LOCUS       NM_001107182            4603 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus crumbs cell polarity complex component 1 (Crb1),
            mRNA.
ACCESSION   NM_001107182 XM_001067022 XM_222675
VERSION     NM_001107182.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4603)
  AUTHORS   Boon N, Alves CH, Mulder AA, Andriessen CA, Buck TM, Quinn PMJ, Vos
            RM, Koster AJ, Jost CR and Wijnholds J.
  TITLE     Defining Phenotype, Tropism, and Retinal Gene Therapy Using
            Adeno-Associated Viral Vectors (AAVs) in New-Born Brown Norway Rats
            with a Spontaneous Mutation in Crb1
  JOURNAL   Int J Mol Sci 22 (7), 3563 (2021)
   PUBMED   33808129
  REMARK    GeneRIF: Defining Phenotype, Tropism, and Retinal Gene Therapy
            Using Adeno-Associated Viral Vectors (AAVs) in New-Born Brown
            Norway Rats with a Spontaneous Mutation in Crb1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4603)
  AUTHORS   Zhao M, Andrieu-Soler C, Kowalczuk L, Paz Cortes M, Berdugo M,
            Dernigoghossian M, Halili F, Jeanny JC, Goldenberg B, Savoldelli M,
            El Sanharawi M, Naud MC, van Ijcken W, Pescini-Gobert R, Martinet
            D, Maass A, Wijnholds J, Crisanti P, Rivolta C and Behar-Cohen F.
  TITLE     A new CRB1 rat mutation links Muller glial cells to retinal
            telangiectasia
  JOURNAL   J Neurosci 35 (15), 6093-6106 (2015)
   PUBMED   25878282
  REMARK    GeneRIF: This study demonstrate that a new CRB1 rat mutation links
            Muller glial cells to retinal telangiectasia in rats.
REFERENCE   3  (bases 1 to 4603)
  AUTHORS   Luhmann UF, Carvalho LS, Holthaus SM, Cowing JA, Greenaway S, Chu
            CJ, Herrmann P, Smith AJ, Munro PM, Potter P, Bainbridge JW and Ali
            RR.
  TITLE     The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is
            dependent on additional genetic factors
  JOURNAL   Hum Mol Genet 24 (1), 128-141 (2015)
   PUBMED   25147295
REFERENCE   4  (bases 1 to 4603)
  AUTHORS   Kim JY, Song JY, Karnam S, Park JY, Lee JJ, Kim S and Cho SH.
  TITLE     Common and distinctive localization patterns of Crumbs polarity
            complex proteins in the mammalian eye
  JOURNAL   Gene Expr Patterns 17 (1), 31-37 (2015)
   PUBMED   25636444
REFERENCE   5  (bases 1 to 4603)
  AUTHORS   Yang L, Wu L, Yin X, Chen N, Li G and Ma Z.
  TITLE     Novel mutations of CRB1 in Chinese families presenting with retinal
            dystrophies
  JOURNAL   Mol Vis 20, 359-367 (2014)
   PUBMED   24715753
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4603)
  AUTHORS   Kantardzhieva A, Gosens I, Alexeeva S, Punte IM, Versteeg I,
            Krieger E, Neefjes-Mol CA, den Hollander AI, Letteboer SJ, Klooster
            J, Cremers FP, Roepman R and Wijnholds J.
  TITLE     MPP5 recruits MPP4 to the CRB1 complex in photoreceptors
  JOURNAL   Invest Ophthalmol Vis Sci 46 (6), 2192-2201 (2005)
   PUBMED   15914641
REFERENCE   7  (bases 1 to 4603)
  AUTHORS   McKay GJ, Clarke S, Davis JA, Simpson DA and Silvestri G.
  TITLE     Pigmented paravenous chorioretinal atrophy is associated with a
            mutation within the crumbs homolog 1 (CRB1) gene
  JOURNAL   Invest Ophthalmol Vis Sci 46 (1), 322-328 (2005)
   PUBMED   15623792
REFERENCE   8  (bases 1 to 4603)
  AUTHORS   van de Pavert SA, Kantardzhieva A, Malysheva A, Meuleman J,
            Versteeg I, Levelt C, Klooster J, Geiger S, Seeliger MW, Rashbass
            P, Le Bivic A and Wijnholds J.
  TITLE     Crumbs homologue 1 is required for maintenance of photoreceptor
            cell polarization and adhesion during light exposure
  JOURNAL   J Cell Sci 117 (Pt 18), 4169-4177 (2004)
   PUBMED   15316081
REFERENCE   9  (bases 1 to 4603)
  AUTHORS   Mehalow AK, Kameya S, Smith RS, Hawes NL, Denegre JM, Young JA,
            Bechtold L, Haider NB, Tepass U, Heckenlively JR, Chang B, Naggert
            JK and Nishina PM.
