LOCUS       NM_017096               1699 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus C-reactive protein (Crp), mRNA.
ACCESSION   NM_017096
VERSION     NM_017096.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1699)
  AUTHORS   Li,L., Jia,L., Hou,S., Zhang,T., Zhou,M., Chen,T. and Song,J.
  TITLE     Temporal and spatial effects on C-reactive protein's regulation of
            inducible nitric oxide synthase production in periodontal disease
  JOURNAL   J Periodontol 95 (3), 268-280 (2024)
   PUBMED   37515488
  REMARK    GeneRIF: Temporal and spatial effects on C-reactive protein's
            regulation of inducible nitric oxide synthase production in
            periodontal disease.
REFERENCE   2  (bases 1 to 1699)
  AUTHORS   Cheng,R., Xu,X., Yang,S., Mi,Z., Zhao,Y., Wang,C., Shi,X., Gao,J.,
            Yu,F. and Ren,X.
  TITLE     The effect of APN, hs-CRP and APN/hs-CRP in periodontitis with DAA
  JOURNAL   BMC Oral Health 23 (1), 85 (2023)
   PUBMED   36765308
  REMARK    GeneRIF: The effect of APN, hs-CRP and APN/hs-CRP in periodontitis
            with DAA.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1699)
  AUTHORS   Zhang,L., Li,W., Gong,M., Zhang,Z., Xue,X., Mao,J., Zhang,H.,
            Li,S., Liu,X., Wu,F., Shi,J. and Fu,G.
  TITLE     C-reactive protein inhibits C3a/C3aR-dependent podocyte autophagy
            in favor of diabetic kidney disease
  JOURNAL   FASEB J 36 (6), e22332 (2022)
   PUBMED   35503088
  REMARK    GeneRIF: C-reactive protein inhibits C3a/C3aR-dependent podocyte
            autophagy in favor of diabetic kidney disease.
            Erratum:[FASEB J. 2022 Dec;36(12):e22640. doi: 10.1096/fsb2.22640..
            PMID: 36315181]
REFERENCE   4  (bases 1 to 1699)
  AUTHORS   Yang,M., Qiu,S., He,Y., Li,L., Wu,T., Ding,N., Li,F., Zhao,A.Z. and
            Yang,G.
  TITLE     Genetic ablation of C-reactive protein gene confers resistance to
            obesity and insulin resistance in rats
  JOURNAL   Diabetologia 64 (5), 1169-1183 (2021)
   PUBMED   33544171
  REMARK    GeneRIF: Genetic ablation of C-reactive protein gene confers
            resistance to obesity and insulin resistance in rats.
REFERENCE   5  (bases 1 to 1699)
  AUTHORS   Fornvik,K., Maddahi,A., Liljedahl,E., Osther,K., Salford,L.G. and
            Redebrandt,H.N.
  TITLE     What is the role of CRP in glioblastoma?
  JOURNAL   Cancer Treat Res Commun 26, 100293 (2021)
   PUBMED   33385735
  REMARK    GeneRIF: What is the role of CRP in glioblastoma?
REFERENCE   6  (bases 1 to 1699)
  AUTHORS   Rassouli,M., Sambasivam,H., Azadi,P., Dell,A., Morris,H.R.,
            Nagpurkar,A., Mookerjea,S. and Murray,R.K.
  TITLE     Derivation of the amino acid sequence of rat C-reactive protein
            from cDNA cloning with additional studies on the nature of its
            dimeric component
  JOURNAL   J Biol Chem 267 (5), 2947-2954 (1992)
   PUBMED   1737750
REFERENCE   7  (bases 1 to 1699)
  AUTHORS   Youinou,P., Fauquert,P., Pennec,Y.L., Bendaoud,B., Katsikis,P. and
            Le Goff,P.
  TITLE     Raised C-reactive protein response in rheumatoid arthritis patients
            with secondary Sjogren's syndrome
  JOURNAL   Rheumatol Int 10 (1), 39-41 (1990)
   PUBMED   2353152
REFERENCE   8  (bases 1 to 1699)
  AUTHORS   Nunomura,W.
  TITLE     C-reactive protein in rat: in development, pregnancy and effect of
            sex hormones
  JOURNAL   Comp Biochem Physiol A Comp Physiol 96 (4), 489-493 (1990)
   PUBMED   1978818
REFERENCE   9  (bases 1 to 1699)
  AUTHORS   Saxena,U., Nagpurkar,A. and Mookerjea,S.
  TITLE     Inhibition of the binding of low density lipoproteins to liver
            membrane receptors by rat serum phosphorylcholine binding protein
  JOURNAL   Biochem Biophys Res Commun 141 (1), 151-157 (1986)
   PUBMED   3800992
REFERENCE   10 (bases 1 to 1699)
  AUTHORS   Mallya,R.K., Hind,C.R., Berry,H. and Pepys,M.B.
