LOCUS       NM_031019               1196 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Rattus norvegicus corticotropin releasing hormone (Crh), mRNA.
ACCESSION   NM_031019
VERSION     NM_031019.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1196)
  AUTHORS   Takeuchi,E., Hatanaka,T., Iijima,T., Kimura,M. and Katoh,A.
  TITLE     The effects of corticotropin-releasing factor on motor learning
  JOURNAL   Sci Rep 14 (1), 17056 (2024)
   PUBMED   39048594
  REMARK    GeneRIF: The effects of corticotropin-releasing factor on motor
            learning.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1196)
  AUTHORS   Alcantara-Alonso,V., Garcia-Luna,C., Soberanes-Chavez,P.,
            Estrada-Camarena,E. and de Gortari,P.
  TITLE     Two Adverse Early Life Events Induce Differential Changes in Brain
            CRH and Serotonin Systems in Rats along with Hyperphagia and
            Depression
  JOURNAL   J Integr Neurosci 23 (2), 41 (2024)
   PUBMED   38419452
  REMARK    GeneRIF: Two Adverse Early Life Events Induce Differential Changes
            in Brain CRH and Serotonin Systems in Rats along with Hyperphagia
            and Depression.
REFERENCE   3  (bases 1 to 1196)
  AUTHORS   Sheng,Z.F., Zhang,H., Phaup,J.G., Zheng,P., Kang,X., Liu,Z.,
            Chang,H.M., Yeh,E.T.H., Johnson,A.K., Pan,H.L. and Li,D.P.
  TITLE     Corticotropin-releasing hormone neurons in the central nucleus of
            amygdala are required for chronic stress-induced hypertension
  JOURNAL   Cardiovasc Res 119 (8), 1751-1762 (2023)
   PUBMED   37041718
  REMARK    GeneRIF: Corticotropin-releasing hormone neurons in the central
            nucleus of amygdala are required for chronic stress-induced
            hypertension.
REFERENCE   4  (bases 1 to 1196)
  AUTHORS   Tiwari,M.N., Mohan,S., Biala,Y., Shor,O., Benninger,F. and Yaari,Y.
  TITLE     Corticotropin Releasing Factor Mediates KCa3.1 Inhibition,
            Hyperexcitability, and Seizures in Acquired Epilepsy
  JOURNAL   J Neurosci 42 (30), 5843-5859 (2022)
   PUBMED   35732494
  REMARK    GeneRIF: Corticotropin Releasing Factor Mediates KCa3.1 Inhibition,
            Hyperexcitability, and Seizures in Acquired Epilepsy.
REFERENCE   5  (bases 1 to 1196)
  AUTHORS   Bell,R.L., Withers,G.S., Kuypers,F.A., Stehr,W. and Bhargava,A.
  TITLE     Stress and corticotropin releasing factor (CRF) promote necrotizing
            enterocolitis in a formula-fed neonatal rat model
  JOURNAL   PLoS One 16 (6), e0246412 (2021)
   PUBMED   34111125
  REMARK    GeneRIF: Stress and corticotropin releasing factor (CRF) promote
            necrotizing enterocolitis in a formula-fed neonatal rat model.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1196)
  AUTHORS   Behan,D.P., Heinrichs,S.C., Troncoso,J.C., Liu,X.J., Kawas,C.H.,
            Ling,N. and De Souza,E.B.
  TITLE     Displacement of corticotropin releasing factor from its binding
            protein as a possible treatment for Alzheimer's disease
  JOURNAL   Nature 378 (6554), 284-287 (1995)
   PUBMED   7477348
REFERENCE   7  (bases 1 to 1196)
  AUTHORS   Thompson,R.C., Seasholtz,A.F. and Herbert,E.
  TITLE     Rat corticotropin-releasing hormone gene: sequence and
            tissue-specific expression
  JOURNAL   Mol Endocrinol 1 (5), 363-370 (1987)
   PUBMED   3274895
REFERENCE   8  (bases 1 to 1196)
  AUTHORS   De Souza,E.B., Whitehouse,P.J., Price,D.L. and Vale,W.W.
  TITLE     Abnormalities in corticotropin-releasing hormone (CRH) in
            Alzheimer's disease and other human disorders
  JOURNAL   Ann N Y Acad Sci 512, 237-247 (1987)
   PUBMED   3502064
REFERENCE   9  (bases 1 to 1196)
  AUTHORS   Jingami,H., Mizuno,N., Takahashi,H., Shibahara,S., Furutani,Y.,
            Imura,H. and Numa,S.
