LOCUS       NM_134443               1024 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus cAMP responsive element binding protein 1
            (Creb1), transcript variant A, mRNA.
ACCESSION   NM_134443
VERSION     NM_134443.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1024)
  AUTHORS   Harada,H., Mori,M., Murata,Y., Kohno,Y., Terada,K., Ohe,K. and
            Enjoji,M.
  TITLE     Divergent effects of chronic continuous and intermittent social
            defeat stress on emotional behaviors: Impact on phosphorylated CREB
            and BDNF protein levels in the rat hippocampus
  JOURNAL   Neurosci Lett 835, 137851 (2024)
   PUBMED   38838971
  REMARK    GeneRIF: Divergent effects of chronic continuous and intermittent
            social defeat stress on emotional behaviors: Impact on
            phosphorylated CREB and BDNF protein levels in the rat hippocampus.
REFERENCE   2  (bases 1 to 1024)
  AUTHORS   Ahmed,M.A., Kamel,E.O. and Abd-Eldayem,A.M.
  TITLE     Role of cAMP/pCREB and GSK-3beta/NF-kappaB p65 signaling pathways
            in the renoprotective effect of mirabegron against renal
            ischemia-reperfusion injury in rats
  JOURNAL   Eur J Pharmacol 974, 176617 (2024)
   PUBMED   38679120
  REMARK    GeneRIF: Role of cAMP/pCREB and GSK-3beta/NF-kappaB p65 signaling
            pathways in the renoprotective effect of mirabegron against renal
            ischemia-reperfusion injury in rats.
REFERENCE   3  (bases 1 to 1024)
  AUTHORS   Lee,C.C., Park,K.B., Kim,M.S. and Jeon,Y.D.
  TITLE     CBP Expression Contributes to Neuropathic Pain via CREB and MeCP2
            Regulation in the Spared Nerve Injury Rat Model
  JOURNAL   Medicina (Kaunas) 60 (6), 989 (2024)
   PUBMED   38929606
  REMARK    GeneRIF: CBP Expression Contributes to Neuropathic Pain via CREB
            and MeCP2 Regulation in the Spared Nerve Injury Rat Model.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1024)
  AUTHORS   Jian,X., Yang,D., Wang,L. and Wang,H.
  TITLE     CREB1 Silencing Protects Against Inflammatory Response in Rats with
            Deep Vein Thrombosis Through Reducing RPL9 Expression and Blocking
            NF-kappaB Signaling
  JOURNAL   J Cardiovasc Transl Res 17 (3), 570-584 (2024)
   PUBMED   37891366
  REMARK    GeneRIF: CREB1 Silencing Protects Against Inflammatory Response in
            Rats with Deep Vein Thrombosis Through Reducing RPL9 Expression and
            Blocking NF-kappaB Signaling.
REFERENCE   5  (bases 1 to 1024)
  AUTHORS   Malheiros,J., Amaral,C., da Silva,L.S., Guinsburg,R. and Covolan,L.
  TITLE     Neonatal nociceptive stimulation results in pain sensitization,
            reduction of hippocampal 5-HT1A receptor, and p-CREB expression in
            adult female rats
  JOURNAL   Behav Brain Res 466, 114975 (2024)
   PUBMED   38552745
  REMARK    GeneRIF: Neonatal nociceptive stimulation results in pain
            sensitization, reduction of hippocampal 5-HT1A receptor, and p-CREB
            expression in adult female rats.
REFERENCE   6  (bases 1 to 1024)
  AUTHORS   Waeber,G. and Habener,J.F.
  TITLE     Novel testis germ cell-specific transcript of the CREB gene
            contains an alternatively spliced exon with multiple in-frame stop
            codons
  JOURNAL   Endocrinology 131 (4), 2010-2015 (1992)
   PUBMED   1396344
REFERENCE   7  (bases 1 to 1024)
  AUTHORS   Rehfuss,R.P., Walton,K.M., Loriaux,M.M. and Goodman,R.H.
  TITLE     The cAMP-regulated enhancer-binding protein ATF-1 activates
            transcription in response to cAMP-dependent protein kinase A
  JOURNAL   J Biol Chem 266 (28), 18431-18434 (1991)
   PUBMED   1655749
REFERENCE   8  (bases 1 to 1024)
  AUTHORS   Short,M.L., Manohar,C.F., Furtado,M.R., Ghadge,G.D., Wolinsky,S.M.,
            Thimmapaya,B. and Jungmann,R.A.
  TITLE     Nucleotide and derived amino-acid sequences of the CRE-binding
            proteins from rat C6 glioma and HeLa cells
  JOURNAL   Nucleic Acids Res 19 (15), 4290 (1991)
   PUBMED   1831258
REFERENCE   9  (bases 1 to 1024)
  AUTHORS   Sheng,M., Thompson,M.A. and Greenberg,M.E.
