LOCUS       NM_013200               2829 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus carnitine palmitoyltransferase 1B (Cpt1b), mRNA.
ACCESSION   NM_013200
VERSION     NM_013200.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2829)
  AUTHORS   Sepa-Kishi,D.M., Wu,M.V., Uthayakumar,A., Mohasses,A. and
            Ceddia,R.B.
  TITLE     Antilipolytic and antilipogenic effects of the CPT-1b inhibitor
            oxfenicine in the white adipose tissue of rats
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 311 (4), R779-R787 (2016)
   PUBMED   27558315
  REMARK    GeneRIF: In summary, our results show that oxfenicine-induced
            inhibition of CPT-1b markedly affects WAT metabolism, leading to
            reduced adiposity through a mechanism that involves reduced
            lipogenesis in the SC Ing and Epid fat depots of rats.
REFERENCE   2  (bases 1 to 2829)
  AUTHORS   Zhang,L., Li,H., Hu,X., Benedek,D.M., Fullerton,C.S., Forsten,R.D.,
            Naifeh,J.A., Li,X., Wu,H., Benevides,K.N., Le,T., Smerin,S.,
            Russell,D.W. and Ursano,R.J.
  TITLE     Mitochondria-focused gene expression profile reveals common
            pathways and CPT1B dysregulation in both rodent stress model and
            human subjects with PTSD
  JOURNAL   Transl Psychiatry 5 (6), e580 (2015)
   PUBMED   26080315
  REMARK    GeneRIF: CPT1B was significantly over-expressed in the amygdala and
            in the blood of stressed rats compared with non-stressed controls.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2829)
  AUTHORS   Ratner,C., Madsen,A.N., Kristensen,L.V., Skov,L.J., Pedersen,K.S.,
            Mortensen,O.H., Knudsen,G.M., Raun,K. and Holst,B.
  TITLE     Impaired oxidative capacity due to decreased CPT1b levels as a
            contributing factor to fat accumulation in obesity
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 308 (11), R973-R982 (2015)
   PUBMED   25855307
  REMARK    GeneRIF: Increased fat accumulation characterizing obesity may be
            caused by impaired oxidative capacity due to decreased carnitine
            palmitoyltransferase 1b levels in the white adipose tissue.
REFERENCE   4  (bases 1 to 2829)
  AUTHORS   Hada,T., Yamamoto,T., Yamamoto,A., Ohkura,K., Yamazaki,N.,
            Takiguchi,Y. and Shinohara,Y.
  TITLE     Comparison of the catalytic activities of three isozymes of
            carnitine palmitoyltransferase 1 expressed in COS7 cells
  JOURNAL   Appl Biochem Biotechnol 172 (3), 1486-1496 (2014)
   PUBMED   24222496
REFERENCE   5  (bases 1 to 2829)
  AUTHORS   Smith,B.K., Perry,C.G., Koves,T.R., Wright,D.C., Smith,J.C.,
            Neufer,P.D., Muoio,D.M. and Holloway,G.P.
  TITLE     Identification of a novel malonyl-CoA IC(50) for CPT-I:
            implications for predicting in vivo fatty acid oxidation rates
  JOURNAL   Biochem J 448 (1), 13-20 (2012)
   PUBMED   22928974
  REMARK    GeneRIF: The ratio of [P-CoA]/[M-CoA] is critical for regulating
            CPT-I activity & may partially rectify the in vivo disconnect
            between M-CoA content & CPT-I flux within the context of exercise &
            Type 2 diabetes.
REFERENCE   6  (bases 1 to 2829)
  AUTHORS   Wang,G.L., Moore,M.L. and McMillin,J.B.
  TITLE     A region in the first exon/intron of rat carnitine
            palmitoyltransferase Ibeta is involved in enhancement of basal
            transcription
  JOURNAL   Biochem J 362 (Pt 3), 609-618 (2002)
   PUBMED   11879187
  REMARK    GeneRIF: a novel region in the first exon/intron of the CPT-Ibeta
            gene acts as a non-classical transcriptional enhancer
REFERENCE   7  (bases 1 to 2829)
  AUTHORS   Yu,G.S., Lu,Y.C. and Gulick,T.