  TITLE     Cloning and sequence analysis of cDNA for rat
            corticotropin-releasing factor precursor
  JOURNAL   FEBS Lett 191 (1), 63-66 (1985)
   PUBMED   3876950
REFERENCE   10 (bases 1 to 1196)
  AUTHORS   Rivier,J., Spiess,J. and Vale,W.
  TITLE     Characterization of rat hypothalamic corticotropin-releasing factor
  JOURNAL   Proc Natl Acad Sci U S A 80 (15), 4851-4855 (1983)
   PUBMED   6603620
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031019.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X03036.1, CB580075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               JAXUCZ010000002.1  104060889-104061048 c
            161-1196            JAXUCZ010000002.1  104059184-104060219 c
FEATURES             Location/Qualifiers
     source          1..1196
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..1196
                     /gene="Crh"
                     /gene_synonym="CRF"
                     /note="corticotropin releasing hormone"
                     /db_xref="GeneID:81648"
                     /db_xref="RGD:620505"
     exon            1..160
                     /gene="Crh"
                     /gene_synonym="CRF"
                     /inference="alignment:Splign:2.1.0"
     exon            161..1196
                     /gene="Crh"
                     /gene_synonym="CRF"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..738
                     /gene="Crh"
                     /gene_synonym="CRF"
                     /note="corticoliberin; corticotropin-releasing factor"
                     /codon_start=1
                     /product="corticoliberin precursor"
                     /protein_id="NP_112281.1"
                     /db_xref="GeneID:81648"
                     /db_xref="RGD:620505"
                     /translation="MRLRLLVSAGMLLVALSPCLPCRALLSRGSVSGAPRAPQPLNFL
                     QPEQPQQPQPILIRMGEEYFLRLGNLNRSPAARLSPNSTPLTAGRGSRPSHDQAAANF
                     FRVLLQQLQMPQRPLDSSTELAERGAEDALGGHQGALERERRSEEPPISLDLTFHLLR
                     EVLEMARAEQLAQQAHSNRKLMEIIGK"
ORIGIN      
        1 agaaactcag agcccaagta cgttgagaaa ctgaagagaa aggggaaagg caaagaaaag
       61 gagaagagaa aggagaagag gaagaaaacc tgcaggaggc atcctgagag aggtacctcg
      121 cagaacaaca gtgcgggctc acctgccaag ggaggagaag agagcgcccc taacatgcgg
      181 ctgcggctgc tggtgtccgc gggcatgctg ctggtggctc tgtcgccctg tctgccttgc
      241 agggccctgc tgagcagggg atccgtctct ggagcgccgc gggccccgca gccgttgaat
      301 ttcttgcaac cggagcagcc ccagcaacct cagccgattc tgatccgcat gggtgaagaa
      361 tacttcctcc gcctggggaa cctcaacaga agtcccgctg ctcggctgtc ccccaactcc
      421 acgcccctca ccgcgggtcg cggcagccgc ccctcgcacg accaggctgc ggctaacttt
      481 ttccgcgtgt tgctgcagca gctgcagatg cctcagcgcc cgctcgacag cagcacggag
      541 ctggcggaac gcggcgccga ggatgccctc ggtggccacc agggggcgct ggagagggag
      601 aggcggtccg aggagccgcc catctctctg gatctcacct tccaccttct gagggaagtc
      661 ttggaaatgg ccagggcaga gcagttagct cagcaagctc acagcaacag gaaactgatg
      721 gagattatcg ggaaatgaaa tgttgcgctt ggccaaaacg attctgcatt tagcacacaa
      781 gtaaaaataa aaaatttaaa acacagtatt ctgtaccata ctgcagctct gatatcattt
      841 gtttattttt atatagcttg aagcatagaa gatgtacagg gagagagcct atatacccct
      901 taattagcat gcacaaagtg tgtttctttg tagtaacaaa acagcgttat ttgtattgcc
      961 cacgcttagt ttctatgtgc aaataagtgt ctttatagcg atatcttaaa gaaaatgtgg
     1021 atccaaggag gaaaccttta aaaaagcaga tggaagtcac ccagttgttt ttatttggag
     1081 acacagtgta agagaattca ttcttgaggg gtggctagga caaaatgtgt aagctctttg
     1141 aatcaacttt ttcttgtaaa tgtttcaata ataaaacatc tttctgatcc ttggtc
//