  TITLE     Serum C-reactive protein in polymyalgia rheumatica. A prospective
            serial study
  JOURNAL   Arthritis Rheum 28 (4), 383-387 (1985)
   PUBMED   2859021
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Feb 2, 2022 this sequence version replaced NM_017096.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091157.1, FQ218768.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               JAXUCZ010000013.1  87694062-87694237
            177-1699            JAXUCZ010000013.1  87694456-87695978
FEATURES             Location/Qualifiers
     source          1..1699
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1699
                     /gene="Crp"
                     /gene_synonym="Aa1249; Ab1-341; Ab2-196; Ac1-114; Ac1262;
                     Ac2-069; Ba2-693"
                     /note="C-reactive protein"
                     /db_xref="GeneID:25419"
                     /db_xref="RGD:2411"
     exon            1..176
                     /gene="Crp"
                     /gene_synonym="Aa1249; Ab1-341; Ab2-196; Ac1-114; Ac1262;
                     Ac2-069; Ba2-693"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..805
                     /gene="Crp"
                     /gene_synonym="Aa1249; Ab1-341; Ab2-196; Ac1-114; Ac1262;
                     Ac2-069; Ba2-693"
                     /note="C-reactive protein, member of the pentraxin family;
                     C-reactive protein, petaxin related; C-reactive protein,
                     pentraxin-related"
                     /codon_start=1
                     /product="C-reactive protein precursor"
                     /protein_id="NP_058792.1"
                     /db_xref="GeneID:25419"
                     /db_xref="RGD:2411"
                     /translation="MEKLLWCLLITISFSQAFGHEDMSKQAFVFPGVSATAYVSLEAE
                     SKKPLEAFTVCLYAHADVSRSFSIFSYATKTSFNEILLFWTRGQGFSIAVGGPEILFS
                     ASEIPEVPTHICATWESATGIVELWLDGKPRVRKSLQKGYIVGTNASIILGQEQDSYG
                     GGFDANQSLVGDIGDVNMWDFVLSPEQINAVYVGRVFSPNVLNWRALKYETHGDVFIK
                     PQLWPLTDCCES"
     exon            177..1699
                     /gene="Crp"
                     /gene_synonym="Aa1249; Ab1-341; Ab2-196; Ac1-114; Ac1262;
                     Ac2-069; Ba2-693"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tataaatcta aggatgggct gtgcctgagg caggggatcc aggacttctt gcccttgatc
       61 tttcagacag agctctgtcc tcttagtccg gatcccagca gagtcgacag ccatggagaa
      121 gctactatgg tgtcttctga tcacgataag cttctctcag gcttttggtc atgaagacat
      181 gtctaaacag gccttcgtat ttcccggagt gtcagctact gcctatgtgt ccctggaagc
      241 agagtcaaag aagccactgg aagccttcac tgtgtgtctc tatgcccacg ctgatgtgag
      301 ccgaagcttc agcatcttct cttacgctac caagacgagc tttaacgaga ttcttctgtt
      361 ttggactagg ggtcaagggt ttagtattgc agtaggtggg cctgaaatac tgttcagtgc
      421 ttcagaaatt cctgaggtac caacacacat ctgtgccacc tgggagtctg ctacaggaat
      481 tgtagagctt tggcttgacg ggaaacccag ggtgcggaaa agtctgcaga agggctacat
      541 tgtggggaca aatgcaagca tcatcttggg gcaggagcag gactcgtatg gcggtggctt
      601 tgacgcgaat cagtctttgg tgggagacat tggagatgtg aacatgtggg actttgtgct
      661 atctccagaa cagatcaatg cagtctatgt tggtagggta ttcagcccca atgttttgaa
      721 ctggcgggca ctgaagtatg aaacacacgg tgatgtgttt atcaagccgc agctgtggcc
      781 cttgactgac tgttgtgagt cctgaggcac ctcctgggat tacattctct cccttgtccc
      841 tccttatgaa ccttttaacc ccagcagatg ttgtagatct gttttgtgaa tatggccttt
      901 cacttctctg ctctgtggtc ctcagcacta gagcatggaa tttaaatgta aggcttccag
      961 catgtgcatc ccactactct ttatcaaaga gaacctgact tacccacggt gtgtgtatgt
     1021 gtatttaatt aaaaaatttt tagacataat ccttctccct cacacagatg agaaaccaga
     1081 tgcacagaaa ggagaataat tttttattgt ttttgtttca gaatgtcata ttgaatggtg
     1141 tacttatatc ctttctatcc ctccctcttc aaatcctcta ctatcccccc caattctccc
     1201 tcgaattcat gatgtcttat aattagcctt atatgcacat acacatctat ctatctatct
     1261 atctatctat ctatctatct atctatccat ccatccatcc atccatccat ccatccatcc
     1321 atctatctat ctatctatct atctatctat ctatcatcta tcagtaatcc atcttactga
     1381 ttacatttag tgtttcttgt attttgttga acacttgaga ctggataatc tatcaggagg
     1441 tctatccctg aagaaaacgg attgtccttt tctcagcagc tgattacctc tagctcttca
     1501 tatatgggtg tggctttgtg aaatgtttct gtccatgttg catgtcaact ggaatcattg
     1561 tgcaagtctt tttttgggca acccagagtg atggagcact gactacactg tgctcagaat
     1621 cagttctttt ctggaataaa acctgtactt gaactttcca gattcatgaa tcaataaagt
     1681 tacctttggc ttgaacaaa
//
