LOCUS       NM_133381              10107 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus CREB binding protein (Crebbp), mRNA.
ACCESSION   NM_133381
VERSION     NM_133381.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10107)
  AUTHORS   Wang,N., Su,X., Sams,D., Prabhakar,N.R. and Nanduri,J.
  TITLE     P300/CBP Regulates HIF-1-Dependent Sympathetic Activation and
            Hypertension by Intermittent Hypoxia
  JOURNAL   Am J Respir Cell Mol Biol 70 (2), 110-118 (2024)
   PUBMED   37874694
  REMARK    GeneRIF: P300/CBP Regulates HIF-1-Dependent Sympathetic Activation
            and Hypertension by Intermittent Hypoxia.
REFERENCE   2  (bases 1 to 10107)
  AUTHORS   Dong,W., Weng,J.F., Zhu,J.B., Zheng,Y.F., Liu,L.L., Dong,C.,
            Ruan,Y., Fang,X., Chen,J., Liu,W.Y., Peng,X.P. and Chen,X.Y.
  TITLE     CREB-binding protein and HIF-1alpha/beta-catenin to upregulate
            miR-322 and alleviate myocardial ischemia-reperfusion injury
  JOURNAL   FASEB J 37 (9), e22996 (2023)
   PUBMED   37566526
  REMARK    GeneRIF: CREB-binding protein and HIF-1alpha/beta-catenin to
            upregulate miR-322 and alleviate myocardial ischemia-reperfusion
            injury.
REFERENCE   3  (bases 1 to 10107)
  AUTHORS   Cao,Y., Huang,W., Wu,F., Shang,J., Ping,F., Wang,W., Li,Y., Zhao,X.
            and Zhang,X.
  TITLE     ZFP36 protects lungs from intestinal I/R-induced injury and
            fibrosis through the CREBBP/p53/p21/Bax pathway
  JOURNAL   Cell Death Dis 12 (7), 685 (2021)
   PUBMED   34238924
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10107)
  AUTHORS   Sadeghi,H., Esmkhani,S., Pirjani,R., Amin-Beidokhti,M., Gholami,M.,
            Azizi Tabesh,G., Ghasemi,M.R., Gachkar,L. and Mirfakhraie,R.
  TITLE     CREB-binding protein (CREBBP) and preeclampsia: a new promising
            target gene
  JOURNAL   Mol Biol Rep 48 (3), 2117-2122 (2021)
   PUBMED   33625689
REFERENCE   5  (bases 1 to 10107)
  AUTHORS   Sun,H., Fu,S., Cui,S., Yin,X., Sun,X., Qi,X., Cui,K., Wang,J.,
            Ma,L., Liu,F.Y., Liao,F.F., Wang,X.H., Yi,M. and Wan,Y.
  TITLE     Development of a CRISPR-SaCas9 system for projection- and
            function-specific gene editing in the rat brain
  JOURNAL   Sci Adv 6 (12), eaay6687 (2020)
   PUBMED   32206715
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10107)
  AUTHORS   Lill,N.L., Grossman,S.R., Ginsberg,D., DeCaprio,J. and
            Livingston,D.M.
  TITLE     Binding and modulation of p53 by p300/CBP coactivators
  JOURNAL   Nature 387 (6635), 823-827 (1997)
   PUBMED   9194565
REFERENCE   7  (bases 1 to 10107)
  AUTHORS   Yang,X.J., Ogryzko,V.V., Nishikawa,J., Howard,B.H. and Nakatani,Y.
  TITLE     A p300/CBP-associated factor that competes with the adenoviral
            oncoprotein E1A
  JOURNAL   Nature 382 (6589), 319-324 (1996)
   PUBMED   8684459
REFERENCE   8  (bases 1 to 10107)
  AUTHORS   Yuan,W., Condorelli,G., Caruso,M., Felsani,A. and Giordano,A.