  TITLE     CRB1 is essential for external limiting membrane integrity and
            photoreceptor morphogenesis in the mammalian retina
  JOURNAL   Hum Mol Genet 12 (17), 2179-2189 (2003)
   PUBMED   12915475
REFERENCE   10 (bases 1 to 4603)
  AUTHORS   den Hollander AI, ten Brink JB, de Kok YJ, van Soest S, van den
            Born LI, van Driel MA, van de Pol DJ, Payne AM, Bhattacharya SS,
            Kellner U, Hoyng CB, Westerveld A, Brunner HG, Bleeker-Wagemakers
            EM, Deutman AF, Heckenlively JR, Cremers FP and Bergen AA.
  TITLE     Mutations in a human homologue of Drosophila crumbs cause retinitis
            pigmentosa (RP12)
  JOURNAL   Nat Genet 23 (2), 217-221 (1999)
   PUBMED   10508521
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473958.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_222675.4, XM_001067022.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132290, SAMD00132292
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4603
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..4603
                     /gene="Crb1"
                     /note="crumbs cell polarity complex component 1"
                     /db_xref="GeneID:304825"
                     /db_xref="RGD:1309947"
     exon            1..195
                     /gene="Crb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..4343
                     /gene="Crb1"
                     /note="crumbs homolog 1; crumbs family member 1,
                     photoreceptor morphogenesis associated; crumbs 1, cell
                     polarity complex component"
                     /codon_start=1
                     /product="protein crumbs homolog 1 precursor"
                     /protein_id="NP_001100652.1"
                     /db_xref="GeneID:304825"
                     /db_xref="RGD:1309947"
                     /translation="MNMKLKKTAYLLALYLSSSLLICVKNSFCNKNNTRCLSNSCQNN
                     STCKRFPQDSSCCLDTANDLDTDCEDLKDPCLSSPCQGTATCVNIPGERSFLCQCPPG
                     YSGLTCDTATNSCGGNLCQHGGTCHKDPEHPVCICPPGYAGRFCETDHNECDSSPCHN
                     GAVCQDRINGYSCFCVPGYQGRHCDLEVDECVSDPCMNEAVCLNEIGRYTCVCPQEYS
                     GVNCELEIDECGSQPCLHGATCRDALGGYFCDCAPGFLGDHCELNFNECESQPCLHGG
                     LCVDGRNSYHCDCTGSGFRGIHCESLIPLCWSKPCHNDATCEDTVDSYICHCWPGYTG
                     ALCETDINECSSNPCQFGGECAELSSQDLYGNTAGLPSSFSYLGASGYVCICLPGFTG
                     RHCEEDIDECLPNPCLNGGTCQNLPGNYTCHCPFDDTSRTFYGGEDCSEILLGCTHHQ
                     CLNNGKCIPHFQNGQHEFTCQCPSGYAGPLCETVTTLSFESNGFLWVTSGSHTSMGSE
                     CNISLKFQTVQPNALLLVRGNKDMSVKLELLDGCVHLSIEVWNQSKVLLYISHNTSDG
                     EWHLVEVTFAETITLALNGSSCKEKCTTKSSVSIENHQSICALQNSFLGGLPMGTASD
                     SMSVLNIYNVPSTPSFVGCLQDIRFDLNHITLESISSGLSSNVKAGCLRKDWCESQPC
                     QNRGRCINLWQGYRCECDRPYAGSNCLKEYVAGRFGQDDSTGYAAFKVNDNFGQNFNL
                     SMFVRTRQPLGFLLTLGNSTYQYVCVWLEHGSLALKTPGSPKLVANFFLSDGNAHLIS
                     LRIKPNEIELYQSSQNLGFMSVPAWTIQRGDVIFIGGLPDREKTEAYGGFLKGCIQDV
                     RLNSQNLEFFPNSTNSAQHDPVLVNVTQGCPGDNVCKSNPCHNGGVCHSLWDDFSCSC
                     PTNTSGRACDEVQWCQLSPCPPIAECQLVPQGFECIANAAFSGLSSEILFRSNGNITR
                     ELTNITFGFRTQDTNAVILHAEKEPEFLNISIQDSRLLFQLRSGNSFYTLHLTGSQLV
                     NDGAWHRVTFSMIDPRAQTSLWQMEVDDQTPFVISAVATGNLNFLKDNTDIYVGDQAV
                     DNQKGLQGCLSTVQIGGLYLSYFESLHGFTSKPQEEQFLKVSTNVALTGCLPLSACHS
                     SPCLHGGICEDSYSSYRCACLPGWSGAHCEINVDECSSSPCVHGNCSDGVAAYHCRCE
                     PGYTGGNCEAEVDTCKSHQCANGATCVSGAQGYSCLCLGNFTGRFCRHSRLPSTVCGN
