LOCUS       NM_001271791            6312 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus CREB/ATF bZIP transcription factor (Crebzf),
            transcript variant 1, mRNA.
ACCESSION   NM_001271791
VERSION     NM_001271791.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6312)
  AUTHORS   Zhang,R., Rapin,N., Ying,Z., Shklanka,E., Bodnarchuk,T.W.,
            Verge,V.M. and Misra,V.
  TITLE     Zhangfei/CREB-ZF - a potential regulator of the unfolded protein
            response
  JOURNAL   PLoS One 8 (10), e77256 (2013)
   PUBMED   24155933
  REMARK    GeneRIF: Zhangfei had a suppressive effect on most unfolded protein
            response genes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6312)
  AUTHORS   Lee,K.M., Seo,Y.J., Kim,M.K., Seo,H.A., Jeong,J.Y., Choi,H.S.,
            Lee,I.K. and Park,K.G.
  TITLE     Mediation of glucolipotoxicity in INS-1 rat insulinoma cells by
            small heterodimer partner interacting leucine zipper protein
            (SMILE)
  JOURNAL   Biochem Biophys Res Commun 419 (4), 768-773 (2012)
   PUBMED   22387546
  REMARK    GeneRIF: These results collectively suggest that SMILE plays an
            important role in the development of beta cell dysfunction induced
            by glucolipotoxicity
REFERENCE   3  (bases 1 to 6312)
  AUTHORS   Misra,J., Chanda,D., Kim,D.K., Li,T., Koo,S.H., Back,S.H.,
            Chiang,J.Y.L. and Choi,H.S.
  TITLE     Curcumin differentially regulates endoplasmic reticulum stress
            through transcriptional corepressor SMILE (small heterodimer
            partner-interacting leucine zipper protein)-mediated inhibition of
            CREBH (cAMP responsive element-binding protein H)
  JOURNAL   J Biol Chem 286 (49), 41972-41984 (2011)
   PUBMED   21994947
  REMARK    GeneRIF: the curcumin/LKB1/AMPK/SMILE/PGC1alpha pathway
            differentially regulates ER stress-mediated gene transcription
REFERENCE   4  (bases 1 to 6312)
  AUTHORS   Reinke,A.W., Grigoryan,G. and Keating,A.E.
  TITLE     Identification of bZIP interaction partners of viral proteins HBZ,
            MEQ, BZLF1, and K-bZIP using coiled-coil arrays
  JOURNAL   Biochemistry 49 (9), 1985-1997 (2010)
   PUBMED   20102225
REFERENCE   5  (bases 1 to 6312)
  AUTHORS   Xie,Y.B., Park,J.H., Kim,D.K., Hwang,J.H., Oh,S., Park,S.B.,
            Shong,M., Lee,I.K. and Choi,H.S.
  TITLE     Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear
            receptor estrogen receptor-related receptor gamma transactivation
  JOURNAL   J Biol Chem 284 (42), 28762-28774 (2009)
   PUBMED   19690166
REFERENCE   6  (bases 1 to 6312)
  AUTHORS   Hogan,M.R., Cockram,G.P. and Lu,R.
  TITLE     Cooperative interaction of Zhangfei and ATF4 in transactivation of
            the cyclic AMP response element
  JOURNAL   FEBS Lett 580 (1), 58-62 (2006)
   PUBMED   16343488
REFERENCE   7  (bases 1 to 6312)
  AUTHORS   Misra,V., Rapin,N., Akhova,O., Bainbridge,M. and Korchinski,P.
  TITLE     Zhangfei is a potent and specific inhibitor of the host cell
            factor-binding transcription factor Luman
  JOURNAL   J Biol Chem 280 (15), 15257-15266 (2005)
   PUBMED   15705566
REFERENCE   8  (bases 1 to 6312)
  AUTHORS   Lu,R. and Misra,V.