  TITLE     Human p300 protein is a coactivator for the transcription factor
            MyoD
  JOURNAL   J Biol Chem 271 (15), 9009-9013 (1996)
   PUBMED   8621548
REFERENCE   9  (bases 1 to 10107)
  AUTHORS   Kwok,R.P., Lundblad,J.R., Chrivia,J.C., Richards,J.P.,
            Bachinger,H.P., Brennan,R.G., Roberts,S.G., Green,M.R. and
            Goodman,R.H.
  TITLE     Nuclear protein CBP is a coactivator for the transcription factor
            CREB
  JOURNAL   Nature 370 (6486), 223-226 (1994)
   PUBMED   7913207
REFERENCE   10 (bases 1 to 10107)
  AUTHORS   Kozak,L.P., Britton,J.H., Kozak,U.C. and Wells,J.M.
  TITLE     The mitochondrial uncoupling protein gene. Correlation of exon
            structure to transmembrane domains
  JOURNAL   J Biol Chem 263 (25), 12274-12277 (1988)
   PUBMED   3410843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000217.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_133381.5.
            
            On Feb 10, 2021 this sequence version replaced NM_133381.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY462245.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132292
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               JACYVU010000217.1  11027733-11027840
            109-818             JACYVU010000217.1  11059443-11060152
            819-995             JACYVU010000217.1  11083537-11083713
            996-1236            JACYVU010000217.1  11101975-11102215
            1237-1350           JACYVU010000217.1  11103478-11103591
            1351-1593           JACYVU010000217.1  11111377-11111619
            1594-1696           JACYVU010000217.1  11113062-11113164
            1697-1843           JACYVU010000217.1  11113425-11113571
            1844-1961           JACYVU010000217.1  11114262-11114379
            1962-2133           JACYVU010000217.1  11115006-11115177
            2134-2178           JACYVU010000217.1  11115730-11115774
            2179-2303           JACYVU010000217.1  11117653-11117777
            2304-2492           JACYVU010000217.1  11118328-11118516
            2493-2906           JACYVU010000217.1  11119968-11120381
            2907-3086           JACYVU010000217.1  11121476-11121655
            3087-3276           JACYVU010000217.1  11122557-11122746
            3277-3395           JACYVU010000217.1  11128110-11128228
            3396-3635           JACYVU010000217.1  11128998-11129237
            3636-3724           JACYVU010000217.1  11129778-11129866
            3725-3805           JACYVU010000217.1  11135530-11135610
            3806-3862           JACYVU010000217.1  11137358-11137414
            3863-3940           JACYVU010000217.1  11140486-11140563
            3941-4008           JACYVU010000217.1  11140877-11140944
            4009-4159           JACYVU010000217.1  11141890-11142040
            4160-4306           JACYVU010000217.1  11142351-11142497
            4307-4420           JACYVU010000217.1  11143121-11143234
            4421-4586           JACYVU010000217.1  11144223-11144388
            4587-4754           JACYVU010000217.1  11144595-11144762
            4755-4916           JACYVU010000217.1  11146696-11146857
            4917-5198           JACYVU010000217.1  11147140-11147421
