LOCUS       NM_138518               4058 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cysteine-rich secretory protein LCCL domain
            containing 2 (Crispld2), mRNA.
ACCESSION   NM_138518 XM_346523
VERSION     NM_138518.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4058)
  AUTHORS   Su,W., Wong,E.W., Mruk,D.D. and Cheng,C.Y.
  TITLE     The Scribble/Lgl/Dlg polarity protein complex is a regulator of
            blood-testis barrier dynamics and spermatid polarity during
            spermatogenesis
  JOURNAL   Endocrinology 153 (12), 6041-6053 (2012)
   PUBMED   23038739
  REMARK    GeneRIF: Scribble/Lgl/Dlg polarity protein complex is a regulator
            of blood-testis barrier dynamics and spermatid polarity during
            spermatogenesis
REFERENCE   2  (bases 1 to 4058)
  AUTHORS   Wang,T., Liu,Y., Xu,X.H., Deng,C.Y., Wu,K.Y., Zhu,J., Fu,X.Q.,
            He,M. and Luo,Z.G.
  TITLE     Lgl1 activation of rab10 promotes axonal membrane trafficking
            underlying neuronal polarization
  JOURNAL   Dev Cell 21 (3), 431-444 (2011)
   PUBMED   21856246
  REMARK    GeneRIF: the Lgl1 regulation of Rab10 stimulates the trafficking of
            membrane precursor vesicles, whose fusion with the plasmalemma is
            crucial for axonal growth.
REFERENCE   3  (bases 1 to 4058)
  AUTHORS   Ruttenstock,E.M., Doi,T., Dingemann,J. and Puri,P.
  TITLE     Prenatal retinoic acid treatment upregulates late gestation lung
            protein 1 in the nitrofen-induced hypoplastic lung in late
            gestation
  JOURNAL   Pediatr Surg Int 27 (2), 125-129 (2011)
   PUBMED   21069352
  REMARK    GeneRIF: Upregulation of LGL1 pulmonary gene expression after RA
            treatment may promote lung growth by stimulating alveologenesis in
            the nitrofen CDH model.
REFERENCE   4  (bases 1 to 4058)
  AUTHORS   Chiquet,B.T., Henry,R., Burt,A., Mulliken,J.B., Stal,S.,
            Blanton,S.H. and Hecht,J.T.
  TITLE     Nonsyndromic cleft lip and palate: CRISPLD genes and the folate
            gene pathway connection
  JOURNAL   Birth Defects Res A Clin Mol Teratol 91 (1), 44-49 (2011)
   PUBMED   21254358
REFERENCE   5  (bases 1 to 4058)
  AUTHORS   Nadeau,K., Montermini,L., Mandeville,I., Xu,M., Weiss,S.T.,
            Sweezey,N.B. and Kaplan,F.
  TITLE     Modulation of Lgl1 by steroid, retinoic acid, and vitamin D models
            complex transcriptional regulation during alveolarization
  JOURNAL   Pediatr Res 67 (4), 375-381 (2010)
   PUBMED   20057335
  REMARK    GeneRIF: Data show that in rat lung, glucocorticoid stimulates (7-
            to 115-fold) and Vitamin D suppresses (twofold) Lgl1 expression.
REFERENCE   6  (bases 1 to 4058)
  AUTHORS   Nadeau,K., Jankov,R.P., Tanswell,A.K., Sweezey,N.B. and Kaplan,F.
  TITLE     Lgl1 is suppressed in oxygen toxicity animal models of
            bronchopulmonary dysplasia and normalizes during recovery in air
  JOURNAL   Pediatr Res 59 (3), 389-395 (2006)
   PUBMED   16492977
  REMARK    GeneRIF: Data suggest that deficiency of lgl1 contributes to the
            arrested alveolar partitioning observed in bronchopulmonary
            dysplasia and that recovery is associated with normalization of
            lgl1 levels.
REFERENCE   7  (bases 1 to 4058)
  AUTHORS   Oyewumi,L., Kaplan,F. and Sweezey,N.B.
  TITLE     Lgl1, a mesenchymal modulator of early lung branching
            morphogenesis, is a secreted glycoprotein imported by late
            gestation lung epithelial cells
  JOURNAL   Biochem J 376 (Pt 1), 61-69 (2003)
   PUBMED   12880386
  REMARK    GeneRIF: Lgl1 is imported by late gestation lung epithelial cells.
