LOCUS       NM_019301               2094 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus complement C3b/C4b receptor 1 like (Cr1l),
            transcript variant 2, mRNA.
ACCESSION   NM_019301
VERSION     NM_019301.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2094)
  AUTHORS   Detsika,M.G. and Lianos,E.A.
  TITLE     Hemopexin Modulates Expression of Complement Regulatory Proteins in
            Rat Glomeruli
  JOURNAL   Curr Issues Mol Biol 43 (2), 1081-1089 (2021)
   PUBMED   34563046
  REMARK    GeneRIF: Hemopexin Modulates Expression of Complement Regulatory
            Proteins in Rat Glomeruli.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2094)
  AUTHORS   Maehara,N., Arai,S., Mori,M., Iwamura,Y., Kurokawa,J., Kai,T.,
            Kusunoki,S., Taniguchi,K., Ikeda,K., Ohara,O., Yamamura,K.I. and
            Miyazaki,T.
  TITLE     Circulating AIM prevents hepatocellular carcinoma through
            complement activation
  JOURNAL   Cell Rep 9 (1), 61-74 (2014)
   PUBMED   25284781
REFERENCE   3  (bases 1 to 2094)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   4  (bases 1 to 2094)
  AUTHORS   Roversi,P., Johnson,S., Caesar,J.J., McLean,F., Leath,K.J.,
            Tsiftsoglou,S.A., Morgan,B.P., Harris,C.L., Sim,R.B. and Lea,S.M.
  TITLE     Structures of the rat complement regulator CrrY
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 67 (Pt 7), 739-743
            (2011)
   PUBMED   21795784
  REMARK    GeneRIF: structure of rat CrrY domains 1-4 has been determined in
            two distinct crystal forms and reveals a 70 degrees bend between
            domains 3 and 4
REFERENCE   5  (bases 1 to 2094)
  AUTHORS   Renner,B., Coleman,K., Goldberg,R., Amura,C.,
            Holland-Neidermyer,A., Pierce,K., Orth,H.N., Molina,H.,
            Ferreira,V.P., Cortes,C., Pangburn,M.K., Holers,V.M. and
            Thurman,J.M.
  TITLE     The complement inhibitors Crry and factor H are critical for
            preventing autologous complement activation on renal tubular
            epithelial cells
  JOURNAL   J Immunol 185 (5), 3086-3094 (2010)
   PUBMED   20675597
REFERENCE   6  (bases 1 to 2094)
  AUTHORS   Quigg,R.J., Holers,V.M., Morgan,B.P. and Sneed,A.E. 3rd.
  TITLE     Crry and CD59 regulate complement in rat glomerular epithelial
            cells and are inhibited by the nephritogenic antibody of passive
            Heymann nephritis
  JOURNAL   J Immunol 154 (7), 3437-3443 (1995)
   PUBMED   7534798
REFERENCE   7  (bases 1 to 2094)
  AUTHORS   Quigg,R.J., Lo,C.F., Alexander,J.J., Sneed,A.E. 3rd and Moxley,G.
  TITLE     Molecular characterization of rat Crry: widespread distribution of
            two alternative forms of Crry mRNA
  JOURNAL   Immunogenetics 42 (5), 362-367 (1995)
   PUBMED   7590969
REFERENCE   8  (bases 1 to 2094)
  AUTHORS   Quigg,R.J. and Sneed,A.E. 3rd.
  TITLE     Molecular characterization of rat glomerular epithelial cell
            complement receptors
  JOURNAL   J Am Soc Nephrol 4 (11), 1912-1919 (1994)
   PUBMED   7919144
REFERENCE   9  (bases 1 to 2094)
  AUTHORS   Takizawa,H., Okada,N. and Okada,H.
  TITLE     Complement inhibitor of rat cell membrane resembling mouse Crry/p65
  JOURNAL   J Immunol 152 (6), 3032-3038 (1994)
   PUBMED   8144902
REFERENCE   10 (bases 1 to 2094)
  AUTHORS   Sakurada,C., Seno,H., Dohi,N., Takizawa,H., Nonaka,M., Okada,N. and
            Okada,H.
  TITLE     Molecular cloning of the rat complement regulatory protein, 5I2
            antigen
  JOURNAL   Biochem Biophys Res Commun 198 (3), 819-826 (1994)
   PUBMED   8117286
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB775511.1, CB707374.1,
            L36532.1 and D42114.1.
            
            On Oct 4, 2004 this sequence version replaced NM_019301.1.