  TITLE     Zhangfei: a second cellular protein interacts with herpes simplex
            virus accessory factor HCF in a manner similar to Luman and VP16
  JOURNAL   Nucleic Acids Res 28 (12), 2446-2454 (2000)
   PUBMED   10871379
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and FN797334.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR26643298.3878.1, SRR26643429.2558.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-951               JAXUCZ010000001.1  153829762-153830712
            952-1624            FN797334.1         1-673
            1625-6312           JAXUCZ010000001.1  153831386-153836073
FEATURES             Location/Qualifiers
     source          1..6312
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..6312
                     /gene="Crebzf"
                     /gene_synonym="RGD1565584"
                     /note="CREB/ATF bZIP transcription factor"
                     /db_xref="GeneID:293112"
                     /db_xref="RGD:1565584"
     exon            1..6312
                     /gene="Crebzf"
                     /gene_synonym="RGD1565584"
                     /inference="alignment:Splign:2.1.0"
     CDS             519..1586
                     /gene="Crebzf"
                     /gene_synonym="RGD1565584"
                     /codon_start=1
                     /product="CREB/ATF bZIP transcription factor"
                     /protein_id="NP_001258720.1"
                     /db_xref="GeneID:293112"
                     /db_xref="RGD:1565584"
                     /translation="MRHSLTKLLAASGRDFPSRRDSQEPPATRAPPPDPTGAAAGTET
                     SRPGSPDREQPHGDGGEPEARRGSRGSVAVRAPAPSPLKMEEEEEDAIAMVPKEEQED
                     MDFLSGLELADLLDPRQPDWHLEPGLSSPGPLSSSGGGSDSGGLLRGDDDDETAAAEM
                     QRFSDLLQRLLNGIGGCSSGSDRGGGEKRRRKSPGGGGGTNDNNQATTKSPRKAAAAA
                     ARLNRLKKKEYVMGLESRVRGLAAENQELRAENRELGKRVQALQEESRYLRAVLANET
                     GLARLLSRLSGVGLRLTTSLFRDSPAGDHDYALPVGKQPQELLEEDDAAGGVCLHVDK
                     DKVSVEFCSACARKASSSLKM"
ORIGIN      
        1 catagttgtt tttcttgcag tctagagaga aacagcaaaa aataaaactg ctcataaaat
       61 agctttttat ataggtgtgt caaatatgtc tagacttcaa gtattgggtt gcggagattg
      121 gtactgggta gcaccgctgc atgtggggga tagaaaccta ggttttattg tttttgccgc
      181 ggctcctatg acatcaccgc agagcaggag ttactgcacc tcgaaagcgc tcggaatctc
      241 gcgacactct ggctggagag aagcgcgttt ttgtgggcgg ggtggggaga gagtaacttc
      301 cggccaggcc gctgtttggg tggcgcggcc gactcctctc gggcctcgcc gcttcgcgct
      361 tccactgcct tcccccccgc ctcgtgcggg gggttgggcg gccgcgggag gccactcaga
      421 ccttcccggc gcctgtggtc ggcccggcgc tgtggctctg cgcgcggggg cccggggtct
      481 caggggctgc ggcctacccg ggcccgccgc tcagcctcat gaggcacagc ctgaccaagc
      541 tgctggcagc ctcgggccgc gacttcccga gccgccgcga cagccaggag ccgcccgcca
      601 cgcgcgcgcc tcccccggac ccgactgggg cagccgcggg gacggagacg tcaaggcccg
      661 gatcccctga ccgcgagcaa cctcacgggg acgggggcga gccggaggcc cggaggggga
      721 gtcgcggcag cgtggccgtg cgcgcgcccg cgccctcgcc actgaagatg gaggaggagg
      781 aggaggacgc gatcgctatg gtccccaaag aagagcagga ggacatggac tttctctccg
      841 ggctggagct ggccgatctg ctggaccctc ggcaaccgga ctggcacctg gagcccgggc
      901 tcagctcgcc cgggcccctg tcctcgtccg gcggaggctc ggatagtggt ggcctattga
      961 ggggggacga cgacgacgag accgcggccg cagagatgca gcgcttttct gacttgctgc
