LOCUS       NM_001277157            6459 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus CREB3 regulatory factor (Crebrf), mRNA.
ACCESSION   NM_001277157 XM_001064739 XM_220273
VERSION     NM_001277157.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6459)
  AUTHORS   Martyn,A.C., Choleris,E., Gillis,D.J., Armstrong,J.N., Amor,T.R.,
            McCluggage,A.R., Turner,P.V., Liang,G., Cai,K. and Lu,R.
  TITLE     Luman/CREB3 recruitment factor regulates glucocorticoid receptor
            activity and is essential for prolactin-mediated maternal instinct
  JOURNAL   Mol Cell Biol 32 (24), 5140-5150 (2012)
   PUBMED   23071095
REFERENCE   2  (bases 1 to 6459)
  AUTHORS   Audas,T.E., Li,Y., Liang,G. and Lu,R.
  TITLE     A novel protein, Luman/CREB3 recruitment factor, inhibits Luman
            activation of the unfolded protein response
  JOURNAL   Mol Cell Biol 28 (12), 3952-3966 (2008)
   PUBMED   18391022
REFERENCE   3  (bases 1 to 6459)
  AUTHORS   Liang,G., Audas,T.E., Li,Y., Cockram,G.P., Dean,J.D., Martyn,A.C.,
            Kokame,K. and Lu,R.
  TITLE     Luman/CREB3 induces transcription of the endoplasmic reticulum (ER)
            stress response protein Herp through an ER stress response element
  JOURNAL   Mol Cell Biol 26 (21), 7999-8010 (2006)
   PUBMED   16940180
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Mar 15, 2013 this sequence version replaced
            XM_001064739.3, XM_220273.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. There are no full-length
            transcripts supporting this RefSeq in rat and it is unknown if this
            exon combination exists in rat; however, it is predicted based on
            partial transcript alignments and on full-length transcript support
            from the mouse homolog (GeneID 77128 , NM_029870.2 and BC113192.1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.860632.1,
                                           SRR26360194.2304157.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                JAXUCZ010000010.1  16966380-16966430   c
            52-246              JAXUCZ010000010.1  16944190-16944384   c
            247-372             JAXUCZ010000010.1  16941980-16942105   c
            373-1462            JAXUCZ010000010.1  16938306-16939395   c
            1463-1657           JAXUCZ010000010.1  16926115-16926309   c
            1658-1847           JAXUCZ010000010.1  16924232-16924421   c
            1848-1921           JAXUCZ010000010.1  16921825-16921898   c
            1922-2044           JAXUCZ010000010.1  16920620-16920742   c
            2045-6459           JAXUCZ010000010.1  16909032-16913446   c
FEATURES             Location/Qualifiers
     source          1..6459
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..6459
                     /gene="Crebrf"
                     /gene_synonym="RGD1310862"
                     /note="CREB3 regulatory factor"
                     /db_xref="GeneID:303016"
                     /db_xref="RGD:1310862"
     exon            1..51
                     /gene="Crebrf"
                     /gene_synonym="RGD1310862"
                     /inference="alignment:Splign:2.1.0"
     exon            52..246
                     /gene="Crebrf"
                     /gene_synonym="RGD1310862"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..2160
                     /gene="Crebrf"
                     /gene_synonym="RGD1310862"
