LOCUS       NM_001015003            2257 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus cereblon (Crbn), mRNA.
ACCESSION   NM_001015003 XM_216255
VERSION     NM_001015003.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2257)
  AUTHORS   Ko,J.R., Seo,D.Y., Park,S.H., Kwak,H.B., Kim,M., Ko,K.S., Rhee,B.D.
            and Han,J.
  TITLE     Aerobic exercise training decreases cereblon and increases AMPK
            signaling in the skeletal muscle of STZ-induced diabetic rats
  JOURNAL   Biochem Biophys Res Commun 501 (2), 448-453 (2018)
   PUBMED   29730289
  REMARK    GeneRIF: Aerobic exercise training decreases cereblon level in the
            skeletal muscle of diabetic rats.
REFERENCE   2  (bases 1 to 2257)
  AUTHORS   Kim,J., Lee,K.M., Park,C.S. and Park,W.J.
  TITLE     Ablation of cereblon attenuates myocardial ischemia-reperfusion
            injury
  JOURNAL   Biochem Biophys Res Commun 447 (4), 649-654 (2014)
   PUBMED   24755080
  REMARK    GeneRIF: In neonatal cardiomyocytes, overexpression of CRBN
            significantly reduced AMPK activity, as demonstrated by reductions
            in both phosphorylation levels of AMPK and the expression of its
            downstream target genes.
REFERENCE   3  (bases 1 to 2257)
  AUTHORS   Lee,K.M., Jo,S., Kim,H., Lee,J. and Park,C.S.
  TITLE     Functional modulation of AMP-activated protein kinase by cereblon
  JOURNAL   Biochim Biophys Acta 1813 (3), 448-455 (2011)
   PUBMED   21232561
  REMARK    GeneRIF: CRBN directly interacts with the alpha1 subunit of
            AMP-activated protein kinase (AMPK alpha1) and inhibits the
            activation of AMPK activation.
REFERENCE   4  (bases 1 to 2257)
  AUTHORS   Ito,T., Ando,H., Suzuki,T., Ogura,T., Hotta,K., Imamura,Y.,
            Yamaguchi,Y. and Handa,H.
  TITLE     Identification of a primary target of thalidomide teratogenicity
  JOURNAL   Science 327 (5971), 1345-1350 (2010)
   PUBMED   20223979
REFERENCE   5  (bases 1 to 2257)
  AUTHORS   Hohberger,B. and Enz,R.
  TITLE     Cereblon is expressed in the retina and binds to voltage-gated
            chloride channels
  JOURNAL   FEBS Lett 583 (4), 633-637 (2009)
   PUBMED   19166841
  REMARK    GeneRIF: Crbn is expressed in the retina and binds to voltage-gated
            chloride channels.
REFERENCE   6  (bases 1 to 2257)
  AUTHORS   Jo,S., Lee,K.H., Song,S., Jung,Y.K. and Park,C.S.
  TITLE     Identification and functional characterization of cereblon as a
            binding protein for large-conductance calcium-activated potassium
            channel in rat brain
  JOURNAL   J Neurochem 94 (5), 1212-1224 (2005)
   PUBMED   16045448
  REMARK    GeneRIF: CRBN may play an important role in assembly and surface
            expression of functional BK(Ca) channels by direct interaction with
            the cytosolic C-terminus of its alpha-subunit.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB567139.1, BC099779.1 and JAXUCZ010000004.1.
