LOCUS       NM_019302               1080 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus CRK proto-oncogene, adaptor protein (Crk), mRNA.
ACCESSION   NM_019302
VERSION     NM_019302.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1080)
  AUTHORS   Lopez,M.L., Lo,M., Kung,J.E., Dudkiewicz,M., Jang,G.M., Von
            Dollen,J., Johnson,J.R., Krogan,N.J., Pawlowski,K. and Jura,N.
  TITLE     PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member,
            inhibits CrkII through dimerization
  JOURNAL   Proc Natl Acad Sci U S A 116 (31), 15495-15504 (2019)
   PUBMED   31311869
REFERENCE   2  (bases 1 to 1080)
  AUTHORS   Aiello,F.B., Guszczynski,T., Li,W., Hixon,J.A., Jiang,Q.,
            Hodge,D.L., Massignan,T., Di Lisio,C., Merchant,A., Procopio,A.D.,
            Bonetto,V. and Durum,S.K.
  TITLE     IL-7-induced phosphorylation of the adaptor Crk-like and other
            targets
  JOURNAL   Cell Signal 47, 131-141 (2018)
   PUBMED   29581031
REFERENCE   3  (bases 1 to 1080)
  AUTHORS   Huang,Y., Clarke,F., Karimi,M., Roy,N.H., Williamson,E.K.,
            Okumura,M., Mochizuki,K., Chen,E.J., Park,T.J., Debes,G.F.,
            Zhang,Y., Curran,T., Kambayashi,T. and Burkhardt,J.K.
  TITLE     CRK proteins selectively regulate T cell migration into inflamed
            tissues
  JOURNAL   J Clin Invest 125 (3), 1019-1032 (2015)
   PUBMED   25621495
REFERENCE   4  (bases 1 to 1080)
  AUTHORS   Satoh,T.
  TITLE     Rho GTPases in insulin-stimulated glucose uptake
  JOURNAL   Small GTPases 5, e28102 (2014)
   PUBMED   24613967
  REMARK    Review article
REFERENCE   5  (bases 1 to 1080)
  AUTHORS   Gong,X.H., Chen,C., Hou,P., Zhu,S.C., Wu,C.Q., Song,C.L., Ni,W.,
            Hu,J.F., Yao,D.K., Kang,J.H. and Zhu,L.
  TITLE     Overexpression of miR-126 inhibits the activation and migration of
            HSCs through targeting CRK
  JOURNAL   Cell Physiol Biochem 33 (1), 97-106 (2014)
   PUBMED   24480980
  REMARK    GeneRIF: overexpression of miR-126 significantly inhibited the
            activation and migration of hepatic stellate cell through targeting
            CRK.
            Erratum:[Cell Physiol Biochem. 2014;33(3):882]
REFERENCE   6  (bases 1 to 1080)
  AUTHORS   Ribon,V., Printen,J.A., Hoffman,N.G., Kay,B.K. and Saltiel,A.R.
  TITLE     A novel, multifuntional c-Cbl binding protein in insulin receptor
            signaling in 3T3-L1 adipocytes
  JOURNAL   Mol Cell Biol 18 (2), 872-879 (1998)
   PUBMED   9447983
REFERENCE   7  (bases 1 to 1080)
  AUTHORS   Ishiki,M., Sasaoka,T., Ishihara,H., Imamura,T., Usui,I., Takata,Y.
            and Kobayashi,M.
  TITLE     Evidence for functional roles of Crk-II in insulin and epidermal
            growth factor signaling in Rat-1 fibroblasts overexpressing insulin
            receptors
  JOURNAL   Endocrinology 138 (11), 4950-4958 (1997)
   PUBMED   9348226
REFERENCE   8  (bases 1 to 1080)
  AUTHORS   Liu,F., Hill,D.E. and Chernoff,J.
  TITLE     Direct binding of the proline-rich region of protein tyrosine
            phosphatase 1B to the Src homology 3 domain of p130(Cas)
  JOURNAL   J Biol Chem 271 (49), 31290-31295 (1996)
   PUBMED   8940134
REFERENCE   9  (bases 1 to 1080)
  AUTHORS   Kizaka-Kondoh,S., Matsuda,M. and Okayama,H.
