LOCUS       NM_019907               1435 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus CXXC repeat containing interactor of PDZ3 domain
            (Cript), mRNA.
ACCESSION   NM_019907
VERSION     NM_019907.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1435)
  AUTHORS   Omelchenko,A., Menon,H., Donofrio,S.G., Kumar,G., Chapman,H.M.,
            Roshal,J., Martinez-Montes,E.R., Wang,T.L., Spaller,M.R. and
            Firestein,B.L.
  TITLE     Interaction Between CRIPT and PSD-95 Is Required for Proper
            Dendritic Arborization in Hippocampal Neurons
  JOURNAL   Mol Neurobiol 57 (5), 2479-2493 (2020)
   PUBMED   32157575
  REMARK    GeneRIF: Interaction Between CRIPT and PSD-95 Is Required for
            Proper Dendritic Arborization in Hippocampal Neurons.
REFERENCE   2  (bases 1 to 1435)
  AUTHORS   Saro,D., Li,T., Rupasinghe,C., Paredes,A., Caspers,N. and
            Spaller,M.R.
  TITLE     A thermodynamic ligand binding study of the third PDZ domain (PDZ3)
            from the mammalian neuronal protein PSD-95
  JOURNAL   Biochemistry 46 (21), 6340-6352 (2007)
   PUBMED   17474715
REFERENCE   3  (bases 1 to 1435)
  AUTHORS   Valtschanoff,J.G. and Weinberg,R.J.
  TITLE     Laminar organization of the NMDA receptor complex within the
            postsynaptic density
  JOURNAL   J Neurosci 21 (4), 1211-1217 (2001)
   PUBMED   11160391
REFERENCE   4  (bases 1 to 1435)
  AUTHORS   Passafaro,M., Sala,C., Niethammer,M. and Sheng,M.
  TITLE     Microtubule binding by CRIPT and its potential role in the synaptic
            clustering of PSD-95
  JOURNAL   Nat Neurosci 2 (12), 1063-1069 (1999)
   PUBMED   10570482
REFERENCE   5  (bases 1 to 1435)
  AUTHORS   Brenman,J.E., Topinka,J.R., Cooper,E.C., McGee,A.W., Rosen,J.,
            Milroy,T., Ralston,H.J. and Bredt,D.S.
  TITLE     Localization of postsynaptic density-93 to dendritic microtubules
            and interaction with microtubule-associated protein 1A
  JOURNAL   J Neurosci 18 (21), 8805-8813 (1998)
   PUBMED   9786987
REFERENCE   6  (bases 1 to 1435)
  AUTHORS   Niethammer,M., Valtschanoff,J.G., Kapoor,T.M., Allison,D.W.,
            Weinberg,R.J., Craig,A.M. and Sheng,M.
  TITLE     CRIPT, a novel postsynaptic protein that binds to the third PDZ
            domain of PSD-95/SAP90
  JOURNAL   Neuron 20 (4), 693-707 (1998)
   PUBMED   9581762
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF047384.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF047384.1, BC058146.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1435
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..1435
                     /gene="Cript"
                     /note="CXXC repeat containing interactor of PDZ3 domain"
                     /db_xref="GeneID:56725"
                     /db_xref="RGD:621545"
     exon            1..79
                     /gene="Cript"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..369
                     /gene="Cript"
                     /function="binds to the third PDZ domain of PSD-95/SAP90"
                     /note="cysteine-rich interactor of PDZ3; cysteine-rich
                     interactor of PDZ three; postsynaptic protein Cript"
                     /codon_start=1
                     /product="cysteine-rich PDZ-binding protein"
                     /protein_id="NP_063972.1"
                     /db_xref="GeneID:56725"
                     /db_xref="RGD:621545"
                     /translation="MVCEKCEKKLGRVITPDTWKDGARNTTESGGRKLNENKALTSKK
                     ARFDPYGKNKFSTCRICKSSVHQPGSHYCQGCAYKKGICAMCGKKVLDTKNYKQTSV"
     exon            80..145
                     /gene="Cript"
                     /inference="alignment:Splign:2.1.0"
     exon            146..200
                     /gene="Cript"
                     /inference="alignment:Splign:2.1.0"
     exon            201..304
                     /gene="Cript"
                     /inference="alignment:Splign:2.1.0"
     exon            305..1423
                     /gene="Cript"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgatgtattt tggcagctgc tcctgctttg cgggttgagg gggacaggac gacccgtgga
       61 aggatggtgt gtgaaaagtg tgaaaagaaa ctcggcaggg ttatcactcc agacacatgg
      121 aaggacgggg cccggaacac cacagaaagt ggtggaagga agctgaacga aaacaaagct
      181 ctgacttcga agaaagcaag gtttgatcca tatggaaaaa ataagttctc cacttgcaga
      241 atttgtaaaa gttctgtaca ccagccaggt tctcattact gtcaaggctg tgcctacaag
      301 aaaggcatct gtgcgatgtg tggcaaaaag gttttggata ctaaaaacta caagcagact
      361 tccgtctagt ctgttgaaga ttccaactct acggttgtat ttgtgcttca gcttttcaag
      421 cgtaacacgg atgtccatct cacaaaatga cctgtttgag gatgaatgat tcagtctgaa
      481 gcagggacgt tgatcagtat tgatctgtct gctctcatga agttgtgaat gaagtttctg
      541 ccttaggtgg ttattttcct tgtgagcatt ttactgaact agataagtga caaaattaat
      601 gaacgaggtt tcccaacttg tgtacgcact gtctactcga cattatctaa ttaatgagta
      661 cgcactgtct actcgacatt atctgtataa ttaatgagta aggtgttccc tacttctgta
      721 cgcactgtct actagacatt atccatataa ttcctatctg acccacgcgt tttatttata
      781 gatattgcaa atgtgaaatc actgattctt tgctctgaac ttgacatcca gacttgagat
      841 ttctcacttt ctcacaaaca ttgcagttct tagaacaaac agggccttag ttactgcatt
      901 ttcatgagct ataatgtctg agaccatttt tgcagagtgg ttccttggtg accagtcctg
      961 ccacaagtct aagataagtt gcatttttat ttaaagttgc tgttgctgct aaagtgagtt
     1021 tcttttacgt gtgactgagt gccatggggc ccgatgtcca ggcagacact gaagttcaga
     1081 gacgtgcgtt ctgtcagcat tatcttaaat tcaaatgaga atacatttat tctgtttggg
     1141 aatgttcttt gaagaaggat acatagcttt ccttaacacc ccccaacccc cgctgccact
     1201 tcctcagaaa taaagcaggc ctctggcctc tgacattgct gcagcctgcc agggggctgc
     1261 tgtgaatgaa ggtttttctt gttgccttct ttgggttggg ccttccacct ttaaaaccct
     1321 cagcctaccc agagaccaaa agcatattct ctgtttttat ctgcaggatc ttaaatgcat
     1381 atcactgtgt aatgtgagac ctactataaa caatgaaaaa ataaaaaaaa aaaaa
//