                     /codon_start=1
                     /product="CREB3 regulatory factor"
                     /protein_id="NP_001264086.1"
                     /db_xref="GeneID:303016"
                     /db_xref="RGD:1310862"
                     /translation="MPQPSVSGMDPPFGDAFRSHTFSEQTLMSTDLLANSSDPDFMYE
                     LDREMNYQQNPRDNFLSLEDCKDIENLETFTDVLDNEDALTSNWEQWDTYCEDLTKYT
                     KLTSCDIWGTKEVDYLGLDDFSSPYQDEEVISKTPTLAQLNSEDSQSVSDSLYYPDSL
                     FSVKQNPLPPSSFPSKKITSRAAAPVCSSKILQAEVPSSDCVQKASKPTSSTQIMVKT
                     NMYHNEKVNFHVECKDYVKKAKVKINPVQQGRPLLSQVHIDAAKENTCYCGAVVKRQE
                     KRGVEPHQGHGTPALPFRETQELLLSPLPQHGPGLVATAESGSLSASTSVSDSSQKKE
                     EHNYSLFVSDNMREQPTKYSPEDDEDDEDDIDDEDHDEGFGSEHELSENEEEEEEEED
                     YEDDRDDDISDTFSEPGYENDSVEDLKEMTSISSRKRGKRRYFWEYSEQLTPSQQERI
                     LRPSEWNRDTLPSNMYQKNGLHHGKYAVKKSRRTDVEDLTPNPKKLLQIGNELRKLNK
                     VISDLTPVSELPLTARPRSRKEKNKLASRACRLKKKAQYEANKVKLWGLNTEYDNLLF
                     VINSIKQDIVNRVQNPREERGPSMGQKLEILIKDTLGLPVAGQTSEFVNQVLGKTAEG
                     NPTGGLVGLRIPASKV"
     exon            247..372
                     /gene="Crebrf"
                     /gene_synonym="RGD1310862"
                     /inference="alignment:Splign:2.1.0"
     exon            373..1462
                     /gene="Crebrf"
                     /gene_synonym="RGD1310862"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1657
                     /gene="Crebrf"
                     /gene_synonym="RGD1310862"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1847
                     /gene="Crebrf"
                     /gene_synonym="RGD1310862"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1921
                     /gene="Crebrf"
                     /gene_synonym="RGD1310862"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2044
                     /gene="Crebrf"
                     /gene_synonym="RGD1310862"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..6459
                     /gene="Crebrf"
                     /gene_synonym="RGD1310862"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgctgc aacgcggccg gacctagtgc ctgaaccgct ttcagcctca gaaccgcaca
       61 tttatttttt taaaaaagtg gtgacccaag cagttgaact gaaggtattc tggggaaatc
      121 tgctgtttat tgtgaaaatc atctttgatc ttggaattaa aagtaaagct ggaaaggaat
      181 ttacaaacaa gaaaaagaag aagtttggaa ttggactcac agaatctggg cttggaaatg
      241 cctcagccca gcgtaagcgg aatggatccg ccttttgggg atgcctttcg aagccacacc
      301 ttttcagaac agactctgat gagcacagat ctcttagcca acagttctga tccagatttc
      361 atgtatgagc tggatagaga gatgaattat caacagaatc ctagagacaa cttcctttct
      421 ttggaagact gcaaagacat tgaaaatctg gagactttca cagatgtcct ggacaatgag
      481 gatgctttga cttcaaactg ggaacagtgg gatacatact gtgaagactt aactaagtat
      541 accaaactaa ccagctgtga catctggggg acaaaagaag tggattacct gggtcttgat
      601 gacttttcta gcccttacca agatgaagag gtcatcagta aaactccaac cttggcccag
      661 ctcaatagtg aggactctca gtctgtttct gattcccttt attatcctga ttcactcttc
      721 agtgtcaaac aaaacccctt gcccccctct tcttttccta gtaaaaagat cacaagtaga
      781 gcagctgccc ctgtgtgctc ttcaaagata cttcaggctg aggtcccatc gtcagactgt
      841 gtccaaaaag caagcaaacc tacttcaagc acacagatca tggtgaagac caacatgtat
      901 cataatgaaa aagtgaattt tcatgtcgaa tgtaaagact atgtaaaaaa agcaaaagtc
      961 aagatcaacc ctgtgcaaca gggccggccc ttgctgagcc aggtgcacat agatgcggca
