LOCUS       NP_001231796              77 aa            linear   ROD 04-JUN-2024
DEFINITION  cysteine-rich protein 1 [Rattus norvegicus].
ACCESSION   NP_001231796
VERSION     NP_001231796.1
DBSOURCE    REFSEQ: accession NM_001244867.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 77)
  AUTHORS   Latonen,L., Jarvinen,P.M., Suomela,S., Moore,H.M.,
            Saarialho-Kere,U. and Laiho,M.
  TITLE     Ultraviolet B radiation regulates cysteine-rich protein 1 in human
            keratinocytes
  JOURNAL   Photodermatol Photoimmunol Photomed 26 (2), 70-77 (2010)
   PUBMED   20415737
REFERENCE   2  (residues 1 to 77)
  AUTHORS   Chen,B., Young,J. and Leng,F.
  TITLE     DNA bending by the mammalian high-mobility group protein AT hook 2
  JOURNAL   Biochemistry 49 (8), 1590-1595 (2010)
   PUBMED   20108983
REFERENCE   3  (residues 1 to 77)
  AUTHORS   Hao,J., Serohijos,A.W., Newton,G., Tassone,G., Wang,Z., Sgroi,D.C.,
            Dokholyan,N.V. and Basilion,J.P.
  TITLE     Identification and rational redesign of peptide ligands to CRIP1, a
            novel biomarker for cancers
  JOURNAL   PLoS Comput Biol 4 (8), e1000138 (2008)
   PUBMED   18670594
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 77)
  AUTHORS   Wang,Q., Williamson,M., Bott,S., Brookman-Amissah,N., Freeman,A.,
            Nariculam,J., Hubank,M.J., Ahmed,A. and Masters,J.R.
  TITLE     Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer
  JOURNAL   Oncogene 26 (45), 6560-6565 (2007)
   PUBMED   17486081
REFERENCE   5  (residues 1 to 77)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   6  (residues 1 to 77)
  AUTHORS   Perez-Alvarado,G.C., Kosa,J.L., Louis,H.A., Beckerle,M.C.,
            Winge,D.R. and Summers,M.F.
  TITLE     Structure of the cysteine-rich intestinal protein, CRIP
  JOURNAL   J Mol Biol 257 (1), 153-174 (1996)
   PUBMED   8632452
REFERENCE   7  (residues 1 to 77)
  AUTHORS   Tsui,S.K., Yam,N.Y., Lee,C.Y. and Waye,M.M.
  TITLE     Isolation and characterization of a cDNA that codes for a
            LIM-containing protein which is developmentally regulated in heart
  JOURNAL   Biochem Biophys Res Commun 205 (1), 497-505 (1994)
   PUBMED   7999070
REFERENCE   8  (residues 1 to 77)
  AUTHORS   Levenson,C.W., Shay,N.F. and Cousins,R.J.
  TITLE     Cloning and initial characterization of the promoter region of the
            rat cysteine-rich intestinal protein gene
  JOURNAL   Biochem J 303 (Pt 3) (Pt 3), 731-736 (1994)
   PUBMED   7980439
REFERENCE   9  (residues 1 to 77)
  AUTHORS   Hempe,J.M. and Cousins,R.J.
  TITLE     Cysteine-rich intestinal protein binds zinc during transmucosal
            zinc transport
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9671-9674 (1991)
   PUBMED   1946385
REFERENCE   10 (residues 1 to 77)
  AUTHORS   Birkenmeier,E.H. and Gordon,J.I.
  TITLE     Developmental regulation of a gene that encodes a cysteine-rich
            intestinal protein and maps near the murine immunoglobulin heavy
            chain locus
  JOURNAL   Proc Natl Acad Sci U S A 83 (8), 2516-2520 (1986)
   PUBMED   3085096
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ223262.1 and AI716760.1.
            
            Transcript Variant: This variant (1) is the predominant transcript.
            Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223262.1, CB729183.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..77
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     Protein         1..77
                     /product="cysteine-rich protein 1"
                     /note="cysteine-rich intestinal protein; cysteine-rich
                     protein 1 (intestinal)"
                     /calculated_mol_wt=8419
     Region          4..57
                     /region_name="LIM_CRIP"
                     /note="The LIM domain of Cysteine-Rich Intestinal Protein
                     (CRIP); cd09478"
                     /db_xref="CDD:188862"
     Site            order(4,7,25,28,31,34,52,56)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188862"
     Site            9
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P50238; propagated from
                     UniProtKB/Swiss-Prot (P63255.2)"
     Site            22
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P63254; propagated from
                     UniProtKB/Swiss-Prot (P63255.2)"
     Site            68
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:P63254; propagated from
                     UniProtKB/Swiss-Prot (P63255.2)"
     CDS             1..77
                     /gene="Crip1"
                     /gene_synonym="Crip; Crp-1"
                     /coded_by="NM_001244867.1:63..296"
                     /db_xref="GeneID:691657"
                     /db_xref="RGD:1597237"
ORIGIN      
        1 mpkcpkcdke vyfaervtsl gkdwhrpclk cekcgktlts gghaehegkp ycnhpcysam
       61 fgpkgfgrgg aeshtfk
//
