LOCUS       NM_031559               4356 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus carnitine palmitoyltransferase 1A (Cpt1a), mRNA.
ACCESSION   NM_031559
VERSION     NM_031559.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4356)
  AUTHORS   Yan,J., Song,K., Bai,Z. and Ge,R.L.
  TITLE     WY14643 improves left ventricular myocardial mitochondrial and
            systolic functions in obese rats under chronic persistent hypoxia
            via the PPARalpha pathway
  JOURNAL   Life Sci 266, 118888 (2021)
   PUBMED   33310031
REFERENCE   2  (bases 1 to 4356)
  AUTHORS   Lin,L., Hao,Z., Zhang,S., Shi,L., Lu,B., Xu,H. and Ji,L.
  TITLE     Study on the protection of water extracts of Polygoni Multiflori
            Radix and Polygoni Multiflori Radix Praeparata against NAFLD and
            its mechanism
  JOURNAL   J Ethnopharmacol 252, 112577 (2020)
   PUBMED   31953200
REFERENCE   3  (bases 1 to 4356)
  AUTHORS   Liu,M.E., Chou,C.H., Li,L., Wu,Y.S., Lin,Y.L., Tu,D.G. and
            Chen,Y.C.
  TITLE     Modulation effects of black-vinegar-based supplement against a
            high-fat dietary habit: antiobesity/hypolipidemic, antioxidative,
            and energy-metabolism effects
  JOURNAL   J Sci Food Agric 100 (6), 2380-2388 (2020)
   PUBMED   31901136
REFERENCE   4  (bases 1 to 4356)
  AUTHORS   Huo,X., Meng,X., Zhang,J. and Zhao,Y.
  TITLE     Hepatoprotective effect of different combinations of 18alpha-and
            18beta-Glycyrrhizic acid against CCl4-induced liver injury in rats
  JOURNAL   Biomed Pharmacother 122, 109354 (2020)
   PUBMED   31918260
REFERENCE   5  (bases 1 to 4356)
  AUTHORS   Wu,Z., Zhang,Y., Gong,X., Cheng,G., Pu,S. and Cai,S.
  TITLE     The preventive effect of phenolic-rich extracts from Chinese sumac
            fruits against nonalcoholic fatty liver disease in rats induced by
            a high-fat diet
  JOURNAL   Food Funct 11 (1), 799-812 (2020)
   PUBMED   31930271
REFERENCE   6  (bases 1 to 4356)
  AUTHORS   Esser,V., Brown,N.F., Cowan,A.T., Foster,D.W. and McGarry,J.D.
  TITLE     Expression of a cDNA isolated from rat brown adipose tissue and
            heart identifies the product as the muscle isoform of carnitine
            palmitoyltransferase I (M-CPT I). M-CPT I is the predominant CPT I
            isoform expressed in both white (epididymal) and brown adipocytes
  JOURNAL   J Biol Chem 271 (12), 6972-6977 (1996)
   PUBMED   8636126
REFERENCE   7  (bases 1 to 4356)
  AUTHORS   Britton,C.H., Schultz,R.A., Zhang,B., Esser,V., Foster,D.W. and
            McGarry,J.D.
  TITLE     Human liver mitochondrial carnitine palmitoyltransferase I:
            characterization of its cDNA and chromosomal localization and
            partial analysis of the gene
  JOURNAL   Proc Natl Acad Sci U S A 92 (6), 1984-1988 (1995)
   PUBMED   7892212
REFERENCE   8  (bases 1 to 4356)
  AUTHORS   Kolodziej,M.P. and Zammit,V.A.
  TITLE     Mature carnitine palmitoyltransferase I retains the N-terminus of
            the nascent protein in rat liver
  JOURNAL   FEBS Lett 327 (3), 294-296 (1993)
   PUBMED   8348957
REFERENCE   9  (bases 1 to 4356)
  AUTHORS   Esser,V., Britton,C.H., Weis,B.C., Foster,D.W. and McGarry,J.D.
  TITLE     Cloning, sequencing, and expression of a cDNA encoding rat liver
            carnitine palmitoyltransferase I. Direct evidence that a single
            polypeptide is involved in inhibitor interaction and catalytic
            function
  JOURNAL   J Biol Chem 268 (8), 5817-5822 (1993)
   PUBMED   8449948
REFERENCE   10 (bases 1 to 4356)
  AUTHORS   Esser,V., Kuwajima,M., Britton,C.H., Krishnan,K., Foster,D.W. and
            McGarry,J.D.
  TITLE     Inhibitors of mitochondrial carnitine palmitoyltransferase I limit
            the action of proteases on the enzyme. Isolation and partial amino
            acid analysis of a truncated form of the rat liver isozyme
  JOURNAL   J Biol Chem 268 (8), 5810-5816 (1993)
   PUBMED   8449947
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC072522.1 and AA875270.1.