  TITLE     Rat carnitine palmitoyltransferase Ibeta mRNA splicing isoforms
  JOURNAL   Biochim Biophys Acta 1393 (1), 166-172 (1998)
   PUBMED   9714790
REFERENCE   8  (bases 1 to 2829)
  AUTHORS   Wang,D., Harrison,W., Buja,L.M., Elder,F.F. and McMillin,J.B.
  TITLE     Genomic DNA sequence, promoter expression, and chromosomal mapping
            of rat muscle carnitine palmitoyltransferase I
  JOURNAL   Genomics 48 (3), 314-323 (1998)
   PUBMED   9545636
REFERENCE   9  (bases 1 to 2829)
  AUTHORS   Esser,V., Brown,N.F., Cowan,A.T., Foster,D.W. and McGarry,J.D.
  TITLE     Expression of a cDNA isolated from rat brown adipose tissue and
            heart identifies the product as the muscle isoform of carnitine
            palmitoyltransferase I (M-CPT I). M-CPT I is the predominant CPT I
            isoform expressed in both white (epididymal) and brown adipocytes
  JOURNAL   J Biol Chem 271 (12), 6972-6977 (1996)
   PUBMED   8636126
REFERENCE   10 (bases 1 to 2829)
  AUTHORS   Yamazaki,N., Shinohara,Y., Shima,A. and Terada,H.
  TITLE     High expression of a novel carnitine palmitoyltransferase I like
            protein in rat brown adipose tissue and heart: isolation and
            characterization of its cDNA clone
  JOURNAL   FEBS Lett 363 (1-2), 41-45 (1995)
   PUBMED   7729550
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013200.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085761.1, SRR26643293.42877.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                JAXUCZ010000007.1  122380005-122380024 c
            21-180              JAXUCZ010000007.1  122379373-122379532 c
            181-320             JAXUCZ010000007.1  122378905-122379044 c
            321-498             JAXUCZ010000007.1  122378429-122378606 c
            499-600             JAXUCZ010000007.1  122378104-122378205 c
            601-738             JAXUCZ010000007.1  122377806-122377943 c
            739-816             JAXUCZ010000007.1  122377642-122377719 c
            817-924             JAXUCZ010000007.1  122376571-122376678 c
            925-1009            JAXUCZ010000007.1  122376410-122376494 c
            1010-1205           JAXUCZ010000007.1  122375687-122375882 c
            1206-1391           JAXUCZ010000007.1  122375207-122375392 c
            1392-1497           JAXUCZ010000007.1  122374415-122374520 c
            1498-1614           JAXUCZ010000007.1  122374220-122374336 c
            1615-1779           JAXUCZ010000007.1  122373714-122373878 c
            1780-1914           JAXUCZ010000007.1  122373496-122373630 c
            1915-2067           JAXUCZ010000007.1  122373250-122373402 c
            2068-2181           JAXUCZ010000007.1  122372380-122372493 c
            2182-2274           JAXUCZ010000007.1  122371702-122371794 c
            2275-2829           JAXUCZ010000007.1  122370974-122371528 c
FEATURES             Location/Qualifiers
     source          1..2829
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2829
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /note="carnitine palmitoyltransferase 1B"
                     /db_xref="GeneID:25756"
                     /db_xref="RGD:2397"
     exon            1..20
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            21..180
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..2358
