LOCUS       NM_001014258            1921 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus cardiolipin synthase 1 (Crls1), mRNA.
ACCESSION   NM_001014258 XM_345438
VERSION     NM_001014258.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1921)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1921)
  AUTHORS   Ohlig,T., Le,D.V., Gardemann,A., Wolke,C., Gurtler,S., Peter,D.,
            Schild,L. and Lendeckel,U.
  TITLE     Effects of siRNA-dependent knock-down of cardiolipin synthase and
            tafazzin on mitochondria and proliferation of glioma cells
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1863 (4), 379-387 (2018)
   PUBMED   29325722
  REMARK    GeneRIF: Knock-down of cardiolipin synthase affected the cellular
            CL content in the presence of linoleic acid (LA) in the culture
            medium.
REFERENCE   3  (bases 1 to 1921)
  AUTHORS   Ren,M., Phoon,C.K. and Schlame,M.
  TITLE     Metabolism and function of mitochondrial cardiolipin
  JOURNAL   Prog Lipid Res 55, 1-16 (2014)
   PUBMED   24769127
  REMARK    Review article
REFERENCE   4  (bases 1 to 1921)
  AUTHORS   Cheng,H., Mancuso,D.J., Jiang,X., Guan,S., Yang,J., Yang,K.,
            Sun,G., Gross,R.W. and Han,X.
  TITLE     Shotgun lipidomics reveals the temporally dependent, highly
            diversified cardiolipin profile in the mammalian brain: temporally
            coordinated postnatal diversification of cardiolipin molecular
            species with neuronal remodeling
  JOURNAL   Biochemistry 47 (21), 5869-5880 (2008)
   PUBMED   18454555
  REMARK    GeneRIF: CL has roles in in neuronal signaling, mitochondrial
            bioenergetics, and apoptosis
REFERENCE   5  (bases 1 to 1921)
  AUTHORS   Schlame,M. and Hostetler,K.Y.
  TITLE     Solubilization, purification, and characterization of cardiolipin
            synthase from rat liver mitochondria. Demonstration of its
            phospholipid requirement
  JOURNAL   J Biol Chem 266 (33), 22398-22403 (1991)
   PUBMED   1657995
REFERENCE   6  (bases 1 to 1921)
  AUTHORS   Hostetler,K.Y.
  TITLE     Effect of thyroxine on the activity of mitochondrial cardiolipin
            synthase in rat liver
  JOURNAL   Biochim Biophys Acta 1086 (1), 139-140 (1991)
   PUBMED   1659453
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085849.1.
            
            On Apr 20, 2005 this sequence version replaced XM_345438.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085849.1, SRR8487227.254384.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1921
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..1921
                     /gene="Crls1"
                     /gene_synonym="RGD1311037"
                     /note="cardiolipin synthase 1"
                     /db_xref="GeneID:366196"
                     /db_xref="RGD:1311037"
     exon            1..438
                     /gene="Crls1"
                     /gene_synonym="RGD1311037"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1041
                     /gene="Crls1"
                     /gene_synonym="RGD1311037"
                     /EC_number="2.7.8.41"
                     /note="cardiolipin synthetase; CLS"
                     /codon_start=1
                     /product="cardiolipin synthase (CMP-forming)"
                     /protein_id="NP_001014280.1"
                     /db_xref="GeneID:366196"
                     /db_xref="RGD:1311037"
                     /translation="MLAWRVARGAWGSLRVAVRPPGARLGRGGSRRALLPPAACCLGC
                     LAERWRLRPAAFALRLPGTSPRTHCSGAGKAAPEPAAGGDAAAQAPSARWVRASATSS
                     YENPWTIPNLLSMTRIGLAPVLGYLILEEDFNVALGVFALAGLTDLLDGFIARNWANQ
