LOCUS       NM_001135761            6304 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus crumbs cell polarity complex component 2 (Crb2),
            mRNA.
ACCESSION   NM_001135761 XM_345347
VERSION     NM_001135761.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6304)
  AUTHORS   Ramkumar,N., Omelchenko,T., Silva-Gagliardi,N.F., McGlade,C.J.,
            Wijnholds,J. and Anderson,K.V.
  TITLE     Crumbs2 promotes cell ingression during the
            epithelial-to-mesenchymal transition at gastrulation
  JOURNAL   Nat Cell Biol 18 (12), 1281-1291 (2016)
   PUBMED   27870829
REFERENCE   2  (bases 1 to 6304)
  AUTHORS   Ramkumar,N., Harvey,B.M., Lee,J.D., Alcorn,H.L.,
            Silva-Gagliardi,N.F., McGlade,C.J., Bestor,T.H., Wijnholds,J.,
            Haltiwanger,R.S. and Anderson,K.V.
  TITLE     Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse
            Gastrulation through Modification of the Apical Polarity Protein
            CRUMBS2
  JOURNAL   PLoS Genet 11 (10), e1005551 (2015)
   PUBMED   26496195
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6304)
  AUTHORS   Kim,J.Y., Song,J.Y., Karnam,S., Park,J.Y., Lee,J.J., Kim,S. and
            Cho,S.H.
  TITLE     Common and distinctive localization patterns of Crumbs polarity
            complex proteins in the mammalian eye
  JOURNAL   Gene Expr Patterns 17 (1), 31-37 (2015)
   PUBMED   25636444
REFERENCE   4  (bases 1 to 6304)
  AUTHORS   Alves,C.H., Pellissier,L.P., Vos,R.M., Garcia Garrido,M.,
            Sothilingam,V., Seide,C., Beck,S.C., Klooster,J., Furukawa,T.,
            Flannery,J.G., Verhaagen,J., Seeliger,M.W. and Wijnholds,J.
  TITLE     Targeted ablation of Crb2 in photoreceptor cells induces retinitis
            pigmentosa
  JOURNAL   Hum Mol Genet 23 (13), 3384-3401 (2014)
   PUBMED   24493795
REFERENCE   5  (bases 1 to 6304)
  AUTHORS   Pellissier,L.P., Alves,C.H., Quinn,P.M., Vos,R.M., Tanimoto,N.,
            Lundvig,D.M., Dudok,J.J., Hooibrink,B., Richard,F., Beck,S.C.,
            Huber,G., Sothilingam,V., Garcia Garrido,M., Le Bivic,A.,
            Seeliger,M.W. and Wijnholds,J.
  TITLE     Targeted ablation of CRB1 and CRB2 in retinal progenitor cells
            mimics Leber congenital amaurosis
  JOURNAL   PLoS Genet 9 (12), e1003976 (2013)
   PUBMED   24339791
REFERENCE   6  (bases 1 to 6304)
  AUTHORS   Xiao,Z., Patrakka,J., Nukui,M., Chi,L., Niu,D., Betsholtz,C.,
            Pikkarainen,T., Vainio,S. and Tryggvason,K.
  TITLE     Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and
            results in embryonic lethality in mice
  JOURNAL   Dev Dyn 240 (12), 2646-2656 (2011)
   PUBMED   22072575
  REMARK    Erratum:[Dev Dyn. 2012 Feb;241(2):431. Pikkarainan, Timo [corrected
            to Pikkarainen, Timo]]
REFERENCE   7  (bases 1 to 6304)
  AUTHORS   Mitsuishi,Y., Hasegawa,H., Matsuo,A., Araki,W., Suzuki,T.,
            Tagami,S., Okochi,M., Takeda,M., Roepman,R. and Nishimura,M.
