LOCUS       NM_001106306            3498 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus carboxypeptidase X (M14 family), member 2
            (Cpxm2), mRNA.
ACCESSION   NM_001106306 XM_001054321 XM_215106
VERSION     NM_001106306.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3498)
  AUTHORS   Grabowski K, Herlan L, Witten A, Qadri F, Eisenreich A, Lindner D,
            Schadlich M, Schulz A, Subrova J, Mhatre KN, Primessnig U, Plehm R,
            van Linthout S, Escher F, Bader M, Stoll M, Westermann D, Heinzel
            FR and Kreutz R.
  TITLE     Cpxm2 as a novel candidate for cardiac hypertrophy and failure in
            hypertension
  JOURNAL   Hypertens Res 45 (2), 292-307 (2022)
   PUBMED   34916661
  REMARK    GeneRIF: Cpxm2 as a novel candidate for cardiac hypertrophy and
            failure in hypertension.
REFERENCE   2  (bases 1 to 3498)
  AUTHORS   Didangelos A, Yin X, Mandal K, Baumert M, Jahangiri M and Mayr M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   3  (bases 1 to 3498)
  AUTHORS   Xin X, Day R, Dong W, Lei Y and Fricker LD.
  TITLE     Identification of mouse CPX-2, a novel member of the
            metallocarboxypeptidase gene family: cDNA cloning, mRNA
            distribution, and protein expression and characterization
  JOURNAL   DNA Cell Biol 17 (10), 897-909 (1998)
   PUBMED   9809751
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001054321.1, XM_215106.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3498
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..3498
                     /gene="Cpxm2"
                     /gene_synonym="RGD1310955"
                     /note="carboxypeptidase X (M14 family), member 2"
                     /db_xref="GeneID:293566"
                     /db_xref="RGD:1310955"
     exon            1..458
                     /gene="Cpxm2"
                     /gene_synonym="RGD1310955"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..2425
                     /gene="Cpxm2"
                     /gene_synonym="RGD1310955"
                     /note="inactive carboxypeptidase-like protein X2;
                     carboxypeptidase X 2 (M14 family); carboxypeptidase X2;
                     metallocarboxypeptidase 2"
                     /codon_start=1
                     /product="inactive carboxypeptidase-like protein X2
                     precursor"
                     /protein_id="NP_001099776.1"
                     /db_xref="GeneID:293566"
                     /db_xref="RGD:1310955"
                     /translation="MARLGTAFPAVALALVAVALAGVRAQGEAFEEPDYYSQELWRRG
                     RYYENGEPEPEPELFSPSQHEDLRVEEQEQQEPHQQGPRKPKKATKPKKAPKREKLVA
                     ETPPPGKNSNRKGRRSKNLEKAARDDHGVPVVREDVRESCPPLGLETLKITDFQLHAS
                     TTKRYGLGAHRGRLNIQAGINENDFYDGAWCAGRNDLHQWIEVDARRLTKFTGVITQG
                     RNSLWLSDWVTSYKVMVSNDSHTWVTVKNGSGDMIFEGNNEKETPVLNELPVPMVARY
                     IRINPQSWFDNGSICMRMEILGCPLPDPNNYYHRRNEMTTTDDLDFKHHNYKEMRQLM
                     KVVNEMCPNITRIYNIGKSHQGLKLYAVEISDHPGEHEVGEPEFHYIAGAHGNEVLGR
                     ELLLLLLEFLCQEYLAQNTRIVRLVEETRIHILPSLNPDGYEKAYEGGSELGGWSLGR
                     WTHDGIDINNNFPDLNTLLWEAEDRQNAPRKVPNHYIAIPEWFLSENATVAMETRAII
                     AWMEKIPFVLGGNLQGGELVVAYPYDMVRSLWKTQEHTPTPDDHVFRWLAYSYASTHR