     1021 agaggctgtt aaatggcatc ggaggctgca gcagcggcag cgaccgcggc ggcggggaaa
     1081 agaggcggag aaagtctccg ggaggaggcg gtggcaccaa cgacaacaac caagcgacga
     1141 ctaagagtcc tcggaaggcg gcggcggccg ctgcccgact taatcggctc aagaagaagg
     1201 agtatgtgat ggggctggag agtcgagtcc ggggactggc agccgagaac caggagctgc
     1261 gggccgagaa tcgggagctg ggcaaacggg tgcaagcact gcaggaggag agtcgctacc
     1321 tacgggctgt cctagccaac gagaccggac tggctcgcct gctgagccgg ctgagcggcg
     1381 tgggactgcg gctgaccact tcactcttca gagactcgcc cgccggtgac catgactacg
     1441 ccctgccggt tgggaagcag cctcaggagc tgctggaaga ggacgacgcg gcgggaggag
     1501 tgtgtctcca tgtggacaag gataaggtgt cggtggagtt ctgctcggcg tgcgctcgga
     1561 aggcgtcgtc ttctcttaaa atgtagggtc aagtaatctg ctctttatcc gcgtttaccc
     1621 ctttctacac ccttacacca tgtaaaacac cttagtggga catcttcacc ggacgcattt
     1681 gagaggcgga aaaaaagtaa tattaagtct tttaagtgtt tagctaaaag catgaatgtg
     1741 acactgtaac caactcctaa tgataacctg tgactattaa atctctctga cagtttcttt
     1801 tttaggtgat ttccttcctg ccaggctccg ttgtaggggt tacagaacag tcgttcccgc
     1861 ctcacaacct ggtaaggatc catctcttca cgtaacgctc atgctctgct gcttagccta
     1921 atttaatggg caaacatctc aatgtgtgtg tgtgatacct tttttgtttg tttctttttt
     1981 ctttttaaag gtgggagggc agtcttaatt tgggccttgt ccaccctgga aacagacttg
     2041 tgctggtcat taatgtactt aagttgctaa tggttgaaat agctgttaaa tgtgtcccct
     2101 tgttcagagt tttgcgtgta cctagctctt ctgtccccag tgtggacatg gccttggatg
     2161 acatcggttc caactgtaca ctgaaacctg ctaatagaga tacagtttgg agacagtgaa
     2221 acaggtgaag ttgaatggaa gttccgagtt gtacaaggtg caaattggaa ttccaattgt
     2281 agagcaactt ttcaaaggtt gacaataagt attgaggcat gcgcaaatgt ggtatttttc
     2341 tggagatgac aaatctccta aaatacttaa gaatgccttc tagttttcag tagaaaatgc
     2401 agaaatacaa tctatttaaa gatcctaata tttcaccact tgagaagatg gaaattaatt
     2461 tacccatcag atttgtgttt taattagaag acgataaatg aaatgtttct ttgaggacca
     2521 gcacagtata cctatcaatg agtatgaaga aattgttgaa agtatttatt tttgttgtat
     2581 taaaatttag gctaaatttc tgtacgatta ttagatattg aaggttgtga aatgtgaatg
     2641 aaaacatgta aagtgaggct tcacaaagaa tcttctccct atttctaaaa cttttgtcct
     2701 acttaaaaat actttttaaa actaattata tgattgatac tgtttttcca aagatggaaa
     2761 catctttctt ctattgtcca catgtctaaa tgtgtgttct gatgctctga aatgcaagag
     2821 atatattaaa ttctttgtga aacatcactg tttgataaag gatatccgta tttagcatcc
     2881 ttgtttttct ttgtgctaaa gtggatacag ctgttggggc agaagagacg ggaccagctg
     2941 ctggccacat ttcctgcttt attttaaaag gtagtataag aaataaggaa acagaggtaa
     3001 tatcagggct tctgctgtct tttattttta aaatgttcat aattaagtat tttccagcag
     3061 tccaaagatg taagttatct tacacataag atgttttatt ttgttatttg gttatggaaa
     3121 tggaatcttg ttcttgcaca actaactgta aatgttttgt tgctagataa tatgattttg
     3181 agacctacat tagtctctgg tttcagtata tcacattttg taaaattatc tactgcactt
     3241 gagcatgaat gggtagtagc caaactcaca acttggagtg acggacctgc ttctacaagg
     3301 gtaggaacaa gcccctacaa tgcagctgca tggattttag tgcctactga attatatata
     3361 tatacatata tatataaacc aaaagtagtt ggaaatttat ttcaaatgac taatttgtgc
     3421 tttttctgaa gtatgttaaa tgtagctttt gaaacagaag ccttgaattg aaatttaata
     3481 cttgaacatt tttgtatata tttctttgta tataattttg tgcagaaccg atgacaaaaa
     3541 tatggtgtca taataaaatc aggtttgttg atctttcagt tatgggctca aagaatttat
     3601 tcatctctaa catgacattg gaaagtaatg gatgaaaata agaaaaatgg ttgttgttaa