  TITLE     Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor
            protein by binding to the presenilin complex
  JOURNAL   J Biol Chem 285 (20), 14920-14931 (2010)
   PUBMED   20299451
REFERENCE   8  (bases 1 to 6304)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 8, 2022 this sequence version replaced NM_001135761.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN11044071,
                              SAMN12840105 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               JAXUCZ010000003.1  41951900-41952072
            174-497             JAXUCZ010000003.1  41958276-41958599
            498-693             JAXUCZ010000003.1  41962251-41962446
            694-833             JAXUCZ010000003.1  41962530-41962669
            834-1019            JAXUCZ010000003.1  41963079-41963264
            1020-1133           JAXUCZ010000003.1  41963441-41963554
            1134-2006           JAXUCZ010000003.1  41965712-41966584
            2007-2515           JAXUCZ010000003.1  41966670-41967178
            2516-2681           JAXUCZ010000003.1  41967635-41967800
            2682-3459           JAXUCZ010000003.1  41968692-41969469
            3460-3576           JAXUCZ010000003.1  41969965-41970081
            3577-3703           JAXUCZ010000003.1  41970804-41970930
            3704-6304           JAXUCZ010000003.1  41972029-41974629
FEATURES             Location/Qualifiers
     source          1..6304
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q11"
     gene            1..6304
                     /gene="Crb2"
                     /gene_synonym="RGD1309368"
                     /note="crumbs cell polarity complex component 2"
                     /db_xref="GeneID:366031"
                     /db_xref="RGD:1309368"
     exon            1..173
                     /gene="Crb2"
                     /gene_synonym="RGD1309368"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..3928
                     /gene="Crb2"
                     /gene_synonym="RGD1309368"
                     /note="crumbs family member 2; crumbs 2, cell polarity
                     complex component"
                     /codon_start=1
                     /product="protein crumbs homolog 2 precursor"
                     /protein_id="NP_001129233.1"
                     /db_xref="GeneID:366031"
                     /db_xref="RGD:1309368"
                     /translation="MALLGPVIWGFRRDVYLLLLLLLLLLPPWVPAGLVPSETPNVCA
                     SDPCAPGTRCQATESGGFTCEPLELGGCAAQPCHHGALCVPQGPDPNGFRCYCVPGFQ
                     GPHCELDIDECASRPCHHGGTCRNLADHYECHCPLGYAGVTCEAEVDECSSAPCLHGG
                     SCLDGVGSYRCVCAPGYAGASCQLDVDECQSQPCEHGGVCHDLVNGFRCDCADTGYEG
                     ARCEQEVLECASAPCVHNASCLDGFRSFRCLCWPGFSGERCEVDEDECASDPCHNGGR
                     CSQRSDPTLYGGVQAIFPGAFSFSQAAGFLCSCPPGFAGDDCSVDVNECASEPCLNGG
                     SCQDLPNGFQCYCQDGYTGLTCQEDTDECQSEPCLHGGTCSDTVAGYICQCPEAWGGH
                     DCSVQLTGCQGHACPLAATCIPTFKSGFHSYICRCLPGTYGSFCDQNTTFSVVSGSSV
                     WGLVPAGASLAFALRFRTTLLAGALATLKDSRDSLELVLVGAMLQATLWRRGTADLVL
                     TLPDLALNDGHWHQVEVTLRLGTLELRLWHEGCPGQLCVVSGTVATDPTASVASGSPE
                     PYSIHLGGRAFAGCFQDVRVEGHLLLPEELKGSVLLGCERTEPCQPLPCANGGACVDL
                     WTDFRCDCPRPYHGSKCTDEVPAATFGLGGVMSSATFLLHQMLGPNLTVSFFLRTREP
                     ASLLLQFANDSVASLTVSLSEGQIRAEVLGHPAVILPGRRDDGLRHLVVLSFGPDQLQ
                     DLGQWLYVGGRLYPDDTQPWGGPFRGCLQDLQLNGIHLPFFSSPMENSSWPSELEAGQ