                     LMTDARRRVCHTEEFQKEEGTVNGASWHTVAGSLNDFSYLHTNCFELSIYVGCDKYPH
                     ESELPEEWENNRESLIVFMEQVHRGIKGIVRDLQGKGISNAIISVEGVNHDIRTASDG
                     DYWRLLNPGEYVVTAKAEGFITSTKNCMVGYDMGATRCDFTLSKTNLARIREIMETFG
                     KQPVNLPARRLKLRGRKRRQRG"
     exon            459..557
                     /gene="Cpxm2"
                     /gene_synonym="RGD1310955"
                     /inference="alignment:Splign:2.1.0"
     exon            558..667
                     /gene="Cpxm2"
                     /gene_synonym="RGD1310955"
                     /inference="alignment:Splign:2.1.0"
     exon            668..807
                     /gene="Cpxm2"
                     /gene_synonym="RGD1310955"
                     /inference="alignment:Splign:2.1.0"
     exon            808..892
                     /gene="Cpxm2"
                     /gene_synonym="RGD1310955"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1043
                     /gene="Cpxm2"
                     /gene_synonym="RGD1310955"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1132
                     /gene="Cpxm2"
                     /gene_synonym="RGD1310955"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1256
                     /gene="Cpxm2"
                     /gene_synonym="RGD1310955"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1453
                     /gene="Cpxm2"
                     /gene_synonym="RGD1310955"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1633
                     /gene="Cpxm2"
                     /gene_synonym="RGD1310955"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1931
                     /gene="Cpxm2"
                     /gene_synonym="RGD1310955"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2071
                     /gene="Cpxm2"
                     /gene_synonym="RGD1310955"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2171
                     /gene="Cpxm2"
                     /gene_synonym="RGD1310955"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..3498
                     /gene="Cpxm2"
                     /gene_synonym="RGD1310955"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcctgtcc cacccatcat ctgcacccgc tgcagcgccc gcgcccccgt cccgggccat
       61 agccatcatt tgtagcccgc ctgctgctcc cggggaccgg gacgcgactc agcccgggtt
      121 gcgggataga gcgggcatgg cccgtctggg gaccgccttc cccgcggtgg ccctggcact
      181 tgtggcagtg gccctggctg gagtcagagc ccagggcgaa gccttcgagg agcctgacta
      241 ttacagccag gagctctgga ggcgcgggcg ctactatgag aatggggagc cagagcctga
      301 gccggagctc ttctcgcctt cacagcatga ggacctacgg gtggaggagc aggaacagca
      361 ggagccgcac cagcaggggc ccaggaagcc caagaaggcc actaagccca aaaaggctcc
      421 caagagggag aagttagttg cagagacgcc tccaccaggt aaaaatagca acagaaaagg
      481 cagaaggagc aagaatcttg agaaagctgc ccgcgatgac catggtgtcc ctgtggttcg
      541 tgaggatgtc agagagagtt gtccacctct tggtctggaa acattaaaaa tcacagactt
      601 ccagctacat gcctccacaa caaagcgtta tggtctggga gcccatcgtg ggagactcaa
      661 catccaggca ggcattaatg aaaacgactt ttacgatggg gcttggtgtg ccggtaggaa
      721 cgacttgcat cagtggatcg aagtggacgc ccggcgcctg actaagttca caggggtcat
      781 tacccaagga aggaactctc tctggctgag tgactgggtg acgtcctaca aagtcatggt
      841 gagcaatgac agccacacat gggttaccgt gaagaatgga tctggtgaca tgatatttga
