LOCUS       NM_001034925            2747 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus carnitine palmitoyltransferase 1c (Cpt1c), mRNA.
ACCESSION   NM_001034925 XM_218625
VERSION     NM_001034925.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2747)
  AUTHORS   Fado,R., Soto,D., Minano-Molina,A.J., Pozo,M., Carrasco,P.,
            Yefimenko,N., Rodriguez-Alvarez,J. and Casals,N.
  TITLE     Novel Regulation of the Synthesis of
            alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA)
            Receptor Subunit GluA1 by Carnitine Palmitoyltransferase 1C (CPT1C)
            in the Hippocampus
  JOURNAL   J Biol Chem 290 (42), 25548-25560 (2015)
   PUBMED   26338711
REFERENCE   2  (bases 1 to 2747)
  AUTHORS   Rinaldi,C., Schmidt,T., Situ,A.J., Johnson,J.O., Lee,P.R.,
            Chen,K.L., Bott,L.C., Fado,R., Harmison,G.H., Parodi,S.,
            Grunseich,C., Renvoise,B., Biesecker,L.G., De Michele,G.,
            Santorelli,F.M., Filla,A., Stevanin,G., Durr,A., Brice,A.,
            Casals,N., Traynor,B.J., Blackstone,C., Ulmer,T.S. and
            Fischbeck,K.H.
  TITLE     Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic
            Paraplegia
  JOURNAL   JAMA Neurol 72 (5), 561-570 (2015)
   PUBMED   25751282
  REMARK    Erratum:[JAMA Neurol. 2015 May;72(5):608. doi:
            10.1001/jamaneurol.2015.0528.. PMID: 25961183]
REFERENCE   3  (bases 1 to 2747)
  AUTHORS   Hada,T., Yamamoto,T., Yamamoto,A., Ohkura,K., Yamazaki,N.,
            Takiguchi,Y. and Shinohara,Y.
  TITLE     Comparison of the catalytic activities of three isozymes of
            carnitine palmitoyltransferase 1 expressed in COS7 cells
  JOURNAL   Appl Biochem Biotechnol 172 (3), 1486-1496 (2014)
   PUBMED   24222496
REFERENCE   4  (bases 1 to 2747)
  AUTHORS   Carrasco,P., Sahun,I., McDonald,J., Ramirez,S., Jacas,J.,
            Gratacos,E., Sierra,A.Y., Serra,D., Herrero,L., Acker-Palmer,A.,
            Hegardt,F.G., Dierssen,M. and Casals,N.
  TITLE     Ceramide levels regulated by carnitine palmitoyltransferase 1C
            control dendritic spine maturation and cognition
  JOURNAL   J Biol Chem 287 (25), 21224-21232 (2012)
   PUBMED   22539351
REFERENCE   5  (bases 1 to 2747)
  AUTHORS   Schwenk,J., Harmel,N., Brechet,A., Zolles,G., Berkefeld,H.,
            Muller,C.S., Bildl,W., Baehrens,D., Huber,B., Kulik,A., Klocker,N.,
            Schulte,U. and Fakler,B.
  TITLE     High-resolution proteomics unravel architecture and molecular
            diversity of native AMPA receptor complexes
  JOURNAL   Neuron 74 (4), 621-633 (2012)
   PUBMED   22632720
REFERENCE   6  (bases 1 to 2747)
  AUTHORS   Lohse,I., Reilly,P. and Zaugg,K.
  TITLE     The CPT1C 5'UTR contains a repressing upstream open reading frame
            that is regulated by cellular energy availability and AMPK
  JOURNAL   PLoS One 6 (9), e21486 (2011)
   PUBMED   21961029
REFERENCE   7  (bases 1 to 2747)
  AUTHORS   Roomets,E., Kivela,T. and Tyni,T.
  TITLE     Carnitine palmitoyltransferase I and Acyl-CoA dehydrogenase 9 in
            retina: insights of retinopathy in mitochondrial trifunctional
            protein defects
  JOURNAL   Invest Ophthalmol Vis Sci 49 (4), 1660-1664 (2008)
   PUBMED   18385088
  REMARK    GeneRIF: Accumulation of 3-hydroxylated intermediates of long-chain
            fatty acids may contribute to the pathogenesis of retinopathy in
            MTP deficiencies.
REFERENCE   8  (bases 1 to 2747)
  AUTHORS   Sierra,A.Y., Gratacos,E., Carrasco,P., Clotet,J., Urena,J.,
            Serra,D., Asins,G., Hegardt,F.G. and Casals,N.