            
            On Oct 11, 2005 this sequence version replaced NM_001015003.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127455.1, SRR26643285.17230.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                CB567139.1         11-25
            16-1817             BC099779.1         1-1802
            1818-2257           JAXUCZ010000004.1  141257243-141257682 c
FEATURES             Location/Qualifiers
     source          1..2257
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q41"
     gene            1..2257
                     /gene="Crbn"
                     /note="cereblon"
                     /db_xref="GeneID:297498"
                     /db_xref="RGD:1310533"
     exon            1..80
                     /gene="Crbn"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1351
                     /gene="Crbn"
                     /codon_start=1
                     /product="protein cereblon"
                     /protein_id="NP_001015003.1"
                     /db_xref="GeneID:297498"
                     /db_xref="RGD:1310533"
                     /translation="MAGEGDHQDAAHNMGNHLPLLPADSEDEDDEIEMEVEDQDSKEA
                     RKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPEVMMILIPGQTLPL
                     QLSHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQEFGIEVVKV
                     KAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPISW
                     EDQYSCKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKEDSL
                     PANPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEI
                     TTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTVHSWFPGYAWTIA
                     QCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPETEDEISPDKVILCL"
     exon            81..196
                     /gene="Crbn"
                     /inference="alignment:Splign:2.1.0"
     exon            197..399
                     /gene="Crbn"
                     /inference="alignment:Splign:2.1.0"
     exon            400..549
                     /gene="Crbn"
                     /inference="alignment:Splign:2.1.0"
     exon            550..709
                     /gene="Crbn"
                     /inference="alignment:Splign:2.1.0"
     exon            710..772
                     /gene="Crbn"
                     /inference="alignment:Splign:2.1.0"
     exon            773..857
                     /gene="Crbn"
                     /inference="alignment:Splign:2.1.0"
     exon            858..973
                     /gene="Crbn"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1038
                     /gene="Crbn"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1170
                     /gene="Crbn"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..2257
                     /gene="Crbn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggtaaaca gacatggccg gcgagggaga tcaccaggac gctgcgcaca acatgggaaa
       61 ccacctgccg cttctgcctg ctgacagtga agatgaagat gatgaaattg aaatggaagt
      121 tgaagaccag gacagtaaag aagccagaaa accaaatatc ataaactttg ataccagtct
      181 gccaacctca catacatacc tgggagctga tatggaagag tttcacggca ggactttgca
      241 cgacgacgac agctgtcagg tgattccagt tcttcctgag gtgatgatga tcttgattcc
      301 tgggcagacg ttaccactgc agctttctca cccgcaagaa gtcagtatgg ttcggaattt
      361 aatccagaag gacagaacct ttgcagttct tgcatacagt aatgtgcaag aaagggaagc
      421 acagtttgga actacagcag agatctatgc gtatcgagag gagcaggagt ttggaattga
      481 agtagtgaaa gtgaaagcaa tcggacggca gaggttcaag gtccttgaac ttcgaacaca
      541 gtcagatgga atccagcaag ctaaagtgca aattttgcca gagtgtgtgt tgccgtcaac
      601 catgtctgca gttcagttag aatcactcaa taagtgccag atatttcctt caaaacctat
      661 ctcttgggaa gaccagtatt catgtaaatg gtggcagaaa taccagaaga ggaagtttca
      721 ctgtgcaaat ctgacatcat ggcctcgctg gctgtattca ttatatgatg ctgaaacatt
      781 aatggataga attaagaaac agctacgtga atgggatgaa aatctcaaag aggactctct
      841 tcctgcaaac ccaatagact tttcttacag agtagctgct tgtcttccta ttgatgatgt
      901 attaagaatt cagctcctta aaattggcag tgctattcaa cggcttcgct gtgagttaga
      961 catcatgaac aaatgtactt ccctttgctg taaacaatgt caagaaacag aaataacaac
     1021 aaagaatgaa atatttagct tatccttatg tggtccaatg gcagcatatg tgaatcccca
     1081 tggatatgta catgagacac tgactgtgta taaagcttcc aacctgaatc tgataggccg
     1141 gccttctaca gtgcacagct ggtttcccgg gtatgcatgg accattgccc agtgtaagat
     1201 ttgtgcaagc cacattggat ggaaatttac agccaccaaa aaagacatgt cacctcaaaa
     1261 attttggggc ttaactcgct ctgctctgtt acctacaatt ccagagactg aagatgaaat
     1321 aagtccagac aaagtaatac tttgcttata agtgcacctg taggagtgac tttctgacat
     1381 attttctcaa atcagatctg cccagacatc actgcctctg atatatatgt ataatgggtt
     1441 acagcatttg gctaccaagt tcaagagcaa cctgtttagg gaatgagaaa gcagtataaa
     1501 atgcaaggtt ggattcagaa gtacttgctg ttagtcgctt ggtcccagtg attatcctgt
     1561 tggatatatg tcattgatag gaaaagaata cacaagtgaa ataatgggaa tggctatgga
     1621 acaggaaaaa agcatcgctg ctctaaatga tgaatgttcc agaagctggt ttggtaagca
     1681 caagacagag gcaaggcagt gtaattgtaa aaggactttg ctcctttcaa ttttctttag
     1741 cttgtctaag atactgattt gtaaattttg aaaatattaa agagtaaaat aagcagtttg
     1801 agcagaaaaa aataatagca ttcggtgtat ttgcactatt tatttgatga gcctgtcatg
     1861 tgctagatcc ctttaatgta tatgtccaat ttgcatttca tttgcaaata taagtgaata
     1921 gtatatattt ctaggattat accattcagg aaataaagtt aaagcaactg aagggcatta
     1981 tttaaataaa cctggccaac actacctata tccaaatcta ttctatttag gtgaattatg
     2041 tcaaagtaat caggtaaaaa tacttaaagt gtaagtacag taataaaatg taactcaaga
     2101 ataggcttct cctcaatgtc attttttttt ttaaagttct acttctctac attgaagctg
     2161 cagtaatgaa gtggggggat tatgccttac tgctgcagta tgacctgagg agatccacat
     2221 gctggttacc attactttca gatagtacca tttaaag
//