REFERENCE   8  (bases 1 to 4058)
  AUTHORS   Oyewumi,L., Kaplan,F., Gagnon,S. and Sweezey,N.B.
  TITLE     Antisense oligodeoxynucleotides decrease LGL1 mRNA and protein
            levels and inhibit branching morphogenesis in fetal rat lung
  JOURNAL   Am J Respir Cell Mol Biol 28 (2), 232-240 (2003)
   PUBMED   12540491
  REMARK    GeneRIF: lgl1 plays an important role in fetal airway branching
            morphogenesis.
REFERENCE   9  (bases 1 to 4058)
  AUTHORS   Trexler,M., Banyai,L. and Patthy,L.
  TITLE     The LCCL module
  JOURNAL   Eur J Biochem 267 (18), 5751-5757 (2000)
   PUBMED   10971586
REFERENCE   10 (bases 1 to 4058)
  AUTHORS   Kaplan,F., Ledoux,P., Kassamali,F.Q., Gagnon,S., Post,M.,
            Koehler,D., Deimling,J. and Sweezey,N.B.
  TITLE     A novel developmentally regulated gene in lung mesenchyme: homology
            to a tumor-derived trypsin inhibitor
  JOURNAL   Am J Physiol 276 (6), L1027-L1036 (1999)
   PUBMED   10362728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK600175.1, JAXUCZ010000019.1, CB732240.1, CK367026.1 and
            CA509993.1.
            
            On Oct 23, 2007 this sequence version replaced NM_138518.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1398927.1, AF109674.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               CK600175.1         489-638
            151-309             JAXUCZ010000019.1  64979106-64979264
            310-428             JAXUCZ010000019.1  64981224-64981342
            429-460             JAXUCZ010000019.1  64983155-64983186
            461-719             CB732240.1         53-311
            720-778             JAXUCZ010000019.1  64986066-64986124
            779-922             JAXUCZ010000019.1  64990655-64990798
            923-936             JAXUCZ010000019.1  64993098-64993111
            937-1576            CK367026.1         1-640
            1577-3514           JAXUCZ010000019.1  65017633-65019570
            3515-4058           CA509993.1         1-544               c
FEATURES             Location/Qualifiers
     source          1..4058
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..4058
                     /gene="Crispld2"
                     /gene_synonym="Lcrisp2; Lgl1"
                     /note="cysteine-rich secretory protein LCCL domain
                     containing 2"
                     /db_xref="GeneID:171547"
                     /db_xref="RGD:620860"
     exon            1..309
                     /gene="Crispld2"
                     /gene_synonym="Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1563
                     /gene="Crispld2"
                     /gene_synonym="Lcrisp2; Lgl1"
                     /note="late gestation lung protein 1"
                     /codon_start=1
                     /product="cysteine-rich secretory protein LCCL
                     domain-containing 2 precursor"
                     /protein_id="NP_612527.2"
                     /db_xref="GeneID:171547"
                     /db_xref="RGD:620860"
                     /translation="MSCLLNNMVPVGLALLVCGVQAFFLPNTMSLERLLSKYQHTEPH
                     SRVRRAIPMSDRQEILMLHNKLRGQVYPPASNMEYMTWDEELERSAAAWAQRCLWEHG
                     PASLLVSIGQNLAVHWGRYRSPGFHVQSWYDEVKDYTYPYPHECNPWCPERCSGAMCT
                     HYTQMVWATTNKIGCAVHTCRSMSVWGDIWENAVYLVCNYSPKGNWIGEAPYKHGRPC
                     SECPSSYGGGCRNNLCYREEHYHQKPEVDEMNEVESPPAPEETHVWVQPRVVKPSKTK
                     KTPVVNFMTQVVHCDTKMKDSCKGSTCNRYQCPAGCLNNKAKVFGSLFYESSSSICRA
