LOCUS       NM_001244867             428 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus cysteine rich protein 1 (Crip1), transcript
            variant 1, mRNA.
ACCESSION   NM_001244867
VERSION     NM_001244867.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 428)
  AUTHORS   Latonen,L., Jarvinen,P.M., Suomela,S., Moore,H.M.,
            Saarialho-Kere,U. and Laiho,M.
  TITLE     Ultraviolet B radiation regulates cysteine-rich protein 1 in human
            keratinocytes
  JOURNAL   Photodermatol Photoimmunol Photomed 26 (2), 70-77 (2010)
   PUBMED   20415737
REFERENCE   2  (bases 1 to 428)
  AUTHORS   Chen,B., Young,J. and Leng,F.
  TITLE     DNA bending by the mammalian high-mobility group protein AT hook 2
  JOURNAL   Biochemistry 49 (8), 1590-1595 (2010)
   PUBMED   20108983
REFERENCE   3  (bases 1 to 428)
  AUTHORS   Hao,J., Serohijos,A.W., Newton,G., Tassone,G., Wang,Z., Sgroi,D.C.,
            Dokholyan,N.V. and Basilion,J.P.
  TITLE     Identification and rational redesign of peptide ligands to CRIP1, a
            novel biomarker for cancers
  JOURNAL   PLoS Comput Biol 4 (8), e1000138 (2008)
   PUBMED   18670594
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 428)
  AUTHORS   Wang,Q., Williamson,M., Bott,S., Brookman-Amissah,N., Freeman,A.,
            Nariculam,J., Hubank,M.J., Ahmed,A. and Masters,J.R.
  TITLE     Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer
  JOURNAL   Oncogene 26 (45), 6560-6565 (2007)
   PUBMED   17486081
REFERENCE   5  (bases 1 to 428)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   6  (bases 1 to 428)
  AUTHORS   Perez-Alvarado,G.C., Kosa,J.L., Louis,H.A., Beckerle,M.C.,
            Winge,D.R. and Summers,M.F.
  TITLE     Structure of the cysteine-rich intestinal protein, CRIP
  JOURNAL   J Mol Biol 257 (1), 153-174 (1996)
   PUBMED   8632452
REFERENCE   7  (bases 1 to 428)
  AUTHORS   Tsui,S.K., Yam,N.Y., Lee,C.Y. and Waye,M.M.
  TITLE     Isolation and characterization of a cDNA that codes for a
            LIM-containing protein which is developmentally regulated in heart
  JOURNAL   Biochem Biophys Res Commun 205 (1), 497-505 (1994)
   PUBMED   7999070
REFERENCE   8  (bases 1 to 428)
  AUTHORS   Levenson,C.W., Shay,N.F. and Cousins,R.J.
  TITLE     Cloning and initial characterization of the promoter region of the
            rat cysteine-rich intestinal protein gene
  JOURNAL   Biochem J 303 (Pt 3) (Pt 3), 731-736 (1994)
   PUBMED   7980439
REFERENCE   9  (bases 1 to 428)
  AUTHORS   Hempe,J.M. and Cousins,R.J.
  TITLE     Cysteine-rich intestinal protein binds zinc during transmucosal
            zinc transport
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9671-9674 (1991)
   PUBMED   1946385
REFERENCE   10 (bases 1 to 428)
  AUTHORS   Birkenmeier,E.H. and Gordon,J.I.
  TITLE     Developmental regulation of a gene that encodes a cysteine-rich
            intestinal protein and maps near the murine immunoglobulin heavy
            chain locus
  JOURNAL   Proc Natl Acad Sci U S A 83 (8), 2516-2520 (1986)
   PUBMED   3085096
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ223262.1 and AI716760.1.
            
            Transcript Variant: This variant (1) is the predominant transcript.
            Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223262.1, CB729183.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-384               FQ223262.1         1-384
            385-428             AI716760.1         1-44                c
FEATURES             Location/Qualifiers
     source          1..428
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..428
                     /gene="Crip1"
                     /gene_synonym="Crip; Crp-1"
                     /note="cysteine rich protein 1"
                     /db_xref="GeneID:691657"
                     /db_xref="RGD:1597237"
     exon            1..102
                     /gene="Crip1"
                     /gene_synonym="Crip; Crp-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..296
                     /gene="Crip1"
                     /gene_synonym="Crip; Crp-1"
                     /note="cysteine-rich intestinal protein; cysteine-rich
                     protein 1 (intestinal)"
                     /codon_start=1
                     /product="cysteine-rich protein 1"
                     /protein_id="NP_001231796.1"
                     /db_xref="GeneID:691657"
                     /db_xref="RGD:1597237"
                     /translation="MPKCPKCDKEVYFAERVTSLGKDWHRPCLKCEKCGKTLTSGGHA
                     EHEGKPYCNHPCYSAMFGPKGFGRGGAESHTFK"
     exon            103..197
                     /gene="Crip1"
                     /gene_synonym="Crip; Crp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            198..255
                     /gene="Crip1"
                     /gene_synonym="Crip; Crp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            256..302
                     /gene="Crip1"
                     /gene_synonym="Crip; Crp-1"
                     /inference="alignment:Splign:2.1.0"
     exon            303..411
                     /gene="Crip1"
                     /gene_synonym="Crip; Crp-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccagagcc tacaacctac ttccttctag ctgcagccac ttgtgcagga ccaggtgccg
       61 ccatgccgaa gtgccccaag tgcgacaagg aggtgtattt cgctgagcga gtgacgtcac
      121 taggcaagga ctggcatcgt ccctgcctga agtgcgagaa atgtggaaag acactgacct
      181 ctgggggtca tgctgagcat gaaggcaagc cctactgcaa ccatccctgc tactccgcca
      241 tgtttgggcc caaaggcttt gggcgaggtg gagctgaaag ccacactttc aagtagactg
      301 aggttgtgga aactctccct acccgcccag gcgagtgcca ggccttgtcc ctagacagca
      361 gggctctccg cagccctcca tgcctttaat aaacttgatc tttggaatgc caaaaaaaaa
      421 aaaaaaaa
//
