LOCUS       NM_001039393            1394 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cysteine-rich secretory protein 1 (Crisp1), mRNA.
ACCESSION   NM_001039393
VERSION     NM_001039393.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1394)
  AUTHORS   Turunen,H.T., Sipila,P., Krutskikh,A., Toivanen,J., Mankonen,H.,
            Hamalainen,V., Bjorkgren,I., Huhtaniemi,I. and Poutanen,M.
  TITLE     Loss of cysteine-rich secretory protein 4 (Crisp4) leads to
            deficiency in sperm-zona pellucida interaction in mice
  JOURNAL   Biol Reprod 86 (1), 1-8 (2012)
   PUBMED   21865554
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1394)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 1394)
  AUTHORS   Gibbs,G.M., Orta,G., Reddy,T., Koppers,A.J., Martinez-Lopez,P., de
            la Vega-Beltran,J.L., Lo,J.C., Veldhuis,N., Jamsai,D., McIntyre,P.,
            Darszon,A. and O'Bryan,M.K.
  TITLE     Cysteine-rich secretory protein 4 is an inhibitor of transient
            receptor potential M8 with a role in establishing sperm function
  JOURNAL   Proc Natl Acad Sci U S A 108 (17), 7034-7039 (2011)
   PUBMED   21482758
REFERENCE   4  (bases 1 to 1394)
  AUTHORS   Nolan,M.A., Wu,L., Bang,H.J., Jelinsky,S.A., Roberts,K.P.,
            Turner,T.T., Kopf,G.S. and Johnston,D.S.
  TITLE     Identification of rat cysteine-rich secretory protein 4 (Crisp4) as
            the ortholog to human CRISP1 and mouse Crisp4
  JOURNAL   Biol Reprod 74 (5), 984-991 (2006)
   PUBMED   16467491
  REMARK    GeneRIF: Our data identify rat Crisp4 as the true ortholog to human
            CRISP1 and mouse Crisp4, and demonstrate its interaction with
            spermatozoa in the epididymis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ200907.1 and JAXUCZ010000009.1.
            
            On Sep 1, 2012 this sequence version replaced NM_001039393.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ200907.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN16418971
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-622               DQ200907.1         1-622
            623-121768772       JAXUCZ010000009.1  1-121768150
            121768773-121769255 DQ200907.1         624-1106
            121769256-243537405 JAXUCZ010000009.1  1-121768150
            243537406-243537512 DQ200907.1         1108-1214
            243537513-365305662 JAXUCZ010000009.1  1-121768150
            365305663-365305841 DQ200907.1         1216-1394
FEATURES             Location/Qualifiers
     source          1..1394
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..1394
                     /gene="Crisp1"
                     /gene_synonym="Crisp4"
                     /note="cysteine-rich secretory protein 1"
                     /db_xref="GeneID:654517"
                     /db_xref="RGD:1590757"
     exon            1..158
                     /gene="Crisp1"
                     /gene_synonym="Crisp4"
                     /inference="alignment:Splign:2.1.0"
     exon            159..235
                     /gene="Crisp1"
                     /gene_synonym="Crisp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..925
                     /gene="Crisp1"
                     /gene_synonym="Crisp4"
                     /note="cysteine-rich secretory protein 4"
                     /codon_start=1
                     /product="cysteine-rich secretory protein 4 precursor"
                     /protein_id="NP_001034482.2"
                     /db_xref="GeneID:654517"
                     /db_xref="RGD:1590757"
                     /translation="MAMKLILLLFLAATLTVFVPVVTLRHLKLDRALYNQLITESQTE
                     PQEEIVDTHNAFRRNVSPPARNMLKMSWSSAAAENARILARYCDKSDSDSLERRLPNT
                     FCGENMHMENYPSSWSNVIEIWYNESKYFKYGEWPSTDDDIETYHYTQMVWASSYLIG
                     CDVASCRRQKAATYLYVCHYCHEGNSQDTLNMPYKEGPPCQDCPNNCEDGLCTNPCLY
                     YDEYNNCDKQVKLLGCSHPAVRPFCKAFCLCKTEIK"
     exon            236..370
                     /gene="Crisp1"
                     /gene_synonym="Crisp4"
                     /inference="alignment:Splign:2.1.0"
     exon            371..461
                     /gene="Crisp1"
                     /gene_synonym="Crisp4"
                     /inference="alignment:Splign:2.1.0"
     exon            462..610
                     /gene="Crisp1"
                     /gene_synonym="Crisp4"
                     /inference="alignment:Splign:2.1.0"
     exon            611..708
                     /gene="Crisp1"
                     /gene_synonym="Crisp4"
                     /inference="alignment:Splign:2.1.0"
     exon            709..797
                     /gene="Crisp1"
                     /gene_synonym="Crisp4"
                     /inference="alignment:Splign:2.1.0"
     exon            798..1375
                     /gene="Crisp1"
                     /gene_synonym="Crisp4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atatccgttc ctgttccttg atctgatgaa gctggtcccc ttgtactaac tgcctcattg
       61 agcagattgt ctttgtgaaa tgtcatttaa ctcattagta cacaatacaa agacctggtt
      121 tgtagcagca caaaatttta agagctacat ggatgtgggt atggcaatga aactcatctt
      181 gttattgttt cttgctgcta ctcttactgt ctttgttcct gttgtgactc tcagacatct
      241 caaactggat agagctctct ataatcaact gatcacggaa tcacaaactg aaccacagga
      301 agaaattgtt gatacacaca atgccttcag gagaaacgtg tccccgccag ccaggaacat
      361 gctgaaaatg agttggagtt cagctgctgc agaaaatgct agaattctgg cgaggtactg
      421 cgacaagtca gacagtgact cacttgaaag gagactacca aatacatttt gtggagaaaa
      481 tatgcatatg gaaaactatc cctcttcctg gtcaaatgta attgaaatct ggtacaatga
      541 gtcgaaatat ttcaaatacg gagaatggcc atccacagat gatgacattg aaacttatca
      601 ctacacccag atggtctggg cctcttccta cctcattggc tgtgatgttg catcatgccg
      661 caggcaaaag gcagctacgt atctctatgt gtgtcactat tgccatgagg ggaatagtca
      721 agacacatta aacatgcctt ataaggaggg gccgccatgt caagactgtc caaacaactg
      781 tgaagatgga ctgtgtacca acccctgcct ttattacgat gaatataaca actgtgataa
      841 gcaagtaaaa cttcttggat gctcacatcc agcagtccgg ccattctgta aggctttttg
      901 tctgtgtaaa actgaaataa aataacctat tgcttgctgc tatgctgtgg ggtaaaaggg
      961 tgttttcaag atcatctatt tcacctaatg taatggacta taggaccttc tactgaattt
     1021 cacttgtttt taaatttgtg ctcaataact taatttttaa gcatcattta cagacatcag
     1081 catatttcat caagactgtg ccctttccag gcagtaaaat aactttaaac ttccttgttt
     1141 aatgaaaggg caagtcaaat tcttgcccca atttaataca tgtgatttgt gttgtgtagt
     1201 tcgacataac cccactaatg caggagctct tcatctattt actggcagta aaacagtctt
     1261 ttacataacc ccttttccta atatccccat ttcccctaca atcctaatgt ttttgtttaa
     1321 tgtttcaatt ttcattctat tttgaatcaa gcattaaaaa tattcaacaa gtgaaaaaaa
     1381 aaaaaaaaaa aaaa
//
