LOCUS       NM_001105966            2091 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus cellular repressor of E1A-stimulated genes 1
            (Creg1), mRNA.
ACCESSION   NM_001105966 XM_001075616 XM_213921
VERSION     NM_001105966.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2091)
  AUTHORS   Tai TT, Zhou Y, Xu GX, Wu T, Huang ZX and Zhao FF.
  TITLE     CREG improves cardiac function by regulating cardiomyocytes'
            autophagy in diabetic myocardial infarction rats
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (21), 11233-11242 (2020)
   PUBMED   33215442
  REMARK    GeneRIF: CREG improves cardiac function by regulating
            cardiomyocytes' autophagy in diabetic myocardial infarction rats.
REFERENCE   2  (bases 1 to 2091)
  AUTHORS   Liu ML, Song HX, Tian XX, Liu YX, Liu D, Hou ZW, Li JY, Yan CH and
            Han YL.
  TITLE     Recombinant Cellular Repressor of E1A-Stimulated Genes Protects
            against Renal Fibrosis in Dahl Salt-Sensitive Rats
  JOURNAL   Am J Nephrol 51 (5), 401-410 (2020)
   PUBMED   32320986
  REMARK    GeneRIF: Recombinant Cellular Repressor of E1A-Stimulated Genes
            Protects against Renal Fibrosis in Dahl Salt-Sensitive Rats.
REFERENCE   3  (bases 1 to 2091)
  AUTHORS   Zhang TZ, Hua T, Han LK, Zhang Y, Li GY, Zhang QL and Su GF.
  TITLE     Antiapoptotic role of the cellular repressor of E1A-stimulated
            genes (CREG) in retinal photoreceptor cells in a rat model of
            light-induced retinal injury
  JOURNAL   Biomed Pharmacother 103, 1355-1361 (2018)
   PUBMED   29864918
  REMARK    GeneRIF: CREG protected retinal cells against apoptosis by
            inhibiting P38/MAPK and JNK/MAPK signaling pathways and activating
            the PI3K-AKT signaling pathway.
REFERENCE   4  (bases 1 to 2091)
  AUTHORS   Li Y, Liu Y, Tian X, Zhang Y, Song H, Liu M, Zhang X, Liu H, Zhang
            J, Zhang Q, Liu D, Peng C, Yan C and Han Y.
  TITLE     Cellular Repressor of E1A-Stimulated Genes Is a Critical
            Determinant of Vascular Remodeling in Response to Angiotensin II
  JOURNAL   Arterioscler Thromb Vasc Biol 37 (3), 485-494 (2017)
   PUBMED   28062494
  REMARK    GeneRIF: CREG is a novel mediator of vascular remodeling in
            response to Ang II.
REFERENCE   5  (bases 1 to 2091)
  AUTHORS   Thaysen-Andersen M, Venkatakrishnan V, Loke I, Laurini C, Diestel
            S, Parker BL and Packer NH.
  TITLE     Human neutrophils secrete bioactive paucimannosidic proteins from
            azurophilic granules into pathogen-infected sputum
  JOURNAL   J Biol Chem 290 (14), 8789-8802 (2015)
   PUBMED   25645918
REFERENCE   6  (bases 1 to 2091)
  AUTHORS   Peng CF, Han YL, Jie-Deng, Yan CH, Jian-Kang, Bo-Luan and Jie-Li.
  TITLE     Overexpression of cellular repressor of E1A-stimulated genes
            inhibits TNF-alpha-induced apoptosis via NF-kappaB in mesenchymal
            stem cells
  JOURNAL   Biochem Biophys Res Commun 406 (4), 601-607 (2011)
   PUBMED   21354106
  REMARK    GeneRIF: The results of this study indicate that CREG acts as a
            novel and potent survival factor in mesenchymal stem cells.
REFERENCE   7  (bases 1 to 2091)
  AUTHORS   Deng J, Han Y, Yan C, Tian X, Tao J, Kang J and Li S.
  TITLE     Overexpressing cellular repressor of E1A-stimulated genes protects
            mesenchymal stem cells against hypoxia- and serum
            deprivation-induced apoptosis by activation of PI3K/Akt
  JOURNAL   Apoptosis 15 (4), 463-473 (2010)
   PUBMED   19997978
  REMARK    GeneRIF: This study indicates that CREG is a novel and potent
            survival factor for mesenchymal stem cells.
REFERENCE   8  (bases 1 to 2091)
  AUTHORS   Xu L, Liu JM and Chen LY.
  TITLE     CREG, a new regulator of ERK1/2 in cardiac hypertrophy
  JOURNAL   J Hypertens 22 (8), 1579-1587 (2004)
   PUBMED   15257182
  REMARK    GeneRIF: CREG was found to inhibit cardiac cell growth as a novel
            regulator of ERK1/2 and might participate in the development of
            cardiac hypertrophy under pressure overload
REFERENCE   9  (bases 1 to 2091)
  AUTHORS   Veal E, Eisenstein M, Tseng ZH and Gill G.
