LOCUS       NM_139183               1636 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus corticotropin releasing hormone binding protein
            (Crhbp), mRNA.
ACCESSION   NM_139183
VERSION     NM_139183.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1636)
  AUTHORS   Slater,P.G., Cerda,C.A., Pereira,L.A., Andres,M.E. and Gysling,K.
  TITLE     CRF binding protein facilitates the presence of CRF type 2alpha
            receptor on the cell surface
  JOURNAL   Proc Natl Acad Sci U S A 113 (15), 4075-4080 (2016)
   PUBMED   27035969
  REMARK    GeneRIF: show that CRF-BP physically interacts with the CRF2alphaR
            but not the CRF2betaR isoform, increasing CRF2alphaR on the cell
            surface. Thus, CRF-BP emerges as a GPCR escort protein increasing
            the understanding of GPCR trafficking
REFERENCE   2  (bases 1 to 1636)
  AUTHORS   Slater,P.G., Noches,V. and Gysling,K.
  TITLE     Corticotropin-releasing factor type-2 receptor and
            corticotropin-releasing factor-binding protein coexist in rat
            ventral tegmental area nerve terminals originated in the lateral
            hypothalamic area
  JOURNAL   Eur J Neurosci 43 (2), 220-229 (2016)
   PUBMED   26503565
  REMARK    GeneRIF: Corticotropin-releasing factor type-2 receptor and
            corticotropin-releasing factor-binding protein mRNA and protein are
            expressed in the lateral hypothalamic area, and that both proteins
            are present in orexin-positive ventral tegmental area synaptosomes.
REFERENCE   3  (bases 1 to 1636)
  AUTHORS   Levran,O., Randesi,M., Li,Y., Rotrosen,J., Ott,J., Adelson,M. and
            Kreek,M.J.
  TITLE     Drug addiction and stress-response genetic variability: association
            study in African Americans
  JOURNAL   Ann Hum Genet 78 (4), 290-298 (2014)
   PUBMED   24766650
REFERENCE   4  (bases 1 to 1636)
  AUTHORS   Blanco,E.H., Zuniga,J.P., Andres,M.E., Alvarez,A.R. and Gysling,K.
  TITLE     Corticotropin-releasing factor binding protein enters the regulated
            secretory pathway in neuroendocrine cells and cortical neurons
  JOURNAL   Neuropeptides 45 (4), 273-279 (2011)
   PUBMED   21624661
  REMARK    GeneRIF: Results show that CRF-BP is efficiently sorted to the
            regulated secretory pathway in two cellular contexts, suggesting
            that the extracellular levels of CRF-BP in the central nervous
            system depends on neuronal activity.
REFERENCE   5  (bases 1 to 1636)
  AUTHORS   Ray,L.A.
  TITLE     Stress-induced and cue-induced craving for alcohol in heavy
            drinkers: Preliminary evidence of genetic moderation by the OPRM1
            and CRH-BP genes
  JOURNAL   Alcohol Clin Exp Res 35 (1), 166-174 (2011)
   PUBMED   21039637
REFERENCE   6  (bases 1 to 1636)
  AUTHORS   Peto,C.A., Arias,C., Vale,W.W. and Sawchenko,P.E.
  TITLE     Ultrastructural localization of the corticotropin-releasing
            factor-binding protein in rat brain and pituitary
  JOURNAL   J Comp Neurol 413 (2), 241-254 (1999)
   PUBMED   10524337
REFERENCE   7  (bases 1 to 1636)
  AUTHORS   Cortright,D.N., Goosens,K.A., Lesh,J.S. and Seasholtz,A.F.
  TITLE     Isolation and characterization of the rat corticotropin-releasing
            hormone (CRH)-binding protein gene: transcriptional regulation by
            cyclic adenosine monophosphate and CRH
  JOURNAL   Endocrinology 138 (5), 2098-2108 (1997)
   PUBMED   9112410
REFERENCE   8  (bases 1 to 1636)
  AUTHORS   Smith,M.A., Weiss,S.R., Berry,R.L., Zhang,L.X., Clark,M.,
            Massenburg,G. and Post,R.M.
  TITLE     Amygdala-kindled seizures increase the expression of
            corticotropin-releasing factor (CRF) and CRF-binding protein in
            GABAergic interneurons of the dentate hilus
  JOURNAL   Brain Res 745 (1-2), 248-256 (1997)
   PUBMED   9037416
REFERENCE   9  (bases 1 to 1636)
  AUTHORS   Cortright,D.N., Nicoletti,A. and Seasholtz,A.F.
  TITLE     Molecular and biochemical characterization of the mouse brain
            corticotropin-releasing hormone-binding protein
  JOURNAL   Mol Cell Endocrinol 111 (2), 147-157 (1995)
   PUBMED   7556876
REFERENCE   10 (bases 1 to 1636)
  AUTHORS   Potter,E., Behan,D.P., Fischer,W.H., Linton,E.A., Lowry,P.J. and
            Vale,W.W.
