LOCUS       NM_012930               2296 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus carnitine palmitoyltransferase 2 (Cpt2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_012930
VERSION     NM_012930.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2296)
  AUTHORS   Li,J., Ni,Y., Zhang,Y. and Liu,H.
  TITLE     GBA3 promotes fatty acid oxidation and alleviates non-alcoholic
            fatty liver by increasing CPT2 transcription
  JOURNAL   Aging (Albany NY) 16 (5), 4591-4608 (2024)
   PUBMED   38428407
  REMARK    GeneRIF: GBA3 promotes fatty acid oxidation and alleviates
            non-alcoholic fatty liver by increasing CPT2 transcription.
REFERENCE   2  (bases 1 to 2296)
  AUTHORS   Akieda,K., Takegawa,K., Ito,T., Nagayama,G., Yamazaki,N.,
            Nagasaki,Y., Nishino,K., Kosako,H. and Shinohara,Y.
  TITLE     Unique Behavior of Bacterially Expressed Rat Carnitine
            Palmitoyltransferase 2 and Its Catalytic Activity
  JOURNAL   Biol Pharm Bull 47 (1), 23-27 (2024)
   PUBMED   38171776
  REMARK    GeneRIF: Unique Behavior of Bacterially Expressed Rat Carnitine
            Palmitoyltransferase 2 and Its Catalytic Activity.
REFERENCE   3  (bases 1 to 2296)
  AUTHORS   Gunasti,O., Ozdemir,C., Ozgunen,K.T., Yilmaz,M.B., Oksuz,H.,
            Zorludemir,S. and Kurdak,S.S.
  TITLE     The effects of exercise on skeletal and heart muscle citrate
            synthase and carnitine palmitoyltransferase mRNA expressions in
            high-calorie fed rats
  JOURNAL   Gen Physiol Biophys 40 (4), 341-350 (2021)
   PUBMED   34350838
  REMARK    GeneRIF: The effects of exercise on skeletal and heart muscle
            citrate synthase and carnitine palmitoyltransferase mRNA
            expressions in high-calorie fed rats.
REFERENCE   4  (bases 1 to 2296)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2296)
  AUTHORS   Gu,J.J., Yao,M., Yang,J., Cai,Y., Zheng,W.J., Wang,L., Yao,D.B. and
            Yao,D.F.
  TITLE     Mitochondrial carnitine palmitoyl transferase-II inactivity
            aggravates lipid accumulation in rat hepatocarcinogenesis
  JOURNAL   World J Gastroenterol 23 (2), 256-264 (2017)
   PUBMED   28127199
  REMARK    GeneRIF: Low CPT-II expression might lead to abnormal hepatic lipid
            accumulation, which should promote the malignant transformation of
            hepatocytes.
REFERENCE   6  (bases 1 to 2296)
  AUTHORS   de Vries,Y., Arvidson,D.N., Waterham,H.R., Cregg,J.M. and
            Woldegiorgis,G.
  TITLE     Functional characterization of mitochondrial carnitine
            palmitoyltransferases I and II expressed in the yeast Pichia
            pastoris
  JOURNAL   Biochemistry 36 (17), 5285-5292 (1997)
   PUBMED   9136891
REFERENCE   7  (bases 1 to 2296)
  AUTHORS   Verderio,E., Cavadini,P., Montermini,L., Wang,H., Lamantea,E.,
            Finocchiaro,G., DiDonato,S., Gellera,C. and Taroni,F.
  TITLE     Carnitine palmitoyltransferase II deficiency: structure of the gene
            and characterization of two novel disease-causing mutations
  JOURNAL   Hum Mol Genet 4 (1), 19-29 (1995)
   PUBMED   7711730
REFERENCE   8  (bases 1 to 2296)
  AUTHORS   Taroni,F., Verderio,E., Fiorucci,S., Cavadini,P., Finocchiaro,G.,
            Uziel,G., Lamantea,E., Gellera,C. and DiDonato,S.
  TITLE     Molecular characterization of inherited carnitine
            palmitoyltransferase II deficiency
  JOURNAL   Proc Natl Acad Sci U S A 89 (18), 8429-8433 (1992)
   PUBMED   1528846
REFERENCE   9  (bases 1 to 2296)
  AUTHORS   Brown,N.F., Esser,V., Gonzalez,A.D., Evans,C.T., Slaughter,C.A.,
            Foster,D.W. and McGarry,J.D.
