LOCUS       NM_001008386            2645 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus CDP-L-ribitol pyrophosphorylase A (Crppa), mRNA.
ACCESSION   NM_001008386
VERSION     NM_001008386.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2645)
  AUTHORS   Riemersma,M., Froese,D.S., van Tol,W., Engelke,U.F., Kopec,J., van
            Scherpenzeel,M., Ashikov,A., Krojer,T., von Delft,F., Tessari,M.,
            Buczkowska,A., Swiezewska,E., Jae,L.T., Brummelkamp,T.R., Manya,H.,
            Endo,T., van Bokhoven,H., Yue,W.W. and Lefeber,D.J.
  TITLE     Human ISPD Is a Cytidyltransferase Required for Dystroglycan
            O-Mannosylation
  JOURNAL   Chem Biol 22 (12), 1643-1652 (2015)
   PUBMED   26687144
REFERENCE   2  (bases 1 to 2645)
  AUTHORS   Wright,K.M., Lyon,K.A., Leung,H., Leahy,D.J., Ma,L. and Ginty,D.D.
  TITLE     Dystroglycan organizes axon guidance cue localization and axonal
            pathfinding
  JOURNAL   Neuron 76 (5), 931-944 (2012)
   PUBMED   23217742
REFERENCE   3  (bases 1 to 2645)
  AUTHORS   Roscioli,T., Kamsteeg,E.J., Buysse,K., Maystadt,I., van
            Reeuwijk,J., van den Elzen,C., van Beusekom,E., Riemersma,M.,
            Pfundt,R., Vissers,L.E., Schraders,M., Altunoglu,U., Buckley,M.F.,
            Brunner,H.G., Grisart,B., Zhou,H., Veltman,J.A., Gilissen,C.,
            Mancini,G.M., Delree,P., Willemsen,M.A., Ramadza,D.P., Chitayat,D.,
            Bennett,C., Sheridan,E., Peeters,E.A., Tan-Sindhunata,G.M., de
            Die-Smulders,C.E., Devriendt,K., Kayserili,H., El-Hashash,O.A.,
            Stemple,D.L., Lefeber,D.J., Lin,Y.Y. and van Bokhoven,H.
  TITLE     Mutations in ISPD cause Walker-Warburg syndrome and defective
            glycosylation of alpha-dystroglycan
  JOURNAL   Nat Genet 44 (5), 581-585 (2012)
   PUBMED   22522421
REFERENCE   4  (bases 1 to 2645)
  AUTHORS   Willer,T., Lee,H., Lommel,M., Yoshida-Moriguchi,T., de
            Bernabe,D.B., Venzke,D., Cirak,S., Schachter,H., Vajsar,J.,
            Voit,T., Muntoni,F., Loder,A.S., Dobyns,W.B., Winder,T.L.,
            Strahl,S., Mathews,K.D., Nelson,S.F., Moore,S.A. and Campbell,K.P.
  TITLE     ISPD loss-of-function mutations disrupt dystroglycan
            O-mannosylation and cause Walker-Warburg syndrome
  JOURNAL   Nat Genet 44 (5), 575-580 (2012)
   PUBMED   22522420
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY769992.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY769992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132301
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2645
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16-q21"
     gene            1..2645
                     /gene="Crppa"
                     /gene_synonym="Ispd; Nip"
                     /note="CDP-L-ribitol pyrophosphorylase A"
                     /db_xref="GeneID:493574"
                     /db_xref="RGD:1359368"
     exon            1..343
                     /gene="Crppa"
                     /gene_synonym="Ispd; Nip"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1436
                     /gene="Crppa"
                     /gene_synonym="Ispd; Nip"
                     /EC_number="2.7.7.40"
                     /note="2-C-methyl-D-erythritol 4-phosphate
                     cytidylyltransferase-like protein; isoprenoid synthase
                     domain-containing protein; notch1-induced protein;
                     isoprenoid synthase domain containing"
                     /codon_start=1
                     /product="D-ribitol-5-phosphate cytidylyltransferase"
                     /protein_id="NP_001008387.1"
                     /db_xref="GeneID:493574"
                     /db_xref="RGD:1359368"
                     /translation="MESGPCSRPAEPRHCVSGRAGAGLAFPAFPLSAAGAEPGSRIGT
                     VAAVLPAGGCGERMGVRTPKQFCRVLERPLISYTLQAMERVCWIKDIVVTVTGENMEA
                     MRSIIQRYGHKRISLAEAGATRHRSIFNGLKALAEDQPGCELTRPEVVIIHDAVRPFV
                     EEDILLRVVLAAKEHGAAGAIRPLVSTVVSPSADGHLDHSLDRAKHRASEMPQAFHFD
                     VIYEAYQKCSDFDLEFGTECLQLALKYCHRKAKLVEGTPDLWKVTYKQDLCAAEAMIK
                     EKISQEICVVVNTKDEESVGHLLEEVLRNELNCIKVTSTVLDRTSGDIENFIDQCYSF
                     ICVNVVSSESRETRKLLSILEESSLPLLYPVVVVLVHCFDFTVVPLAQKMENLVWIRE
                     LAKEAKGRNVLLSGVLLNHSQDEQKLQESLVQSAAIIAALVKERNSALVGQLLVA"
     exon            344..620
                     /gene="Crppa"
                     /gene_synonym="Ispd; Nip"
                     /inference="alignment:Splign:2.1.0"