                     SSNLTQGCVSEDTCNPNPCFNGGTCHITWNDFYCTCPDNFTGPTCAQQRWCPRQPCLP
                     PATCEEVPDGFVCVAEATFREGPPAVFTGHNVSSSRALSRVTLAFRTRDLEAGLLRAA
                     SAAGAHSNIWLAVRNGLLAVDVAGSVLPAPGPRVADGAWHRVRLAREFPQAAASRWLL
                     WLDGAATPVALHGLGGDLGFLQGPGAVPLLLAENFTGCLGRVALGDLPLPLAPPRSGA
                     MSGAREHFMAWPGSPPAVSLGCRGGPVCTPSPCLHGGACLDLFDVFACSCGPAWEGPR
                     CEIHADPCRSSPCVRGQCNTRPDGRFECRCPPGFSGPRCRLPTLPQGCSLNSTCKDGA
                     PCGGGPLGTNCSCQEGLAGLRCQSLDQPCEASPCLNGGTCRVTSGIFECTCSAGFSGQ
                     FCEVVKTLPLPLPFPLLEVAVPAACACLLLLLLGLLSGILAARKRRQSEGTYSPSQQE
                     VAGARLEMDSVLKVPPEERLI"
     exon            174..497
                     /gene="Crb2"
                     /gene_synonym="RGD1309368"
                     /inference="alignment:Splign:2.1.0"
     exon            498..693
                     /gene="Crb2"
                     /gene_synonym="RGD1309368"
                     /inference="alignment:Splign:2.1.0"
     exon            694..833
                     /gene="Crb2"
                     /gene_synonym="RGD1309368"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1019
                     /gene="Crb2"
                     /gene_synonym="RGD1309368"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1133
                     /gene="Crb2"
                     /gene_synonym="RGD1309368"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..2006
                     /gene="Crb2"
                     /gene_synonym="RGD1309368"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2515
                     /gene="Crb2"
                     /gene_synonym="RGD1309368"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2681
                     /gene="Crb2"
                     /gene_synonym="RGD1309368"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..3459
                     /gene="Crb2"
                     /gene_synonym="RGD1309368"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..3576
                     /gene="Crb2"
                     /gene_synonym="RGD1309368"
                     /inference="alignment:Splign:2.1.0"
     exon            3577..3703
                     /gene="Crb2"
                     /gene_synonym="RGD1309368"
                     /inference="alignment:Splign:2.1.0"
     exon            3704..6304
                     /gene="Crb2"
                     /gene_synonym="RGD1309368"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgctggtt ggagggacga aggggcgcgg agcccgccga gcagagggtt cccataggca
       61 agcagagccg gctgccatgg cgctgttggg gcctgtgatc tggggcttta gacgagatgt
      121 ctacctcctg ttgctgctac tgctgctgtt gctgccgccc tgggtcccgg ctgggctggt
      181 tccttcagag accccgaatg tctgtgcctc agacccatgt gctccaggga ccaggtgcca
      241 ggctacagaa agtggtggct ttacctgtga gcccttagag cttggaggct gtgctgctca
      301 accgtgccac catggtgcac tgtgtgtgcc ccagggccca gatcctaacg gcttccgttg
      361 ctactgtgtg cctggattcc agggacccca ctgtgagctg gacatcgatg agtgtgcctc
      421 ccggccttgc caccatgggg gcacctgccg aaatctggca gatcactacg agtgccactg
      481 ccccctcggc tatgcaggcg tgacctgtga ggcggaggtg gacgagtgct catcagcgcc
      541 ctgcctgcac ggaggctcgt gcctggacgg tgtgggctcc taccgctgtg tgtgcgcacc
      601 tggatacgcc ggcgcgagct gtcagctgga cgtggacgag tgccagagcc agccgtgcga
      661 gcacggtggc gtgtgtcacg acctggtcaa cggtttccgg tgcgactgtg cggacacggg
      721 ttacgaaggc gcgcgctgtg agcaggaggt gctggagtgc gcctctgcgc cctgcgtgca
