LOCUS       NM_001008284            2803 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus CRK like proto-oncogene, adaptor protein (Crkl),
            mRNA.
ACCESSION   NM_001008284 XM_221260
VERSION     NM_001008284.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2803)
  AUTHORS   Aiello,F.B., Guszczynski,T., Li,W., Hixon,J.A., Jiang,Q.,
            Hodge,D.L., Massignan,T., Di Lisio,C., Merchant,A., Procopio,A.D.,
            Bonetto,V. and Durum,S.K.
  TITLE     IL-7-induced phosphorylation of the adaptor Crk-like and other
            targets
  JOURNAL   Cell Signal 47, 131-141 (2018)
   PUBMED   29581031
REFERENCE   2  (bases 1 to 2803)
  AUTHORS   Haller,M., Mo,Q., Imamoto,A. and Lamb,D.J.
  TITLE     Murine model indicates 22q11.2 signaling adaptor CRKL is a
            dosage-sensitive regulator of genitourinary development
  JOURNAL   Proc Natl Acad Sci U S A 114 (19), 4981-4986 (2017)
   PUBMED   28439006
REFERENCE   3  (bases 1 to 2803)
  AUTHORS   Hallock,P.T., Chin,S., Blais,S., Neubert,T.A. and Glass,D.J.
  TITLE     Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine
            Receptor Cluster Formation
  JOURNAL   Mol Cell Biol 36 (2), 262-270 (2015)
   PUBMED   26527617
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2803)
  AUTHORS   Huang,Y., Clarke,F., Karimi,M., Roy,N.H., Williamson,E.K.,
            Okumura,M., Mochizuki,K., Chen,E.J., Park,T.J., Debes,G.F.,
            Zhang,Y., Curran,T., Kambayashi,T. and Burkhardt,J.K.
  TITLE     CRK proteins selectively regulate T cell migration into inflamed
            tissues
  JOURNAL   J Clin Invest 125 (3), 1019-1032 (2015)
   PUBMED   25621495
REFERENCE   5  (bases 1 to 2803)
  AUTHORS   Racedo,S.E., McDonald-McGinn,D.M., Chung,J.H., Goldmuntz,E.,
            Zackai,E., Emanuel,B.S., Zhou,B., Funke,B. and Morrow,B.E.
  TITLE     Mouse and human CRKL is dosage sensitive for cardiac outflow tract
            formation
  JOURNAL   Am J Hum Genet 96 (2), 235-244 (2015)
   PUBMED   25658046
REFERENCE   6  (bases 1 to 2803)
  AUTHORS   Singer,C.F., Hudelist,G., Lamm,W., Mueller,R., Handl,C., Kubista,E.
            and Czerwenka,K.
  TITLE     Active (p)CrkL is overexpressed in human malignancies: potential
            role as a surrogate parameter for therapeutic tyrosine kinase
            inhibition
  JOURNAL   Oncol Rep 15 (2), 353-359 (2006)
   PUBMED   16391854
REFERENCE   7  (bases 1 to 2803)
  AUTHORS   Arevalo,J.C., Pereira,D.B., Yano,H., Teng,K.K. and Chao,M.V.
  TITLE     Identification of a switch in neurotrophin signaling by selective
            tyrosine phosphorylation
  JOURNAL   J Biol Chem 281 (2), 1001-1007 (2006)
   PUBMED   16284401
REFERENCE   8  (bases 1 to 2803)
  AUTHORS   Birchmeier,C., Birchmeier,W., Gherardi,E. and Vande Woude,G.F.
  TITLE     Met, metastasis, motility and more
  JOURNAL   Nat Rev Mol Cell Biol 4 (12), 915-925 (2003)
   PUBMED   14685170
  REMARK    Review article
REFERENCE   9  (bases 1 to 2803)
  AUTHORS   Guris,D.L., Fantes,J., Tara,D., Druker,B.J. and Imamoto,A.
  TITLE     Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy
            neurocristopathies of DiGeorge syndrome
  JOURNAL   Nat Genet 27 (3), 293-298 (2001)
   PUBMED   11242111
REFERENCE   10 (bases 1 to 2803)
  AUTHORS   Rhodes,J., York,R.D., Tara,D., Tajinda,K. and Druker,B.J.
  TITLE     CrkL functions as a nuclear adaptor and transcriptional activator
            in Bcr-Abl-expressing cells
  JOURNAL   Exp Hematol 28 (3), 305-310 (2000)
   PUBMED   10720695
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085865.1.