                     AIHYGVIDDRGGLVDVTRNGMVPFFVKSQKNGLESLSKYKPSSSFTVSKVKETAVDCH
                     TTVAQLCPFEKPATHCPRVRCPSRCGEEPSYWAPVYGTNIYADTSSICKAAVHAGVIV
                     DEVGGYADVMPVDKKKSYVGSLRNGVQSESPSTPQNGNAFRIFPVRQ"
     exon            310..428
                     /gene="Crispld2"
                     /gene_synonym="Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..561
                     /gene="Crispld2"
                     /gene_synonym="Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..677
                     /gene="Crispld2"
                     /gene_synonym="Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..778
                     /gene="Crispld2"
                     /gene_synonym="Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..922
                     /gene="Crispld2"
                     /gene_synonym="Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..983
                     /gene="Crispld2"
                     /gene_synonym="Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1050
                     /gene="Crispld2"
                     /gene_synonym="Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1181
                     /gene="Crispld2"
                     /gene_synonym="Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1225
                     /gene="Crispld2"
                     /gene_synonym="Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1298
                     /gene="Crispld2"
                     /gene_synonym="Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1374
                     /gene="Crispld2"
                     /gene_synonym="Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1508
                     /gene="Crispld2"
                     /gene_synonym="Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..4043
                     /gene="Crispld2"
                     /gene_synonym="Lcrisp2; Lgl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaccttccag tgcccagccc tacttcagga gtgccctgtc cccttagtcg tggctgcagg
       61 cgtggagcca tgagctgtct tctgaacaat atggtcccgg tggggctggc tctgctggtc
      121 tgcggagtac aggccttttt ccttcccaac accatgagcc tggagaggct gctcagcaag
      181 taccagcaca cagagccaca ctcacgcgtg cgcagggcca tccccatgtc agaccgtcag
      241 gaaatcctca tgctgcacaa caagctgcga ggtcaggtgt atccccctgc ctccaacatg
      301 gagtacatga cctgggatga ggagctggag aggtcggcag ccgcgtgggc acagaggtgc
      361 ctgtgggagc atgggcccgc cagccttctc gtgtccatcg ggcagaacct ggctgtgcac
      421 tggggcaggt accgctctcc tgggttccac gtgcagtcgt ggtatgacga ggtgaaggat
      481 tacacctacc cgtaccccca cgagtgcaac ccatggtgcc ccgagcgctg ctcaggagcc
      541 atgtgcaccc actacacaca gatggtttgg gccaccacca acaagattgg ctgtgctgtg
      601 cacacctgtc ggagcatgag cgtctgggga gacatctggg agaacgccgt gtatctcgtc
      661 tgcaattatt ctccaaaggg aaactggatt ggtgaggctc cctacaaaca tggccgcccc
      721 tgctctgagt gtccgtccag ctatggaggt ggctgtcgga acaacctgtg ttaccgagaa
      781 gagcactacc atcagaaacc agaggtggat gagatgaacg aggtggaatc gccccctgct
      841 cccgaggaaa cccatgtctg ggttcaaccc agggtggtca aaccctcaaa gaccaagaag
      901 accccagtcg tcaacttcat gacccaagtg gtccactgtg acacaaagat gaaggactca
      961 tgcaagggat ccacatgtaa caggtaccag tgcccagcag gctgtctgaa caacaaggcg
     1021 aaggtctttg gctctctgtt ttatgaaagt tcttccagta tatgtcgagc tgctatccac
     1081 tatggtgtca tcgatgatcg aggtggcctg gtggatgtca ccaggaatgg gatggtaccc
     1141 ttctttgtca aatctcagaa aaatggcttg gagtccctga gtaaatacaa gccgtctagc
     1201 tccttcactg tgtccaaagt gaaagagacg gctgtggact gccacaccac agttgcacag