            5199-10107          JACYVU010000217.1  11148760-11153668
FEATURES             Location/Qualifiers
     source          1..10107
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..10107
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /note="CREB binding protein"
                     /db_xref="GeneID:54244"
                     /db_xref="RGD:2401"
     exon            1..108
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..7358
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /EC_number="2.3.1.48"
                     /note="protein-lysine acetyltransferase CREBBP"
                     /codon_start=1
                     /product="histone lysine acetyltransferase CREBBP"
                     /protein_id="NP_596872.3"
                     /db_xref="GeneID:54244"
                     /db_xref="RGD:2401"
                     /translation="MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDEL
                     IPNGELSLLNSGNLVPDAASKHKQLSELLRGGSGSSITPGIGNVSASSPVQQGLGGQA
                     QGQPNSTSMASLGAMGKSPLNPGDSSTPSLPKQAASTSGPTPPASQALNPQAQKQVGL
                     VTSSPATSQTGPGICMNANFNQTHPGLLNSNSGHSLMNQAQQGQAQVMNGSLGAAGRG
                     RGAGMPYPAPAMQGATSSVLAETLTQVSPQMAGHAGLNTAQAGGMTKMGMTGNTSPFG
                     QPFSQTGGQPMGATGVNPQLASKQSMVNSLPAFPTDIKNTSVTTVPNMSQLQTSVGIV
                     PAQGIATGPTADPEKRKLIQQQLVLLLHAHKCQRREQANGEVRACSLPHCRTMKNVLN
                     HMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPAS
                     GIQNTIGSVGAGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQP
                     AQPPAHQQMRTLNALGNNPMSIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSN
                     SGSIGSLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRR
                     MENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQP
                     ALPAPGAQPPVIPPTQSVRPPNGPLSLPVNRVQVSQGMNSFNPMSLGNVQLPQAPMGP
                     RAASPMNHSVQMNSMASVPGMAISPSRMPQPPNMMGTHANNIMAQAPTQNQFLPQNQF
                     PSSSGAMSVNSVGMGQPATQAGVSQGQVPGGTLPNPLNMLAPQTSQLPCPPVTQSPLH
                     PTPPPASTAAGMPSLQHPTPPGMTPPQPAAPTQPSTPVSSGQTPTPTPGSVPSAAQTQ
                     STPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHTQPPGTPLSQAAASIDNR
                     VPTPSSVTSAETSSQQPGPDVPMLEMKTEVQTDDAEPDPAESKGEPRSEMMEEDLQGS
                     SQVKEETDTTEQKSEPMEVEEKKPEVKVEAKEEEENSANGTASQSTSPSQPRKKIFKP
                     EELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTG
                     QYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRK
                     YEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTT
                     ISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPR
                     KENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKS
                     RFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLD
                     SIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKI
                     PKPKRLQEWYKKMLDKAFAERIINDYKDIFKQANEDRLTSAKELPYFEGDFWPNVLEE
                     SIKELEQEEEERKKEESTAASETPEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPS
                     MPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVISTQPPIVDPDPLLSCDLMDGRDAF
                     LTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCED
                     YDLCINCYNTKSHTHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHAC
                     QCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVP
                     FCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPST
                     PQTPQPPAQPQPSPVNMSPAGFPSVARTQPPTIVSAGKPTNQVPAPPPPAQPPPAAVE
                     AARQIEREAQQQQHLYRANINNGMPPGRAGMGTPGSQMAPVGLNVPRPNQVSGPVMSS
                     MPPGQWQQAPIPQQQPMPGMPRPVMSMQAQAAVAGPRMPNVQPPRSISPSALQDLLRT
                     LKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQP
                     GMHQQPSLQNLNAMQAGVPRPGVPPPQQAMGGLNPQGQALNIMNPGHNPNMANMNPQY
                     REMVRRQLLQHQQQQQQQQQQQQQQQQQQSSASLAGGMAGHSQFQQPQGPGGYAPAMQ
                     QQRMQQHLPIQGSSMGQMAAPMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQ
                     IGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSS
                     PSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSMDQGHLGNPEQSAMLPQLNTPNRSAL
                     SSELSLVGDTTGDTLEKFVEGL"
     exon            109..818
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            819..995
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1236
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1350
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1593
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1696
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1843
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1961
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2133
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2178
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2303
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2492
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2906
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3086
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3276
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3395
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3635
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3724
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3725..3805
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3806..3862
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3863..3940
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            3941..4008
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            4009..4159
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            4160..4306
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            4307..4420
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            4421..4586
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            4587..4754
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            4755..4916
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            4917..5198
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
     exon            5199..10107
                     /gene="Crebbp"
