGVPGFEVSASGLELGLGLEDELRMEPLGLEGLTMLSDPCALLPDPAVE
                     DSFRSDRLQ"
     exon            263..364
                     /gene="Crtc2"
                     /gene_synonym="RGD1308903; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            365..481
                     /gene="Crtc2"
                     /gene_synonym="RGD1308903; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..543
                     /gene="Crtc2"
                     /gene_synonym="RGD1308903; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..612
                     /gene="Crtc2"
                     /gene_synonym="RGD1308903; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            613..716
                     /gene="Crtc2"
                     /gene_synonym="RGD1308903; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            717..746
                     /gene="Crtc2"
                     /gene_synonym="RGD1308903; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            747..811
                     /gene="Crtc2"
                     /gene_synonym="RGD1308903; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            812..861
                     /gene="Crtc2"
                     /gene_synonym="RGD1308903; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1106
                     /gene="Crtc2"
                     /gene_synonym="RGD1308903; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1513
                     /gene="Crtc2"
                     /gene_synonym="RGD1308903; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1777
                     /gene="Crtc2"
                     /gene_synonym="RGD1308903; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1964
                     /gene="Crtc2"
                     /gene_synonym="RGD1308903; Torc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2614
                     /gene="Crtc2"
                     /gene_synonym="RGD1308903; Torc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggcggcgg cggcggcggc ggctactaag gctgaaggag ccgggccggg cccgcggcgg
       61 aggccgtggc tggatctgga aaggtggcgg ggagggacgc ggggataaga tggcgacgtc
      121 aggggcgaac gggccgggtt ccgccacagc ctcggcgtcc aatccacgca agtttagtga
      181 aaagatcgcg ctgcagaagc agcgtcaggc cgaggagacg gcggcctttg aggaggtgat
      241 gatggacatc ggctccactc ggttacaggc ccaaaagctg cgactggctt atacaaggag
      301 ctcccattat ggtggttctc tgcccaatgt taaccagatt ggctgtggcc tggctgagtt
      361 ccagagcccc cttcattcac ctttggattc atctcggagc actcggcacc atggattggt
      421 ggaacgggta caacgagacc ctcgcagaat ggtgtcccca ctccgccgat acccccgcca
      481 cattgacagt tctccctata gccctgccta cttatctcct ccccctgagt ctggctggcg
      541 aaggatgatg ccctggggca acctcccagc tgagaagggg cagttgttta gactgccatc
      601 tgcacttaac aggacaagct ctgactctgc tcttcacaca agtgtgatga accctaaccc
      661 ccaagacact tatccaggcc ctacacctcc cagtgtcctg cccagccggc gaggaggttt
      721 tctggatggc gagatggatg ctaaagtccc tgctattgag gagaacttgg tagatgacaa
      781 gcatttgctg aaaccttggg atgctaagaa gctgtcctca tcttcctctc gacctcgatc
      841 ctgtgaagtc cctggaatca acatctttcc atctcctgac cagcctgcta atgtgcctgt
      901 cctcccacct gccatgagca cagggggctc cctacctgac ctcaccaacc tacacttccc
      961 ccctccactg cccacgcccc tggaccctga ggagacagtc tatcccagcc tgagtggggg
     1021 caacagtacc accaatttga ctcacactat gacccatttg ggcatcagtg gaggtctggg
     1081 cttgggcccc agctatgatg taccaggact tcactcacct cttagccacc cgtccctgca
     1141 gtcctcccta agcaatccca acctccaggc ttccctaagc agtcctcagc cccagctcca
     1201 gggctcccat agtcacccat cactgcctgc ctcctccttg gcccaccatg cactgcccac
     1261 cacctccctg ggccacccgt cacttagtgc cccagccctt tcctcctcct cttcctcttc
     1321 gtccacttca tctcctgtcc tgagtgcccc cccttaccca gcttctactc ctggggcctc
     1381 tccccgccac cgtcgtgtgc ccctcagccc cctgagcttg cctgcaggcc cagccgacgc
     1441 cagaaggtcc caacagcagc tgcccaaaca gttttcgcca acaatgtcac ccaccttgtc
     1501 ttccatcact cagggcgtcc ccttggatac cagtaaactg cctactgacc agcgattgcc
     1561 cccataccca tatagccccc caagtctagt tatacccagc catccaccca ccccaaagtc
     1621 tctacagcag ttgccctctc aggcctgctt agtacagccc tcaggtggac agcctccagg
     1681 caggcagcca cattatggga cactgtaccc acctgggtcc agtggacatg ggcaacagcc
     1741 ttaccaccgc ccaataaatg acttcagcct ggggaatctg gagcaattca acatggagag
     1801 cccatctacc agcctggtgc tggatccccc tgccttttct gaaggtcctg gatttttagg
     1861 gagtgaggga tcagtgagtg gcccccagga ctctcatgtc ctcaatcacc agaacttgac
     1921 ccactgttcc cgccatggct caggacctaa tatcatactc acaggagact cttccccagg
     1981 tttctctaag gagattgcag cagccctggc tggagtacct ggctttgagg tgtcagcatc
     2041 tgggttggag ctgggactgg ggctggaaga tgagttgcgc atggagccac tgggcctgga
     2101 aggactaacc atgctgagtg acccttgtgc tctgctgcct gaccctgctg tggaagactc
     2161 attccgtagt gatcggctac agtgagggga ccttactgct atccttcttc atggcccttt
     2221 cccgtcactg tcttttcatc ccttccccct ggccaatgga gactactctc tgcccccaga
     2281 tcctttttct aatatgaatg aaggatccta aaactgagga aagggaaggg gcttggccag
     2341 gtggcccctg aatgttgtac atctggtggg ctcggggagt tcaagggagg gcccaaaagc
     2401 acttgtaact ttgaaaatcg tctgtctgga ggtcagagcc tgttggaaag caaggtgtag
     2461 aggggaatct tggagagagg gcttgtccag aaaagggtgg gcatttccag cccctcccta
     2521 tttctcttcc ccttgcaatg gaagagagag ccagagtgga tattattttt tattaaatat
     2581 attatatgtt aataaaaaat cctattaaac cttt
//
