LOCUS       NM_022859               1496 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Rattus norvegicus cysteine-rich secretory protein 3 (Crisp3), mRNA.
ACCESSION   NM_022859 XM_346849
VERSION     NM_022859.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1496)
  AUTHORS   Zhao,L., Zhang,Q., Liang,J., Li,J., Tan,X. and Tang,N.
  TITLE     Astrocyte elevated gene-1 induces autophagy in diabetic
            cardiomyopathy through upregulation of KLF4
  JOURNAL   J Cell Biochem 120 (6), 9709-9715 (2019)
   PUBMED   30520133
  REMARK    GeneRIF: Knockdown of AEG-1 suppresses autophagy in DCM by
            downregulating the expression of KLF4. This study provide
            first-notion evidence for the potential value of AEG-1 as a
            therapeutic target for the treatment of the patients with DCM.
REFERENCE   2  (bases 1 to 1496)
  AUTHORS   Maldera,J.A., Vasen,G., Ernesto,J.I., Weigel-Munoz,M., Cohen,D.J.
            and Cuasnicu,P.S.
  TITLE     Evidence for the involvement of zinc in the association of CRISP1
            with rat sperm during epididymal maturation
  JOURNAL   Biol Reprod 85 (3), 503-510 (2011)
   PUBMED   21593480
  REMARK    GeneRIF: involvement of CRISP1-Zn(2+) complexes in the association
            of the loosely bound population of CRISP1 with sperm during
            epididymal maturation
REFERENCE   3  (bases 1 to 1496)
  AUTHORS   Roberts,K.P., Ensrud-Bowlin,K.M., Piehl,L.B., Parent,K.R.,
            Bernhardt,M.L. and Hamilton,D.W.
  TITLE     Association of the protein D and protein E forms of rat CRISP1 with
            epididymal sperm
  JOURNAL   Biol Reprod 79 (6), 1046-1053 (2008)
   PUBMED   18703418
  REMARK    GeneRIF: CRISP1 interacts with sperm transiently, possibly with a
            specific receptor on the sperm surface, consistent with its action
            in suppressing capacitation during epididymal storage of sperm
REFERENCE   4  (bases 1 to 1496)
  AUTHORS   Ellerman,D.A., Busso,D., Maldera,J.A. and Cuasnicu,P.S.
  TITLE     Immunocontraceptive properties of recombinant sperm protein DE:
            implications for the development of novel contraceptives
  JOURNAL   Fertil Steril 89 (1), 199-205 (2008)
   PUBMED   17482178
  REMARK    GeneRIF: Recombinant Crisp1 is able to elicit a specific immune
            response and inhibit male and female fertility, supporting the use
            of this sperm epididymal protein for the development of an
            immunocontraceptive approach.
REFERENCE   5  (bases 1 to 1496)
  AUTHORS   Busso,D., Cohen,D.J., Maldera,J.A., Dematteis,A. and Cuasnicu,P.S.
  TITLE     A novel function for CRISP1 in rodent fertilization: involvement in
            sperm-zona pellucida interaction
  JOURNAL   Biol Reprod 77 (5), 848-854 (2007)
   PUBMED   17671267
  REMARK    GeneRIF: CRISP1 participates not only in sperm-egg fusion but also
            in the prior stage of sperm-ZP interaction.
REFERENCE   6  (bases 1 to 1496)
  AUTHORS   Udby,L., Calafat,J., Sorensen,O.E., Borregaard,N. and Kjeldsen,L.
  TITLE     Identification of human cysteine-rich secretory protein 3 (CRISP-3)
            as a matrix protein in a subset of peroxidase-negative granules of
            neutrophils and in the granules of eosinophils
  JOURNAL   J Leukoc Biol 72 (3), 462-469 (2002)
   PUBMED   12223513
REFERENCE   7  (bases 1 to 1496)
  AUTHORS   Udby,L., Cowland,J.B., Johnsen,A.H., Sorensen,O.E., Borregaard,N.
            and Kjeldsen,L.