      901 aggaaacaat gagaaggaga cccctgtgct caatgagctg ccagtcccca tggtggcccg
      961 ctacattcgc ataaaccctc agtcctggtt tgataatggg agcatctgta tgaggatgga
     1021 gatcttgggc tgcccactgc cagatcctaa taactattat caccgacgta atgagatgac
     1081 caccactgat gacctggatt ttaagcacca caactataag gaaatgcgcc agttgatgaa
     1141 ggttgtgaat gagatgtgcc ccaatattac caggatttac aacattggca aaagtcacca
     1201 gggcctgaag ttgtatgcag tagagatttc tgaccatcct ggggaacacg aagttggtga
     1261 gcccgagttc cactacatcg caggggccca tggcaatgag gttctgggcc gagagctgct
     1321 gctgctgctg ctggagttcc tctgccagga gtacttggcg cagaacacac gcatcgtccg
     1381 cttggtggag gagactcgga ttcacattct accctccctc aatcctgatg gctatgaaaa
     1441 ggcctatgaa ggaggttccg agttgggagg ctggtccctg ggacgttgga cccatgatgg
     1501 cattgacatc aacaacaact ttccggattt aaacacgctg ctctgggagg cagaggaccg
     1561 gcagaacgcc ccaaggaaag ttcccaacca ctacattgcc atccctgagt ggtttctgtc
     1621 tgagaatgcc acagtggcca tggagaccag agccatcatt gcttggatgg agaagatccc
     1681 gtttgtgctg ggaggcaacc tacagggggg tgagctggtt gtagcatacc cctacgacat
     1741 ggtgcggtcc ctgtggaaga cccaggagca caccccgaca cccgacgatc acgtgttccg
     1801 ctggctggct tactcttatg cctccactca ccgcctcatg accgatgcca ggaggcgagt
     1861 gtgccacaca gaggaatttc agaaggaaga aggcaccgtc aatggggctt cctggcacac
     1921 cgtggctgga agtctaaatg acttcagtta cctccatacg aactgctttg agctgtccat
     1981 ctacgtgggc tgcgataaat acccacacga gagtgagctg cccgaggaat gggagaataa
     2041 ccgggagtct ctgattgtgt tcatggaaca ggttcatcga ggcatcaaag gcatagtgag
     2101 agacttacaa gggaaaggga tttctaatgc catcatctct gtggaaggtg ttaaccatga
     2161 catccggaca gccagcgatg gggattattg gcgcctactg aaccctggtg aatacgtggt
     2221 cacagcgaaa gcagaaggct ttatcacctc caccaagaac tgcatggttg gctatgacat
     2281 gggagcaact cggtgtgact tcacactcag caagaccaac ctggctagga taagagaaat
     2341 catggagaca tttgggaagc agcctgtcaa cctacctgcc aggcgcctga agctgcgggg
     2401 acgaaaaagg cggcagcgcg ggtgactctc ttggacactt gagacatacc ccagactgtg
     2461 caaataaaat ccactccagt agtaactctg tagcaggctc tccctgttgt tttgactgta
     2521 attcaagaga cacccaggag catgcccgca tagcttggct ggccccaaag gggagggctg
     2581 gcggctcagg gtgttttctt tcctttgttc tcatttatcc aaataccttg gacagagcag
     2641 cagagaaagg ctggtggcag tgagggaatt cagtctgaga atctgaacca ctggccagga
     2701 agggaagcca ggccttcccc tgtttgcgtg acatccaagt ttgccagtgc atttgcaaat
     2761 ggcacagttg acattgcagc acttcgcccc agatgttatc atgtgagatg ctcttatgca
     2821 gcctaagaaa atccatcctc cttggcccca ggggacaatc taagcttcag tatatgcact
     2881 ctgcattcta ttgacaatag aggcatttat taccaagtgt gcatcgctga gtcctaagtc
     2941 agttctgatc ctttttccaa caaagctagt cttcctaagg gcagacagaa gtggaaagca
     3001 tctgagagtg attgctgggc agcagacctt gcggggtttg ttacatgccg agagagcccc
     3061 taaacccttt gctactccat tagccttttg gggtggggag agccagactt cttaaggagg
     3121 ctagagcaga tagtctgggc catcctggaa aagagcttga aggaagcaaa accagaattt
     3181 ctttctcttg ctccaggata ggagagctcc aagttggccc cccgtcagga ggggagttac
     3241 gatgagcata caggaggcca catctttcca atcaagcatc atctaatgaa aaagcaagca
     3301 atcttaggat tacctgggac acatcagtct gggagaggtg gttgaatcat tgtgtaaggg
     3361 aatagtaggt ctcatctctg ttcgtcctgc tgccttgttg acctgggaag aatgaaacaa
     3421 gcaagcaagc aagcaagcaa gcaaacaaac aaacaaacaa acaaataaat aaataaataa
     3481 agcaaatggt aagattct
//
