LOCUS       NM_001012115            1956 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cAMP responsive element binding protein 3-like 3
            (Creb3l3), mRNA.
ACCESSION   NM_001012115 XM_234917
VERSION     NM_001012115.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1956)
  AUTHORS   Tong,X., Christian,P., Zhao,M., Wang,H., Moreau,R. and Su,Q.
  TITLE     Activation of hepatic CREBH and Insig signaling in the
            anti-hypertriglyceridemic mechanism of R-alpha-lipoic acid
  JOURNAL   J Nutr Biochem 26 (9), 921-928 (2015)
   PUBMED   26007286
  REMARK    GeneRIF: Data suggest that expression of hepatocyte Crebh and
            Insig1/Insig2a (insulin induced gene products 1/2) can be
            up-regulated by dietary factors (here, dietary supplementation with
            R-alpha-lipoic acid, an anti-hypertriglyceridemic agent).
REFERENCE   2  (bases 1 to 1956)
  AUTHORS   Wang,S. and Kaufman,R.J.
  TITLE     The impact of the unfolded protein response on human disease
  JOURNAL   J Cell Biol 197 (7), 857-867 (2012)
   PUBMED   22733998
  REMARK    Review article
REFERENCE   3  (bases 1 to 1956)
  AUTHORS   Chanda,D., Kim,D.K., Li,T., Kim,Y.H., Koo,S.H., Lee,C.H.,
            Chiang,J.Y. and Choi,H.S.
  TITLE     Cannabinoid receptor type 1 (CB1R) signaling regulates hepatic
            gluconeogenesis via induction of endoplasmic reticulum-bound
            transcription factor cAMP-responsive element-binding protein H
            (CREBH) in primary hepatocytes
  JOURNAL   J Biol Chem 286 (32), 27971-27979 (2011)
   PUBMED   21693703
  REMARK    GeneRIF: a novel mechanism of action of activated CB1R signaling to
            induce hepatic gluconeogenesis via direct activation of CREBH
REFERENCE   4  (bases 1 to 1956)
  AUTHORS   Zhang,K., Shen,X., Wu,J., Sakaki,K., Saunders,T., Rutkowski,D.T.,
            Back,S.H. and Kaufman,R.J.
  TITLE     Endoplasmic reticulum stress activates cleavage of CREBH to induce
            a systemic inflammatory response
  JOURNAL   Cell 124 (3), 587-599 (2006)
   PUBMED   16469704
REFERENCE   5  (bases 1 to 1956)
  AUTHORS   Stirling,J. and O'hare,P.
  TITLE     CREB4, a transmembrane bZip transcription factor and potential new
            substrate for regulation and cleavage by S1P
  JOURNAL   Mol Biol Cell 17 (1), 413-426 (2006)
   PUBMED   16236796
REFERENCE   6  (bases 1 to 1956)
  AUTHORS   Omori,Y., Imai,J., Watanabe,M., Komatsu,T., Suzuki,Y., Kataoka,K.,
            Watanabe,S., Tanigami,A. and Sugano,S.
  TITLE     CREB-H: a novel mammalian transcription factor belonging to the
            CREB/ATF family and functioning via the box-B element with a
            liver-specific expression
  JOURNAL   Nucleic Acids Res 29 (10), 2154-2162 (2001)
   PUBMED   11353085
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089877.1.
            
            On Feb 11, 2005 this sequence version replaced XM_234917.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089877.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1956
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1956
                     /gene="Creb3l3"
                     /note="cAMP responsive element binding protein 3-like 3"
                     /db_xref="GeneID:314638"
                     /db_xref="RGD:1308152"
     exon            1..107
                     /gene="Creb3l3"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1493
                     /gene="Creb3l3"
                     /note="transcription factor CREB-H; cAMP-responsive
                     element-binding protein 3-like protein 3"
                     /codon_start=1
                     /product="cyclic AMP-responsive element-binding protein
                     3-like protein 3"
                     /protein_id="NP_001012115.1"
                     /db_xref="GeneID:314638"
                     /db_xref="RGD:1308152"
                     /translation="MDGDISTGKMASPACAMAPLDSMEVLDLLFDGQDGILRNVDLAE
                     SWILTREEQKVLPNSDSDEFLNSILGPGDSDPSSPIWSPADSDSGISEDLPSDSQDTP