                     EKTNFTCYNGGSCSVFQEDWKCVCRPGFTGEWCEENINECASDPCINGGLCRDLVNRF
                     QCICDVAFAGERCELDLADDRLVGIITAVGSGTLVLLFILLLAAIVSLIASNKRATQG
                     TYSPSGQEKAGPRVEMWSRMPPPALERLI"
     exon            196..774
                     /gene="Crb1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..970
                     /gene="Crb1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1110
                     /gene="Crb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1293
                     /gene="Crb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..2250
                     /gene="Crb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2798
                     /gene="Crb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2964
                     /gene="Crb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3871
                     /gene="Crb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3872..4000
                     /gene="Crb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4001..4127
                     /gene="Crb1"
                     /inference="alignment:Splign:2.1.0"
     exon            4128..4603
                     /gene="Crb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catggagggt gggacagaga tggcatcccg gctctctgaa gcacctgctc ctctctgagc
       61 cacacacagt caggagccat ccagggatag cttcatcaac atttcagaga gtgttgaaca
      121 tgaacatgaa gctcaagaaa actgcctacc ttctcgccct ctacctcagt tcctcactgc
      181 tcatctgcgt aaagaattca ttttgcaaca aaaacaatac caggtgtctc tcaaactctt
      241 gccaaaacaa ttctacgtgc aagcgtttcc cacaagacag cagttgttgc ttagacacag
      301 ccaatgattt ggacacagac tgtgaagatc tgaaagaccc ctgcttgtcc agtccctgcc
      361 aaggaaccgc cacttgtgtg aatatcccag gggaaaggag cttcctgtgc caatgtcctc
      421 ccgggtacag tgggctaacc tgtgacactg ccaccaattc ctgtggaggg aatttgtgcc
      481 aacatggagg cacctgccat aaagaccctg agcatcctgt ctgtatctgc cctcctgggt
      541 atgctggaag gttctgtgag acagatcaca atgagtgtga ttctagccct tgccacaatg
      601 gggctgtgtg ccaagacaga atcaacggct actcctgctt ctgtgtgcct ggataccaag
      661 gcaggcattg tgacttggaa gtggatgaat gtgtttctga tccctgcatg aatgaggctg
      721 tgtgcctcaa cgagatagga aggtacactt gtgtctgtcc tcaagagtac tctggcgtga
      781 actgcgagtt ggagattgat gaatgcggat cccagccatg tctacatggt gccacgtgtc
      841 gggacgccct tgggggctac ttctgcgact gtgcacctgg attccttgga gaccactgtg
      901 aactcaactt taatgaatgt gaaagtcagc cgtgtctcca tggaggtcta tgcgtagatg
      961 gaagaaacag ttaccactgt gactgcacgg gtagtggatt cagagggatc cactgtgagt
     1021 ccttgattcc tctttgttgg tcaaagcctt gtcacaatga tgcgacatgt gaagacactg
     1081 ttgacagcta tatttgtcac tgctggcctg gatacacagg tgctctgtgt gagacggaca
     1141 taaatgaatg cagtagcaac ccctgccaat ttggggggga atgtgccgag ctgtcctcac
     1201 aggatctata tggaaacacc gctggcctgc cttcctcctt cagctacctt ggagcctcgg
     1261 gctatgtttg tatctgtctg cctggattca cagggaggca ctgtgaagaa gacattgatg
     1321 aatgtttacc aaacccctgc ctaaatggtg gtacttgtca gaacttgcct gggaattata
     1381 cctgtcactg cccctttgat gatacttcta ggacatttta tggaggagaa gactgctctg
     1441 aaattctcct gggttgcact catcaccagt gtctgaacaa tggaaaatgt atccctcact
     1501 tccaaaacgg ccagcacgaa ttcacctgcc agtgtccttc tggctacgcc ggtccactgt
     1561 gtgaaactgt caccacactt tcttttgaga gcaatggctt cctgtgggtc accagtggct
     1621 cccatacaag catggggtca gaatgtaaca tatccttgaa gtttcagact gttcagccaa
     1681 atgcacttct ccttgtacga ggcaacaagg atatgtctgt gaagctggag ttgctggacg
     1741 gctgtgttca cttatcaatc gaagtctgga atcagtcaaa ggtgctcttg tatatttccc