  TITLE     Mitochondrial import and processing of rat liver carnitine
            palmitoyltransferase II defines the amino terminus of the mature
            protein. Possibility of differential modification of the rat and
            human isoforms
  JOURNAL   J Biol Chem 266 (23), 15446-15449 (1991)
   PUBMED   1869564
REFERENCE   10 (bases 1 to 2296)
  AUTHORS   Woeltje,K.F., Esser,V., Weis,B.C., Sen,A., Cox,W.F., McPhaul,M.J.,
            Slaughter,C.A., Foster,D.W. and McGarry,J.D.
  TITLE     Cloning, sequencing, and expression of a cDNA encoding rat liver
            mitochondrial carnitine palmitoyltransferase II
  JOURNAL   J Biol Chem 265 (18), 10720-10725 (1990)
   PUBMED   2355018
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J05470.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_012930.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05470.1, U88295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2296
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..2296
                     /gene="Cpt2"
                     /gene_synonym="CPTII"
                     /note="carnitine palmitoyltransferase 2"
                     /db_xref="GeneID:25413"
                     /db_xref="RGD:2398"
     exon            1..214
                     /gene="Cpt2"
                     /gene_synonym="CPTII"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..2039
                     /gene="Cpt2"
                     /gene_synonym="CPTII"
                     /EC_number="2.3.1.21"
                     /note="carnitine O-palmitoyltransferase 2, mitochondrial;
                     CPT II; carnitine palmitoyltransferase II"
                     /codon_start=1
                     /product="carnitine O-palmitoyltransferase 2,
                     mitochondrial precursor"
                     /protein_id="NP_037062.1"
                     /db_xref="GeneID:25413"
                     /db_xref="RGD:2398"
                     /translation="MMPRLLFRAWPRCPSLVLGAPSRPLSAVSGPDDYLQHSIVPTMH
                     YQDSLPRLPIPKLEDTMKRYLNAQKPLLDDSQFRRTEALCKNFETGVGKELHAHLLAQ
                     DKQNKHTSYISGPWFDMYLTARDSIVLNFNPFMAFNPDPKSEYNDQLTRATNLTVSAV
                     RFLKTLQAGLLEPEVFHLNPSKSDTDAFKRLIRFVPPSLSWYGAYLVNAYPLDMSQYF
                     RLFNSTRIPRPNRDELFTDTKARHLLVLRKGHFYVFDVLDQDGNIVNPLEIQAHLKYI
                     LSDSSPVPEFPVAYLTSENRDVWAELRQKLIFDGNEETLKKVDSAVFCLCLDDFPMKD
                     LIHLSHTMLHGDGTNRWFDKSFNLIVAEDGTAAVHFEHSWGDGVAVLRFFNEVFRDST
                     QTPAITPQSQPAATNSSASVETLSFNLSGALKAGITAAKEKFDTTVKTLSIDSIQFQR
                     GGKEFLKKKQLSPDAVAQLAFQMAFLRQYGQTVATYESCSTAAFKHGRTETIRPASIF
                     TKRCSEAFVRDPSKHSVGELQHMMAECSKYHGQLTKEAAMGQGFDRHLYALRYLATAR
                     GLNLPELYLDPAYQQMNHNILSTSTLNSPAVSLGGFAPVVPDGFGIAYAVHDDWIGCN
                     VSSYSGRNAREFLHCVQKCLEDIFDALEGKAIKT"
     exon            215..295
                     /gene="Cpt2"
                     /gene_synonym="CPTII"
                     /inference="alignment:Splign:2.1.0"
     exon            296..402
                     /gene="Cpt2"
                     /gene_synonym="CPTII"
                     /inference="alignment:Splign:2.1.0"