  TITLE     CREB: a Ca(2+)-regulated transcription factor phosphorylated by
            calmodulin-dependent kinases
  JOURNAL   Science 252 (5011), 1427-1430 (1991)
   PUBMED   1646483
REFERENCE   10 (bases 1 to 1024)
  AUTHORS   Gonzalez,G.A., Yamamoto,K.K., Fischer,W.H., Karr,D., Menzel,P.,
            Biggs,W. 3rd, Vale,W.W. and Montminy,M.R.
  TITLE     A cluster of phosphorylation sites on the cyclic AMP-regulated
            nuclear factor CREB predicted by its sequence
  JOURNAL   Nature 337 (6209), 749-752 (1989)
   PUBMED   2521922
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 27, 2020 this sequence version replaced NM_134443.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X60002.1, SRR26643296.24363.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               JAXUCZ010000009.1  73415228-73415341
            115-261             JAXUCZ010000009.1  73422268-73422414
            262-362             JAXUCZ010000009.1  73429648-73429748
            363-505             JAXUCZ010000009.1  73432842-73432984
            506-688             JAXUCZ010000009.1  73436986-73437168
            689-839             JAXUCZ010000009.1  73439104-73439254
            840-1024            JAXUCZ010000009.1  73460575-73460759
FEATURES             Location/Qualifiers
     source          1..1024
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q32"
     gene            1..1024
                     /gene="Creb1"
                     /gene_synonym="Creb"
                     /note="cAMP responsive element binding protein 1"
                     /db_xref="GeneID:81646"
                     /db_xref="RGD:620218"
     CDS             1..984
                     /gene="Creb1"
                     /gene_synonym="Creb"
                     /note="isoform A is encoded by transcript variant A;
                     cyclic AMP-responsive element-binding protein 1; CREB-1;
                     cAMP response element binding protein 1; Y protein"
                     /codon_start=1
                     /product="cyclic AMP-responsive element-binding protein 1
                     isoform A"
                     /protein_id="NP_604392.2"
                     /db_xref="GeneID:81646"
                     /db_xref="RGD:620218"
                     /translation="MTMDSGADNQQSGDAAVTEAESQQMTVQAQPQIATLAQVSMPAA
                     HATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVD
                     SVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPI
                     YQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQ
                     ILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRL
                     MKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD"
     exon            1..114
                     /gene="Creb1"
                     /gene_synonym="Creb"
                     /inference="alignment:Splign:2.1.0"
     exon            115..261
                     /gene="Creb1"
                     /gene_synonym="Creb"
                     /inference="alignment:Splign:2.1.0"
     exon            262..362
                     /gene="Creb1"
                     /gene_synonym="Creb"
                     /inference="alignment:Splign:2.1.0"
     exon            363..505
                     /gene="Creb1"
                     /gene_synonym="Creb"
                     /inference="alignment:Splign:2.1.0"
     exon            506..688
                     /gene="Creb1"
                     /gene_synonym="Creb"
                     /inference="alignment:Splign:2.1.0"
     exon            689..839
                     /gene="Creb1"
                     /gene_synonym="Creb"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1024
                     /gene="Creb1"
                     /gene_synonym="Creb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaccatgg actctggagc agacaaccag cagagtggag atgctgctgt aacagaagct
       61 gaaagtcaac aaatgacagt tcaagcccag ccacagattg ccacattagc ccaggtatcc
      121 atgccagcag ctcatgcgac gtcatctgct cccactgtaa ccttagtgca gctgcccaat
      181 gggcagacag tccaggtcca tggggtcatc caggcggccc agccatcagt tattcagtct
      241 ccacaagtcc aaacagttca gatttcaact attgcagaaa gtgaagattc acaggagtct
      301 gtggatagtg taactgattc ccaaaaacga agggaaatcc tttcaaggag gccttcctac
      361 aggaaaattt tgaatgactt atcttctgat gcaccagggg tgccaaggat tgaagaagaa
      421 aaatcagaag aagagacttc agcccctgcc atcaccactg taacagtgcc aaccccgatt
      481 taccaaacta gcagtgggca gtatattgcc attacccagg gaggagcaat acagctggct
      541 aacaatggta ccgatggggt acagggcctg cagacattaa ccatgaccaa tgcagctgcc
      601 actcagccgg gtactaccat tctacaatat gcacagacca ctgatggaca gcagattcta
      661 gtgcccagca accaagttgt tgttcaagct gcctctggtg atgtacaaac ataccagatt
      721 cgcacagcac ccactagcac cattgcccct ggagttgtta tggcgtcctc cccagcactt
      781 cctacacagc ctgctgaaga agcagcacga aagagagagg ttcgtctaat gaagaacagg
      841 gaagcagcaa gagaatgtcg tagaaagaag aaagaatatg tgaaatgttt agagaacaga
      901 gtggcagtgc ttgaaaacca aaacaaaaca ttgattgagg agctaaaagc acttaaggac
      961 ctttactgcc acaagtcaga ttaatttggg atttaaattt tcacctattg tggtggaaaa
     1021 tgga
//
