LOCUS       NM_031766               2150 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus carboxypeptidase Z (Cpz), mRNA.
ACCESSION   NM_031766
VERSION     NM_031766.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2150)
  AUTHORS   Wang,L., Shao,Y.Y. and Ballock,R.T.
  TITLE     Carboxypeptidase Z (CPZ) links thyroid hormone and Wnt signaling
            pathways in growth plate chondrocytes
  JOURNAL   J Bone Miner Res 24 (2), 265-273 (2009)
   PUBMED   18847325
  REMARK    GeneRIF: These data indicate that thyroid hormone may regulate
            terminal differentiation of growth plate chondrocytes in part by
            modulating Wnt signaling pathways through the induction of CPZ and
            subsequent CPZ-enhanced activation of Wnt-4.
REFERENCE   2  (bases 1 to 2150)
  AUTHORS   Genter,M.B., Burman,D.M., Vijayakumar,S., Ebert,C.L. and
            Aronow,B.J.
  TITLE     Genomic analysis of alachlor-induced oncogenesis in rat olfactory
            mucosa
  JOURNAL   Physiol Genomics 12 (1), 35-45 (2002)
   PUBMED   12419858
REFERENCE   3  (bases 1 to 2150)
  AUTHORS   Novikova,E., Fricker,L.D. and Reznik,S.E.
  TITLE     Metallocarboxypeptidase Z is dynamically expressed in mouse
            development
  JOURNAL   Mech Dev 102 (1-2), 259-262 (2001)
   PUBMED   11287206
REFERENCE   4  (bases 1 to 2150)
  AUTHORS   Novikova,E.G., Reznik,S.E., Varlamov,O. and Fricker,L.D.
  TITLE     Carboxypeptidase Z is present in the regulated secretory pathway
            and extracellular matrix in cultured cells and in human tissues
  JOURNAL   J Biol Chem 275 (7), 4865-4870 (2000)
   PUBMED   10671522
REFERENCE   5  (bases 1 to 2150)
  AUTHORS   Xin,X., Day,R., Dong,W., Lei,Y. and Fricker,L.D.
  TITLE     Cloning, sequence analysis, and distribution of rat
            metallocarboxypeptidase Z
  JOURNAL   DNA Cell Biol 17 (4), 311-319 (1998)
   PUBMED   9570147
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF017637.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF017637.1, AF017638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2150
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2150
                     /gene="Cpz"
                     /note="carboxypeptidase Z"
                     /db_xref="GeneID:83575"
                     /db_xref="RGD:620496"
     exon            1..160
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..2022
                     /gene="Cpz"
                     /codon_start=1
                     /product="carboxypeptidase Z precursor"
                     /protein_id="NP_113954.1"
                     /db_xref="GeneID:83575"
                     /db_xref="RGD:620496"
                     /translation="MPTTPLLLAALAALAALAVAAYPSCSPGPDPSGKCQRLASTHSA
                     TCVDLHLRTCADAAYNHTSFPTPLEHRSWEAVEASPEYTLLGVLHFLLEGQCNPDLRL
                     LGCSVLAPRCQGGHTQRPCRRVCEGLREACQPAFDAIDMAWPYFLDCTQYFAPEEEGC
                     YDPLEQLRGELDVEEALPSGLPPTFIRFAHHSYAQMVRVLKRTAARCSQVAKTYSIGR
                     SFEGKDLVVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREILIYLAQYLCSEYLLGN
                     PRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSE
                     YYRLASTRGVRTDHIPISQYYWWGKVAPETKAIMKWIQTIPFVLSASLHGGDLVVSYP
                     FDFSKHPHEEKMFSPTPDEKMFKLLARAYADVHPMMMDRSENRCGGNFLKRGSIINGA
                     DWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYGLWQHNKEPLLNFLEMVHRG
                     IKGVVTDKYGKPVKNARILVKGIRHDVTTAPDGDYWRLLPPGSHIVIAQAPGYSKVMK