     exon            621..770
                     /gene="Crppa"
                     /gene_synonym="Ispd; Nip"
                     /inference="alignment:Splign:2.1.0"
     exon            771..875
                     /gene="Crppa"
                     /gene_synonym="Ispd; Nip"
                     /inference="alignment:Splign:2.1.0"
     exon            876..921
                     /gene="Crppa"
                     /gene_synonym="Ispd; Nip"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1016
                     /gene="Crppa"
                     /gene_synonym="Ispd; Nip"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1106
                     /gene="Crppa"
                     /gene_synonym="Ispd; Nip"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1199
                     /gene="Crppa"
                     /gene_synonym="Ispd; Nip"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1331
                     /gene="Crppa"
                     /gene_synonym="Ispd; Nip"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..2630
                     /gene="Crppa"
                     /gene_synonym="Ispd; Nip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagtccga tcggtgatct cggcccaggt ccggtgttgg cgtttcgctc ttagttccca
       61 tctgcacctt ggggttctgc gctctgctcg ccatggagtc cgggccgtgc agcaggcccg
      121 ctgagcctcg gcattgcgtg agcggccggg cgggcgcggg tttagcgttc ccggcgttcc
      181 cattgtccgc tgccggggcg gagcccggga gccgcattgg aactgtagcc gctgtgctgc
      241 cggctggggg ctgcggagaa aggatgggcg tccgcacccc gaagcagttc tgccgggtcc
      301 tggagaggcc gctcatcagc tacacactgc aggctatgga gagagtatgc tggataaagg
      361 acattgttgt gacagtgaca ggggagaaca tggaagcgat gagaagcatc attcagaggt
      421 atgggcataa gcgcatctca ctagctgagg ccggagccac gcgccacaga tcaattttca
      481 atggactgaa agccctggca gaagatcagc caggctgtga actcactaga ccagaagttg
      541 tgattatcca cgatgccgtg agaccttttg ttgaggaaga tatcctcctg agagttgtcc
      601 tagcagctaa ggagcatggg gcagcaggag caattcgacc tctggtgtcc actgtcgtca
      661 gtccgtctgc tgatggtcac ttagaccact cactggaccg tgccaagcac agggcaagcg
      721 aaatgcccca ggcttttcac tttgatgtga tctatgaagc gtatcagaag tgtagtgatt
      781 ttgacttgga atttggaaca gagtgcttgc agttggccct aaaatactgt cacaggaaag
      841 caaaacttgt agaagggacc cctgacctct ggaaggtgac ctacaaacaa gacctgtgtg
      901 cagctgaagc catgattaag gaaaaaattt cacaagagat ttgtgtggtc gtgaacacaa
      961 aagatgaaga atctgtagga catcttcttg aggaagtgct aagaaatgaa ctaaattgta
     1021 ttaaagtcac atccacagtt ttggatcgca ccagtggaga cattgagaac ttcatagacc
     1081 aatgctacag tttcatctgt gtgaatgttg tgtcctctga gagtcgagaa accaggaagt
     1141 tactgagtat cctcgaagag agcagccttc ctcttctgta tcccgtcgtt gtcgttttgg
     1201 tgcattgctt tgatttcacg gtagtgccgc tcgctcagaa gatggagaac ctggtgtgga
     1261 tcagggaatt agcaaaggaa gcaaaaggaa ggaatgttct attaagtgga gtcctcctaa
     1321 atcactcaca ggatgagcag aagctacaag agagtttagt acaaagtgca gccatcatag
     1381 ctgccttggt taaggaaaga aattctgcac tcgtcgggca gctcctggtg gcatgaagaa
     1441 cacagacaaa aatcatctat aagcttccaa agatccttcc ctaaggcccc ccaccccact
     1501 tgactgcctc gccacctcaa tgtctcttcc ttgtgcatac aatattttca ttgttttctt
     1561 atcttgccac ttattggatg tgacgcttag gttgtgacaa ttggttaatg tgtgtgttca
     1621 tgaacttatg tatcaaatac aattggctcc aactagaaaa ggataaataa atggaaaata
     1681 ttgctttcat gtaaagaata tgttcactac tgcagcaagt ccaattgaca tgatagggtt
     1741 agccattcct tcaagggcaa gagtttagac agcttggtgg ttatggtaag tttatgctaa
     1801 ttaacatatt attcacatta tagtggagct aatgaatagg cttcagaatt atacccaatt
     1861 ccaaaatcat cgacttccta tgtgagaatg catcttttga cttgttttgg aattcactgc
     1921 accttataaa gagtagggaa gctgggaagt tggcttagtg ggcaagctct tgtctagtgt
     1981 ggatagagca acatcacaga agaaaaagaa aaacatgctg gtaaatattg ggcagaagtc
     2041 agaaagggga tgtctccagt ttccttcccc tttgtctttt atgttcttga tctttagaga
     2101 tttctaaaga gactgagatt cactctttta ctagtttaaa ttgtatcttt tctttggttt
     2161 atgagatgtc gtgctgacat tattttaaag agtctctact tcttctaggt tagtttcaga
     2221 aatgtctgga gagcttcatg aaggttgagt tgcttcggtc tgtccgtgcc tatgatcttc
     2281 tgaaaagcag gggggccagt gaagtggagt tagctaatgt tgatgtagga atggtggcct
     2341 tgctaaatca agattcattc tttacaatct ctattgccta tacattatat tgtcttttat
     2401 gttgcactta ataattatat atacatatgg ttgtgaaaat gccttttgtt gcaacataaa
     2461 ttttttatta aagtatgtta aatcattaca ttctagaact tacactggat aaagaaatta
     2521 taaaagctgc atgaaatgtg tttactcagg attgtcaata aatatgtcta ctttctgaaa
     2581 tgtctcctgc aacatgttaa ataaatttcc tctatatttt tgaatttcaa aaaaaaaaaa
     2641 aaaaa
//