  TITLE     A cellular repressor of E1A-stimulated genes that inhibits
            activation by E2F
  JOURNAL   Mol Cell Biol 18 (9), 5032-5041 (1998)
   PUBMED   9710587
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473958.2.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_213921.4, XM_001075616.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166446.1, EX491567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2091
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q23"
     gene            1..2091
                     /gene="Creg1"
                     /gene_synonym="Creg"
                     /note="cellular repressor of E1A-stimulated genes 1"
                     /db_xref="GeneID:289185"
                     /db_xref="RGD:1306804"
     exon            1..377
                     /gene="Creg1"
                     /gene_synonym="Creg"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..686
                     /gene="Creg1"
                     /gene_synonym="Creg"
                     /note="protein CREG1"
                     /codon_start=1
                     /product="protein CREG1 precursor"
                     /protein_id="NP_001099436.1"
                     /db_xref="GeneID:289185"
                     /db_xref="RGD:1306804"
                     /translation="MAARAPELARSLLAALLAPALVALLVSPAWGRGGRDHGDWDVDR
                     RLPPLPPRDDGPRVARFVTHVSDWGSLATISTREEVRGRPFADIISISDGPPGEGSGE
                     PYMYLSPLQQAVSDLQGNPEATLTMSLAQTAYCRNHGFDPQSPLCVHIMMSGTVIKVN
                     ETEEGYARDSLFIRHPEMKHWPPSHKWFFAKLKISNIWVLDYFGGPKVVTPEEYFNVT
                     LQ"
     exon            378..497
                     /gene="Creg1"
                     /gene_synonym="Creg"
                     /inference="alignment:Splign:2.1.0"
     exon            498..682
                     /gene="Creg1"
                     /gene_synonym="Creg"
                     /inference="alignment:Splign:2.1.0"
     exon            683..2091
                     /gene="Creg1"
                     /gene_synonym="Creg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaggtgctc tgcagtcagc gccatggctg cccgcgctcc tgagctcgcg cgctccctgc
       61 ttgctgccct tctggctccc gcgctagtgg cactactggt gtcgccggcc tggggacgcg
      121 gaggccggga ccacggggac tgggacgtgg acaggcgact gcctccactg ccaccccgcg
      181 atgacgggcc gcgcgtggcc cgcttcgtga ctcacgtctc ggactggggc tcgctggcca
      241 ctatctccac gagagaggag gtgcgcggca ggcccttcgc ggacatcatc tcaattagtg
      301 acggtcctcc gggagaaggc tcaggcgagc cctacatgta cctgagtccg ctgcaacaag
      361 cagtgagcga cctgcaggga aatccagagg ctacgctgac tatgtcttta gcacagactg
      421 cctactgtag gaaccatgga tttgatcccc agagtcccct ctgtgttcat ataatgatgt
      481 ccgggactgt gatcaaagta aatgagacag aagagggcta cgcacgggac tcgctattca
      541 tcagacaccc tgagatgaaa cactggcctc ctagccataa gtggttcttt gctaagttaa
      601 aaataagcaa tatctgggtt ttggactact ttggtggacc gaaagtagtg acacctgaag
      661 aatattttaa cgtcacactg cagtgaagca aatacggtga actggatcac accagcgaca
      721 ggtcttccaa ggctcatgca cacagagggc tcgaccctgc ctggctgcta gcccactctg
      781 ccacctcttg tttcgatttc ctttgcttgt ctttgcagag tgttgtccat tagaagacgt
      841 gcttgctgga tttaaaaaaa aaaaaaaaag tcttgaagcc attttcagag aaaaatgccc
      901 ttctttatga tcaaggaagc catgctcggt gctttttcct cagtggtgcc ctcagtaggg
      961 tgacatatac cagctgtaga ccgcccattg gcactggagg tccagaggtg cagatgctct
     1021 gtgcctgatg gccactgtgc ctgaaggtgc tgtgctcacc cagctgcctc aggagccagt
     1081 gcagaggggc cgtatgaatc ctccagtcca ggacagcagt gaccacggat gcagcgtccc
     1141 attcacgtca acctgtatag ctgatcagca caaggcaaag ctgggtcttc tgtaaaactc
     1201 cataaacgtc ttacattcta aagtcatcgt tacccagaac aaaataaatc agaaagattt
     1261 tcctgcatcc attctccatc taagtagact gtacactcac tcctcatcct tcggaatgtg
     1321 cacgcctgag ctggggcgca gctttcttgg cacagagctt gccaagcatg aatgggacca
     1381 taacgtcgaa acaaccagcc agccacagac gacatcttta tgtgcatgaa aaagcaacct
     1441 cagaagaaaa aggatttcgc atatgttggg ctctttttcg taagacttaa ccctgtgcca
     1501 gccgcaatcc aagccctcct ccggcattct gtatcttgaa gctcctggtg ctgccgcctg
     1561 cgtcctctgt gggatgtacc acggtactgt ggcataaaaa caaactacaa caacaacaaa
     1621 acatgtctct gcaccagagg atggctcagc ttgtaagatg actgctctag cagaggaccc
     1681 aagttcagta cccgcaaggg gtcagacagg cacatatgcc cagaactcca gctccaggag
     1741 atcaaatacc tctagcctcc aaggtcacct gcactggaat acacacaccc acacatagac
     1801 acacagcgac acaatttcaa acagtacatc ttttattcca aagaggtact acttagttta
     1861 attacctgtt tcatgctctt ggatgacata agatttcttt taacagagtg tgggggaatc
     1921 aagacactga cttaaacagc caaaaaaaaa aaaaaaaaag ttaactatga accatcatgt
     1981 tggagaaaga gatggtaatc ataacagaaa tccagcaaac gacgtctcag tcaaaaccca
     2041 ctaaacagta aggatcttgt tattgaaatc agtaattaaa agcattatta t
//