  TITLE     Cloning and characterization of the cDNAs for human and rat
            corticotropin releasing factor-binding proteins
  JOURNAL   Nature 349 (6308), 423-426 (1991)
   PUBMED   1846945
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Apr 25, 2008 this sequence version replaced NM_139183.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.452052.1,
                                           SRR26360172.1622466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840106
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               JAXUCZ010000002.1  28439248-28439446   c
            200-293             JAXUCZ010000002.1  28438817-28438910   c
            294-451             JAXUCZ010000002.1  28438380-28438537   c
            452-662             JAXUCZ010000002.1  28436762-28436972   c
            663-811             JAXUCZ010000002.1  28434765-28434913   c
            812-929             JAXUCZ010000002.1  28431200-28431317   c
            930-1636            JAXUCZ010000002.1  28427139-28427845   c
FEATURES             Location/Qualifiers
     source          1..1636
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..1636
                     /gene="Crhbp"
                     /gene_synonym="Crfbp"
                     /note="corticotropin releasing hormone binding protein"
                     /db_xref="GeneID:29625"
                     /db_xref="RGD:2403"
     exon            1..199
                     /gene="Crhbp"
                     /gene_synonym="Crfbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1087
                     /gene="Crhbp"
                     /gene_synonym="Crfbp"
                     /note="corticotropin-releasing factor-binding protein;
                     CRF-BP; CRH-BP; CRF-binding protein"
                     /codon_start=1
                     /product="corticotropin-releasing factor-binding protein
                     precursor"
                     /protein_id="NP_631922.1"
                     /db_xref="GeneID:29625"
                     /db_xref="RGD:2403"
                     /translation="MSPNFKLQCHFTLILLTALRGESRYLEVQEAAVYDPFLLFSANL
                     KRNLAEEQPYRRALRCLDMLSLPGQFTFTADQPQLHCAAFFIGEPEEFITIHFDLVSI
                     DCQGGDFLKVFDGWILKGEKFPSSQDHPLPTRERYTDFCESGLTRRSVTSSQNVAMVF
                     FRVHEPGNGFTITIKTDPNLFPCNIISQTPSGRFTLVVPYQHQNCSFSIIYPVTIKIS
                     DLALGHLHGLQLKKPAAGCGGTGDFVELLGGTGLDTSKMMLLVDLCYPFHGPAQMKIS
                     CDNAVVRMVSSGKHMNRVTFEYRQLEPLELETSTRNSIPEYCLSSL"
     exon            200..293
                     /gene="Crhbp"
                     /gene_synonym="Crfbp"
                     /inference="alignment:Splign:2.1.0"
     exon            294..451
                     /gene="Crhbp"
                     /gene_synonym="Crfbp"
                     /inference="alignment:Splign:2.1.0"
     exon            452..662
                     /gene="Crhbp"
                     /gene_synonym="Crfbp"
                     /inference="alignment:Splign:2.1.0"
     exon            663..811
                     /gene="Crhbp"
                     /gene_synonym="Crfbp"
                     /inference="alignment:Splign:2.1.0"
     exon            812..929
                     /gene="Crhbp"
                     /gene_synonym="Crfbp"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1636
                     /gene="Crhbp"
                     /gene_synonym="Crfbp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagagaccc aggaaaggga ccctagcagc ttcgagttct cagtgtgggc gaaggcgagg
       61 gaagaaacgc ctaagatctc cgcagccgag ctcaccagct gcagacacaa ggccagccat
      121 gtcaccgaac ttcaaactcc aatgccactt cactctgatc ctcctgacag ctctaagggg
      181 agagagccgc tacctagagg tgcaagaagc cgcagtctac gaccctttcc tgcttttcag
      241 cgccaatttg aagcggaacc tggcagagga gcagccctac cgacgggctc tgcgctgcct
      301 ggacatgctg agcctccctg gccagttcac cttcaccgct gaccagccgc agctgcactg
      361 cgccgccttc ttcatcggcg agccggagga gttcatcacc atccactttg acctggtctc
      421 catcgactgc cagggtgggg atttcctgaa ggtatttgat ggttggatcc ttaaggggga
      481 gaagttccca agttctcagg atcaccctct gcccaccagg gagaggtaca cagatttctg
      541 tgagagcggt ctcaccagaa ggagtgttac atcttcccag aatgtggcca tggtcttctt
      601 ccgggtccat gaaccaggaa atggattcac gataaccata aagacagacc ccaacctctt
      661 cccttgcaat atcatctctc agactccgag tggaagattt actttggtgg ttccatacca
      721 gcaccaaaac tgcagctttt ccatcattta tccggtgacc atcaaaatct ctgacctcgc
      781 cctgggacac ctgcatggcc ttcagttgaa gaaacctgcg gctggctgtg gtggaactgg
      841 agactttgtg gagctgctgg gaggaactgg actggacacc tccaagatga tgctcttagt
      901 ggacctgtgt tacccctttc atggccctgc ccagatgaaa attagctgcg acaatgctgt
      961 ggtgaggatg gtctccagtg gaaaacacat gaaccgtgtg acttttgagt atcgtcagct
     1021 ggaaccactc gagctggaaa cctcgaccag aaacagcatc ccggagtact gcttgtctag
     1081 tctttgaatg accagcttca gtgactggca tgccgttagc ccagtgagtt ctccacagtt
     1141 attttggacg gagtgaaaag ccttccagtc agtattccag gctttgaaaa cctgcacaca
     1201 tgacttccaa tttcgcttcc ttttgttata atgtatcaac gagcagaagg cagataacag
     1261 gtgcctgttg gaaatgcttg gccattttgg tgtgctgcag acaagaactg gtgaaacaag
     1321 ggtccagcaa gtgaggaaga gagctgtgtg gcaagggcag gtgctccaaa gagaaagaaa
     1381 tggcagcact caccgtttca tggcataata ataataataa taataataat aataataata
     1441 ataataaaag tcttgagtat accaaaggaa ttgtatctgt tatttttact tcatacttct
     1501 gtttacaaat tgtagctatc cgttattaat tggtagtact tgttttttaa acaacacttt
     1561 gtagcatggg aacaaaacct cctttctatt cataaatcca aatgcaaata aatgtatgca
     1621 gaatgttggc atcttg
//
