LOCUS       NM_030999               2527 bp    mRNA    linear   ROD 27-FEB-2024
DEFINITION  Rattus norvegicus corticotropin releasing hormone receptor 1
            (Crhr1), transcript variant 1, mRNA.
ACCESSION   NM_030999
VERSION     NM_030999.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2527)
  AUTHORS   Rouzer,S.K. and Diaz,M.R.
  TITLE     Moderate prenatal alcohol exposure modifies sex-specific CRFR1
            activity in the central amygdala and anxiety-like behavior in
            adolescent offspring
  JOURNAL   Neuropsychopharmacology 47 (12), 2140-2149 (2022)
   PUBMED   35478009
  REMARK    GeneRIF: Moderate prenatal alcohol exposure modifies sex-specific
            CRFR1 activity in the central amygdala and anxiety-like behavior in
            adolescent offspring.
REFERENCE   2  (bases 1 to 2527)
  AUTHORS   Wang,T.Y., Xia,F.Y., Gong,J.W., Xu,X.K., Lv,M.C., Chatoo,M.,
            Shamsi,B.H., Zhang,M.C., Liu,Q.R., Liu,T.X., Zhang,D.D., Lu,X.J.,
            Zhao,Y., Du,J.Z. and Chen,X.Q.
  TITLE     CRHR1 mediates the transcriptional expression of pituitary hormones
            and their receptors under hypoxia
  JOURNAL   Front Endocrinol (Lausanne) 13, 893238 (2022)
   PUBMED   36147561
  REMARK    GeneRIF: CRHR1 mediates the transcriptional expression of pituitary
            hormones and their receptors under hypoxia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2527)
  AUTHORS   Mousa,S.A., Shaqura,M., Khalefa,B.I., Li,L., Al-Madol,M.,
            Treskatsch,S. and Schafer,M.
  TITLE     Functional and Anatomical Characterization of
            Corticotropin-Releasing Factor Receptor Subtypes of the Rat Spinal
            Cord Involved in Somatic Pain Relief
  JOURNAL   Mol Neurobiol 58 (11), 5459-5472 (2021)
   PUBMED   34331656
  REMARK    GeneRIF: Functional and Anatomical Characterization of
            Corticotropin-Releasing Factor Receptor Subtypes of the Rat Spinal
            Cord Involved in Somatic Pain Relief.
REFERENCE   4  (bases 1 to 2527)
  AUTHORS   Yuan,P.Q., Wu,S.V., Stengel,A., Sato,K. and Tache,Y.
  TITLE     Activation of CRF1 receptors expressed in brainstem autonomic
            nuclei stimulates colonic enteric neurons and secreto-motor
            function in male rats
  JOURNAL   Neurogastroenterol Motil 33 (11), e14189 (2021)
   PUBMED   34215021
  REMARK    GeneRIF: Activation of CRF1 receptors expressed in brainstem
            autonomic nuclei stimulates colonic enteric neurons and
            secreto-motor function in male rats.
REFERENCE   5  (bases 1 to 2527)
  AUTHORS   Xu,G., Rabadan-Diehl,C., Nikodemova,M., Wynn,P., Spiess,J. and
            Aguilera,G.
  TITLE     Inhibition of corticotropin releasing hormone type-1 receptor
            translation by an upstream AUG triplet in the 5' untranslated
            region
  JOURNAL   Mol Pharmacol 59 (3), 485-492 (2001)
   PUBMED   11179443
REFERENCE   6  (bases 1 to 2527)
  AUTHORS   Heinrichs,S.C., Lapsansky,J., Lovenberg,T.W., De Souza,E.B. and
            Chalmers,D.T.
  TITLE     Corticotropin-releasing factor CRF1, but not CRF2, receptors
            mediate anxiogenic-like behavior
  JOURNAL   Regul Pept 71 (1), 15-21 (1997)
   PUBMED   9299637
REFERENCE   7  (bases 1 to 2527)
  AUTHORS   Tsai-Morris,C.H., Buczko,E., Geng,Y., Gamboa-Pinto,A. and
            Dufau,M.L.
  TITLE     The genomic structure of the rat corticotropin releasing factor
            receptor. A member of the class II G protein-coupled receptors
  JOURNAL   J Biol Chem 271 (24), 14519-14525 (1996)
   PUBMED   8662941
REFERENCE   8  (bases 1 to 2527)
  AUTHORS   Chang,C.P., Pearse,R.V. 2nd, O'Connell,S. and Rosenfeld,M.G.