     1261 ctatgcccct tcgagaagcc agccacccac tgcccgagag tccggtgtcc ttcacgatgt
     1321 ggagaggagc catcctattg ggcccctgtg tatggaacca acatctacgc tgacacttcc
     1381 agcatctgta aggcggctgt gcatgcaggc gtcattgtcg acgaggttgg tggctatgca
     1441 gatgtgatgc ccgtggacaa aaagaagagc tacgtgggct ccctcaggaa cggggttcag
     1501 tcagagagcc cgagcactcc tcagaacgga aacgccttcc ggatcttccc cgtcaggcag
     1561 tgaatatgga gacctgggga gaagggggtg tcgtctactg ggattcgggg gtcctgcttt
     1621 ttatctgtac tttgtccttt gggggtggga gggttacaga gagtcaagaa tcttcctttc
     1681 ggtgtcgttg actgtcctgg gcctccgtgg cttttggtga cggtgacaga gcaccttccc
     1741 ctcatgagca gcatgccgtg gagtctcttg ctggacaacc agtgcccaga ctggccaggt
     1801 ggcggtcccc atctggtggc tcatctcctc tcaggagatg ctcaccgaga cactctttgc
     1861 cacattttct ttggtgttgg aggggggaag gctttcgaac tcttgaggat acagggttga
     1921 gattcgttgt gaagggggct cttgtctgga tgacaagagt ggacagccct aaggttacag
     1981 tccgtcctac caacagagaa atagggtctg tgtttgctgg tcagacagat gggctgcagg
     2041 gagaagccct gggcaaaacc tgggctctgc cctggtggta tccgtgctca tgtccccaac
     2101 cttcttggca gtcacgtgtt cgtatgacca gcagagctgg tctatttaaa gttggtagca
     2161 ctccagagat ttatcttttc tttgtccttg tccttgtcct tgtggcccgt tttcacatga
     2221 cctttggtct catggaagac cagtgcatca ggagccttcc ccaccattcc gtgtccctgt
     2281 gtcgagcatc tgccccaccc caaggaggtc tagattgtcc tcctttgggg cttggctttg
     2341 caagaggctc caggtcttag atgtctgctt actccttaga acaagggctc tctcacggtt
     2401 gctgttagag tggcagctcg acatcgcttc cccatggttt gggtgaccta gtttttagct
     2461 gtgggaggac cggattcctg gcgcattcct cctgggggtt aatggagtga cctgtggttg
     2521 taaaaccacc catgacacac cagccaccag agagagaggg gcagggacac acaggaagaa
     2581 cccctcagcg cttgccagag tcccgggctc caagagtgtg gtgagtcctg gcttccatca
     2641 cttaggagcc tggtccaaac ccgctgtaaa atgaaacctg cttttgtaaa cagctttctc
     2701 tagagaaggt ggaatcccac cccagtcctg gggatggggc acagttgcct gtgaatgttg
     2761 gcctcaaaca gggtttcatg atccagccaa acatttctta gacaaaagaa agggggtggg
     2821 agtagaaaat aaaacagaat gctgtccccc agttgaaagg ctggggaggt gacttggtga
     2881 ttaacagctc taccagagga cctgagctca gttcccacga ctcacagact ataactataa
     2941 cccacctatg actaactcta ggagatccat gatctccaca gacgccacac gcatccacat
     3001 gagcaaaagt acaaatggtt cctaaaaaaa aaaaataaaa aaacatctaa gggagtctga
     3061 acaaaacctt ccctgtagag aaccgtgtgg acctagttga gttgaatgtt tccttatttg
     3121 tttgagacag tttcactatg tagtccaggc tggccttgac tcgttatgta gcccaggctg
     3181 gcctcctgag tactgagata gctccccccc aaatccatcc cttctgggga gtttataaga
     3241 tgcacacgac cttgaaccag ctctagctag cctttcacca ggctgtttct gcctcatgtg
     3301 tgtgggtgtg gtgtctttgg agcatcaaca cttccactcc agatgttgga gcaaacatct
     3361 gctcagcctg tggaaggaga cttctggttg ctaccaaaca tccgggaaac ttcccgatgc
     3421 aaggagtcct gtgggaccct tcacccagcc tgcagggcaa ggttgagatg gtaagggaaa
     3481 accatacccc tcctgggttt ctagaatgag caaccaatcc catctccagg gaactcgcgg
     3541 tgtgagtctg taccggggtc ctcagtgctc cctggctgcc cttccactag gcacagaggc
     3601 ctcgcgcaga gcctggctga gcagccttga tcttcttcat tgatagtttg aaaccggaag
     3661 ccctttactg tggaagaaac agaaacaaaa ccaccaatga caagacccta aatcagagcc
     3721 ctctgatcct gtgtgcccgt cagctctccc aagcttcaag tgaccacgcc catcccagct
     3781 gcatccccat tccgtcctac atccggtgat agtttccatt tgcctccgag ctgtgcccgg
     3841 tctgttcaga ggggtgtgcc gactctccat gatctgtagg ctctctcggc ccgcagttta
     3901 ctgtgtgctt ttttctatga aaaatgatat attttacaac ttcctatgta caaaagttta
     3961 ttgtaagttt ttgtgcttcg catgaacagg gccacactgg ttgttgctat ggtttcaata
     4021 aaatggattt gatttctaac acaaaaaaaa aaaaaaaa
//