                     PGSGPGSANVAARCHPSKQGEGPCPSYLPSTACPEPPRTQVHESSVAIDLDMWSTDTL
                     YPEEQAGSPSRFNLTVKELLLSGGGGDLQQHPLAASQLLGPGSGHCQELVLTEDEKKL
                     LAKEGVTLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLENRMSACTA
                     QNQELQRKVLHLEKQNLSLLEQLKHLQALVVQSTSKPAHAGTCIAVLLLSFVLIILPS
                     ISPFTANKVDSPGDFIPVRVFSRTLHNHAASRVAPDVTPGPEVPGPHKGSSGGLSADW
                     GNFLEIPMLDDPTEELDNTTLVLANSTEDLGRATLLDWVASEPLLGQMGLEIPGEEIW
                     LSWVPRWLRVRVVQDALGVL"
     exon            108..239
                     /gene="Creb3l3"
                     /inference="alignment:Splign:2.1.0"
     exon            240..537
                     /gene="Creb3l3"
                     /inference="alignment:Splign:2.1.0"
     exon            538..644
                     /gene="Creb3l3"
                     /inference="alignment:Splign:2.1.0"
     exon            645..782
                     /gene="Creb3l3"
                     /inference="alignment:Splign:2.1.0"
     exon            783..889
                     /gene="Creb3l3"
                     /inference="alignment:Splign:2.1.0"
     exon            890..958
                     /gene="Creb3l3"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1043
                     /gene="Creb3l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1140
                     /gene="Creb3l3"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1928
                     /gene="Creb3l3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcgggagga ggagacgtgg caaaggctgc ggcaggcagt gacaggggcc cgaaacgagg
       61 ctgccatagg tgcaggactc atggatgggg acatatcgac gggaaagatg gcgtcccctg
      121 cctgtgccat ggctccctta gatagcatgg aagtccttga cctcctgttc gacgggcagg
      181 atggcatcct gagaaatgta gacctggctg agagctggat cctcaccaga gaggaacaga
      241 aagttctacc aaattctgac tctgatgaat tcctaaattc catcctggga cctggagact
      301 ctgaccccag ctccccaata tggtccccag ctgacagtga cagcggcatc tctgaggatc
      361 taccttccga ttcccaggac acccctcctg gtagtggacc tggatccgct aacgttgcag
      421 ccaggtgtca tccaagcaag caaggcgagg ggccctgccc ctcctacctt cctagcacag
      481 catgccctga gcctccaagg acacaagtcc atgagtcctc ggtggccatt gacctggaca
      541 tgtggagcac agacaccctg tacccggagg agcaggctgg ctcgccctcc cgcttcaacc
      601 tcactgtgaa ggaattgctg ctgtctggtg gtggcgggga cttgcaacag catcccttgg
      661 ccgcctccca gctgctggga cctgggagtg ggcactgcca ggagctggta ctgacagagg
      721 atgagaagaa gttgctggct aaagaggggg tgacccttcc cacccagctg cccctcacca
      781 agtatgagga acgggtgttg aaaaaaatcc gcagaaagat ccggaacaaa cagtcagctc
      841 aagaaagcag aaagaagaaa aaagaataca tcgatggttt ggagaaccgg atgtcagcgt
      901 gtaccgccca gaaccaggag ctgcagagga aggtcttgca cttagaaaag caaaatttgt
      961 ctcttctgga gcagctcaaa cacctgcagg ctcttgtggt ccagtcaacc agcaagcctg
     1021 cccatgcagg cacctgcata gcggtccttc tgctgtcctt cgtcctgatc atcctccctt
     1081 ccatcagccc tttcactgcc aacaaagtcg acagccctgg tgacttcatt ccagtgcgag
     1141 tgttttccag aaccctgcac aaccatgctg catcccgcgt ggctcccgac gtcaccccag
     1201 gacccgaggt cccaggaccc cacaaaggct cttctggcgg cctcagtgca gactggggga
     1261 attttctaga aattccaatg ttggatgacc caacagaaga gttagacaac accaccctgg
     1321 tgctggccaa ctccacagag gacctgggac gggccactct gctggactgg gtggcttcag
     1381 aaccactgct tggccagatg gggctggaga taccagggga ggagatatgg ctgtcctggg
     1441 taccgaggtg gctcagggtc cgtgtggtgc aagatgcttt gggggtgcta tgacaggaac
     1501 agcaggccga ctcagacagc cctgggaact cacagcctcc ttgagaagct gacccccata
     1561 tcagtggaag tggggtttcc aggtacaaga acatgaagac cctggtgtag aacaagaatc
     1621 agagcccttt acccagacag acagacagac acttaacacc tgaaccctaa gcccaaccat
     1681 agaatgccta ctctgccctg accactagga cgacgctgag cctacgggga cctgggcttc
     1741 ccaacagcaa ggtccagccc acgagcttct gtcgtcctct tggagagagg tcttactctg
     1801 gtagaccagg ctggcctcaa atcctgagct agctctacct gcctgtgtct cgactgctgg
     1861 gattaaaggt gtgtgctacc acccactttt ctaagactgt gagaccgtca ataaaatatt
     1921 ttgacaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