     1801 ataacaccag tgatggagaa tggcatttgg tggaagtaac attcgcagaa actataaccc
     1861 ttgccctgaa tggcagctcc tgcaaggaga aatgcaccac taagtcttct gtttccattg
     1921 agaatcatca atcaatatgt gctttgcaga actctttttt gggtggctta ccaatgggga
     1981 cagctagcga cagcatgtct gttcttaaca tctataatgt gccgtccaca ccttcctttg
     2041 taggttgtct ccaagatatt agatttgatt tgaatcacat tactctggag agcatttcat
     2101 ctggcttgtc atcaaatgtc aaagcaggct gcctgagaaa ggactggtgt gaaagtcaac
     2161 cctgtcaaaa cagaggacgc tgcatcaact tgtggcaggg ttatcggtgt gaatgtgaca
     2221 ggccctatgc aggctccaac tgcctgaaag agtatgtagc gggaagattt ggccaggatg
     2281 actccaccgg atatgctgcc tttaaagtta atgataattt tggacagaac ttcaatctct
     2341 ccatgtttgt ccgaacacgt caacccctgg gcttccttct gacgttagga aacagtactt
     2401 accagtatgt ctgtgtctgg ctagagcatg gcagtctagc actgaagact ccgggctctc
     2461 ccaagttagt agcaaatttt tttctcagtg atggaaatgc ccacttaata tctttgagaa
     2521 tcaaaccaaa tgaaattgaa ctgtatcagt cttcacaaaa cctaggcttc atgtctgttc
     2581 ctgcatggac aattcaaaga ggagatgtca tcttcattgg tggtctacct gacagagaga
     2641 agactgaagc ttatggtggc ttcctcaaag gctgtattca agatgtaaga ttaaacagcc
     2701 agaatctgga attctttccc aattcaacaa acagtgcaca gcatgatcca gttcttgtca
     2761 atgtgactca aggctgccct ggagacaacg tctgtaagtc caacccctgc cataatggag
     2821 gtgtctgcca ctccctgtgg gatgacttct cctgctcctg ccctacaaac acttcgggga
     2881 gagcctgcga cgaagttcag tggtgtcagc tcagcccatg tcctcccatt gcagaatgcc
     2941 agctggtccc tcaagggttt gaatgtatcg ccaatgctgc tttcagcgga ttaagcagcg
     3001 aaatattgtt cagaagcaat gggaatatta ccagagaact caccaacatc acatttggtt
     3061 tcagaacaca ggatacaaat gcggtgatac tgcatgcaga aaaagaacca gagtttctca
     3121 atattagcat tcaagactcc agactactct ttcaactgcg aagtggcaac agcttttata
     3181 cgctgcatct gacgggttcc caattggtga atgacggcgc atggcaccga gtgacttttt
     3241 ccatgataga cccacgggcc cagacctccc tgtggcagat ggaggtggac gaccagacac
     3301 cctttgtgat aagtgcagtt gctactggaa acctgaactt tctgaaggac aatactgaca
     3361 tctatgtggg tgaccaagct gttgacaatc agaaaggcct gcagggctgt ctgagcacag
     3421 tacagatagg agggctatat ctctcttact ttgaaagtct tcatggtttc actagtaagc
     3481 cccaagaaga gcagtttctc aaagtttcta caaatgtggc acttactggc tgtttgccac
     3541 tcagtgcctg ccactctagc ccctgtctgc atggaggaat ttgcgaagac agctacagct
     3601 cttatcggtg tgcctgtctc ccgggatggt cgggggcaca ctgcgaaatc aacgttgatg
     3661 agtgctcctc cagcccctgt gtccatggca actgctcgga cggggttgca gcctaccact
     3721 gcaggtgtga gcctggctat actggtggga actgtgaagc ggaggtagac acttgcaaga
     3781 gtcatcagtg tgccaatggg gccacctgcg tcagtggcgc tcagggctac tcttgcctct
     3841 gtcttggaaa ttttaccggc agattttgca gacacagcag attaccctca acagtctgtg
     3901 ggaacgagaa gacaaacttc acttgctaca acggaggcag ctgctccgtg ttccaggagg
     3961 actggaaatg tgtgtgccgg ccaggtttca ctggagagtg gtgtgaagag aacatcaatg
     4021 aatgtgcctc tgacccctgc atcaacggag gcctgtgcag ggacttggtc aacagattcc
     4081 agtgcatctg tgatgtggcc tttgcgggcg agcgctgtga gctggatttg gctgatgaca
     4141 ggctcgtggg cattatcacc gccgtgggct ccggaacgtt ggtcctgtta ttcatcctct
     4201 tgcttgctgc aattgtttct cttatcgctt ccaacaagag ggcgactcaa ggaacctaca
     4261 gccccagtgg tcaggagaag gccggccctc gagtggaaat gtggagcagg atgccgcccc
     4321 cagcactgga aaggctcatc taggaagccc cctgctcctc tcagaacaga gcagagcatg
     4381 ttgagtaccc tggtcatgcc ggaccgaagg tggttttaca tcagtagaga tacttactgg
     4441 aactgtcgga agggtttcca tagatacctc atagaccttc ctgagggttc gccttacatg
     4501 actgtttagt tatgtcatcc attcacagaa gagtgtccct gtgtcatgtc tgtcagcctc
     4561 agaattagca aaccatcttc cagacagaga acacagtatt tta
//
