LOCUS       NM_001134963            4433 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus cysteine-rich secretory protein LCCL domain
            containing 1 (Crispld1), mRNA.
ACCESSION   NM_001134963 XM_001062036 XM_237258
VERSION     NM_001134963.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4433)
  AUTHORS   Chiquet BT, Henry R, Burt A, Mulliken JB, Stal S, Blanton SH and
            Hecht JT.
  TITLE     Nonsyndromic cleft lip and palate: CRISPLD genes and the folate
            gene pathway connection
  JOURNAL   Birth Defects Res A Clin Mol Teratol 91 (1), 44-49 (2011)
   PUBMED   21254358
REFERENCE   2  (bases 1 to 4433)
  AUTHORS   Balharry D, Sexton K, Oreffo V and Berube KA.
  TITLE     A novel application for Cocoacrisp protein as a biomarker for
            experimental pulmonary fibrosis
  JOURNAL   Biomarkers 14 (6), 366-371 (2009)
   PUBMED   19552621
  REMARK    GeneRIF: Crispld1 signal was primarily detected on the alveolar
            surface in experimental pulmonary fibrosis
REFERENCE   3  (bases 1 to 4433)
  AUTHORS   Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE and
            Yates JR.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473984.1.
            
            On or before Sep 15, 2008 this sequence version replaced
            XM_001062036.1, XM_237258.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169118.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4433
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..4433
                     /gene="Crispld1"
                     /gene_synonym="RGD1564813"
                     /note="cysteine-rich secretory protein LCCL domain
                     containing 1"
                     /db_xref="GeneID:316482"
                     /db_xref="RGD:1564813"
     exon            1..707
                     /gene="Crispld1"
                     /gene_synonym="RGD1564813"
                     /inference="alignment:Splign:2.1.0"
     exon            708..1027
                     /gene="Crispld1"
                     /gene_synonym="RGD1564813"
                     /inference="alignment:Splign:2.1.0"
     CDS             770..2272
                     /gene="Crispld1"
                     /gene_synonym="RGD1564813"
                     /note="cocoacrisp"
                     /codon_start=1
                     /product="cysteine-rich secretory protein LCCL
                     domain-containing 1"
                     /protein_id="NP_001128435.1"
                     /db_xref="GeneID:316482"
                     /db_xref="RGD:1564813"
                     /translation="MMCKAQEWLRMTALLFVARAVPAMVVPNATLLEKLLEKYMDEDD
                     EWWTAKQRGKRAITDNDMQSILDLHNKLRSQVYPAASNMEYMTWDVELERSAESWAET
                     CLWEHGPTSLLPSIGQNLGAHWGRYRPPTFHVQAWYDEVRDFSYPYEHECDPYCPFRC
                     SGPVCTHYTQVVWATSSRIGCAINLCHNMNIWGQIWPKAVYLVCNYSPKGNWWGHAPY
                     KHGKPCSACPPSFGGGCRENLCYKEGSDQYYTPQEEETNEIERQESQVHDTHVRTRSD
                     DSNRNDVISTQQMSQIVSCEVRLRDQCKGTTCNRYECPAGCLDSKAKVIGSVHYEMQS
                     SICRAAIHYGIIDNEGGWVDVTRQGRKHYFIKSNRNGIQTIGKYRSANSFIVSKVTVQ
                     AVTCETTVEQLCPFHKPASHCPRVYCPRNCMQANPHYARVIGSRIYSDLSSICRAAVH
                     AGVIRNHGGYVDVMPVDKRRMYTASFQNGIFSESLQNPTGGKAFRVFAVV"
     exon            1028..1146
                     /gene="Crispld1"
                     /gene_synonym="RGD1564813"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1279
                     /gene="Crispld1"
                     /gene_synonym="RGD1564813"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1395