      781 caacgcatcc tgcctcgacg gcttccggag cttccgctgc ctctgctggc caggcttcag
      841 tggagagcgg tgcgaagtgg atgaggatga gtgtgcatcg gatccctgtc ataatggggg
      901 ccggtgctcg cagcgctctg acccgacctt gtatgggggt gttcaggcca tcttccccgg
      961 agccttcagc ttcagccaag ccgctggctt cctttgcagc tgtcctccgg gctttgctgg
     1021 ggatgactgc agcgtggacg tgaatgagtg tgcctcagag ccatgtctca acggaggtag
     1081 ctgccaggac ctgcccaatg gtttccagtg ctactgtcag gatggataca caggactgac
     1141 atgtcaggag gatacggacg agtgccagtc ggaaccatgc ctgcacggtg ggacctgcag
     1201 cgacactgta gcaggctaca tctgccagtg ccccgaggcc tggggtggac atgactgttc
     1261 tgtgcagctc acaggctgcc agggccacgc ctgcccactg gctgccacct gcatccccac
     1321 cttcaagtct ggtttccaca gttatatctg ccgttgcctg cctgggacct atgggtcttt
     1381 ctgtgaccag aataccactt tctcggttgt gtctgggagt tccgtgtggg gattggtgcc
     1441 agctggtgcc tccctggctt ttgcactgag atttcgtacc accctgcttg ctggagccct
     1501 ggctactctt aaggactcac gggacagctt ggagctggtt ctggtggggg ccatgctcca
     1561 agccacactc tggagacgtg gcactgctga ccttgtcctt acactgccag acctagcctt
     1621 aaatgacggg cattggcatc aggtggaagt gacactccgc ctgggaaccc tggagctgcg
     1681 gctctggcat gagggctgcc ctggccagct ctgtgtggtc tctggcactg tggctacaga
     1741 tcctacagcc tcggtggctt ctgggtctcc ggagccctac tccatccatt tgggcggcag
     1801 ggcctttgca ggctgcttcc aggatgtgcg tgtggaaggg caccttctgc tgcctgagga
     1861 gctcaaggga agtgtgctcc tgggttgtga gcgcacagag ccttgccaac ctctgccctg
     1921 tgccaatgga ggggcctgtg tggacctgtg gactgacttc cgctgcgact gcccgagacc
     1981 ttaccatggg tccaagtgca ctgatgaggt tcctgctgcc acctttggct tgggcggtgt
     2041 catgagctca gccaccttcc tgctccacca gatgctaggc ccgaacctca ccgtgtcgtt
     2101 tttcctccgc actcgtgagc ccgccagcct gttgctccag tttgccaatg attcagttgc
     2161 tagcctaact gtgtccctga gtgagggcca gatccgggca gaggtgctgg gtcatcctgc
     2221 tgtgatcctc cctgggcgcc gggatgatgg actccgtcac ttggtggtgc tcagctttgg
     2281 gcctgaccag ctccaggacc tgggccagtg gctgtatgtg ggtgggaggc tctaccctga
     2341 tgatacccag ccctggggtg ggcccttccg aggctgtctc caggacctac aactcaacgg
     2401 catccacctc cccttcttct cttctcccat ggagaactca agttggccca gtgaactgga
     2461 agctggtcag tcctccaacc tcacccaggg ctgtgtctct gaggacacgt gcaatcccaa
     2521 tccctgtttc aatggtggaa catgccacat cacctggaat gacttctact gcacttgccc
     2581 tgacaacttc acggggccca cctgtgccca gcagcgatgg tgccccaggc agccatgcct
     2641 gccgcctgcc acctgtgagg aggttccaga tggctttgtg tgtgtggccg aagccacgtt
     2701 ccgcgagggc cctcctgctg tgttcacagg ccacaacgtg tcctcatcgc gcgcgctcag
     2761 cagggtcacc ctggccttcc gcacacgcga cctggaggct gggctgctgc gcgctgcctc
     2821 tgccgcgggt gcccactcca atatctggct ggcggtgcgc aatggcttgc tggcagtaga
     2881 tgtggcgggc tcggtgctgc cggcgcccgg gccgcgcgtg gctgacggtg cctggcatcg
     2941 cgtgcgccta gcccgggagt ttccacaggc cgccgcctca cgctggctgc tgtggctgga
     3001 cggcgcggcg acacccgtgg ctttgcacgg cttgggcggc gacctgggtt tccttcaggg
     3061 cccgggtgcc gtgcctctgc tactggccga gaacttcacg ggctgcctgg gccgggtggc
     3121 gctcggcgac ctccccttac ccttggcgcc accgcggtcc ggcgcgatgt ctggggcacg
     3181 cgagcacttc atggcttggc ctgggtctcc gccggcagtg agcctaggct gccggggcgg
     3241 gccagtatgc acgccctcgc cctgcctgca cggcggtgcc tgcctcgacc tcttcgacgt
     3301 ctttgcttgt tcctgcggcc ccgcctggga aggaccccgc tgcgagatcc acgctgatcc
     3361 atgtcgctca tcgccctgtg tccggggcca atgcaacacg cgcccggacg gccgcttcga
     3421 gtgtcggtgc cctccgggtt tctccggccc gcgctgcagg ttgcctacct tgcctcaggg
     3481 gtgtagcctc aactccacct gcaaggatgg tgccccttgt gggggtggcc ccttaggcac
