LOCUS       NM_053797               2353 bp    mRNA    linear   ROD 19-MAR-2024
DEFINITION  Rattus norvegicus crooked neck pre-mRNA splicing factor 1 (Crnkl1),
            mRNA.
ACCESSION   NM_053797 NM_001329889 XM_003749580 XM_003753805
VERSION     NM_053797.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2353)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   2  (bases 1 to 2353)
  AUTHORS   Jayaraman,S.S., Rayhan,D.J., Hazany,S. and Kolodney,M.S.
  TITLE     Mutational landscape of basal cell carcinomas by whole-exome
            sequencing
  JOURNAL   J Invest Dermatol 134 (1), 213-220 (2014)
   PUBMED   23774526
REFERENCE   3  (bases 1 to 2353)
  AUTHORS   Chanarat,S. and Strasser,K.
  TITLE     Splicing and beyond: the many faces of the Prp19 complex
  JOURNAL   Biochim Biophys Acta 1833 (10), 2126-2134 (2013)
   PUBMED   23742842
  REMARK    Review article
REFERENCE   4  (bases 1 to 2353)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 2353)
  AUTHORS   Amada,N., Tezuka,T., Mayeda,A., Araki,K., Takei,N., Todokoro,K. and
            Nawa,H.
  TITLE     A novel rat orthologue and homologue for the Drosophila crooked
            neck gene in neural stem cells and their immediate descendants
  JOURNAL   J Biochem 133 (5), 615-623 (2003)
   PUBMED   12801913
REFERENCE   6  (bases 1 to 2353)
  AUTHORS   Raisin-Tani,S. and Leopold,P.
  TITLE     Drosophila crooked-neck protein co-fractionates in a multiprotein
            complex with splicing factors
  JOURNAL   Biochem Biophys Res Commun 296 (2), 288-292 (2002)
   PUBMED   12163015
REFERENCE   7  (bases 1 to 2353)
  AUTHORS   Chung,S., Zhou,Z., Huddleston,K.A., Harrison,D.A., Reed,R.,
            Coleman,T.A. and Rymond,B.C.
  TITLE     Crooked neck is a component of the human spliceosome and implicated
            in the splicing process
  JOURNAL   Biochim Biophys Acta 1576 (3), 287-297 (2002)
   PUBMED   12084575
REFERENCE   8  (bases 1 to 2353)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC085718.1.
            
            On or before May 21, 2021 this sequence version replaced
            NM_001329889.1, XM_003749580.1, XM_003753805.1, NM_053797.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC085718.1 [ECO:0000345]
            RNAseq introns           :: mixed sample support SAMD00132261,
                                        SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2353              BC085718.1         1-2353
FEATURES             Location/Qualifiers
     source          1..2353
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2353
                     /gene="Crnkl1"
                     /gene_synonym="Crn"
                     /note="crooked neck pre-mRNA splicing factor 1"
                     /db_xref="GeneID:100910202"
                     /db_xref="RGD:620507"
     exon            1..137
                     /gene="Crnkl1"
                     /gene_synonym="Crn"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..2159
                     /gene="Crnkl1"
                     /gene_synonym="Crn"
                     /note="crooked neck homolog; Crn, crooked neck-like 1;
                     crooked neck-like protein 1-like; crooked neck pre-mRNA
                     splicing factor-like 1; crooked neck-like 1 protein-like"
                     /codon_start=1
                     /product="crooked neck-like protein 1"
                     /protein_id="NP_446249.1"
                     /db_xref="GeneID:100910202"
                     /db_xref="RGD:620507"
                     /translation="MAASTAAGKQRIPKVAKVKNKAPAEVQITAEQLLREAKERELEL
                     LPPPPQQKITDEEELNDYKLRKRKTFEDNIRKNRTVISNWIKYAQWEESLKEIQRARS
                     IYERALDVDYRNITLWLKYAEMEMKNRQVNHARNIWDRAITTLPRVNQFWYKYTYMEE
                     MLGNVAGARQVFERWMEWQPEEQAWHSYINFELRYKEVERARTIYERFVLVHPAVKNW
                     IKYARFEEKHAYFAHARKVYERAVEFFGDEHMDEHLYVAFAKFEENQKEFERVRVIYK
                     YALDRISKQEAQELFKNYTIFEKKFGDRRGIEDIIVSKRRFQYEEEVKANPHNYDAWF
                     DYLRLVESDAEADTVREVYERAIANVPPIQEKRHWKRYIYLWVNYALYEELEAKDPER
                     TRQVYQASLELIPHKKFTFAKMWLYYAQFEIRQKNLPFARRALGTSIGKCPKNKLFKG
                     YIELELQLREFDRCRKLYEKFLEFGPENCTSWIKFAELETILGDIERARAIYELAISQ
                     PRLDMPEVLWKSYIDFEIEQEETERTRNLYRQLLQRTQHVKVWISFAQFELSSGKEGS
                     VAKCRQIYEEANKTMRNCEEKEERLMLLESWRSFEDEFGTVSDKERVDKLMPEKVKKR
                     RKVQADDGSDAGWEEYYDYIFPEDAANQPNLKLLAMAKLWKKQQQEREAAEQDPDKDI
                     DESESSSF"
     exon            138..290
                     /gene="Crnkl1"
                     /gene_synonym="Crn"
                     /inference="alignment:Splign:2.1.0"