  TITLE     CPT1c is localized in endoplasmic reticulum of neurons and has
            carnitine palmitoyltransferase activity
  JOURNAL   J Biol Chem 283 (11), 6878-6885 (2008)
   PUBMED   18192268
  REMARK    GeneRIF: CPT1c is localized in endoplasmic reticulum of neurons and
            has carnitine palmitoyltransferase activity
            Erratum:[J Biol Chem. 2008 May 2;283(18):12680]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB802617.1, JAXUCZ010000001.1, CB698393.1, CB544967.1, CK598550.1
            and BC105882.1.
            
            On Sep 6, 2008 this sequence version replaced NM_001034925.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.542863.1,
                                           SRR26360172.2467922.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-411               CB802617.1         1-411
            412-476             JAXUCZ010000001.1  104591973-104592037 c
            477-661             CB698393.1         1-185
            662-876             CB544967.1         220-434
            877-1436            CK598550.1         80-639
            1437-2747           BC105882.1         200-1510
FEATURES             Location/Qualifiers
     source          1..2747
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2747
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /note="carnitine palmitoyltransferase 1c"
                     /db_xref="GeneID:308579"
                     /db_xref="RGD:1305384"
     exon            1..184
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            185..339
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..2604
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /EC_number="3.1.2.22"
                     /note="carnitine palmitoyltransferase I"
                     /codon_start=1
                     /product="palmitoyl thioesterase CPT1C"
                     /protein_id="NP_001030097.2"
                     /db_xref="GeneID:308579"
                     /db_xref="RGD:1305384"
                     /translation="MAEAHQASSLLSSLSSDGAEVELSSSVWQEIYLSALRSWKRNLW
                     RVWNDFLAGVVPATPLSWLFLFSTIQLACLLQLDPSLGLMEKIKELLPDWGGQHHQLQ
                     GLLAAAVFASCLWGTLIFTLHVALRLLLSHHGWLLEPHGTMSSPTKTWLALVRIFSGR
                     HPRLFSFQRALPRQPVPGAQETVRKYLESMRPVLRDDAFDSVVALANDFLRLQAPRLQ
                     LYLQLKSWCASNYVSDWWEEFVYLRSRGSLVNSTYYMMDFLYVTPTPLQAARAGNAVH
                     TLLLYRHLLNRQEIPPTLLMGMRPLCSAQYERMFNTTRIPGVEKDYLCHLQDSQHVAV
                     FHQGRFFRVGTHSSNGLLSPRALEQQFQYILDDPSPACPLEEHLAALTAAPRSMWAQV
                     RESVKTHAATALETVEGAAFFVSLDSEPAGLTRENPAASLDTYAHTLLTGQGHDRWFD
                     KSFTLIVFSNGKLGLSVEHSWADCPVAGHLWEFTLATECFQLGYATDGHCKGHPDPAL
                     PKPQRLQWDLPKQIQPSISLALRGAKTLSGNIDCHVFPFFHFGKSFIKGCHVSSDSFI
                     QLVLQLAHFRDRGQFCLTYESAMTRLFLEGRTETVRSCTREACQFVRAMENKERTDQQ
                     CLALFREAVDKHQALLKAAMSGQGIDRHLFALYIMSRLLHMQSPFLTQVQSQQWLLST
                     SQIPVQQTHLFDVHNYPDYVSSGGGFGPAHDHGYGVSYIFMGENAISFHISSKQSSTE
                     TDSHRLGQHIEDALLDVASLFQAGQQFKRQFTGLGESSGWKYSNLSCKTVDPNIPKSS
                     TNL"
     exon            340..479
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            480..651
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            652..753
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            754..891
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            892..966
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1074
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1159
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1355
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1538
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1644
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1761
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1926