                     /gene_synonym="CBP; RSTS; RTS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtttccg cgagcaggtg aagatggccg agaacttgct ggacggaccg cccaacccca
       61 aacgagccaa actcagctcg cccggcttct ccgcgaatga cagcacagat tttggatcat
      121 tgtttgactt ggaaaatgat cttcctgatg agctgatccc caatggagaa ttaagccttt
      181 taaacagtgg gaaccttgtt ccagatgctg cgtccaaaca taaacaactg tcagagcttc
      241 ttagaggagg cagcggctct agcatcaccc ccgggatagg caatgtgagt gccagcagcc
      301 ctgtgcagca gggccttggt ggccaggctc aggggcagcc gaacagtaca agcatggcca
      361 gtttaggtgc catgggcaag agccctctga acccaggaga ctcatcaaca cccagcctgc
      421 ccaaacaggc agccagcacc tctgggccca ctccccctgc ctcccaagca ctgaatccgc
      481 aagcacaaaa gcaagtgggg ctggtgacca gtagtcctgc cacatcacag actggacctg
      541 ggatctgcat gaatgctaac ttcaaccaga cccacccagg ccttctcaat agtaactctg
      601 gccatagctt aatgaatcag gctcaacaag ggcaagctca agtcatgaat ggatctcttg
      661 gggctgctgg aagaggaagg ggagctggaa tgccctaccc tgctccagcc atgcaggggg
      721 ccacaagcag tgtgctggct gagactttga cacaggtttc tccacaaatg gctggccatg
      781 ctggactgaa tacggcacag gcaggaggca tgaccaagat ggggatgact ggtaacacaa
      841 gtccgtttgg acaacccttt agtcaaactg gagggcagcc gatgggagcc actggagtga
      901 accctcagtt agccagcaaa cagagcatgg tcaatagttt gcctgctttt cctacagata
      961 tcaagaatac ttcagtcacc actgtgccaa atatgtccca gttgcaaaca tcagtgggaa
     1021 ttgtacccgc acaaggaatt gcaaccggcc ccacagcaga ccctgagaag cgcaaactga
     1081 tacagcagca gctggttcta ctgcttcatg cccacaaatg tcagcgacga gagcaagcga
     1141 atggagaggt tcgggcctgt tctctcccac actgtcgaac catgaaaaat gttttgaatc
     1201 acatgacaca ttgtcaggct gggaaagcct gccaagttgc ccattgtgca tcttcacgac
     1261 aaatcatctc tcattggaag aactgcacac gacatgactg tcctgtttgc ctccctttga
     1321 aaaatgccag tgacaagcga aaccaacaaa ccatcctggg atctccagct agtggaattc
     1381 aaaacacaat tggttctgtt ggtgcagggc aacagaatgc cacttcttta agtaacccaa
     1441 atcccataga ccccagttcc atgcagcggg cctatgctgc tctaggactc ccctacatga
     1501 accagcctca gacgcagctg cagcctcagg ttcctggcca gcaaccagca caacctccag
     1561 cccaccagca gatgaggact ctgaatgctc taggaaacaa cccaatgagt attccagcag
     1621 gaggaataac aacagatcag cagccgccaa acttgatttc agaatcagct cttccaactt
     1681 ctttgggggc taccaatccg ctgatgaatg atggctccaa ctctggtagc attggaagcc
     1741 tcagcacgat acccacagca gcacctcctt ccagcactgg tgttcgaaaa ggctggcatg
     1801 aacatgtgac tcaggacctg cggagccatc tagtgcataa actcgttcaa gccatcttcc
     1861 cgactcctga cccggcagct ctgaaggatc gccgcatgga gaacctggtt gcctatgcta
     1921 agaaagtgga gggagacatg tatgagtctg ctaatagcag ggatgaatac tatcatttat
     1981 tagcagagaa aatctataaa atacaaaaag aactagaaga aaaacgaagg tcacgtttac
     2041 ataagcaagg catcctgggt aaccagccag cattaccagc tcctggggct cagccccctg
     2101 tgatcccacc aacccagtct gtgagacctc caaatgggcc cctgtctttg ccagtgaatc
     2161 gtgtgcaggt ttctcaagga atgaattcat ttaacccaat gtccctgggg aacgtccagt
     2221 tgccacaggc acccatggga cctcgcgcag cctcccccat gaaccactct gtccagatga
     2281 acagcatggc ctcagttccg ggtatggcca tttctccttc ccggatgcct cagcctccca
     2341 atatgatggg cacccatgcc aacaacatta tggcccaggc acctactcag aaccagtttc
     2401 tgccacagaa ccagtttcca tcatccagtg gggcaatgag tgtgaacagt gtaggcatgg
     2461 ggcagcccgc aacccaggca ggtgtttcac agggccaggt gcctggaggt acacttccta