     exon            291..382
                     /gene="Crnkl1"
                     /gene_synonym="Crn"
                     /inference="alignment:Splign:2.1.0"
     exon            383..541
                     /gene="Crnkl1"
                     /gene_synonym="Crn"
                     /inference="alignment:Splign:2.1.0"
     exon            542..708
                     /gene="Crnkl1"
                     /gene_synonym="Crn"
                     /inference="alignment:Splign:2.1.0"
     exon            709..887
                     /gene="Crnkl1"
                     /gene_synonym="Crn"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1058
                     /gene="Crnkl1"
                     /gene_synonym="Crn"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1250
                     /gene="Crnkl1"
                     /gene_synonym="Crn"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1310
                     /gene="Crnkl1"
                     /gene_synonym="Crn"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1391
                     /gene="Crnkl1"
                     /gene_synonym="Crn"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1631
                     /gene="Crnkl1"
                     /gene_synonym="Crn"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1733
                     /gene="Crnkl1"
                     /gene_synonym="Crn"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1982
                     /gene="Crnkl1"
                     /gene_synonym="Crn"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2326
                     /gene="Crnkl1"
                     /gene_synonym="Crn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctgtggtg ctggccgcgg gattttgagg cgtgtatctg aagtccgggt gtgggccagg
       61 gtcgctcgcg ttccgcggct acaatcatgg cggcttccac ggcagccggg aaacagcgga
      121 ttcctaaagt ggccaaggtg aagaacaaag cgccagcaga ggtgcagata accgcagagc
      181 agctcttaag ggaggctaaa gaaagagagc tcgagctcct cccaccccca cctcagcaga
      241 agatcacaga cgaggaagaa ctaaacgatt acaaactacg gaaaaggaag actttcgaag
      301 ataatataag aaaaaacaga actgtgatta gcaactggat caaatacgca caatgggagg
      361 aaagtctgaa ggaaattcaa agggcccgat ccatatacga gcgtgcttta gatgtcgact
      421 accgaaatat cacactctgg ctgaaatatg cagaaatgga aatgaagaac cgccaggtca
      481 accatgcccg aaatatctgg gaccgtgcca taacaaccct gccgcgagtc aaccagttct
      541 ggtacaaata cacgtacatg gaggagatgc tgggcaatgt tgccggtgct cgtcaggtgt
      601 ttgagcgctg gatggaatgg cagcctgagg agcaggcctg gcactcctac atcaacttcg
      661 agctgagata caaagaggtg gagcgggccc gcaccattta tgaacgcttt gtgctcgtgc
      721 accctgctgt gaagaactgg atcaagtacg ctcgatttga agagaagcat gcgtattttg
      781 cccatgcgcg gaaagtctac gagagagcag ttgagttttt tggggatgag catatggacg
      841 aacacctcta tgtggccttt gctaaatttg aagaaaatca aaaagaattt gaaagggtac
      901 gagttatcta caaatatgcc ctggatagga tttccaagca agaggcccaa gagctcttta
      961 aaaactatac catctttgag aagaagtttg gtgaccggag gggtatagaa gacatcatcg
     1021 tgagcaaacg gagattccag tatgaagaag aagtgaaggc taatccacac aattatgatg
     1081 catggtttga ttatttacgc ttggtggaaa gtgatgcaga agcggacact gtgcgggaag
     1141 tctatgagcg agccattgcc aatgtgccac ccatccagga gaagaggcac tggaaacgct
     1201 acatctacct ctgggttaac tacgcactct atgaagagct ggaggccaag gatcctgaga
     1261 ggacaagaca ggtgtatcaa gcatctttgg aactaattcc tcacaaaaag ttcacgtttg
     1321 ccaaaatgtg gttatattac gcacagtttg aaataagaca gaaaaatctg ccatttgcca
     1381 gaagagcttt gggaacttcc ataggcaaat gtcccaagaa caagttattc aaaggttaca
     1441 tagaactgga actgcagctt cgagaatttg acagatgcag gaagctttac gaaaagtttt
     1501 tggaatttgg acctgaaaat tgtacctcgt ggattaagtt tgcagaatta gaaacaatcc
     1561 ttggtgatat tgagagagct cgggcaatct atgaattagc catcagccag ccacgcttgg
     1621 atatgccaga ggtactttgg aaatcatata ttgattttga gattgagcag gaagaaactg
     1681 agagaacacg aaatctttac cgacagttgc ttcagcgaac acagcacgtc aaggtatgga
     1741 tcagttttgc tcagtttgaa ttatcttctg ggaaagaagg aagtgtggct aaatgcagac
     1801 agatttatga agaagctaac aaaaccatga gaaactgtga agaaaaagaa gagaggctta
     1861 tgttgctgga gtcctggcga agtttcgaag atgaatttgg aacagtatca gacaaggaga
     1921 gagtagacaa actcatgcca gaaaaggtca agaagagaag aaaggtccag gctgacgatg
     1981 ggtctgatgc cggatgggaa gagtactatg actacatctt tccagaggat gctgccaacc
     2041 agcctaacct caagctgctg gcgatggcca agctttggaa gaaacagcaa caagaaagag
     2101 aagctgccga acaggatcca gataaggaca ttgatgagag tgaatcctca tctttttaaa
     2161 tgttattatt gctttgtata aattaacagt ttagaacttt gacttctgga tgtttttata
     2221 tatttaccca gtaaggagtt gtttgacatc tttgaattat tttttaaaat ctcctgggtt
     2281 aactatggat gagaaactgc aagtaaagga aatttttgta acagttaaaa aaaaaaaaaa
     2341 aaaaaaaaaa aaa
//