     1021 aaggagaaca cctgctactg tggcgctgtg gtaaagaggc aggagaagag gggggtggag
     1081 cctcaccagg gtcatggcac tcctgctttg cctttcagag aaacccagga actattactt
     1141 agtcctctgc cccagcatgg tcctgggttg gttgccacag cagagagtgg cagcctttct
     1201 gccagcactt ctgtttcaga ttcgtcccag aaaaaagaag agcacaatta ttctcttttt
     1261 gtctctgaca acatgagaga acagccaacc aaatacagtc ctgaagatga tgaggatgat
     1321 gaagatgata ttgatgatga ggaccatgat gaagggtttg gcagtgagca tgagctttct
     1381 gaaaatgaag aggaggaaga agaggaagag gattatgagg atgacagaga tgatgatatc
     1441 agcgacacat tctctgaacc aggctatgaa aacgactctg tagaggactt gaaggagatg
     1501 acttccatat cttctcggaa gagagggaaa agaaggtact tctgggagta tagtgagcag
     1561 ttgacgccat cacagcaaga gaggattctg aggccatctg agtggaatcg agacaccttg
     1621 ccaagtaata tgtaccagaa aaatggctta catcatggga aatacgcagt taagaagtca
     1681 cggagaactg atgtggaaga cctgactcca aatcctaaaa aactactcca gattggtaat
     1741 gaactacgga aactgaataa ggtgatcagt gacctgactc cagttagtga gcttccctta
     1801 acagcgaggc caaggtcaag gaaagaaaaa aataagctgg cttccagagc ttgtaggctg
     1861 aagaagaaag cccagtatga agccaataaa gtgaagctct ggggcctcaa cactgaatat
     1921 gacaatttat tatttgtaat caactccatc aagcaagaca ttgtaaaccg agttcagaat
     1981 ccaagagagg agagaggacc cagcatgggg cagaagcttg aaatcctcat taaagacaca
     2041 ctcggtctcc cagtcgctgg gcaaacctca gaatttgtta accaagtgtt agggaagact
     2101 gctgaaggca accccactgg aggccttgta ggactaagga taccagcatc aaaagtgtaa
     2161 tcagcctcat tggaccactg gtcagaaatg tctgtttttt gtcacgttat ccattgtaaa
     2221 ttttcattct gttttgcatg tcaattagca ttatgtaaac atttataatt aggttacatt
     2281 gttttgagaa cttgtagcat aagtgaagca tgatccaaaa tacttgatta ttgcattttc
     2341 agagcataaa ccagtgaccc tgctgctggc attagaaaga agctcacaca ttaagtaaat
     2401 gtgagttaca gattataaac atttgttgaa gcagaatgtt ttggatgagt gaatatatta
     2461 gtatgatgct aagtgttaag gtgggtttat gctctgaacc acacaaaaat accgaggaag
     2521 cattttttca aagtccatta gattgttttt agaatgactg ctttttgttc taatttttta
     2581 cagccattaa tctcacttgt acatggcgca cccagcactc acatgtgtac catgtttaga
     2641 tgtttatttt cagaactcaa tatgatatat ataaatacat agattatata tatatatata
     2701 tatatatata attgtctgtg caagtaagaa aaaagcatat tctttgtgcc ttgtattttg
     2761 gggaaactct aaaactggta atattttgta tgatgaaaac cctaatgagg aaaaccaaga
     2821 tatatagatg agaaaattgt ggggtttaaa tgtctttttg ttccaactct ttttcagatt
     2881 ttttgaatgt atataggact atgttgaaat gtagatatat gccacagagt ctgtgtattg
     2941 tataaaaaac aaaacaacaa aaacaaacaa aaaaagatgg ctctagaaaa ctcctatttc
     3001 ggtacttgac cggaagaaat acttgcacat tattacgatt gttttatttt ttctaccaaa
     3061 gacaaatgca actggtatgg cagactgcca gtctaagtaa agttttgcac agcttacatg
     3121 atactgtatg aatgtatgaa aaaaagagaa aaaattaaaa ggtcagggtt agggatctta
     3181 ctcaactgtg aattttattt ctgtttgggt ccaattatct acagaaggag catccataca
     3241 tacaaatatt attttgctgt cctctagttt gcttccatag tagataagtt ggtggccact
     3301 taggtgtctt ttatttctgc agttattgta ggaaatttta atatatttca tattagtaag
     3361 ctattgataa aatagttttt gactttgaaa attaaagttt atttagctta ttgtagtata
     3421 cttccaccaa acaaccaaaa tacagattat ttttattgta ttatgtatat atatgtaaag
     3481 aaagaaaaga gctaaaaata tctaatactt tagttgccac ttttccaatt gatgtattat
     3541 tgtgcatgta atattttcaa agatcaacac aagcttaaac aaatttataa attttatatt
     3601 tttgtacagg tattttcttc aaacgtccat gtgacttatc ttctgtagtc tctagacttg
     3661 agaacatgaa cacgtttagt tttaggtgct cttctttgct cacataagcg gctttagtag