  TITLE     Identification of a seven transmembrane helix receptor for
            corticotropin-releasing factor and sauvagine in mammalian brain
  JOURNAL   Neuron 11 (6), 1187-1195 (1993)
   PUBMED   8274282
REFERENCE   9  (bases 1 to 2527)
  AUTHORS   Perrin,M.H., Donaldson,C.J., Chen,R., Lewis,K.A. and Vale,W.W.
  TITLE     Cloning and functional expression of a rat brain corticotropin
            releasing factor (CRF) receptor
  JOURNAL   Endocrinology 133 (6), 3058-3061 (1993)
   PUBMED   8243338
REFERENCE   10 (bases 1 to 2527)
  AUTHORS   McKenzie,I.F., Pang,T. and Blanden,R.V.
  TITLE     The use of H-2 mutants as models for the study of T cell activation
  JOURNAL   Immunol Rev 35, 179-230 (1977)
   PUBMED   70397
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JACYVU010000220.1 and
            EU012436.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_030999.6.
            
            On Jul 25, 2022 this sequence version replaced NM_030999.4.
            
            Summary: This gene encodes a member of the G-protein coupled
            receptor family. The encoded protein is a receptor for
            corticotropin-releasing factor (CRH) and urocortin (UCN). The
            interaction of this protein with CRH and UCN triggers G-protein
            coupled signaling. This protein plays a pivotal role in mediating
            the CRH-elicited effects in depression and anxiety. Alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L24096.1, L25438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            regulatory uORF        :: PMID: 11179443
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               JACYVU010000220.1  45865044-45865338
            296-383             JACYVU010000220.1  45886163-45886250
            384-503             JACYVU010000220.1  45892201-45892320
            504-589             JACYVU010000220.1  45896554-45896639
            590-696             JACYVU010000220.1  45900446-45900552
            697-817             JACYVU010000220.1  45901250-45901370
            818-971             JACYVU010000220.1  45901543-45901696
            972-1032            JACYVU010000220.1  45901901-45901961
            1033-1105           JACYVU010000220.1  45904347-45904419
            1106-1157           JACYVU010000220.1  45906083-45906134
            1158-1163           EU012436.1         893-898
            1164-1191           JACYVU010000220.1  45906140-45906167
            1192-1327           JACYVU010000220.1  45906372-45906507
            1328-1369           JACYVU010000220.1  45906666-45906707
            1370-2527           JACYVU010000220.1  45907182-45908339
FEATURES             Location/Qualifiers
     source          1..2527
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2527
                     /gene="Crhr1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1"
                     /note="corticotropin releasing hormone receptor 1"
                     /db_xref="GeneID:58959"
                     /db_xref="RGD:61276"
     exon            1..295
                     /gene="Crhr1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      214..246
                     /regulatory_class="uORF"
                     /gene="Crhr1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:11179443]"
                     /note="this uORF is predicted to encode a 10 aa peptide
                     (PMID:11179443)"
     CDS             263..1510
                     /gene="Crhr1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; corticotropin-releasing factor receptor 1;
                     corticotrophin releasing hormone receptor 1; corticotropin
                     releasing hormone 1"
                     /codon_start=1
                     /product="corticotropin-releasing factor receptor 1
                     isoform 1 precursor"
                     /protein_id="NP_112261.2"
                     /db_xref="GeneID:58959"
                     /db_xref="RGD:61276"
                     /translation="MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQC
                     NASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSEC
                     QEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLIS
                     AFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIV
                     LTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPM
                     ILVLLINFIFLFNIVRILMTKLRASTTSETNQYRKAVKATLVLLPLLGITYMLFFVNP
                     GEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVA
                     RAMSIPTSPTRVSFHSIKQSTAV"
     exon            296..383
                     /gene="Crhr1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1"
                     /inference="alignment:Splign:2.1.0"
     exon            384..503
                     /gene="Crhr1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..589
                     /gene="Crhr1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..696
                     /gene="Crhr1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..817
                     /gene="Crhr1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..971
                     /gene="Crhr1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1032
                     /gene="Crhr1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1105
                     /gene="Crhr1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1191
                     /gene="Crhr1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1327
                     /gene="Crhr1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1369
                     /gene="Crhr1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..2527
                     /gene="Crhr1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R; CRH-R 1; CRH-R-1; CRH-R1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcaaggcg ggatccaggc agtagagagg tggccgccgg cccggctgag tcgggagaag
       61 gctaccagac ttgctcgcga agggcgagcc agagcctgcc ggtggggcgg ggcggggcgg
      121 aagggtgcga agcccggcac ctgggcgcag atcagcggcc cggggagacc ggccgcccac
      181 cggagaccgc agccgcccgc cctccgctct gggatgtcgg agcgatccag gcatccagga
      241 cgctgacgga gcgagcccga ggatgggacg gcgcccgcag ctccggctcg tgaaggccct
      301 tctccttctg gggctgaacc ctgtgtccac ctcccttcag gatcagcgct gtgagaacct
      361 gtccctgacc agcaatgttt ctggcctgca gtgcaatgca tccgtggacc tcattggcac
      421 ctgctggccc cggagccctg cgggccagtt ggtggtccga ccctgccctg cctttttcta
      481 cggtgtccgc tacaacacga caaacaatgg ctaccgggag tgcctggcca acggcagctg
      541 ggcagcccgt gtgaattatt ctgagtgcca ggagattctc aacgaagaga agaagagcaa
      601 agtacactac catgttgcag tcatcatcaa ctacctgggt cactgcatct ccctggtagc
      661 cctcctggtg gcctttgtcc tcttcttgcg gctcaggagc atccggtgcc tgagaaacat
      721 catccactgg aacctcatct cggctttcat cctacgcaac gccacgtggt ttgtggtcca
      781 gctcaccgtg agccccgagg tgcaccagag caatgtggcc tggtgtaggt tggtgacagc
      841 cgcctacaat tacttccatg taaccaactt cttctggatg ttcggtgagg gctgctacct
      901 gcacacagcc attgtgctca cgtactccac cgaccgtctg cgcaagtgga tgttcgtctg
      961 cattggctgg ggtgtacctt tccccatcat tgtggcttgg gccattggga agctgcacta
     1021 cgacaatgaa aagtgctggt ttggcaaacg tcctggggta tacactgact acatctacca
     1081 gggccccatg atcctggtcc tgctgatcaa ctttatcttt ctcttcaaca ttgtccgcat
     1141 cctcatgacc aaactccggg catccactac atctgagacc aatcagtaca ggaaggctgt
     1201 gaaggccact ctggtgctcc tgccccttct gggcatcacc tacatgttgt tcttcgtcaa
     1261 ccctggagag gacgaggtct ccagggtcgt cttcatctac ttcaactctt ttctggagtc
     1321 ctttcagggc ttctttgtgt ctgtgttcta ctgttttctg aacagtgagg tccgctccgc
     1381 tatccggaag aggtggcgtc ggtggcagga caagcactcc atcagagccc gagtggcccg
     1441 agctatgtcc atccccacct ccccgaccag agtcagcttt cacagcatca agcagtccac
     1501 agcagtgtga gctccaggcc acagagcagc ccccaagacc tgaggccggg gagatgatgc
     1561 aagctcactg acgagccagt ctgcagacgc aagcagcctt cccattccta cccctgcggc
     1621 tgcagacctg agagcctacc cagccatgga gaataatggc tctcagcact gggttgggcc
     1681 cacagcatct ggctccctgc tgcccatgct ccctggaaag ttgaaatggg catgggggct
     1741 agaaaccttg cagcagttta atgggccctg tgagagctgt cttctcccag agcagctcag
     1801 ggaagatctg tagtcttcaa cagctgttgg ggaggcccct tgttaccccg ggcatcatgg
     1861 gaaactctct tgtgagattg taaagcctct ggtgttcaag atgccttggg atgctaccga
     1921 gaagcagggt cacatggtcc agtcaggaga taactttaga aatctggaag cattatcaga
     1981 ccgcactcca cctcccttag ccactcctga gccaccagaa tgtcatcagc accgcggcac
     2041 tgccaccaga aagccctgcc ttgctgcctt gctaccttgc accattagac tcttactatt
     2101 ctgcaggcca atccagcttt ctgtcactta tccactgaca gcaacggtcc ccctcacccc
     2161 caagtcctcc aacctctgga tatcttctaa cctgtgggaa gatcggggtc gggaaaggga
     2221 cttgagttat ctgtgaggga gaaccagaat tggcccagcc tatgaggaag gagtggcccc
     2281 tgggtaccag gccactgact ttcaggtggc tggcctcttg aacatggtca caagctgggt
     2341 aaagggagaa agggcctctg tactcgagcg ccctgaactg tgacaggtgg ctcctgggac
     2401 aactaacgga caaagccctg gctcccaggg ttggaatggt ccagtcctca ctgggtggga
     2461 gggctgagga gccgcagcgg gactgaggtg ggggggacga tataaataat atttatcttt
     2521 tcaacta
//