            
            Summary: This gene encodes a membrane-bound inhibitor of complement
            activation, which contains several tandemly arranged short
            consensus repeats (SCRs) of approximately 60 amino acids. The
            encoded protein may play a role in tumor immune surveillance, which
            is unrelated to complement inhibition. Three alternatively spliced
            transcript variants encoding distinct isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks an in-frame exon, which
            is one of the three identical exons, as compared to variant 1. The
            encoded isoform 2 thus lacks an internal segment, or a short
            consensus repeat, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061736.1, L36532.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676807, SAMN16676810
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               CB775511.1         16-137
            123-239             CB707374.1         75-191
            240-2035            L36532.1           8-1803
            2036-2094           D42114.1           1659-1717
FEATURES             Location/Qualifiers
     source          1..2094
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q27"
     gene            1..2094
                     /gene="Cr1l"
                     /gene_synonym="Cr1; Crry"
                     /note="complement C3b/C4b receptor 1 like"
                     /db_xref="GeneID:54243"
                     /db_xref="RGD:2399"
     exon            1..361
                     /gene="Cr1l"
                     /gene_synonym="Cr1; Crry"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..1935
                     /gene="Cr1l"
                     /gene_synonym="Cr1; Crry"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; 5I2 antigen; complement regulatory protein
                     Crry-like; complement receptor type 1; antigen 5I2;
                     Complement receptor related protein; complement component
                     (3b/4b) receptor 1-like; complement component receptor
                     1-like protein"
                     /codon_start=1
                     /product="complement component receptor 1-like protein
                     isoform 2 precursor"
                     /protein_id="NP_062174.1"
                     /db_xref="GeneID:54243"
                     /db_xref="RGD:2399"
                     /translation="MEASSPLDPVGRLVAFCRGGVHLAVLLLFLSPSTLGQCPAPPLF
                     PYAKPINPTDESTFPVGTSLKYECRPGYIKRQFSITCEVNSVWTSPQDVCIRKQCETP
                     LDPQNGIVHVNTDIRFGSSITYTCNEGYRLIGSSSAMCIISDQSVAWDAEAPICESIP
                     CEIPPSIPNGDFFSPNREDFHYGMVVTYQCNTDARGKKLFNLVGEPSIHCTSIDGQVG
                     VWSGPPPQCIELNKCTPPHVENAVIVSKNKSLFSLRDMVEFRCQDGFMMKGDSSVYCR
                     SLNRWEPQLPSCFKVKSCGAFLGELPNGHVFVPQNLQLGAKVTFVCNTGYQLKGNSSS
                     HCVLDGVESIWNSSVPVCEQVICKLPQDMSGFQKGLQMKKDYYYGDNVALECEDGYTL
                     EGSSQSQCQSDASWDPPLPKCVSQVICKLPQDMSGFQKGLQMKKDYYYGDNVALECED
                     GYTLEGSSQSQCQSDASWDPPLPKCVSRSNSGLIAGIFIGIIVLILFIIFSYWMIMKF
                     KKRNSTNEKCKEVGIYLNSKEDSCVQPQSLLTSQENNSTSSPARNSLTQEV"
     exon            362..541
                     /gene="Cr1l"
                     /gene_synonym="Cr1; Crry"
                     /inference="alignment:Splign:2.1.0"
     exon            542..641
                     /gene="Cr1l"
                     /gene_synonym="Cr1; Crry"
                     /inference="alignment:Splign:2.1.0"
     exon            642..727
                     /gene="Cr1l"
                     /gene_synonym="Cr1; Crry"
                     /inference="alignment:Splign:2.1.0"
     exon            728..1126
                     /gene="Cr1l"
                     /gene_synonym="Cr1; Crry"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1229
                     /gene="Cr1l"
                     /gene_synonym="Cr1; Crry"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1315
                     /gene="Cr1l"