     3721 tcagttccta actgtgctca agctttacct cttgatgaga attcctctgt caaggcagca
     3781 ttataaacct ttgccacata tccttccatc ctgtctttct tgactgtttt atctcaaatc
     3841 ttgtgtttgg aactatgaaa actggtgact tcaaaagtta aaaactatct agaaggaaag
     3901 cctgacatgt cagacatagt tgctgtttct ccaccacctt ttgatagaac taaggtagct
     3961 gttcttggtc tgcacaggag tttctttcct tttctttttc ctccccttct gtaagctata
     4021 gcacatgaag gttcaattag agaacacagt tacaatccaa aaatgtgtct tacttgcctc
     4081 tttgacatca tgaatcctaa gaaaccaaga cttgtcttga cacgttagct gaaactgtga
     4141 caaggttcct gtgtgtttgg tggaaatgta cctgttagtt cattcatcct aacagataat
     4201 aagctcacat ggctcacagg gttagtagaa ttcaaggttt tacttttgag gtgggaaaaa
     4261 gcaaaccata ggttcacaaa tggaagtctt gaaggtgttc cacagtctgg cacttttgca
     4321 gtcaagggca tatcgcttca tgatagcgat tcagttggta aagtttataa acttgcccct
     4381 ttctagctat cctgttagga attctggttt tttgataccc ttttcttgtc tgcaaaccag
     4441 aatttgattt ttttggtctt gcatttcaaa aaactttgaa tctgtttagt agattccata
     4501 cccgtgcatt tcagtgtttt atatgtactc cttaagttaa atagttgaaa gcctttaaat
     4561 agttgagctt tttaatgttg acactttatt ttgtacctat ttatatatgt atgtatatct
     4621 tagaaaagca ctttgttata aaattgcatt ttatatgatt cctgccattt gctgctaaac
     4681 ctgggctggt cagagcgccg cagcgatact tgatctagtc aaacctggca gtgaaatgta
     4741 gagtgcaagt taatcctcct gctgttggag atgacatagg caagctgtgc agctttacat
     4801 tttcaccagg ggactctgtg gcatttaaaa ccgtctagaa atggctgtac ttttaatgcc
     4861 agtaatgaac tgcttcctct attgtcttta aaatacctgt acctagtgtg tcacgacagt
     4921 tctcacaagc atgtaaaaac ccagcacttg tacatgttgt gttttgtaaa atcgtggcat
     4981 gtgtttttgg gtggaaatca ttagagtgag agctgtctaa aggttgtctg tgttcataca
     5041 tggtatacag atagctcatg aagtccagaa ccttccctca agtgaaggca ttgtgaattc
     5101 tcctcagata acccactgtt ccaaaagcaa ccaaaactga ctatagtact actacagtaa
     5161 aaaataataa tgaaccttct gcttcctggt ttcagataca ctggattctt gtagtctgtg
     5221 cccacatgag agcatgctgc tgggctgctc ctgttaaggt catgtgtgag tttttcaagt
     5281 cagtgtggtt gcttgctgtg ctgtaccacg tatggttctt gtcctttcca cgtccttcat
     5341 tcgagattcg ggtgtggctt aatcttgtgc cttacttgta cacttaaatg agacatcttc
     5401 attccttccc aattcccaaa ccttaacttt gtccttcttg taagagaatc agaactattc
     5461 cagaagcatc atgaaggatt tcagatgggt gtggtttcat agttccctct ctctgtattg
     5521 ttttatactt ctatgagaga ccagttttga atgacctttg agtaatcttt gctacatccc
     5581 ttctctctgg cttttgtgag gttgtcctgc atctctatga tgcttggctt cattcgcacc
     5641 ttagcgagag tctgcattta cagacaggtg tgttcacttc atctgcttga aagtgattat
     5701 tttgttttcc agaacttttt aggagaagaa tacccatttt gtttgttttt ttacaaccga
     5761 tgacaagtct ctttaaaaga aactgaagta cagtactttt gaaatacaat gctattggta
     5821 tgaatttctc ttttatatat aatattcata caattatctg atgtttgcct tcattaataa
     5881 agctgttagt ttattcacca aaatgtcaag aatggatgtg ctttttcttt attccataca
     5941 tttaaacaat attttagctg ctaagattta gttaacttcc taagaaatga attcaagttg
     6001 ccttcagcaa gaattaacaa aactcatgtc ccctttcttt atatagtctt cctaaaattc
     6061 tgtttaacta ctttctagtt aattatgtga cagaatgtta gcatctctct aaatcttgaa
     6121 acttgaattt tgagaatgca ttgaatttca gtgttaatgg aaaaggtctc aactatgttt
     6181 gtagtggagt cttttgtgga ataccatttc ccatggaact gcgaccactt gcacaacttt
     6241 gcacagaact gcagtcttgt tcttccctgg atcgtgacaa atgagtctca cacagtgccg
     6301 taatacttgt ggattctacc gtgatctttg tcatcttaaa taagggcatt atgagaaaat
     6361 gatgccatgt cttctttgtt aatatttcaa acacagtgag atgtaacaac aatgtcagaa
     6421 gtaggatggt ggttttgttt taaggagtaa gcatgttgg
//