     2521 accctctgaa catgctggcg ccccagacca gccagcttcc ttgcccacca gtgacacagt
     2581 cacctttgca cccgactcca cctcctgctt ccacagctgc tggcatgccc tctctccagc
     2641 atccgacacc accagggatg acccctcccc agccagcagc tcccactcag ccatccactc
     2701 ctgtgtcatc tgggcagact cctaccccaa ctcctggctc agtgcccagt gctgcccaaa
     2761 cacagagcac cccaacagtg caggcagcag cacaggctca ggtgacccca cagcctcaga
     2821 ctccagtgca gccaccatct gtggccactc ctcagtcatc acagcagcaa ccaacgcctg
     2881 tgcatactca gcctcctggc acaccgcttt ctcaggcagc agccagcatt gataatagag
     2941 tccctactcc ctcctctgtg accagtgctg aaaccagttc ccagcagcca ggacctgatg
     3001 tgcccatgct ggaaatgaag acagaggtgc agacagatga tgctgaacct gatcctgctg
     3061 aatccaaggg ggaaccccgc tctgagatga tggaagagga tttacaaggt tcttcccaag
     3121 taaaagaaga aacagataca acagagcaga agtcagaacc aatggaagta gaagaaaaga
     3181 aacccgaagt aaaagtggaa gctaaagagg aagaagagaa cagtgctaac ggcacagcct
     3241 cacagtcaac atccccttcc cagccacgca aaaaaatctt taaacctgag gagctacgcc
     3301 aggcactcat gccaactcta gaagcactct atcgacagga cccagagtct ctgccttttc
     3361 ggcagcctgt agatcctcag ctcctaggaa tcccagatta ttttgatatt gtgaagaatc
     3421 ctatggacct ttctaccatc aagcgaaagc tggacacagg gcaatatcaa gaaccctggc
     3481 agtatgtgga cgatgtctgg cttatgttca acaatgcgtg gctgtataat cgtaagacgt
     3541 cccgggtata taaattttgc agtaaacttg cagaggtctt tgaacaagaa attgaccctg
     3601 tcatgcagtc tcttggatat tgctgtggcc gaaagtatga gttctcccca cagactttgt
     3661 gctgctatgg aaagcagctg tgtacaattc ctcgtgatgc agcctactac agctatcaga
     3721 ataggtatca tttctgtgag aagtgtttca cagagatcca gggcgagaat gtgaccctgg
     3781 gtgacgaccc ttcccaacct cagacgacaa tttccaagga tcaatttgaa aagaagaaaa
     3841 atgacacctt agatcctgaa ccctttgttg actgcaaaga gtgtggccgg aagatgcatc
     3901 agatttgcgt tctacactat gacatcattt ggccttcagg ttttgtgtgt gacaactgct
     3961 tgaagaaaac tggcagacct cggaaagaaa acaaattcag tgctaagagg ctgcagacca
     4021 cacggttggg aaaccatttg gaagaccgag tgaacaagtt tttgcggcgc cagaatcacc
     4081 ctgaagctgg ggaggttttt gtcagagtgg tggccagctc agacaagact gtggaggtca
     4141 agccaggaat gaagtcaagg tttgtggatt ctggagaaat gtctgaatct ttcccatatc
     4201 gtaccaaagc actcttcgct tttgaggaga ttgatggagt cgatgtgtgc ttttttggga
     4261 tgcatgtaca agaatatggc tccgattgcc ccccacctaa tacaaggcgc gtctatatat
     4321 cttatctgga cagtattcat ttcttccggc cccgctgtct ccgcaccgct gtttaccatg
     4381 agatcctcat tggatatcta gagtatgtga agaaattggg gtatgtgaca ggacacattt
     4441 gggcctgtcc cccaagtgaa ggagatgact acatctttca ttgccacccc cctgaccaga
     4501 aaatccccaa accaaaacga ctacaggagt ggtacaagaa gatgctggac aaggcattcg
     4561 cagagaggat cattaacgac tataaggaca tcttcaaaca agcgaacgaa gacaggctca
     4621 cgagtgccaa ggagttgccc tatttcgaag gagatttctg gcctaatgtg ttggaagaaa
     4681 gcattaagga gctagaacaa gaagaagaag aaaggaagaa agaagagagt actgcagcga
     4741 gtgagactcc tgagggcagt cagggtgaca gcaagaatgc caagaaaaag aacaacaaga
     4801 agaccaacaa aaacaaaagc agcattagcc gcgccaacaa gaagaagccc agcatgccca
     4861 atgtttccaa cgacctgtcg cagaagctgt atgctaccat ggagaagcac aaggaggtct
     4921 tctttgtgat ccacctgcat gctgggcctg tcatcagcac tcagcccccc atcgtggacc
     4981 ctgatcccct gcttagctgt gacctcatgg acgggcggga tgccttcctc accctggcca
