LOCUS       NM_001395632            2289 bp    mRNA    linear   ROD 24-SEP-2023
DEFINITION  Rattus norvegicus cAMP responsive element binding protein 3
            (Creb3), mRNA.
ACCESSION   NM_001395632 XM_006238050
VERSION     NM_001395632.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2289)
  AUTHORS   Liu H, Liu J, Liu C, Niu X and Liu J.
  TITLE     Transplantation of endothelial progenitor cells improves myocardial
            hypertrophy in spontaneously hypertensive rats through
            HO-1/CREB3/AKT axis
  JOURNAL   Arch Biochem Biophys 746, 109739 (2023)
   PUBMED   37678424
  REMARK    GeneRIF: Transplantation of endothelial progenitor cells improves
            myocardial hypertrophy in spontaneously hypertensive rats through
            HO-1/CREB3/AKT axis.
REFERENCE   2  (bases 1 to 2289)
  AUTHORS   Hasmatali JCD, De Guzman J, Zhai R, Yang L, McLean NA, Hutchinson
            C, Johnston JM, Misra V and Verge VMK.
  TITLE     Axotomy Induces Phasic Alterations in Luman/CREB3 Expression and
            Nuclear Localization in Injured and Contralateral Uninjured Sensory
            Neurons: Correlation With Intrinsic Axon Growth Capacity
  JOURNAL   J Neuropathol Exp Neurol 78 (4), 348-364 (2019)
   PUBMED   30863858
  REMARK    GeneRIF: alterations in neuronal injury-associated Luman/CREB3
            expression support that a multiphasic cell body response occurs and
            reveal a novel contralateral plasticity in axon growth capacity at
            1-week post-injury
REFERENCE   3  (bases 1 to 2289)
  AUTHORS   Ying Z, Zhai R, McLean NA, Johnston JM, Misra V and Verge VM.
  TITLE     The Unfolded Protein Response and Cholesterol Biosynthesis Link
            Luman/CREB3 to Regenerative Axon Growth in Sensory Neurons
  JOURNAL   J Neurosci 35 (43), 14557-14570 (2015)
   PUBMED   26511246
  REMARK    GeneRIF: identification of creb3 as a regulator of the
            injury-induced unfolded protein response and cholesterol at levels
            that benefit the intrinsic ability of axotomized adult rat sensory
            neurons to undergo axonal regeneration reveals new therapeutic
            targets
REFERENCE   4  (bases 1 to 2289)
  AUTHORS   Ying Z, Zhang R, Verge VM and Misra V.
  TITLE     Cloning and characterization of rat Luman/CREB3, a transcription
            factor highly expressed in nervous system tissue
  JOURNAL   J Mol Neurosci 55 (2), 347-354 (2015)
   PUBMED   24894591
REFERENCE   5  (bases 1 to 2289)
  AUTHORS   Ying Z, Misra V and Verge VM.
  TITLE     Sensing nerve injury at the axonal ER: activated Luman/CREB3 serves
            as a novel axonally synthesized retrograde regeneration signal
  JOURNAL   Proc Natl Acad Sci U S A 111 (45), 16142-16147 (2014)
   PUBMED   25349404
  REMARK    GeneRIF: Sensing nerve injury at the axonal ER: activated
            Luman/CREB3 serves as a novel axonally synthesized retrograde
            regeneration signal.
REFERENCE   6  (bases 1 to 2289)
  AUTHORS   Ko J, Jang SW, Kim YS, Kim IS, Sung HJ, Kim HH, Park JY, Lee YH,
            Kim J and Na DS.
  TITLE     Human LZIP binds to CCR1 and differentially affects the chemotactic
            activities of CCR1-dependent chemokines
  JOURNAL   FASEB J 18 (7), 890-892 (2004)
   PUBMED   15001559
REFERENCE   7  (bases 1 to 2289)
  AUTHORS   Jin DY, Wang HL, Zhou Y, Chun AC, Kibler KV, Hou YD, Kung H and
            Jeang KT.
  TITLE     Hepatitis C virus core protein-induced loss of LZIP function
            correlates with cellular transformation
  JOURNAL   EMBO J 19 (4), 729-740 (2000)
   PUBMED   10675342
REFERENCE   8  (bases 1 to 2289)
  AUTHORS   Lu R and Misra V.