     exon            403..1707
                     /gene="Cpt2"
                     /gene_synonym="CPTII"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..2296
                     /gene="Cpt2"
                     /gene_synonym="CPTII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgcttgct caggaactcc ctcagccgcc gcgttctcta gccgccgttg ctgcccggga
       61 cgatgatgcc gcgcctgctg tttcgtgcct ggccccgctg cccctcgctt gtcctgggag
      121 cccctagtag gcccttaagt gctgtctcgg ggccggacga ttatctgcag cacagcatcg
      181 tgcccaccat gcactaccag gacagcctgc ccaggctgcc tatccctaaa cttgaagaca
      241 ccatgaagag atacctcaat gcacagaagc ctctcttgga tgacagccag ttcaggagaa
      301 cagaagcgtt gtgtaagaat tttgagactg gcgttgggaa ggagctgcat gcccacctgc
      361 ttgctcagga taagcagaat aagcacacca gctacatctc aggcccctgg ttcgatatgt
      421 atttaactgc tcgagactct atcgttttaa actttaatcc atttatggca ttcaatccgg
      481 acccaaagtc tgagtataat gaccagctta ccagggcaac caacttgact gtttctgcag
      541 tccggtttct gaagacactt caggctggcc ttttagaacc agaagtgttc cacttgaacc
      601 cttccaaaag tgacacagac gccttcaaaa gactcattcg ctttgttcct ccctctctgt
      661 cctggtatgg agcctacctg gtcaacgcat atcccctgga tatgtcccag tatttccggc
      721 ttttcaattc aactcgtata cccagaccca atcgtgatga actctttact gacaccaagg
      781 ctagacacct cctggtccta agaaaaggac atttctatgt ctttgatgtc ctcgatcaag
      841 atgggaacat tgtgaatccc ttagagattc aggcacatct aaagtacatt ctctcagaca
      901 gcagccctgt gcccgagttt cctgtggcat atctgaccag tgagaaccga gatgtctggg
      961 cagagctcag acagaagttg atttttgatg gcaatgagga aaccctgaag aaagtggact
     1021 ctgctgtctt ctgcctctgc ctagatgact tcccgatgaa ggatcttatt cacttgtcac
     1081 acaccatgct gcacggcgat ggcacaaacc gctggtttga taagtccttt aacctcattg
     1141 tagccgagga cggcactgct gcagtccact tcgagcactc gtggggggat ggggtggcag
     1201 tgcttaggtt tttcaatgaa gtgttcagag acagcactca gacccctgcc atcactcccc
     1261 agagccagcc tgccgccacc aactcctctg cgtctgtgga gacgctcagc ttcaacctca
     1321 gcggtgctct caaggctggc atcactgctg ccaaggagaa gttcgacacc acggtgaaaa
     1381 ccctcagcat tgactccatt cagttccaga gaggtggcaa ggagttcctg aagaagaagc
     1441 agctgagccc cgatgcggtg gcccagctgg ccttccagat ggccttcctg agacagtatg
     1501 gccagacggt ggctacctat gagtcctgca gcactgcagc cttcaagcac ggccgcacag
     1561 agactatccg cccagcctcc atctttacta agagatgctc cgaggcgttt gtcagggacc
     1621 cctccaagca cagtgtgggc gagcttcagc acatgatggc tgagtgttcc aaataccatg
     1681 gccagctgac caaagaagca gcgatgggcc agggctttga ccgacacttg tatgctctgc
     1741 gctatctggc aacggccaga ggactcaacc tacctgagct ctatctggat cctgcatacc
     1801 agcagatgaa ccacaacatc ctgtccacca gcactctgaa cagcccagca gtgagccttg
     1861 ggggctttgc ccctgtggtc cctgatggct ttggcattgc atatgctgtt cacgatgact
     1921 ggataggctg caatgtctcc tcctactcag gacgcaatgc ccgagagttt ctccactgtg
     1981 tccagaagtg cttggaagac attttcgatg ctctagaagg caaagccatc aaaacttagc
     2041 ttcctagtcg ctgaaaagcc tccattcttc ctcatgaaca tggatgttca tgtagctgga
     2101 aggtgccatc ttgtgcccaa caaaactaat cccaaggtgc ttccacagcc agtgctgcag
     2161 gctgagctgg aagagcccaa ctgaaggtag tgagaggtcg cagctgtaaa gccctctttg
     2221 ttcaggagat agggtttgga aaactaactc agctgtattt attgtttaaa tagaaataaa
     2281 acctggtgtt gcttag
//