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /EC_number="2.3.1.21"
                     /note="carnitine palmitoyltransferase Ibeta 2; carnitine
                     palmitoyltransferase 1b, muscle; CPT-Ibeta 1; carnitine
                     palmitoyltransferase Ibeta 1; CPT-Ibeta 3; carnitine
                     palmitoyltransferase Ibeta 3; CPT I; CPT1-M; CPTI-M;
                     carnitine palmitoyltransferase I-like protein; Carnitine
                     palmitoyltransferase 1, muscle"
                     /codon_start=1
                     /product="carnitine O-palmitoyltransferase 1, muscle
                     isoform"
                     /protein_id="NP_037332.2"
                     /db_xref="GeneID:25756"
                     /db_xref="RGD:2397"
                     /translation="MAEAHQAVAFQFTVTPDGVDFRLSREALRHIYLSGINSWKKRLI
                     RIKNGILRGVYPGSPTSWLVVVMATVGSNYCKVDISMGLVHCIQRCLPTRYGSYGTPQ
                     TETLLSMVIFSTGVWATGIFLFRQTLKLLLSYHGWMFEMHSKTSHATKIWAICVRLLS
                     SRRPMLYSFQTSLPKLPVPSVPATIHRYLDSVRPLLDDEAYFRMESLAKEFQDKIAPR
                     LQKYLVLKSWWATNYVSDWWEEYVYLRGRSPIMVNSNYYAMDFVLIKNTSQQAARLGN
                     TVHAMIMYRRKLDREEIKPVMALGMVPMCSYQMERMFNTTRIPGKETDLLQHLSESRH
                     VAVYHKGRFFKVWLYEGSCLLKPRDLEMQFQRILDDTSPPQPGEEKLAALTAGGRVEW
                     AEARQKFFSSGKNKMSLDTIERAAFFVALDEDSHCYNPDDEASLSLYGKSLLHGNCYN
                     RWFDKSFTLISCKNGQLGLNTEHSWADAPIIGHLWEFVLATDTFHLGYTETGHCVGEP
                     NTKLPPPQRMQWDIPEQCQTAIENSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSP
                     DAFVQIALQLAHFRDKGKFCLTYEASMTRMFREGRTETVRSCTSESTAFVRAMMTGSH
                     KKQDLQDLFRKASEKHQNMYRLAMTGAGIDRHLFCLYIVSKYLGVRSPFLDEVLSEPW
                     SLSTSQIPQFQICMFDPKQYPNHLGAGGGFGPVADHGYGVSYMIAGENTMFFHVSSKL
                     SSSETNALRFGNHIRQALLDIADLFKISKTDS"
     exon            181..320
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            321..498
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            499..600
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            601..738
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            739..816
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            817..924
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1009
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1205
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1391
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1497
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1614
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1779
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1914
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2067
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2181
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2274
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2829
                     /gene="Cpt1b"
                     /gene_synonym="CPT-IB; M-CPTI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacagaagca aacctgagct gtgctgacta aaccccagga tggcggaagc acaccaggca
       61 gtagctttcc agttcactgt gaccccagac ggggtcgact tccggcttag tcgggaggct
      121 ctgagacaca tctacctgtc tggaatcaac tcctggaaga aacgccttat tcgaatcaag