            
            On Dec 16, 2004 this sequence version replaced XM_221260.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085865.1, SRR8487227.48657.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2803
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..2803
                     /gene="Crkl"
                     /note="CRK like proto-oncogene, adaptor protein"
                     /db_xref="GeneID:287942"
                     /db_xref="RGD:1308531"
     exon            1..793
                     /gene="Crkl"
                     /inference="alignment:Splign:2.1.0"
     CDS             483..1394
                     /gene="Crkl"
                     /note="v-crk avian sarcoma virus CT10 oncogene
                     homolog-like; crk-like protein-like"
                     /codon_start=1
                     /product="crk-like protein"
                     /protein_id="NP_001008285.1"
                     /db_xref="GeneID:287942"
                     /db_xref="RGD:1308531"
                     /translation="MSSARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTC
                     PGDYVLSVSENSRVSHYIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPA
                     PRYPNPPMGSVSAPNLSTAEENLEYVRTLYDFPGNDAEDLPFKKGELLVIIEKPEEQW
                     WSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPT
                     VASTPGAAINPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWE
                     GEVNGRKGLFPFTHVKIFDPQNPDDNE"
     exon            794..1259
                     /gene="Crkl"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..2773
                     /gene="Crkl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccggtcgc ttctcccgcg tccgccattt tgttgctgtg gctattggga acgggtaggg
       61 taggacggtc cgggaggcgc gactgttgtt ggagtgcggt gcttcgtgtg acggcgagga
      121 accgtgcggg ctcttgaggc tgcggagccg gcggcttcca ggacagaagt cgctggatcc
      181 tactccggac agctgagaag cccgaggcgg cctctgctac tgctctgttt cgcccacctc
      241 gacccagggg ttttgcccac tgttcccgga ccggctctct ccgagaggcg gccctgtgca
      301 ggagggcggt ggcggaggat gctgcggggc ccggagccta gaggaacgtc ctgaccaagc
      361 cctctgattg ttcctcgaag tgttcgagaa gaggcccttc ctcgacccca aagccgacag
      421 cgggtaaagg cttccagagc aagcgagagc agcagacgcc gcccatcccc gggcccaaca
      481 ccatgtcctc cgccaggttt gattcttcag accgttctgc ctggtacatg gggccagtgt
      541 ctcgccagga ggcgcagacc cgtctccagg gccagcgcca tggcatgttc ctagtccggg
      601 actcatctac ctgccctggg gactatgtac tgtccgtgtc cgagaactcg cgtgtctcgc
      661 actacatcat caactccctg cccaaccgcc gctttaagat cggggaccag gagtttgacc
      721 atttgccggc cttgctggag ttctacaaga tccactacct ggatactacc accttaatcg
      781 aaccagcgcc caggtacccc aacccaccaa tgggttctgt ctcagcaccc aacttatcta
      841 cagcagaaga aaatctggaa tatgtacgga ctctgtatga ttttcctggg aatgatgctg
      901 aagacctacc ctttaaaaag ggtgagcttc tagtgataat agaaaagcct gaagaacagt
      961 ggtggagtgc ccgcaacaag gacggccggg ttgggatgat tcctgtccct tacgttgaaa
     1021 agcttgtgag gtcctcacca catggaaagc atggaaatag gaattctaac agttatggca
     1081 tcccagaacc tgctcacgca tatgctcaac ctcagaccac aactcctcta cctacagttg
     1141 ccagtactcc tggggcagcg atcaaccctt tgccatccac acagaatgga cctgtctttg
     1201 caaaagcaat ccagaagaga gtaccttgtg cttatgacaa gactgccttg gcattggagg
     1261 ttggtgacat tgtgaaagtc acaaggatga atatcaatgg ccagtgggaa ggcgaggtga
     1321 atgggcgcaa ggggcttttc cccttcacac atgttaaaat ctttgaccct cagaaccccg
     1381 atgataacga gtgattgctg tgctgtccct gctgctgcct ccttctgcct gtcagtcttc
     1441 tttgaagtgg gaagcactct gtcacatgca agttacacca agctgctggt ggccgacttt
     1501 catatgttgg cagtccctgc acctgcggaa tgcctcagca gcagcctcgg catttgtatc
     1561 atagtcatgc tgtcaaagag tagctgattt agagttcttg tggattatga gctggaaaca
     1621 ctggcggaag cacccagtag agagaattta acctagaaag ggtcttcctt ctcatcactg
     1681 ccttgtttgt actggaggcc aatggtcgtg ctcgccagag agagtgagcc tgctggtggt
     1741 ctacatggag atggtgaggc ttagcaagat ctcgctgttg ctggttcaca gaacagtggc
     1801 tttgccacca acttgatatt ctttggacaa cagaggaagt aaaactccag acaattctgt
     1861 ccgaactcct gaagtgtctg gcttgttttc attttctttt gtttagtttt gtttttggaa
     1921 gactaattaa atatagttgt gtgttctgaa cagattttta aatagtaggt tggatttttg
     1981 tgatgggcta aggaacaatc catgtccctg agcttccaaa ctgaagccgc tgtatgtaac
     2041 taaaaatgtg tgaagacacc ctgaagtgag gcctttatct tttggttgcc ataatacctt
     2101 gtttaccatg tggcaaacag tgtacacaag cagcatttgc tgtgtgccgt gctgtgaatc
     2161 accaaggtgg ggtgtgggcc tgttgtcatt gttgcctctg acaggagcaa acagggtgga
     2221 ccccttcagt gagcacaccc ctttgagaac acagtgaagc ccatgggctt actagattca
     2281 tgagttaaat tgcgttgcca tgttctgcca cacaggctcc tcagcccttc ctgcactgac
     2341 ctatcttgtc caggctgccc gagagtggtg gctgttctgg ttctgcagaa ccagaataca
     2401 gtgcttctga gcaaaagaag atgcccatcg accatgagcc actttcctgc atgtcagcta
     2461 gtacagatgt gtgtctgacc cctcatacac acatctagac cagagttcta gaaccttctc
     2521 tagtgtgctc tgttcagcta gaccctgacg aggacaagcc tccacccagc gcagcagact
     2581 cagaacagtg gttattactg agtggctcca gcatcggtgt cttctgtagc gatggctctg
     2641 gctctagagg cctcaggctt tgagaactga ggaacatatt caggtgacag aaccaataaa
     2701 accatttgtc cactgtattt atttctctta aagacttttt aaaattttgt ttatgttagg
     2761 catggtggct ataaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