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2061
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2214
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2328
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2421
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2731
                     /gene="Cpt1c"
                     /gene_synonym="CPT I-C; CPT IC; CPT1-B; CPTI-B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggaggtgcc cgcaaggtgg ctctgggttt cgggataaca gccaaagacg gttgatcagt
       61 tcgtggattc attacacggg gattagatgt atgtacaagg gaaacagtag tggactcaaa
      121 actgggggac ggaggtctat atggaattga ccccaggaac cgcagctgct tacctctgac
      181 cggtgggtcc cagggaacat ggctgaggca caccaggcct cgagcttgct gtcttcactc
      241 agttccgacg gggcagaagt ggagctcagc tcctcagtgt ggcaggagat ttacctctct
      301 gccctacgct cctggaaaag gaatctctgg cgtgtctgga atgactttct tgctggtgtg
      361 gtcccggcaa cgcccctcag ctggcttttc ctcttcagta caatccagct tgcttgtctc
      421 ctccagctgg acccttccct aggactgatg gagaagatta aagagttgct gccagactgg
      481 ggcggacagc accaccagct ccaggggctc ctggcagcag cagtctttgc ctcgtgtttg
      541 tggggaaccc tgatcttcac acttcatgtg gctctgaggc tcctgctgtc ccaccacggc
      601 tggcttctgg aacctcatgg caccatgtcc tcacccacga agacctggct ggcattggtc
      661 agaatctttt cggggaggca cccgaggctc ttcagctttc aacgtgcgct cccgcggcag
      721 ccagtgcccg gagcgcaaga gaccgtgcgc aagtacctag agtccatgcg ccctgtgctc
      781 cgagacgacg ctttcgacag cgttgtggcg ctggcaaacg acttcctgag gttgcaggcg
      841 ccacgactcc agctctattt gcaactcaag tcctggtgcg cttccaacta cgtcagcgac
      901 tggtgggaag agtttgtgta cctgcgttct cgaggctcgc tggttaatag cacctactac
      961 atgatggatt ttctgtatgt cacccccaca ccactgcagg cagcccgtgc gggcaatgcc
     1021 gtgcataccc tgctcctgta tcgccacctt ctgaaccggc aggagatccc accgaccttg
     1081 ctgatgggga tgcgcccctt gtgctccgcc cagtacgaga ggatgttcaa cactacacgg
     1141 attccagggg tggaaaaaga ctacctttgt cacctccaag acagccaaca tgtggctgtc
     1201 ttccaccagg gcagattctt ccgtgtaggg acccactctt ccaatggcct gctgtcccca
     1261 cgggccctgg aacagcagtt ccagtacatc ctggatgacc cctccccagc ctgtcccctt
     1321 gaggaacatc tagctgcttt gactgccgct cccaggagta tgtgggccca ggtacgtgag
     1381 tctgtgaaga cccatgcggc cactgccctg gagactgtgg aaggggctgc cttctttgtg
     1441 tccctggatt ctgagcccgc gggactgacc agagagaacc ccgcagcttc cctggacacc
     1501 tatgcccaca ctctgctgac tggccaaggc catgaccgtt ggtttgacaa atccttcacc
     1561 ctcatcgtct tctccaacgg gaagctgggc ctcagcgtgg agcactcatg ggctgactgc
     1621 cctgtcgcgg gacatttatg ggagttcacc ctggccacag agtgcttcca gttgggatat
     1681 gccacagatg gccactgtaa ggggcacccc gaccctgccc tgccgaagcc ccagcgcctg
     1741 cagtgggacc ttccaaagca gatccagccg tccatctctc tggccctgag gggagccaag
     1801 accttgtctg gcaatattga ctgccatgtc ttccccttct tccacttcgg caagagcttc
     1861 atcaaaggct gtcatgtctc ttcagacagt ttcatccagc tggtcctgca gctggcccac
     1921 ttccgggaca ggggtcaatt ctgcctgact tatgaatcag ccatgacccg actgtttctg
     1981 gaaggcagga cggagacggt gaggtcttgc actagagagg cctgccaatt tgtgagagcc
     2041 atggaaaaca aggagaggac agaccaacag tgccttgccc tgttccggga agccgtggac
     2101 aagcaccagg ccctgctgaa ggcagcaatg agtgggcaag ggatcgaccg tcacctcttc
     2161 gcactgtaca tcatgtcccg gcttctccac atgcagtcgc ccttcctgac ccaggtccag
     2221 tcgcagcaat ggcttctgtc taccagccag atccctgtgc agcagacaca cctgttcgat
     2281 gtccacaatt acccggatta tgtttcctct ggaggtggat ttgggcctgc ccatgaccat
     2341 gggtatggcg tctcgtatat cttcatgggg gaaaacgcaa tcagcttcca catctccagc
     2401 aagcaatcaa gcacagaaac agactcacac cggctggggc agcacattga agatgccctg
     2461 ttggatgtag cctccctgtt ccaggctgga cagcaattca agcgccagtt cacagggctc
     2521 ggggagagtt caggttggaa atacagcaat ctctcctgta agactgtgga ccccaatatc
     2581 cccaaatcct ccaccaactt gtgagcccct cagcagggag ctggtctccc tcaggaagga
     2641 gggcattgct cccaggactt ggctggcgca gacaggggta ttggggatcc ccacaccctc
     2701 ctggtaataa agatgggagt tggatgcagt aaaaaaaaaa aaaaaaa
//