                     KSALGSALDPLADKVLISILYISLTYADLIPVPLTYMIISRDVMLIAAVFYVRYRTLP
                     TPRTLAKYFNPCYATARLKPTFISKVNTAVQLILVAASLAAPVFNYADSIYLQILWCC
                     TAFTTAASAYSYYHYGRKTVQVIKGK"
     exon            439..576
                     /gene="Crls1"
                     /gene_synonym="RGD1311037"
                     /inference="alignment:Splign:2.1.0"
     exon            577..706
                     /gene="Crls1"
                     /gene_synonym="RGD1311037"
                     /inference="alignment:Splign:2.1.0"
     exon            707..792
                     /gene="Crls1"
                     /gene_synonym="RGD1311037"
                     /inference="alignment:Splign:2.1.0"
     exon            793..861
                     /gene="Crls1"
                     /gene_synonym="RGD1311037"
                     /inference="alignment:Splign:2.1.0"
     exon            862..953
                     /gene="Crls1"
                     /gene_synonym="RGD1311037"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1875
                     /gene="Crls1"
                     /gene_synonym="RGD1311037"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccagtgtgt ggaaattagt atggagctat ccgtacggcc ttggaaccgc tcgatttcta
       61 tagagaagct ggcggctggt gccagtggct tctgagttct cgattcttgg actccgagaa
      121 ggctgcaagg ccatgctggc ttggcgcgtg gcacgcggcg cgtgggggtc ccttcgcgtg
      181 gccgtccggc ctccaggggc gcggctcggc aggggcggct cccgcagggc cctgctacca
      241 cccgcggcct gctgcctggg ctgcctggcc gagcgctggc ggctgcgtcc ggccgcgttc
      301 gccttgcggc tgccaggcac cagcccgcgg acccactgct ccggcgccgg gaaggcagcc
      361 ccggagcccg cagccggagg agatgccgcc gcgcaggccc ctagtgcccg gtgggtccgg
      421 gcgagcgcaa ccagctcgta tgaaaatcca tggacaatcc caaatttatt gtcaatgaca
      481 agaattggcc tggccccggt gttgggctat ctgattcttg aagaagattt taatgttgca
      541 ctgggtgttt ttgctttagc tgggctaacg gatttgttgg atggatttat tgctcgaaac
      601 tgggccaatc aaaaatcagc tttgggaagt gctcttgatc cacttgctga taaggttctt
      661 atcagcatct tatatattag cctgacctat gcagatctta ttccagtccc actcacttac
      721 atgataattt caagagatgt aatgttgatc gctgctgtgt tttatgtcag ataccgaact
      781 ctgccaacac cgcgaacact agctaagtac ttcaatcctt gctatgccac tgctaggtta
      841 aaaccaacat tcatcagcaa ggtcaataca gcagtccagt taattttggt ggcagcttct
      901 ctggcagctc cagttttcaa ttatgctgac agcatttatc ttcagatact atggtgttgt
      961 acagcattca ctacagctgc gtccgcatac agttattatc actatggtcg gaaaactgtt
     1021 caggtgataa agggcaaatg acaggcaccc agatccagca gcaagggagc gactcgcgtc
     1081 atcggcagca gcgccagcga aagccacagg actttcccga tcttggtgtt cagcttgcga
     1141 aaggtcttgt cagacaaacc atgtcttcaa aaccgaagaa atgtacgtcc aaaataagct
     1201 cgatcatggg cctatacaga atttccagtg tatttttaaa tacaaataaa aatataatgt
     1261 agaattttta atcttaggtt tttgattaat tggcgagatt attctagttt ttttttttaa
     1321 tgtttttaaa aaaacagttg gtaacataga aacaaaggaa agcaggaggg aatccccgag
     1381 attaaatgca taccacacac ggcatggcta tatattgtta tgcttaaatt ttaaatctat
     1441 aaacacatag cagttcatgt gactaatgct tggtcatttg agaagtgaga gtagacctag
     1501 ctgtgggaag tgtaaaggga tacagagcat tcaaatgcag taagttttga aaataaaaaa
     1561 gagcaaacaa aatagaaggc attgaagttt accagtagtt ccagcctctc agttaccaaa
     1621 cagtttctgt atcaggatag cagacaacac aggagtcaga agggagacca cgagtattag
     1681 gcatcgcatc taaaaggcag agaattacat catgccttct cactgtttct catgggacgt
     1741 ttgtatgata ctggaacctg tactcatatg tcatgtaaat agtatgaaac tttctatttt
     1801 tcaaagtttt ttttttttta actttgggga atcttctatt gttaacatga taagaaaata
     1861 aaagagctgg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1921 a
//