     3661 tatagactta atcgaaaggt tctggaagca gtaagtttgt tttcctaaaa gattatgcca
     3721 tttctgtgga atattttctt aacctcagtg cttttcctac atttgaagtg tgaacttggg
     3781 gagaatcagt ttctgaattg ggatgttttg atattccaag tagagtttaa actgtcattt
     3841 tataaatggc agtttggaga attaggagtc tcagcagtgg caagattaga gtgtcctatt
     3901 tttaaagctg ctttcttagg tccctatgtc ttattaactg tcttttctgt ttccatttca
     3961 ttgtttcttt tctagttttg gtgacagtga tttttgtcat tttttgcatc aactcatggt
     4021 cttgttttta catggtaact gcatgtatta ggacctatca gggcctttaa ataaatttga
     4081 tcatatttat gtgtaagcac attttactgt aaatgtttgg atttcttaat ttacagcagt
     4141 tgtttatttc agtgtgtagt aaacagtatc ttaagtgtcc tgttcactac ttgttaatta
     4201 aaaaagttat taatataaaa ctgttgtctt actattttta gaaaattgtg ttgtgaatta
     4261 gtattttgat agagagttct gaaatataaa atagattgct ttgaaatttt caggtttggg
     4321 tgtatttact gtgatgattg agaacaattt agtatttggg gaactgtttc aggttttatt
     4381 cctgattttt ccctgtgtaa aaatgatcga aaaccaaaga atgtagcttt taaatacctg
     4441 tcttcctatg atagttaata ttcatacatt aattgactaa cacatattgg catagtattt
     4501 ctatcatagt gacttaagtt tttgtccttt ttttaaccat acttaaaagt atgtttgtta
     4561 aaaaatgtag tcacacctct ggtatatcca acaaagtatt caaaatattt taaatatctg
     4621 tacatttcat actcgctaaa ttaatctttt tctcttctct ttaaacagct tagcagtatc
     4681 tgcaaaaacg aatcttttcc tacaacctgt taactgactg gactgatggt aacagtaatt
     4741 gtgggagcca tgtcggtcaa aaatttggca tctgctgaaa aacatgaatg ccatttccaa
     4801 ggtcccaaat tacttctata ctgattacac tttccagaaa tggagatatg aaaagattct
     4861 ctggaatgct tgaaagactt aatagagatc catgagacta agttaatttt ggaacaaaat
     4921 tacacctttt tttcccccat tcatggcaat aacactaaat ttatcacata cttttaaaaa
     4981 attgtaattg gagaagagaa ttatagtttc atcaagaaac attagatttt acacaatcaa
     5041 ggacattaga tttagtgggt tagaatgaca taaataggct agcagtgatc acaaacctct
     5101 cgagtgtatt tctggaatgt aaagagctgc tgtggaagac agacaccttg ttgagtagaa
     5161 tgaagtctgt atctaaaaga ttagtgtttt aaaatagatg cattgattgt atgttttgaa
     5221 aaagtgattc tgatagacaa tgtgtgggtg ctaacttagg gtatcaagag catgtgtgca
     5281 atcccagggt ttggcatctt ggatcttctg agtacttgat ctcattgaat gtgttcaagt
     5341 ttctgatgaa tgatagagtt tctattggtc tgtgttaaaa tttctggagt attctgtaag
     5401 aatctttata ttctggatga gaaaggctaa tttcctacta taagtaaaaa agcactcaga
     5461 aaccagtcat ttttcattat tgttggaatc tgctaatgca tttgtcatcc ggtctagact
     5521 tagttattta tttatttttt ggttcatttg ggaaatatgc agatagaaga ggaagatgat
     5581 atgaaatagt tggtttacac tgtaacttgg atactcaaaa ttcattcagg ttgcttttag
     5641 aactgcaacg taaaaatgtg ctgggatagt tttagcatag taaacagttt gcacttatca
     5701 agcagcttgg ttatatcatt ggattctgaa ttactaagtt gattatatac catctgtatt
     5761 acctaagaaa ttaatgtagt aattatatta tttttacttt gatcaattga attactcatt
     5821 agttaaaagt gagaatgtag gtgggcagct ttgtatcaga aaacctttgc ttttgctatt
     5881 attccttgta aaataggcaa tcatatacaa agcacatttt tacattgcag ttctaaaagt
     5941 aaaacattaa atcatgggga ctctagaaag aaagcaaaag aaatcacata actaacctag
     6001 ggcaagatac tgtaaacacc ttccctttct cttggaaact tccttccctc ataattatac
     6061 tcttaaaaaa actgaataga gaatacattt tgtgtgtttt ttgaaagaac aagtcacagc
     6121 attctgaaaa ctgctacatt tgactaatat tttagtaatg accttgtttt gttgatggag
     6181 acaagggtct tgcattggat gagaaatcac tagctagcct caaacctgag gccctgcctt
     6241 ttcttcccac ttgctaggca cgccatggta ttttttttct ttcaataaaa gcctatttaa
     6301 cacatccaaa aa
//
