LOCUS       NM_022714               1627 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus corticotropin releasing hormone receptor 2
            (Crhr2), mRNA.
ACCESSION   NM_022714 XM_346702 XM_347369
VERSION     NM_022714.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1627)
  AUTHORS   Ness,T.J., DeWitte,C. and Randich,A.
  TITLE     The Double Insult of Neonatal Cystitis Plus Adult Somatic
            Inflammation Results in Corticotropin Releasing Factor Type II
            Receptor-Dependent Bladder Hypersensitivity in Female Rats
  JOURNAL   J Pain 23 (12), 2167-2178 (2022)
   PUBMED   36089237
  REMARK    GeneRIF: The Double Insult of Neonatal Cystitis Plus Adult Somatic
            Inflammation Results in Corticotropin Releasing Factor Type II
            Receptor-Dependent Bladder Hypersensitivity in Female Rats.
REFERENCE   2  (bases 1 to 1627)
  AUTHORS   Mousa,S.A., Shaqura,M., Khalefa,B.I., Li,L., Al-Madol,M.,
            Treskatsch,S. and Schafer,M.
  TITLE     Functional and Anatomical Characterization of
            Corticotropin-Releasing Factor Receptor Subtypes of the Rat Spinal
            Cord Involved in Somatic Pain Relief
  JOURNAL   Mol Neurobiol 58 (11), 5459-5472 (2021)
   PUBMED   34331656
  REMARK    GeneRIF: Functional and Anatomical Characterization of
            Corticotropin-Releasing Factor Receptor Subtypes of the Rat Spinal
            Cord Involved in Somatic Pain Relief.
REFERENCE   3  (bases 1 to 1627)
  AUTHORS   Malta,M.B., Martins,J., Novaes,L.S., Dos Santos,N.B., Sita,L.,
            Camarini,R., Scavone,C., Bittencourt,J. and Munhoz,C.D.
  TITLE     Norepinephrine and Glucocorticoids Modulate Chronic Unpredictable
            Stress-Induced Increase in the Type 2 CRF and Glucocorticoid
            Receptors in Brain Structures Related to the HPA Axis Activation
  JOURNAL   Mol Neurobiol 58 (10), 4871-4885 (2021)
   PUBMED   34213722
  REMARK    GeneRIF: Norepinephrine and Glucocorticoids Modulate Chronic
            Unpredictable Stress-Induced Increase in the Type 2 CRF and
            Glucocorticoid Receptors in Brain Structures Related to the HPA
            Axis Activation.
REFERENCE   4  (bases 1 to 1627)
  AUTHORS   Yarur,H.E., Gonzalez,M.P., Verbel-Vergara,D., Andres,M.E. and
            Gysling,K.
  TITLE     Cross-talk between dopamine D1 and corticotropin releasing factor
            type 2 receptors leads to occlusion of their ERK1/2 signaling
  JOURNAL   J Neurochem 155 (3), 264-273 (2020)
   PUBMED   32215915
  REMARK    GeneRIF: Cross-talk between dopamine D1 and corticotropin releasing
            factor type 2 receptors leads to occlusion of their ERK1/2
            signaling.
REFERENCE   5  (bases 1 to 1627)
  AUTHORS   Airapetov,M.I., Eresko,S.O., Sekste,E.A., Lebedev,A.A.,
            Bychkov,E.R. and Shabanov,P.D.
  TITLE     [Ethanol withdrawal leads to an increase in the CRFR2 mRNA level in
            the ventricular tegmental region of the rat brain]
  JOURNAL   Biomed Khim 65 (5), 385-387 (2019)
   PUBMED   31666410
  REMARK    GeneRIF: During the period of alcohol withdrawal, the level of
            CRFR2 mRNA in the ventral tegmental area of the brain on the
            seventh day of abstinence was significantly increased in comparison
            with the control group
REFERENCE   6  (bases 1 to 1627)
  AUTHORS   Coste,S.C., Kesterson,R.A., Heldwein,K.A., Stevens,S.L.,
            Heard,A.D., Hollis,J.H., Murray,S.E., Hill,J.K., Pantely,G.A.,
            Hohimer,A.R., Hatton,D.C., Phillips,T.J., Finn,D.A., Low,M.J.,
            Rittenberg,M.B., Stenzel,P. and Stenzel-Poore,M.P.
  TITLE     Abnormal adaptations to stress and impaired cardiovascular function
            in mice lacking corticotropin-releasing hormone receptor-2
  JOURNAL   Nat Genet 24 (4), 403-409 (2000)
   PUBMED   10742107
REFERENCE   7  (bases 1 to 1627)
  AUTHORS   Gottowik,J., Goetschy,V., Henriot,S., Kitas,E., Fluhman,B.,
            Clerc,R.G., Moreau,J.L., Monsma,F.J. and Kilpatrick,G.J.