                     RVTIPLRMKRAGRVDFILQPLGTGPKNFLPGPSRALPRSLDPQGAPAQLDFEPPRARR
                     QPASGSKPWWWAYFTSLSPHKPRWLLKY"
     exon            161..193
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     exon            194..568
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     exon            569..781
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     exon            782..978
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1140
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1299
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1435
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1575
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1675
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..2144
                     /gene="Cpz"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcgcgctc cccgagtgcc acatcactgc gccctcccgc gcatccgcgc atctgtgccc
       61 accatgccta caacgccgct gctgctggct gcgctagctg ctttggccgc gctggccgtt
      121 gctgcgtacc ccagctgctc gcctggacct gacccctccg gtaaatgtca gagactggcc
      181 tccacacaca gtgccacctg tgtggacctg catctcagga cctgtgcgga tgcggcctat
      241 aaccatacat cgttccccac acccctggag caccgttcgt gggaggcagt ggaggccagc
      301 cctgaataca cactgttggg tgtgctgcac tttctcctgg agggtcagtg caaccctgat
      361 ctgcggctgc tagggtgctc tgtgctggcc cccagatgcc aaggaggcca cacacaaagg
      421 ccctgccgcc gtgtctgtga gggcctgcgg gaggcctgcc agccagcctt tgacgccatc
      481 gacatggcct ggccctactt cctagactgt acccaatact ttgcaccaga ggaggaaggc
      541 tgctatgacc ctctcgaaca gctccgggga gagctggatg tcgaggaggc tctgccctct
      601 ggcctgccac ctaccttcat tcgctttgcc caccactcct atgctcagat ggtccgggta
      661 ctgaagagga cagcggctcg ctgctcccag gtggccaaga cgtacagcat cgggcgcagc
      721 tttgaaggca aggacctggt agtcatcgag ttctcaagcc gtccaggcca gcatgaactg
      781 atggagcctg aggtgaagct cattgggaac atccatggca acgaggtggc aggacgggaa
      841 atactcatct acctggccca gtacctgtgc tccgagtacc tgctgggcaa cccccgtatc
      901 cagcgcctgc tgaacaccac ccgcatccac ctgctgccat ccatgaaccc tgatggctac
      961 gaggtggcgg ctgcagaggg tgctggctac aacggctgga ccagtgggag gcagaatgca
     1021 cagaacctgg atctgaaccg caacttccct gacctcacgt cagagtacta ccggctggcc
     1081 tccactcgcg gtgtgcgcac ggaccacatc cccatctcgc agtactactg gtggggtaag
     1141 gtggcccccg agaccaaggc catcatgaag tggatacaga ccattccctt cgtcctctca
     1201 gccagcctgc atgggggtga cctggtggta tcctacccct tcgacttctc caagcacccc
     1261 catgaggaga agatgttttc tcccactccg gatgagaaga tgtttaagct gctggccaga
     1321 gcctatgctg atgtccaccc catgatgatg gacaggtcgg agaacaggtg tgggggcaac
     1381 ttcctgaagc gggggagcat catcaacggg gcggactggt acagcttcac tggaggtatg
     1441 tctgacttca actacctaca caccaactgc tttgagatca cagtggagct gggatgtgtg
     1501 aagttcccac cagaggaggc gctctacggc ctgtggcaac acaacaagga gcccctactg
     1561 aacttcctgg agatggtaca ccgaggaatc aagggtgtgg tgacagataa atacggaaag
     1621 cccgtcaaaa acgcacggat tctagtgaaa ggcatccgcc atgacgtcac cacagcccct
     1681 gatggtgact attggagact ccttcccccg ggttcgcaca tcgttattgc tcaggcccct
     1741 ggctactcca aggtaatgaa gagagtcacc attcccttgc gcatgaagag ggccggccgt
     1801 gtggacttca tcctccagcc tctggggaca ggacctaaga acttccttcc tggaccttca
     1861 agagccttac ctcggtccct ggatccacag ggagcgcctg cacagctgga ttttgagccc
     1921 cccagggcgc gtaggcagcc agctagtggg agcaagccat ggtggtgggc ttacttcaca
     1981 tccctgagtc cacacaagcc acgctggctt cttaagtact agcacccctc tcaggcccag
     2041 ccctgatgtc cacctccacg gcccgggctt ctgtctggag tctgccagcc acagacatca
     2101 cacacagcct ctgcggctta ttaaagtgtg tttacccact gtgaaaaaaa
//