     5041 gagacaagca ctgggagttc tcttccttac gccgctccaa atggtccact ctgtgcatgc
     5101 tggtggagct gcacacacag ggccaggacc gctttgtcta tacctgcaac gagtgcaaac
     5161 accatgtaga aacacgctgg cactgcactg tgtgtgagga ctatgacctt tgtatcaatt
     5221 gctacaacac aaagagccac acccataaga tggtgaagtg ggggctaggc ctagatgatg
     5281 agggcagcag tcagggtgag ccacagtcca agagccccca ggaatcccgg cgtctcagca
     5341 tccaacgctg catccagtcc ctggtgcatg cctgccagtg tcgcaatgcc aactgctcgc
     5401 tgccatcttg ccagaagatg aagcgagtcg tgcagcacac caagggctgc aagcgcaaga
     5461 ctaatggagg ctgcccagtg tgtaagcagc tcattgctct ttgctgctac cacgccaaac
     5521 actgccaaga aaataaatgc cctgtgccct tctgcctcaa catcaaacac aagctccgcc
     5581 agcagcagat ccagcatcgc ctgcagcagg ctcagctcat gcgccggcga atggcaacca
     5641 tgaacacccg caatgtgcct cagcagagtt tgccttctcc tacctcagca ccacccggga
     5701 ctcctacaca gcagcccagc acaccccaaa caccacagcc cccagcccag cctcagcctt
     5761 cacctgtaaa catgtcacca gctggcttcc ccagtgtagc ccggactcag ccccccacaa
     5821 tagtgtctgc tgggaagcct accaaccagg tgccagctcc cccaccccct gcccagcccc
     5881 cacctgcagc agtggaagca gccaggcaaa ttgaacgtga ggcccagcag cagcagcacc
     5941 tgtaccgagc aaacatcaac aatggcatgc ccccagggcg tgcaggtatg gggaccccag
     6001 gaagccagat ggctcctgtg ggcctgaatg tgccccgtcc caaccaagtc agtgggcctg
     6061 tcatgtctag catgccacct gggcagtggc agcaggcacc catccctcag cagcagccga
     6121 tgccaggcat gcccaggcct gtaatgtcca tgcaggccca ggcagcggtg gctgggccac
     6181 ggatgcccaa tgtacagcca ccaaggagca tctcgccaag tgccctgcaa gacctgcttc
     6241 ggaccctaaa gtcacccagc tctcctcagc agcagcagca ggtgctgaac atcctcaaat
     6301 caaacccaca gctaatggca gctttcatca aacagcgcac agccaagtat gtggccaatc
     6361 agcctggcat gcagccccag cccggacttc aatcccagcc tggtatgcag ccccagcctg
     6421 gcatgcacca gcagcccagc ctgcaaaacc tgaacgcaat gcaagctggt gtgccacggc
     6481 ctggtgtgcc tccaccacag caggcaatgg gaggcctgaa cccccagggt caggctctga
     6541 atatcatgaa cccgggacac aaccccaaca tggcgaacat gaatccgcag taccgagaaa
     6601 tggtgagaag acagctgcta cagcaccaac agcagcagca gcagcagcag cagcagcagc
     6661 agcaacagca acagcaacaa agcagtgcca gcttggccgg gggcatggca ggacacagcc
     6721 agttccagca gccacaagga cctggaggct acgccccagc catgcagcag caacgcatgc
     6781 aacagcacct ccccatccag ggcagctcca tgggccagat ggctgctcca atgggacaac
     6841 ttggccagat ggggcagcct gggctagggg cagacagcac ccctaatatc cagcaggccc
     6901 tgcagcagcg gattctgcag cagcagcaga tgaagcaaca aattgggtca ccaggccagc
     6961 cgaaccccat gagcccccag cagcacatgc tctcaggaca gccacaggct tcacatctcc
     7021 ctggccagca gatcgccaca tcccttagta accaggtgcg gtctccagcc cctgtgcagt
     7081 ctccacggcc ccaatcccaa cctccacatt ccagcccgtc accacggata cagccccagc
     7141 cttcaccaca ccatgtttca ccccagactg gttcccctca ccctggactt gcagtcacca
     7201 tggccagctc catggatcag ggacacctgg ggaaccctga acagagtgca atgctccccc
     7261 agctgaatac ccccaacagg agcgcgctgt ccagtgaact gtccctggtt ggtgatacca
     7321 cgggagacac gctagaaaag tttgtggagg gcttgtagca ttatgagagc attgggtgtt
     7381 tgtttttttg tttttgtttt ggggattttt tgggtctttt tttttttttt ttctccctct
     7441 tttttttttt tttttttttt ttttttggtt tttttttttt tttttttttt tttttgtttt
     7501 tttttttggg tgtttttttt tttttttttt ttttgttttt gttttgttgt ttttcttccc