     3541 taactgcagt tgccaggaag gccttgctgg cctcagatgt cagagtcttg accaaccctg
     3601 tgaagccagt ccttgcttga atgggggcac ctgccgggtg accagtggca tatttgaatg
     3661 tacttgcagt gcaggattct ctggccagtt ctgtgaagtg gtgaaaaccc tgcctctgcc
     3721 tctgccattc ccactgctgg aggtagcagt gcctgcagcc tgtgcctgcc tcctcctcct
     3781 cctcctgggc ctcctctcag gaattctggc tgccagaaag cgccgccagt ctgagggcac
     3841 ttacagccca agtcagcagg aggtagctgg ggctcgtctg gagatggaca gtgtcctcaa
     3901 ggtgccacca gaggagagac ttatctaggc ttggctggct gctatgtcct gaaggcccca
     3961 cagggtcacc acagaacttc tacctggaga cccaaggaga ctgtttccag agatgggaca
     4021 tccacaggat gtgccccggt ggctggcagc ccttgccctg tccatccatg gactcaggaa
     4081 gtgggaaacg actcagggaa gcagagaagg ctgtgaggga atgcacctct ctgacctgct
     4141 gggctgtata cagggcacac gtgggtgtcc atggtatgac agggtgtgtg cgtgtgtgtt
     4201 tgtgtgcatc tttctgtttg gggaagaaag gagaggaaga aagagaatat acatggggat
     4261 gtgttggtca gcagattgta atgtgttatg actgtggtaa gagcttcatg tctggggaca
     4321 acccagatgg atacctctga gacaggggca gcccaaggct gcacgttctc tcacactgaa
     4381 ctggccacag cttacccaag cacctagact ttggtcttga catcttgttc tccaaggaca
     4441 gcccttatcc tggggaagct gggaaataga ggagtatcct tggtttccag aacaaaagcc
     4501 ctttggggta gatctgactt gacagtgcta tggccatggc tgtagggcag gtctgcagga
     4561 accatggagc agctgccctg ggctgtcctg cctgctgtgg gcacttgctg gagtggagca
     4621 acctgtctgc ctacctcacg agggaggcta ttctgaggat ccgagagaca aacaggcaga
     4681 aaacttcaga agtcattaaa attccattct gatggaaaga actggtgccc ttttgggtgt
     4741 tggaaagtgg ctcacctgcc tagagttgaa aggacttctt gggaccttgg aaaggaggca
     4801 gaaggatgga gatgtctttc tcccctgtcc ctggcccctg cagactcacc atcttgtggt
     4861 tctccagcgc aggctacccc tttgcctgca gttctgttgc caaggaagac ctctgttgtg
     4921 tgccaaacag cagtacccgg cagatggacc gcaggcagct tctgcactgg tgctcgtcct
     4981 gtgactactc agtgtgcttg acttctgata ccccctgccc caagcactgg cctgcaggtt
     5041 tagcctccct gaaacctccc agagccctct gacttggaga ggtgtccttt gtcttccttg
     5101 tttaccagga gtttccacgt gcaaatgcca agtgactttt acacatggaa gctggctgtt
     5161 tcaaggtttc agccggctca gaaggcagac gtgggctttg atatgagacc ctggatgcta
     5221 agctaggagg cctgcttggt tcttaccctg tagtggtggg accacttcgc catcagctgt
     5281 ctccatgtcc cttgggagag ggaagaggaa acaggctcct gtgtgaactg ttgcagttgc
     5341 cagctcccaa gatgtttcct gtggaatgcc aactcgatga aacattccag ttccacgtca
     5401 gtgtcaccaa tgtggcctac acaagtactc acttggggta gatgctgttc ttgctgagat
     5461 atggcggagg ggtggaactt gttcgttcgt atagtcctgc cccctgctca tctataatcc
     5521 ctcactggga gggatggtgg ctcagagcct caggtatgca taggctggag tgcagtggcc
     5581 tctacttctg caggatggct ggtggagatg agtacctgct caggctcccc atgcccagag
     5641 ctccttgaag gactcgggac tacagtcctc tgcccagttt cagtgaccac atctagagtt
     5701 catcattggg actgcagctt ctacccggtg agatggacag gtgacaacaa acatgtgcag
     5761 tgggccacag gtgtctgctg cttcctaggc tgccccacac ctcgtcaccc tactgcccac
     5821 tgcttcatct tgtgtggagc ccagagtttg ctggggtgga ggaagtggag ctgagacctg
     5881 tcctgaaaca ccaggatgcc aggaggcttt ccatgaccca ggagagactg ctgtctagtg
     5941 gctgagcaca ccaagacaga gccctgggcg ggatgggggg gctctggcct aggcctcagg
     6001 gacccataaa cctctcagac acagagaggg tccctaaagt gatagggacc tctgatgact
     6061 ccacccccgt gttcccaacc cccagaaacc ctggggttgg ctgtctgacc atttacacat
     6121 aggaaatgag aaatcaggtc aaatgtgcac aatttcctgc atgtctctgt ggatgttttc
     6181 ttaaatggtt agtctgtgtt ttaccttggt ttattgaaag gaatcaattt tcaagattca
     6241 tcaaatcaat aaggtaaaaa ggaaaagcaa gatcaaagaa acaataacaa acatttcatt
     6301 ataa
//