      181 aatggtatcc ttaggggtgt gtaccctggc agccctacca gctggctggt tgttgtcatg
      241 gcaacagttg gttccaacta ctgcaaagtg gacatctcca tggggctggt ccattgcatc
      301 cagagatgcc tcccgacaag gtatggctcc tacgggaccc cacagaccga gacacttctc
      361 agtatggtca tcttctccac cggagtctgg gcgacaggca tttttttatt ccgacaaacc
      421 ctgaagctgc tgctttccta tcatgggtgg atgttcgaga tgcacagcaa gaccagccat
      481 gccaccaaga tctgggctat ctgtgttcgt ctcctgtcca gccggcggcc catgctctat
      541 agcttccaaa catcactgcc caagcttcct gtccccagtg tgccagccac aattcaccgg
      601 tacttggatt ctgtgcggcc cttgctggat gacgaagcct atttccgcat ggagtcgttg
      661 gccaaagaat tccaggacaa gattgccccc agactgcaga aatacctggt gctgaagtca
      721 tggtgggcaa ccaactatgt aagtgactgg tgggaagagt acgtctacct ccgaggcagg
      781 agccccatca tggtgaacag caactattac gccatggatt ttgtgcttat taagaacacg
      841 agccaacaag cagcacgttt gggaaacacc gttcacgcca tgatcatgta tcgccgcaaa
      901 ctggaccgag aagagatcaa gccggtaatg gcactgggta tggtacccat gtgctcctac
      961 cagatggaga ggatgttcaa cactacacgc atcccaggca aagagacaga cttgctacag
     1021 cacctctcag agagcaggca cgtggctgtc taccacaaag gtcgcttctt caaggtttgg
     1081 ctctatgagg gctcgtgcct gctcaagccc cgagacctcg agatgcagtt ccagagaatc
     1141 ctcgatgaca cctccccgcc tcagcctgga gaggaaaagc tggcagccct caccgcagga
     1201 ggaagggtag agtgggcaga agcacgtcag aagttcttta gctctggcaa gaacaagatg
     1261 tccctggata ccatcgaacg tgctgctttc tttgtggccc tggacgaaga ctctcactgt
     1321 tacaaccctg atgacgaggc cagtctcagc ctctacggca aatccctgct gcacggcaac
     1381 tgctataaca ggtggttcga caaatctttc actctcatct cctgcaagaa tggccagctg
     1441 ggcctcaaca cagaacactc atgggcagat gctcccatca tcggtcacct ctgggagttc
     1501 gtcctggcca ctgatacctt tcacctgggc tacacggaga caggacactg tgtgggtgaa
     1561 cccaacacca agttgccgcc gcctcagcgg atgcagtggg acattcccga gcagtgccag
     1621 acagccatcg agaattcgta ccaagtagcc aaggccctgg ctgatgatgt ggagttatac
     1681 tgcttccagt tcttaccctt cggcaaaggc ctgatcaaga agtgtcggac cagccctgat
     1741 gcctttgtgc agattgccct gcagctggct catttccggg acaaaggcaa gttctgcctg
     1801 acctatgagg cctccatgac aagaatgttc cgagaggggc ggacagagac tgtgcgttcc
     1861 tgtactagcg agtccacggc ctttgtgcgg gccatgatga cggggtccca taagaaacaa
     1921 gacctccaag acctcttccg gaaagcctcc gaaaaacacc aaaacatgta ccgcctagcc
     1981 atgacagggg ctgggatcga caggcacctc ttctgcctct acatcgtctc caagtactta
     2041 ggggttagat ctcctttcct ggacgaggtg ctttcggaac cctggagcct ctccaccagc
     2101 cagatccccc agttccagat ctgcatgttt gacccaaagc agtaccccaa tcatctgggt
     2161 gctggaggtg gctttggtcc tgtggccgac cacggatacg gggtttccta catgatcgca
     2221 ggcgaaaaca caatgttctt ccatgtttcc agcaagttat cgagttcaga aacgaacgcc
     2281 ctgcgcttcg ggaaccacat ccgtcaagca ctgctggata tcgccgacct tttcaaaatt
     2341 tccaagactg acagctgaga ccaggagaca caccagctgc cctttggtcc ccacctggtg
     2401 gaggaagagg tctgtggcca gttcacaggc ataaggggtg gcatgcacac gtgcccagtt
     2461 ctgagaccag ctccagcggc aggggctccc caggcagaca ctgctcctcc agggcccggt
     2521 cggaggtggg attggagtgg tgagggaact ttgatctttt tttttccccc ggtcttggta
     2581 gatgctaata aaaataaggc tgtataattc tctctcagcc cttaggtgcc tatgtttggt
     2641 tagagaacta gaaggccttt cccctgcccc tgctcaggtt agggtggtgg cgactgaagg
     2701 gccgggtgaa tgttcataat ggctttttac ctgctttgaa atgtgtgctt ttcctgaata
     2761 atgcggactt cgagagtgct gtccaacctc tcatgtgcac ttggaataaa ttcttacttt
     2821 agaaccttt
//
