LOCUS       NM_001025661            1130 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus crumbs cell polarity complex component 3 (Crb3),
            mRNA.
ACCESSION   NM_001025661 XM_217315
VERSION     NM_001025661.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1130)
  AUTHORS   Gao,Y., Lui,W.Y., Lee,W.M. and Cheng,C.Y.
  TITLE     Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic
            specialization dynamics through its action on F-actin organization
            in Sertoli cells
  JOURNAL   Sci Rep 6, 28589 (2016)
   PUBMED   27358069
  REMARK    GeneRIF: CRB3 is an actin microfilament regulator, playing a
            pivotal role in organizing actin filament bundles at the
            ectoplasmic specialization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1130)
  AUTHORS   Rockich,B.E., Hrycaj,S.M., Shih,H.P., Nagy,M.S., Ferguson,M.A.,
            Kopp,J.L., Sander,M., Wellik,D.M. and Spence,J.R.
  TITLE     Sox9 plays multiple roles in the lung epithelium during branching
            morphogenesis
  JOURNAL   Proc Natl Acad Sci U S A 110 (47), E4456-E4464 (2013)
   PUBMED   24191021
REFERENCE   3  (bases 1 to 1130)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1130)
  AUTHORS   Wong,E.W., Mruk,D.D., Lee,W.M. and Cheng,C.Y.
  TITLE     Par3/Par6 polarity complex coordinates apical ectoplasmic
            specialization and blood-testis barrier restructuring during
            spermatogenesis
  JOURNAL   Proc Natl Acad Sci U S A 105 (28), 9657-9662 (2008)
   PUBMED   18621709
REFERENCE   5  (bases 1 to 1130)
  AUTHORS   Stucke,V.M., Timmerman,E., Vandekerckhove,J., Gevaert,K. and
            Hall,A.
  TITLE     The MAGUK protein MPP7 binds to the polarity protein hDlg1 and
            facilitates epithelial tight junction formation
  JOURNAL   Mol Biol Cell 18 (5), 1744-1755 (2007)
   PUBMED   17332497
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097382.1.
            
            [WARNING] On Jul 23, 2024 this sequence was replaced by
            NM_001025661.2.
            
            On Jul 22, 2005 this sequence version replaced XM_217315.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097382.1, CV115162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1130
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..1130
                     /gene="Crb3"
                     /note="crumbs cell polarity complex component 3"
                     /db_xref="GeneID:301112"
                     /db_xref="RGD:1565035"
     exon            1..55
                     /gene="Crb3"
                     /inference="alignment:Splign:2.1.0"
     exon            56..227
                     /gene="Crb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..499
                     /gene="Crb3"
                     /note="crumbs protein homolog 3; crumbs homolog 3; crumbs
                     family member 3; crumbs 3, cell polarity complex
                     component"
                     /codon_start=1
                     /product="protein crumbs homolog 3 precursor"
                     /protein_id="NP_001020832.1"
                     /db_xref="GeneID:301112"
                     /db_xref="RGD:1565035"
                     /translation="MATPGLGLLLAFGLPMLPSGWSQETPDSFTNSTTQPPDGGGSNG
                     GLSSEAIVAITVVFSILGTLLIAVGLFLLMRKLREKRQTEGTYRPSSEEQVGARAPPP
                     PNLKLPPEERLI"
     exon            228..292
                     /gene="Crb3"
                     /inference="alignment:Splign:2.1.0"
     exon            293..1094
                     /gene="Crb3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgggaaccc gggattggaa acctgagcga agtccctctc tgacgcctgg gtcaggtcct
       61 gggtcgcagg tgccctcctc gacccaagat gcggtaggaa ttggagccct ggggaagtcc
      121 tgtccttggc gccaccaact cgtcgcccaa gctcatggcg accccaggcc tggggctgct
      181 cttggcgttt ggcttgccga tgctgccctc cggctggagc caagaaacac cagactcttt
      241 cacaaatagc acaactcaac ccccagatgg cggcgggtcc aacgggggct tgtcctcaga
      301 ggccatcgtg gccatcactg tggtcttttc cattctggga accctcctca tagcagtggg
      361 gctattcctg ctaatgagaa aacttcgaga aaagcggcag acagagggca cctaccggcc
      421 cagcagtgag gagcaggtgg gtgcccgtgc tccaccaccc cccaacctca agctgccccc
      481 ggaggagcgg ctcatctgaa tttaggggtg ttggccatag gccatcatca cgaccaacgc
      541 ccaggactgc cttggcacac cgagacacac agcagccacc ttggagacaa cagcctctga
      601 tgactcagga ggacttggct tggggaaccc tggggcatcc agctggtggg ctatacagca
      661 tgttgcttct gcttggctct gcatgaaact gggggtgcca ggaccagggg cggggagcct
      721 taccatttac ctcatgtgat cttgcctctg ctgtgtctcc tactgtgacc gcaggcccaa
      781 caaacttcct gtcctttctt tcagttttcc cacgcagcag ctgaggcccg ggccccccag
      841 gactccaagg agccagtgcg gggctgcctg cccatctagc tcctcccctc cttccctgtc
      901 atccatcttc ccttcctggc tgtgtgacct tgtggaaggc ttgggcagtc agactcatac
      961 aatactcaat agaaggggag agagttcttc agagaccttg actttgaggg caagcgagga
     1021 tggggctact cactttttat atatttatat gaaattgata ggtacaataa aggtttcttg
     1081 tttttgtttt tttaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