  TITLE     Potential role for luman, the cellular homologue of herpes simplex
            virus VP16 (alpha gene trans-inducing factor), in herpesvirus
            latency
  JOURNAL   J Virol 74 (2), 934-943 (2000)
   PUBMED   10623756
REFERENCE   9  (bases 1 to 2289)
  AUTHORS   Lu R, Yang P, O'Hare P and Misra V.
  TITLE     Luman, a new member of the CREB/ATF family, binds to herpes simplex
            virus VP16-associated host cellular factor
  JOURNAL   Mol Cell Biol 17 (9), 5117-5126 (1997)
   PUBMED   9271389
REFERENCE   10 (bases 1 to 2289)
  AUTHORS   Burbelo PD, Gabriel GC, Kibbey MC, Yamada Y, Kleinman HK and Weeks
            BS.
  TITLE     LZIP-1 and LZIP-2: two novel members of the bZIP family
  JOURNAL   Gene 139 (2), 241-245 (1994)
   PUBMED   8112612
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000161.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001395632.2.
            
            On Jul 26, 2021 this sequence version replaced XM_006238050.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ219084.1, KJ817427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               JACYVU010000161.1  33241994-33242327
            335-491             JACYVU010000161.1  33242413-33242569
            492-562             JACYVU010000161.1  33242644-33242714
            563-652             JACYVU010000161.1  33242820-33242909
            653-759             JACYVU010000161.1  33244870-33244976
            760-828             JACYVU010000161.1  33245075-33245143
            829-913             JACYVU010000161.1  33245741-33245825
            914-998             JACYVU010000161.1  33245912-33245996
            999-2289            JACYVU010000161.1  33246072-33247362
FEATURES             Location/Qualifiers
     source          1..2289
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..2289
                     /gene="Creb3"
                     /note="cAMP responsive element binding protein 3"
                     /db_xref="GeneID:298400"
                     /db_xref="RGD:1308831"
     exon            1..334
                     /gene="Creb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1321
                     /gene="Creb3"
                     /codon_start=1
                     /product="cyclic AMP-responsive element-binding protein 3"
                     /protein_id="NP_001382561.1"
                     /db_xref="GeneID:298400"
                     /db_xref="RGD:1308831"
                     /translation="MDPGGQDLLALDPGDQDLLALDPGDQDLLGFLLEESGDLWAATE
                     QDIETPLDLELSPSENSVQELSDWEVEDLLSSLLSPSSSPDVLNSSSSSILHDHNYSL
                     PQEHVSIDLDPGSFEKEGFRMNPLRVEETAAEQELSTLILTEEEKRLLEKEGLTLPST
                     LPLTKVEEQVLKRVRRKIRNKRAAQESRKKKKVYVVGLESRVLKYTAQNQELQNKVQH
                     LEEQNLSLLDQLRKLQAMVTEIANKTSSGSTCVLVLLLSFCLLLVPAMYSSDVRGSVP
                     AEYVVLHRKLRALPSEDQHQPKLSALQPELPMGSTNQLESSEHTFLAPSNVSCLNHMA
                     QTEQPPHWPLLDLSSEMPFSGSDLLLQANLTESGGWLSTHSPSSIILQGRYSG"
     exon            335..491
                     /gene="Creb3"
                     /inference="alignment:Splign:2.1.0"
     exon            492..562
                     /gene="Creb3"
                     /inference="alignment:Splign:2.1.0"
     exon            563..652
                     /gene="Creb3"
                     /inference="alignment:Splign:2.1.0"
     exon            653..759
                     /gene="Creb3"