                     /gene="Crispld1"
                     /gene_synonym="RGD1564813"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1496
                     /gene="Crispld1"
                     /gene_synonym="RGD1564813"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1637
                     /gene="Crispld1"
                     /gene_synonym="RGD1564813"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1698
                     /gene="Crispld1"
                     /gene_synonym="RGD1564813"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1765
                     /gene="Crispld1"
                     /gene_synonym="RGD1564813"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1896
                     /gene="Crispld1"
                     /gene_synonym="RGD1564813"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..1940
                     /gene="Crispld1"
                     /gene_synonym="RGD1564813"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2013
                     /gene="Crispld1"
                     /gene_synonym="RGD1564813"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2089
                     /gene="Crispld1"
                     /gene_synonym="RGD1564813"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2220
                     /gene="Crispld1"
                     /gene_synonym="RGD1564813"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..4433
                     /gene="Crispld1"
                     /gene_synonym="RGD1564813"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccacctac ctcacttctg gagctagctc ctttgcagcc agacttgtaa ggaattttaa
       61 catcccaaca gagaactaga gggagggtgc ctgatctgag agaggcggga gaagttaggg
      121 gctctcttcc tgggcaaggc ccagaccttg cccgccccca ctcacagagt cacagctcac
      181 gcccacgaaa gcaagtcgac tcctgtgggc caccggccag gactgggtgg aggtggaggt
      241 ggaggtggag gtggaggtgg gggctgggca aggagagttc gggcatcacg tgcctgctca
      301 gggacctcaa taaatgcccg cgagcgctga ggggcggcgg aagtgcctgg cgccaggtct
      361 ctgcacgctg agatagcacc cagctgaagc actaggtcct gcggatcttt cctttgttcc
      421 acctcatcct ccagctctgg aacacagagg agcccactct gcgagctgct ttctggggcc
      481 acacggctaa ctttggagcc tgtgcctcgt tgcccctccc aggttttcga ggagttgcag
      541 aggaagggac ttaggtcccc aggggtcagc tcctcactga gactccagtg gtggctggcc
      601 cttcgccttc gtcgactctg tgaagagcag agtccaggct gcgagcagct gcagagacaa
      661 gccgtcctgc taggctctgc tctcgggggt aacatcacac tggagagcca aaaggagtgg
      721 aagagcctgt cttggagatt ttcccgggta agccccgagg ccattcatta tgatgtgtaa
      781 ggcacaggag tggctcagaa tgaccgcact gctattcgtg gctagagcag ttccagctat
      841 ggtggttcct aatgccactt tgttggagaa acttttggaa aagtacatgg atgaggatga
      901 tgaatggtgg acagctaaac aaagagggaa aagagccatc acagataatg acatgcagag
      961 catcttggat ctccataata aactgagaag tcaggtgtac ccagccgctt ctaatatgga
     1021 gtatatgaca tgggatgtgg aactggaaag atctgcagaa tcctgggctg aaacgtgttt
     1081 gtgggagcat ggacccacaa gcttgctgcc ctccattgga cagaatttgg gagcgcactg
     1141 gggaagatac agacccccaa cctttcatgt acaagcatgg tatgatgaag tgagagactt
     1201 tagctaccca tatgaacatg agtgcgaccc ttactgtcct ttcagatgct ctggccctgt
     1261 ttgtacacac tacactcagg tggtgtgggc tacaagtagc agaataggct gtgccatcaa
     1321 tctgtgccac aacatgaaca tctgggggca gatatggccc aaggctgtct acttggtgtg
     1381 caattactct cccaagggaa attggtgggg tcatgcccct tacaaacatg gaaaaccttg
     1441 ttctgcttgc ccgcccagtt ttggaggagg ctgtagagaa aacttgtgct acaaagaagg
     1501 gtcggaccag tattataccc ctcaagaaga agaaacaaat gaaattgaac ggcaggagtc
     1561 ccaggtccat gacactcatg ttcggacaag atcagatgat agtaatagaa atgacgtcat