  TITLE     An ELISA for SGP28/CRISP-3, a cysteine-rich secretory protein in
            human neutrophils, plasma, and exocrine secretions
  JOURNAL   J Immunol Methods 263 (1-2), 43-55 (2002)
   PUBMED   12009203
REFERENCE   8  (bases 1 to 1496)
  AUTHORS   Kjeldsen,L., Cowland,J.B., Johnsen,A.H. and Borregaard,N.
  TITLE     SGP28, a novel matrix glycoprotein in specific granules of human
            neutrophils with similarity to a human testis-specific gene product
            and a rodent sperm-coating glycoprotein
  JOURNAL   FEBS Lett 380 (3), 246-250 (1996)
   PUBMED   8601434
REFERENCE   9  (bases 1 to 1496)
  AUTHORS   Charest,N.J., Joseph,D.R., Wilson,E.M. and French,F.S.
  TITLE     Molecular cloning of complementary deoxyribonucleic acid for an
            androgen-regulated epididymal protein: sequence homology with
            metalloproteins
  JOURNAL   Mol Endocrinol 2 (10), 999-1004 (1988)
   PUBMED   2460753
REFERENCE   10 (bases 1 to 1496)
  AUTHORS   Brooks,D.E., Means,A.R., Wright,E.J., Singh,S.P. and Tiver,K.K.
  TITLE     Molecular cloning of the cDNA for androgen-dependent sperm-coating
            glycoproteins secreted by the rat epididymis
  JOURNAL   Eur J Biochem 161 (1), 13-18 (1986)
   PUBMED   3780731
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022859.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M31173.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                JAXUCZ010000009.1  27928591-27928666
            77-107              JAXUCZ010000009.1  27947451-27947481
            108-187             JAXUCZ010000009.1  27950726-27950805
            188-304             JAXUCZ010000009.1  27956057-27956173
            305-392             JAXUCZ010000009.1  27957226-27957313
            393-538             JAXUCZ010000009.1  27959726-27959871
            539-633             JAXUCZ010000009.1  27963471-27963565
            634-722             JAXUCZ010000009.1  27964768-27964856
            723-1496            JAXUCZ010000009.1  27968430-27969203
FEATURES             Location/Qualifiers
     source          1..1496
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..1496
                     /gene="Crisp3"
                     /gene_synonym="Aeg; Crisp-1; Crisp1"
                     /note="cysteine-rich secretory protein 3"
                     /db_xref="GeneID:64827"
                     /db_xref="RGD:619846"
     exon            1..76
                     /gene="Crisp3"
                     /gene_synonym="Aeg; Crisp-1; Crisp1"
                     /inference="alignment:Splign:2.1.0"
     exon            77..107
                     /gene="Crisp3"
                     /gene_synonym="Aeg; Crisp-1; Crisp1"
                     /inference="alignment:Splign:2.1.0"
     exon            108..187
                     /gene="Crisp3"
                     /gene_synonym="Aeg; Crisp-1; Crisp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..850
                     /gene="Crisp3"
                     /gene_synonym="Aeg; Crisp-1; Crisp1"
                     /note="acidic epididymal glycoprotein D/E; SCP; protein D;
                     protein E; protein IV; sialoprotein; 32 kDa epididymal
                     protein; sperm-coating glycoprotein; cysteine-rich
                     secretory protein 1"
                     /codon_start=1
                     /product="cysteine-rich secretory protein 1 precursor"
