LOCUS       NM_001108085             793 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus CASP2 and RIPK1 domain containing adaptor with
            death domain (Cradd), mRNA.
ACCESSION   NM_001108085 XM_001080418 XM_235061
VERSION     NM_001108085.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 793)
  AUTHORS   Puffenberger EG, Jinks RN, Sougnez C, Cibulskis K, Willert RA,
            Achilly NP, Cassidy RP, Fiorentini CJ, Heiken KF, Lawrence JJ,
            Mahoney MH, Miller CJ, Nair DT, Politi KA, Worcester KN, Setton RA,
            Dipiazza R, Sherman EA, Eastman JT, Francklyn C, Robey-Bond S,
            Rider NL, Gabriel S, Morton DH and Strauss KA.
  TITLE     Genetic mapping and exome sequencing identify variants associated
            with five novel diseases
  JOURNAL   PLoS One 7 (1), e28936 (2012)
   PUBMED   22279524
REFERENCE   2  (bases 1 to 793)
  AUTHORS   Oliver TG, Meylan E, Chang GP, Xue W, Burke JR, Humpton TJ, Hubbard
            D, Bhutkar A and Jacks T.
  TITLE     Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive
            feedback loop
  JOURNAL   Mol Cell 43 (1), 57-71 (2011)
   PUBMED   21726810
REFERENCE   3  (bases 1 to 793)
  AUTHORS   Smith AJ, Karpova Y, D'Agostino R Jr, Willingham M and Kulik G.
  TITLE     Expression of the Bcl-2 protein BAD promotes prostate cancer growth
  JOURNAL   PLoS One 4 (7), e6224 (2009)
   PUBMED   19593445
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 793)
  AUTHORS   Berube C, Boucher LM, Ma W, Wakeham A, Salmena L, Hakem R, Yeh WC,
            Mak TW and Benchimol S.
  TITLE     Apoptosis caused by p53-induced protein with death domain (PIDD)
            depends on the death adapter protein RAIDD
  JOURNAL   Proc Natl Acad Sci U S A 102 (40), 14314-14320 (2005)
   PUBMED   16183742
REFERENCE   5  (bases 1 to 793)
  AUTHORS   Jabado O, Wang Q, Rideout HJ, Yeasmin M, Guo KX, Vekrellis K,
            Papantonis S, Angelastro JM, Troy CM and Stefanis L.
  TITLE     RAIDD aggregation facilitates apoptotic death of PC12 cells and
            sympathetic neurons
  JOURNAL   Cell Death Differ 11 (6), 618-630 (2004)
   PUBMED   14765136
  REMARK    GeneRIF: aggregation is important for its death-promoting effects
            and may play a role in neuronal apoptosis
REFERENCE   6  (bases 1 to 793)
  AUTHORS   Razmara M, Srinivasula SM, Wang L, Poyet JL, Geddes BJ, DiStefano
            PS, Bertin J and Alnemri ES.
  TITLE     CARD-8 protein, a new CARD family member that regulates caspase-1
            activation and apoptosis
  JOURNAL   J Biol Chem 277 (16), 13952-13958 (2002)
   PUBMED   11821383
REFERENCE   7  (bases 1 to 793)
  AUTHORS   Ahmad M, Srinivasula SM, Wang L, Talanian RV, Litwack G,
            Fernandes-Alnemri T and Alnemri ES.
  TITLE     CRADD, a novel human apoptotic adaptor molecule for caspase-2, and
            FasL/tumor necrosis factor receptor-interacting protein RIP
  JOURNAL   Cancer Res 57 (4), 615-619 (1997)
   PUBMED   9044836
REFERENCE   8  (bases 1 to 793)
  AUTHORS   Duan H and Dixit VM.
  TITLE     RAIDD is a new 'death' adaptor molecule
  JOURNAL   Nature 385 (6611), 86-89 (1997)
   PUBMED   8985253
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473960.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_235061.4, XM_001080418.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..793
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q13"
     gene            1..793
                     /gene="Cradd"
                     /gene_synonym="RAIDD"
                     /note="CASP2 and RIPK1 domain containing adaptor with
                     death domain"
                     /db_xref="GeneID:314756"
                     /db_xref="RGD:1311010"
     exon            1..155
                     /gene="Cradd"
                     /gene_synonym="RAIDD"
                     /inference="alignment:Splign:2.1.0"
     exon            156..459
                     /gene="Cradd"
                     /gene_synonym="RAIDD"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..659
                     /gene="Cradd"
                     /gene_synonym="RAIDD"
                     /codon_start=1
                     /product="death domain-containing protein CRADD"
                     /protein_id="NP_001101555.1"
                     /db_xref="GeneID:314756"
                     /db_xref="RGD:1311010"
                     /translation="MDARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEI
                     KAQTTGLRKTMLLLDILPSRGPKAFDTFLDSLQEFPWVREKLEKAREEATAELPTAQP
                     RKDHLPEKPFIIRLITAAPREAAPESLSPVAETAQSGQKGRLDQSNSCPSAPVAATEA
                     CLDQS"
     exon            460..793
                     /gene="Cradd"
                     /gene_synonym="RAIDD"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgccttca acaaagatgg tcgcaatact tcctgtctag gacttttgcc ctcaacaaag
       61 atggtgtttg tggtacaggt tccctatcag tttggattcc ggttgtagtt ttatttattt
      121 atttatttat tttttaacga tacgtggtcg cggacggaga aatggatgcc agagacaagc
      181 aagttctccg ctcactgcgt ctggagctgg gtgctgaggt tctggtagaa ggactggttc
      241 ttcagtacct ttaccaggaa ggaattttga cggaaaacca cattcaagaa atcaaagctc
      301 aaaccacagg cctccggaag acaatgcttt tgctggacat tctgccttcc aggggcccca
      361 aagcctttga caccttccta gattccctcc aggaatttcc ctgggtaaga gagaagctgg
      421 agaaggcaag agaggaagcc acggctgagc tgcctacagc tcagccgaga aaagaccatt
      481 tgcctgagaa gccttttatt attaggctta ttaccgcagc gccaagggag gcagcaccag
      541 agtctctcag tccggtcgcg gagactgctc agtcgggcca gaaggggcgt ttggaccaat
      601 caaactcttg cccctccgca cctgtcgcag ccactgaggc ttgtttggac caatcgtagt
      661 cttgtctctt agcactagtc agtcaccagg cttgagtttc acgccattca tgtggccttt
      721 tgtcttagag cgcgaatcac agccgcccct ccgctagacc cctgggggag tgctgcctct
      781 ctcaccatgc tgg
//