     1621 cagcactcag cagatgtctc agattgtttc ttgtgaagta agattgcgag accagtgtaa
     1681 agggaccacc tgcaacagat atgagtgccc tgctggctgc ttggacagta aagctaaagt
     1741 cattgggagt gtacattatg aaatgcaatc cagtatctgc agagctgcca ttcattatgg
     1801 gataattgac aatgaaggcg ggtgggtaga tgtcactcga caagggagaa agcattactt
     1861 catcaaatcc aacagaaatg gcattcaaac aattggcaaa tatcgttctg ctaattcctt
     1921 catagtctcc aaagtaacag ttcaagctgt gacatgtgaa accacagtgg aacagctctg
     1981 tccatttcat aaacctgctt cacattgccc cagagtatac tgtcctcgca actgtatgca
     2041 ggcaaatcca cattatgctc gtgtaattgg atctagaatt tattctgatc tgtctagtat
     2101 ctgcagagcc gcagtacatg ctggggtgat tcgaaatcat ggtggttatg tggatgtcat
     2161 gcctgtggat aaaagaagga tgtacactgc ttcttttcag aatggaatct tctcagaaag
     2221 tttacagaac cctacaggag gaaaggcatt ccgggtattc gctgttgttt gactgggaac
     2281 acttggaagg taaacagaaa gcctgctcca agtaccacat ttctgacatc tatatacaac
     2341 tgtaacaata ctgtacagaa gagagcaagt attgccagcc cacctccaaa gtaccaatgt
     2401 atgccattct tgatagacaa agtctctaaa ataaaacatg ggacattagc tttagggaaa
     2461 gtaatgaaca tttagtagtt ttagaaatcc tgtgttaaat attgctatat tttagcagtt
     2521 atttctacat ttaatttcat agtcatgatg ttctacattt cttatattat attatatggt
     2581 gctttgtata tgccactgct gaagtatatt taaagtgact gtgaaagccc ctagagaatt
     2641 atctgttcct tgaaaagcaa tcaggcctaa aatttaaaga aacttttaag tcactttttt
     2701 gttttcagac gagtccagta ttgtgttatg actattctaa atctctatct gccttaccct
     2761 taggactggc cagtttttct cttgtgttaa gttgcattgt gtcaaatgtt aagtcttgat
     2821 attgcactcg ttattttgta ttaaagtaat ctttatatat ccaagtgaaa atatttggtt
     2881 ccttgggagg ggtcacactg ccatgttccc caggcagtgt tgggagaaca ctcctggtgt
     2941 catatagtaa ctagagggtg agatggcaga cagagtttgc tagcattgtt agaactgaaa
     3001 aatacacttt tgtttgtatc ctggcaaata ctcctgcagg ccaggaagta taatttaaaa
     3061 aaagtctaat gatgatgaac tggtgcatta cattattatt attaccactg gttttcataa
     3121 tggcaaacaa ctttatgtat aaacctttca ttagtgtgat cctatggtag tgatttattt
     3181 gtttatgtaa aaatatattg tgctttgata cttaaattgt gtaaaatgtt agattttttt
     3241 attcctgctg gtgaacttgt tttctataag cacattaaaa ttaatcagtt tcagaagatt
     3301 atttttactt ttaaatgcat actttgactt agaatcattc taaaataaat aaccagagtt
     3361 gattttactt ttctaaattt gacttactga cgtcaatata aataagtgct tactagtaga
     3421 aatgcacaga gtccacctaa tcatgcagat atttgttttg aggaaaaata gtcatttact
     3481 tagaaacatt ataagaaaga gaaatgttga ataagaggag agctatgaat tttataaagg
     3541 agaaatgaag tatcagaaaa taaggtaatg attataatta tgaaagagcc atatagaaaa
     3601 taattcaaat aattttaaat gagtagggat gtaaaagcca ataaaatgga gatcattttc
     3661 atgcagggat cagggaaagc caaataggta atacaaaaga gaaatgaaaa acagagactc
     3721 agaaattatt tcagaaaagt agtttaagaa taaggcaaaa ttacaaggtc atttgttgtg
     3781 gattggccgg cagttaaatt gttcaaaagg taatcaagag taataaagca tagtttccta
     3841 gaattatttt tcccaaaata cacattacca atatattttc catactggga cattttcatt
     3901 gtatatagaa ctagatttca taaggacatt ttatacaagt gtttaattgt aactttcttg
     3961 catgtatatg catgcatgca cctgtctttc acccagtttg tgttctggtc actgatctcc
     4021 ctaaagaatg tccattactt ttgacagtcc ttcagactgg tctctagtta ggcttcactg
     4081 gaaatctttc ctactggtgc actatctcca ccttaccttt atcctgcttt actcctttcc
     4141 agggcatcaa ccaaacccca gtagaattgt tcccttcttt taatttccaa tgcctaaaaa
     4201 aactaaccct atttttaagg cacttactat cacatagttt attttctcta taaaatgtgt
     4261 ctttgggtag cccacttaac tctttaaatt tccatcttac tgcctataaa gtgggacatg
     4321 tgaaacctta tagagattga aacatcatgt atggtgtggc aaaagatatt aggcatgcaa
     4381 catgccatca aagtatgtta gtttttatta tattcatttt aatattcatt ttc
//