  TITLE     CrkII signals from epidermal growth factor receptor to Ras
  JOURNAL   Proc Natl Acad Sci U S A 93 (22), 12177-12182 (1996)
   PUBMED   8901553
REFERENCE   10 (bases 1 to 1080)
  AUTHORS   Ribon,V. and Saltiel,A.R.
  TITLE     Nerve growth factor stimulates the tyrosine phosphorylation of
            endogenous Crk-II and augments its association with p130Cas in
            PC-12 cells
  JOURNAL   J Biol Chem 271 (13), 7375-7380 (1996)
   PUBMED   8631760
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D44481.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D44481.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1080
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1080
                     /gene="Crk"
                     /gene_synonym="CrkII; Crko"
                     /note="CRK proto-oncogene, adaptor protein"
                     /db_xref="GeneID:54245"
                     /db_xref="RGD:2405"
     exon            1..280
                     /gene="Crk"
                     /gene_synonym="CrkII; Crko"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..954
                     /gene="Crk"
                     /gene_synonym="CrkII; Crko"
                     /note="proto-oncogene C-crk; p38; avian sarcoma virus CT10
                     (v-crk) oncogene homolog; v-crk sarcoma virus CT10
                     oncogene homolog; v-crk avian sarcoma virus CT10 oncogene
                     homolog"
                     /codon_start=1
                     /product="adapter molecule crk"
                     /protein_id="NP_062175.1"
                     /db_xref="GeneID:54245"
                     /db_xref="RGD:2405"
                     /translation="MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSP
                     GDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLE
                     FYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILR
                     IRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEP
                     GPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWE
                     GECNGKRGHFPFTHVRLLDQQNPEEDFS"
     exon            281..816
                     /gene="Crk"
                     /gene_synonym="CrkII; Crko"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1080
                     /gene="Crk"
                     /gene_synonym="CrkII; Crko"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgccggcgg cggcccagcg tgaaggcgcg gaggcggcca tggcaggcaa cttcgactcg
       61 gaggagcgga gtagctggta ctggggccgc ttgagccggc aggaggcggt ggcgctattg
      121 cagggccagc ggcacggggt tttcctggtg cgggactcga gcaccagccc cggggactat
      181 gtgctcagcg tctccgaaaa ctcgcgcgtc tcccactaca tcatcaacag cagcggcccg
      241 cgccctccag tgcctccgtc gcccgctcag cctccgccgg gagtgagtcc ctccaggctc
      301 cgaataggag atcaagaatt tgattcattg cctgctttac tggaattcta caaaatacac
      361 tatttggaca ctacaacact gatagaacca gtttccagat caaggcaggg tagtggagtg
      421 attctcaggc aggaggaggc agagtatgtg cgggccctct ttgactttaa tgggaatgat
      481 gaagaagatc ttccctttaa gaaaggagac atcctgagaa tccgggataa gcctgaagag
      541 cagtggtgga atgcagagga cagcgaagga aagaggggga tgattcctgt cccttacgtg
      601 gagaagtata gacccgcctc cgcctcagta tcggctctga ttggaggtaa ccaggagggt
      661 tcccacccac agccactggg tgggccggag cctgggccct atgcccaacc cagcgtcaac
      721 actccgctcc ctaacctcca gaatgggccc atttatgcca gggttatcca gaagcgagtc
      781 cctaatgcct acgacaagac agccttggct ttggaggtcg gtgagctggt aaaggttacg
      841 aagattaatg tgagtggtca gtgggaaggg gagtgtaatg gcaaacgagg tcacttccca
      901 ttcacacatg tccgtctgct ggatcaacag aatcccgagg aggacttcag ctgagtatag
      961 ttccacactt tgctgacaga tgagaacaat ctgtttccac ccccaattgc cgtctataca
     1021 attttcttac aggtgtcaaa gcagtctagt ttatataagc atcctgttgc ctgtgatctt
//