                     /protein_id="NP_074050.1"
                     /db_xref="GeneID:64827"
                     /db_xref="RGD:619846"
                     /translation="MALMLVLLFLAAVLPPSLLQDTTDEWDRDLENLSTTKLSVQEEI
                     INKHNQLRRTVSPSGSDLLRVEWDHDAYVNAQKWANRCIYNHSPLQHRTTTLKCGENL
                     FMANYPASWSSVIQDWYDESLDFVFGFGPKKVGVKVGHYTQVVWNSTFLVACGVAECP
                     DQPLKYFYVCHYCPGGNYVGRLYSPYTEGEPCDSCPGNCEDGLCTNSCEYEDNYSNCG
                     DLKKMVSCDDPLLKEGCRASCFCEDKIH"
     exon            188..304
                     /gene="Crisp3"
                     /gene_synonym="Aeg; Crisp-1; Crisp1"
                     /inference="alignment:Splign:2.1.0"
     exon            305..392
                     /gene="Crisp3"
                     /gene_synonym="Aeg; Crisp-1; Crisp1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..538
                     /gene="Crisp3"
                     /gene_synonym="Aeg; Crisp-1; Crisp1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..633
                     /gene="Crisp3"
                     /gene_synonym="Aeg; Crisp-1; Crisp1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..722
                     /gene="Crisp3"
                     /gene_synonym="Aeg; Crisp-1; Crisp1"
                     /inference="alignment:Splign:2.1.0"
     exon            723..1496
                     /gene="Crisp3"
                     /gene_synonym="Aeg; Crisp-1; Crisp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcctcagg aagaccagca gagtcaacta acctggaccc ttggtagctc ccggcgactg
       61 aatcattaag caaagggaca atatctcatt ctgctctgaa aatagaacca tggcattaat
      121 gttagtgctg ttgttcctgg ctgctgtatt gcccccatct cttcttcaag ataccactga
      181 tgaatgggat agagatcttg agaatttgtc aaccactaaa ctgtcagtcc aagaagagat
      241 cataaacaag cacaaccaat tgagacgaac ggtttctccg tctggtagtg acttactaag
      301 agtggaatgg gaccatgatg cttatgtgaa cgctcagaaa tgggcaaaca ggtgcattta
      361 caatcacagt cctctacaac acaggacaac cacattaaaa tgtggtgaga atttgttcat
      421 ggcaaattac cctgcatcgt ggtcttctgt aatccaagat tggtatgatg aatcccttga
      481 ttttgtcttt ggtttcggcc caaaaaaagt tggtgttaaa gtcggacact atactcaggt
      541 tgtttggaat tcaactttcc tggttgcatg tggagttgct gaatgccctg accaaccatt
      601 gaaatacttt tatgtttgtc actattgtcc tggtggcaat tacgtaggaa gactatactc
      661 accttacaca gaaggagaac cttgtgacag ttgtcctggt aattgtgaag atgggctgtg
      721 caccaatagt tgtgaatatg aagataatta ttctaactgt ggcgatctga agaagatggt
      781 gagctgcgac gatccacttc ttaaagaagg ttgcagagct tcatgcttct gtgaagacaa
      841 aattcattaa atttccagtc cacataatca ggtccatgta gaaaaggaaa ataccctcta
      901 cttagtctta ccatgtccca ccaaaaatat gtaggtttag tacactgaaa taattccaaa
      961 tggtaaagat tctgtttctt ctcctatttc tctctatttt gcattagtca tttaccccaa
     1021 aatattttaa aataacaaaa tcaataccac ctttggaact ggccatatga aatctgtgac
     1081 acatttatgg aatcaaatct agcccacgat tatatattat ttgtctgtat gacttaagtc
     1141 actaaatctc tggcttgaaa atatgaatca tgttcccaga gcacaatgaa gtaagagaac
     1201 agatagcata tagtccctct gtattggcca atcacctttt atttagttct acctccattt
     1261 ttagctaatt atctccagag aaacatttac attaattgtc ttctatttct tctcaccatt
     1321 cattattctt cacattcatc agaattagtg gtttaaattc taaactacca tttatgtttt
     1381 gttgttgggt ctttaagaat gatattaaaa tgtaacttaa taaacagaat ttgcttgttc
     1441 aggggtaatg accttggttg cttcagaaaa aaaataaatc ttaatctcag catatt
//