                     /gene_synonym="Cr1; Crry"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1501
                     /gene="Cr1l"
                     /gene_synonym="Cr1; Crry"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1687
                     /gene="Cr1l"
                     /gene_synonym="Cr1; Crry"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1711
                     /gene="Cr1l"
                     /gene_synonym="Cr1; Crry"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1787
                     /gene="Cr1l"
                     /gene_synonym="Cr1; Crry"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1892
                     /gene="Cr1l"
                     /gene_synonym="Cr1; Crry"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2094
                     /gene="Cr1l"
                     /gene_synonym="Cr1; Crry"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1998..2003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cr1l"
                     /gene_synonym="Cr1; Crry"
     polyA_site      2019
                     /gene="Cr1l"
                     /gene_synonym="Cr1; Crry"
                     /experiment="experimental evidence, no additional details
                     recorded"
     polyA_site      2023
                     /gene="Cr1l"
                     /gene_synonym="Cr1; Crry"
                     /experiment="experimental evidence, no additional details
                     recorded"
ORIGIN      
        1 ggtgcttaca aatggaaaac ttccaacagc tgacttacta tggattgatc cagtgcttgc
       61 gttggtgaat caatctcccg aggaaaattc cacagaaatt ccaggagctt ggagtaaaca
      121 agaccccgcc cagcccagga ggaagctgta gttcgagctt cattccggaa cccagcgcca
      181 tttcccgtac tctgggtggg gccgcctcct ccaccgcttt gccgtgagac tgggcttgag
      241 accgctgtga ggggaatgga ggcttcttcg cctctggacc ccgtggggcg ccttgtagcc
      301 ttctgccgcg gaggagtgca tctggccgtc ctgctgctgt tcttgtcgcc atctactttg
      361 ggccagtgcc cagccccacc actgtttcct tatgccaaac ctataaatcc aactgatgaa
      421 tccacgtttc ccgttggaac atctttgaag tatgaatgtc gtccaggata tatcaagagg
      481 cagttctcta tcacctgcga agtaaactca gtgtggacaa gtcctcaaga cgtgtgtata
      541 cgtaaacaat gtgaaactcc tttagatcct cagaatggca tagtacatgt aaacacagac
      601 atccggtttg gatcctctat cacttatacc tgtaatgaag gataccgcct cattggttcc
      661 tcctctgcta tgtgcataat ctctgatcag agcgttgcct gggatgccga ggcacctatt
      721 tgtgaatcaa ttccttgtga gataccccca agcattccca atggagattt cttcagtcct
      781 aacagagaag attttcatta tggaatggta gttacctacc agtgcaacac tgatgcgaga
      841 gggaagaagc tctttaacct ggtgggtgag ccctccatac actgtaccag catcgatggt
      901 caagttggag tctggagtgg ccctcctcct cagtgcattg aactcaacaa atgtactcct
      961 ccccatgttg aaaatgcagt catagtgtct aaaaacaaaa gcttgttttc cttaagggat
     1021 atggtggagt ttagatgtca ggatggcttt atgatgaaag gagacagcag tgtgtattgt
     1081 cgatccctaa acagatggga gcctcagtta ccaagctgct tcaaggtgaa atcctgtggt
     1141 gctttcctgg gtgagcttcc taatgggcat gtattcgttc cacaaaatct tcaactcggg
     1201 gccaaagtga cctttgtttg taatacaggg tatcaattaa aaggcaattc ttctagtcat
     1261 tgtgttcttg atggagtgga aagcatttgg aatagcagcg ttcctgtgtg tgaacaagtg
     1321 atatgtaaac tccctcagga tatgagtgga ttccagaaag ggttgcaaat gaaaaaagat
     1381 tattactatg gagataatgt agccttggaa tgtgaggatg ggtatactct agaaggcagt
     1441 tctcagagcc agtgccagtc cgatgccagc tgggatcctc ctctgcccaa atgtgtctct
     1501 caagtgatat gtaaactccc tcaggatatg agtggattcc agaaagggtt gcaaatgaaa
     1561 aaagattatt actatggaga taatgtagcc ttggaatgtg aggatgggta tactctagaa
     1621 ggcagttctc agagccagtg ccagtccgat gccagctggg atcctcctct gcccaaatgt
     1681 gtctctcgct caaacagtgg tctaatagct ggaattttca ttgggataat cgtccttatt
     1741 ttattcatca ttttttccta ctggatgatt atgaagttta aaaaacgcaa ttccaccaat
     1801 gaaaagtgta aagaagtggg tatctattta aattctaaag aagacagctg tgttcagcct
     1861 cagtctctgc tcacaagtca ggagaacaac agtaccagta gcccagcacg gaattcactc
     1921 actcaagaag tctaatagcc gccatgtaca gtgatgtctc tgaaacgcaa aacatttcct
     1981 gtctgtatca cttttaaaat aaactatttt cttttaaaat ctagatgtgt tgttcataca
     2041 taaggaatgc aacaaactca tggccactca ggatatttaa cttgtttcaa aaat
//