     7561 cccccccccc ccccctttca tgtttttgga ctttttgtac tgaaaatcca gacatttggg
     7621 ctctttttat taagcctaga tgggactgtg actcccaagc atggaagggc agattgatgt
     7681 ttaaagaaac aatacaaaga atatattttt tgttaaaaac cagttgattt aaatatctgg
     7741 tgtctctctc tctctctttc tctcagcttt ttttctcttt tttttctgtt ttgtttttgg
     7801 ggggtggggg gttgtttgga ttctttttgt cgtcattgct ggtgactcat gccttttttt
     7861 aacgggaaaa acaagttcat tatattcata ttttttattt gtattttcaa gacttaaaca
     7921 tttatgttta aaagtgagaa gaaaaataat actcagaaac tggttccaga aataatgcat
     7981 cttataatgt gtcccgataa cgagctgatg ttgcgggaag atttttttct atagtgaact
     8041 ctgtgggcat ctccaagtat tacccctgga cgataggaat tgactccggc gtgcacacat
     8101 gtacacaccc acacacatct atctatacat gctggcttaa gccagcctct tgtcttgcag
     8161 atgtagaaat tgttgctttg tttctctgat aaaactggtt ttagacaaaa atagggatga
     8221 tcactctctt agaccatgct aatgttaata gagaagaagc attcttttct ttcttctatg
     8281 tgaaacttga aatgaggaaa agcaattcta gtgtaaatca tgcaagcgct ataattacta
     8341 taaataagaa aattcaagaa gattcaatca ctgtatagaa tggtaacgta ccaactcatt
     8401 tcttatatca tattgttaaa taaactgtgt gcaacagaca aaaagggtgg tccttcttga
     8461 attcatgtac atggtattaa cacttagtgt tcgggggttt ttttgttatg aaaatgctgt
     8521 tttcaacatt gtatttggac tatgcatgtg tttttttccc cattgtatat aaagtatcgc
     8581 ttaaaattga tataaattac tgaagttttt aacatgtatt ctgttcttta agatccctgt
     8641 aagaatgttt aaggttttta tttatttata tatatttttg gagtctgttc tttgtaagac
     8701 atggttctga ttgtttgctc agagtggaga ggtcggggct gcagtcacaa ttgcagtggg
     8761 tattggcagc tgagcaatgt cccagtctgt gaccactgag ggagaaaagg ggagctcctt
     8821 gcacagagag tgagggggca gctcaggacc accttgcata tttagtactc acaggtgaat
     8881 gtcacccatg ccaggaaagg actgtcacca ctgggtcaga aacagctctt tgccttcagc
     8941 ccactcttcc tgtcctcttt ggccagctgc ccctgtgggg aggggctcct gccttttttt
     9001 tttttttttt ttccagacag cctccccttt ctctacccag atcccacaat caatgcaaag
     9061 ggtgctccag ggacttgagg tggttcctga cctcccctcc ccaaaagttc agcctgcccc
     9121 atgtggcctc attagggcct tgcaggcctg gtgccaccct gggggctgct acttgatggt
     9181 cttacccact tgtggagtca tggagctaca ggtgcccctc ttgagcaggg gatggtagct
     9241 cctgagtact gtaaatgtta ctctaagagg aggaccactg acaggggact aagttacccc
     9301 tagtctgctg ctcccaggga actttttttt ttttttaaat acctgtcttc caacaaaaga
     9361 gtggtctaga tggggtgggg gctgctaaat ttagaaatca tgacccaaat agccttcctt
     9421 ttggcctttt aagttcacag aagtattttt caaaattccc aactcttgga aatctaaact
     9481 tgaagctatt caagattagc gttttcaaca tagaattttg aatcttgaaa tttagtactg
     9541 tggataagac caggtaagga actgaccatc atctaacatc cccaacttag ccctgtccca
     9601 agtcctccag agctgatgct ccgtctttgc tcaactcgat gggtccttgc acattcttgg
     9661 ctctcttcag aattcccttt gctgccaatt gggaagtccc aagccatgtg ttcaaacaag
     9721 aagaagaact ggagcctcag aggagctgct ctcagcccca ctcaggaggt ggcacttgac
     9781 aatgtgtagc cttttaatgt gggcactggg gacatccttt tcagattatc ctgaaattca
     9841 aagctctgta ccaacctcct tggagcctgc atcctatgca attgtccatc tggctgtcaa
     9901 aggatgtagc tgagagtgtg ggctatggat attatcccta attttgtcct aaggaaattt
     9961 ctgtaagagc tggagtgccc agacactgtg tctcatgctg tatacttaag aggagaagaa
    10021 aaaagtccta tatttgtgat caaaaagagg gaacttgaaa tgtgctggtg tttataataa
    10081 aagctggtaa aactgcttgg attcaaa
//