                     /inference="alignment:Splign:2.1.0"
     exon            760..828
                     /gene="Creb3"
                     /inference="alignment:Splign:2.1.0"
     exon            829..913
                     /gene="Creb3"
                     /inference="alignment:Splign:2.1.0"
     exon            914..998
                     /gene="Creb3"
                     /inference="alignment:Splign:2.1.0"
     exon            999..2289
                     /gene="Creb3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagctgag aggcgggtgt ggcatataga gtaacagcta ggccctggtc cgggagtgac
       61 taaggttaag tcgatgcgac ttgacagact gaggggtcgt gcctaaggtt cggagattgg
      121 atctgcgcag aggagtttct atccataaat attccaaatg gatcctggtg gtcaggacct
      181 gctagctttg gatcctggtg atcaggacct gctagctttg gatcctggtg atcaggacct
      241 gctgggcttc ctgctagagg aaagtggaga tttgtgggct gcgactgagc aggacataga
      301 gactcccctg gacttggagc tgtcgccttc cgagaactcc gtgcaagaat tgagcgactg
      361 ggaggtagag gatttactga gctctctgct cagtccctcg tcatcgccgg atgttctcaa
      421 ctcttctagt tcttctattc tccatgatca caactattcc cttccacagg agcacgtctc
      481 catagatcta gatcctggga gctttgaaaa ggaggggttc cgcatgaatc cattgcgtgt
      541 ggaggagaca gcagcagagc aggaactttc tacactgata ctgacggagg aagagaaaag
      601 gcttttggag aaggaggggc tcactctgcc ctcaacactt cctctcacta aggtggagga
      661 acaagttcta aaacgagtac ggaggaagat tcgtaacaag agagcagctc aagaaagccg
      721 caagaagaag aaggtgtatg tagtggggct agagagcagg gtcttgaaat acacagccca
      781 gaatcaggag cttcagaaca aggtgcagca tctggaggaa cagaatctgt cccttctaga
      841 tcagctgagg aaacttcagg ccatggtgac tgagatagca aacaaaacca gcagtggcag
      901 cacttgcgtt ctggtcctcc tgctgtcctt ctgccttctt ctggtacctg ctatgtactc
      961 ctctgatgtg agggggagtg tgcccgctga gtatgttgtg ttgcaccgca agcttcgtgc
     1021 cctgcccagc gaggaccagc atcagccgaa gctgtctgcc ctacagccag agctaccaat
     1081 gggcagcaca aaccagttgg agagctcaga acatacattc ctggccccca gcaatgtttc
     1141 ctgcctgaac cacatggctc aaacagagca acccccgcac tggccactcc ttgatctttc
     1201 ttcagagatg cccttctcag gctccgacct tctcctgcaa gcaaatctta cagaaagtgg
     1261 aggatggctc tctacccaca gcccttcttc gatcatctta cagggcaggt attcaggtta
     1321 ggtgtgagga tatggggtgt cctcagccca aggactcctg tctgtattca cataaaaagg
     1381 agtaggggag agccagcctt tgctcacggg cctgttagga tgcccaggaa ctcaccacac
     1441 taactagttg tatgagcatt ttatttatac ccatgtgtat ctgttgtccc atgaatagat
     1501 ttggagaaat ttactggcct tgaatacttc atccacagaa ggaatgggaa ggataagaaa
     1561 taaataagtg gttcctcagc cccttcttac tggcacagcg gggtaggaag aggaggggca
     1621 tgattgtcct attggctcag ggctgcagga cttgtgggaa gaggcaggga agccccgtgc
     1681 ggaggctggg cctccacagc tcagtgggat cgctctggac gtaggtttac agtgatctct
     1741 ttggtccgca ttcaggctgt gctgggtgct gtgccttgtg tgactgctgg ccggctgctg
     1801 ttctttttat gctgctgctg ttgaagggcc agctgcatgg cccagatgct caggggccgc
     1861 atgtaggcca gggagcggaa cactcgctgc tggcagtatg cctctggggt ctggaaagcc
     1921 aggcccaggc gttcccatac agtgcggtaa cagccttcag ctgtccggaa accttcccaa
     1981 gtcaggccct gtagggagag gtagaagcca cacataatag ctagttctca gcacaatttc
     2041 cttagcagat aaggcagtaa gctgtttgcc ctaaaggcaa gaacttaaaa ggcaagaggt
     2101 ggaaggcata tccgggaaga gggagctctg tggatgggta agatggcatt aggtggggtt
     2161 ggggatttag ctcagcggta gagcacttgc ctagcaagcg caaggccctg ggttcggtcc
     2221 ccagctccgg aggggggggg ggggagatgg cattaggtgt tcttggaata aactgaatgg
     2281 ctgaggaag
//