  TITLE     Labelling of CRF1 and CRF2 receptors using the novel radioligand,
            [3H]-urocortin
  JOURNAL   Neuropharmacology 36 (10), 1439-1446 (1997)
   PUBMED   9423932
REFERENCE   8  (bases 1 to 1627)
  AUTHORS   Donaldson,C.J., Sutton,S.W., Perrin,M.H., Corrigan,A.Z.,
            Lewis,K.A., Rivier,J.E., Vaughan,J.M. and Vale,W.W.
  TITLE     Cloning and characterization of human urocortin
  JOURNAL   Endocrinology 137 (5), 2167-2170 (1996)
   PUBMED   8612563
  REMARK    Erratum:[Endocrinology. 1996 Sep;137(9):3896. doi:
            10.1210/endo.137.9.8756563.. PMID: 8756563]
REFERENCE   9  (bases 1 to 1627)
  AUTHORS   Lovenberg,T.W., Liaw,C.W., Grigoriadis,D.E., Clevenger,W.,
            Chalmers,D.T., De Souza,E.B. and Oltersdorf,T.
  TITLE     Cloning and characterization of a functionally distinct
            corticotropin-releasing factor receptor subtype from rat brain
  JOURNAL   Proc Natl Acad Sci U S A 92 (3), 836-840 (1995)
   PUBMED   7846062
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1995 Jun 6;92(12):5759]
REFERENCE   10 (bases 1 to 1627)
  AUTHORS   McKenzie,I.F., Pang,T. and Blanden,R.V.
  TITLE     The use of H-2 mutants as models for the study of T cell activation
  JOURNAL   Immunol Rev 35, 179-230 (1977)
   PUBMED   70397
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022714.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U16253.1, SRR26643290.16184.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               JAXUCZ010000004.1  85581146-85581463   c
            319-444             JAXUCZ010000004.1  85580890-85581015   c
            445-530             JAXUCZ010000004.1  85567994-85568079   c
            531-640             JAXUCZ010000004.1  85566380-85566489   c
            641-758             JAXUCZ010000004.1  85565962-85566079   c
            759-912             JAXUCZ010000004.1  85563675-85563828   c
            913-973             JAXUCZ010000004.1  85563129-85563189   c
            974-1046            JAXUCZ010000004.1  85562272-85562344   c
            1047-1132           JAXUCZ010000004.1  85556282-85556367   c
            1133-1268           JAXUCZ010000004.1  85555958-85556093   c
            1269-1310           JAXUCZ010000004.1  85555514-85555555   c
            1311-1627           JAXUCZ010000004.1  85554268-85554584   c
FEATURES             Location/Qualifiers
     source          1..1627
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..1627
                     /gene="Crhr2"
                     /gene_synonym="CRF-R 2; Crf2r; CRH-R 2"
                     /note="corticotropin releasing hormone receptor 2"
                     /db_xref="GeneID:64680"
                     /db_xref="RGD:70547"
     exon            1..318
                     /gene="Crhr2"
                     /gene_synonym="CRF-R 2; Crf2r; CRH-R 2"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..1451
                     /gene="Crhr2"
                     /gene_synonym="CRF-R 2; Crf2r; CRH-R 2"
                     /note="corticotropin-releasing factor receptor 2; CRF2;
                     CRF-R2; CRFR-2; CRH-R2; CRF-R-2; CRH-R-2;
                     corticotropin-releasing factor receptor subtype 2;
                     corticotrophin releasing hormone receptor 2"
                     /codon_start=1
                     /product="corticotropin-releasing factor receptor 2
                     precursor"
                     /protein_id="NP_073205.2"
                     /db_xref="GeneID:64680"
                     /db_xref="RGD:70547"
                     /translation="MDAALLLSLLEANCSLALAEELLLDGWGEPPDPEGPYSYCNTTL
                     DQIGTCWPQSAPGALVERPCPEYFNGIKYNTTRNAYRECLENGTWASRVNYSHCEPIL
                     DDKQRKYDLHYRIALIINYLGHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFI
                     LRNITWFLLQLIDHEVHEGNEVWCRCVTTIFNYFVVTNFFWMFVEGCYLHTAIVMTYS
                     TEHLRKWLFLFIGWCIPCPIIVAWAVGKLYYENEQCWFGKEPGDLVDYIYQGPIILVL
                     LINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDD
                     LSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEVRSALRKRWHRWQDHHALRVPVARAMS
                     IPTSPTRISFHSIKQTAAV"
     exon            319..444
                     /gene="Crhr2"
                     /gene_synonym="CRF-R 2; Crf2r; CRH-R 2"
                     /inference="alignment:Splign:2.1.0"
     exon            445..530
                     /gene="Crhr2"
                     /gene_synonym="CRF-R 2; Crf2r; CRH-R 2"
                     /inference="alignment:Splign:2.1.0"
     exon            531..640
                     /gene="Crhr2"
                     /gene_synonym="CRF-R 2; Crf2r; CRH-R 2"
                     /inference="alignment:Splign:2.1.0"
     exon            641..758
                     /gene="Crhr2"
                     /gene_synonym="CRF-R 2; Crf2r; CRH-R 2"
                     /inference="alignment:Splign:2.1.0"
     exon            759..912
                     /gene="Crhr2"
                     /gene_synonym="CRF-R 2; Crf2r; CRH-R 2"
                     /inference="alignment:Splign:2.1.0"
     exon            913..973
                     /gene="Crhr2"
                     /gene_synonym="CRF-R 2; Crf2r; CRH-R 2"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1046
                     /gene="Crhr2"
                     /gene_synonym="CRF-R 2; Crf2r; CRH-R 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1132
                     /gene="Crhr2"
                     /gene_synonym="CRF-R 2; Crf2r; CRH-R 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1268
                     /gene="Crhr2"
                     /gene_synonym="CRF-R 2; Crf2r; CRH-R 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1310
                     /gene="Crhr2"
                     /gene_synonym="CRF-R 2; Crf2r; CRH-R 2"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1627
                     /gene="Crhr2"
                     /gene_synonym="CRF-R 2; Crf2r; CRH-R 2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcccctc atctccgtga gccccgaggc ttctcttggc caaggtccta ggagtgatcc
       61 gattgagagc ggcgccccaa agctgccggg ctggccgggg tgggcgggga ggcacctgga
      121 cgctgcactc tctggtggct ccgcgtcgcg ccaggtccct cgcagccacg cggggcgcgc
      181 actcccactc ccaacgcgcg cggctccgga gcgcaatgga cgcggcgctg ctcctcagcc
      241 tgctggaggc caactgcagc ctggcactgg ccgaagagct gcttttggac ggctggggag
      301 agcccccgga ccccgaaggt ccctactcct actgcaacac gaccttggac cagatcggga
      361 cctgctggcc ccagagcgcg cctggagccc tagtggagag accatgcccc gaatacttca
      421 acggcatcaa gtacaacacg acccggaatg cctacagaga atgcctggag aatgggacct
      481 gggcctcaag ggtcaactac tcacactgtg aacccatttt ggatgacaag cagaggaagt
      541 atgacctgca ttaccgaatc gccctcatca tcaactacct gggccactgt gtttccgtgg
      601 tggccctggt ggctgctttc ctgcttttcc tagtgctgcg gagtatccgc tgcctgcgga
      661 atgtgatcca ctggaacctc atcaccacct tcatcctgag aaacatcacg tggttcctgc
      721 tgcaactcat cgaccacgaa gtgcatgagg gcaatgaggt ctggtgccgc tgcgtcacca
      781 ccatattcaa ctactttgtg gtcaccaact tcttctggat gtttgtggaa ggctgctacc
      841 tgcacacggc catcgtcatg acgtactcca cggagcatct gcgcaagtgg ctcttcctct
      901 tcattggatg gtgcataccc tgccctatca ttgtcgcctg ggcagttggc aaactctact
      961 atgagaatga gcagtgctgg tttggcaagg aacctggtga cttagtggac tacatctacc
     1021 agggccccat catcctcgtg ctcctcatca attttgtgtt tctgttcaac atcgtcagga
     1081 tcctgatgac aaaactgcga gcctccacca catccgagac catccagtac aggaaggcag
     1141 tgaaggccac cctggtcctc ctccccctgt tgggcatcac ctacatgctc ttctttgtca
     1201 atcctggaga ggacgacctg tcacagattg tgttcatcta cttcaactct ttcctgcagt
     1261 cctttcaggg tttctttgtg tccgttttct actgcttctt caatggagag gtgcgctccg
     1321 ccctgagaaa gcggtggcac cgttggcagg accaccacgc cctccgagtg cctgtggccc
     1381 gggccatgtc cattcccacg tcgcccacca ggatcagctt ccacagcatc aagcagacag
     1441 ctgccgtgtg atcccctgtc acccatctgc ccagcactcc accaccgagg cggcttcctc
     1501 attcttcaca gccttccctg ggtcctcctt gctacactga cccttggggt gcaggagaag
     1561 gggggtggat gaactctcct gccggaagga aaggaaaact atgaaatgga ggctctgaaa
     1621 gaccagg
//