            
            On Dec 11, 2007 this sequence version replaced NM_031559.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072522.1, L07736.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3883              BC072522.1         1-3883
            3884-3890           AA875270.1         455-461             c
            3891-4356           BC072522.1         3890-4355
FEATURES             Location/Qualifiers
     source          1..4356
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..4356
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /note="carnitine palmitoyltransferase 1A"
                     /db_xref="GeneID:25757"
                     /db_xref="RGD:2396"
     exon            1..35
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
     exon            36..189
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..2370
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /EC_number="2.3.1.21"
                     /note="CPT I; CPT1-L; CPTI-L; carnitine
                     palmitoyltransferase 1, liver; carnitine
                     palmitoyltransferase 1a, liver; succinyltransferase CPT1A"
                     /codon_start=1
                     /product="carnitine O-palmitoyltransferase 1, liver
                     isoform"
                     /protein_id="NP_113747.2"
                     /db_xref="GeneID:25757"
                     /db_xref="RGD:2396"
                     /translation="MAEAHQAVAFQFTVTPDGIDLRLSHEALKQICLSGLHSWKKKFI
                     RFKNGIITGVFPANPSSWLIVVVGVISSMHAKVDPSLGMIAKISRTLDTTGRMSSQTK
                     NIVSGVLFGTGLWVAVIMTMRYSLKVLLSYHGWMFAEHGKMSRSTKIWMAMVKVLSGR
                     KPMLYSFQTSLPRLPVPAVKDTVSRYLESVRPLMKEEDFQRMTALAQDFAVNLGPKLQ
                     WYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVNSNYYAMEMLYITPTHIQAARAGNTI
                     HAILLYRRTLDREELKPIRLLGSTIPLCSAQWERLFNTSRIPGEETDTIQHIKDSRHI
                     VVYHRGRYFKVWLYHDGRLLRPRELEQQMQQILDDPSEPQPGEAKLAALTAADRVPWA
                     KCRQTYFARGKNKQSLDAVEKAAFFVTLDESEQGYREEDPEASIDSYAKSLLHGRCFD
                     RWFDKSITFVVFKNSKIGINAEHSWADAPVVGHLWEYVMATDVFQLGYSEDGHCKGDT
                     NPNIPKPTRLQWDIPGECQEVIDASLSSASLLANDVDLHSFPFDSFGKGLIKKCRTSP
                     DAFIQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTMESCNFVQAMMDPKS
                     TAEQRLKLFKIACEKHQHLYRLAMTGAGIDRHLFCLYVVSKYLAVDSPFLKEVLSEPW
                     RLSTSQTPQQQVELFDFEKNPDYVSCGGGFGPVADDGYGVSYIIVGENFIHFHISSKF
                     SSPETDSHRFGKHLRQAMMDIITLFGLTINSKK"
     exon            190..329
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
     exon            330..501
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
     exon            502..603
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
     exon            604..741
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
     exon            742..819
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
     exon            820..927
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1015
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1211
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1400
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1506
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1623
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1788
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1923
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2076
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2190
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2283
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..4328
                     /gene="Cpt1a"
                     /gene_synonym="CPT-Ia"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacagtgct tgctccgggg agtgcagagc aataggtccc cactcaagat ggcagaggct
       61 caccaagctg tggccttcca gttcactgtc acccccgatg gcattgacct ccgcctgagc
      121 cacgaagccc tcaaacagat ctgcctgtcg gggctgcact cctggaagaa gaagttcatc
      181 cggttcaaga atggcatcat cactggtgtg ttccccgcga atccgtccag ctggcttatc
      241 gtggtggtgg gtgtgatttc atccatgcat gccaaagtgg acccctccct gggcatgatc
      301 gcaaagatca gtcggaccct agacaccact ggccgaatgt caagccagac gaagaacatt
      361 gtgagcggcg tcctctttgg tacagggctc tgggtggcag tcatcatgac catgcgctac
      421 tcgctgaagg tgctgctctc ctaccacggc tggatgtttg cagaacacgg caaaatgagc
      481 cgcagcacca agatctggat ggctatggtc aaggtcctct caggtcggaa gcccatgttg
      541 tacagcttcc agacgtctct gccacgcctg cctgtcccag ctgtcaaaga tactgtgagc
      601 aggtacctgg aatctgtgag gccactgatg aaggaagaag acttccagcg catgacagca
      661 ctggcccagg attttgctgt caacctcgga cccaaattgc agtggtattt gaagctaaaa
      721 tcctggtggg ccacaaatta cgtgagtgac tggtgggaag aatatatcta cctgcggggc
      781 cgagggccgc tcatggtcaa cagcaactac tacgccatgg agatgctgta catcacccca
      841 acccatatcc aggcagcgag agctggcaac accatccacg ccatactgct gtatcgtcgc
      901 acattagacc gtgaggaact caaacccatt cgtcttctgg gatccaccat tccactctgc
      961 tcggcccagt gggagcgact cttcaatact tcccggatcc ctggggaaga gacagacacc
     1021 atccaacata tcaaggacag caggcacatt gttgtgtacc acagagggcg gtacttcaag
     1081 gtctggctct accacgatgg gaggctgctg aggccccgag agctggagca gcagatgcag
     1141 cagatcctgg atgatccctc agagccacag cctggggagg ccaagctggc cgccctcact
     1201 gctgcagaca gagtgccctg ggcaaagtgt cggcagacct attttgcacg agggaaaaat
     1261 aagcagtccc tggatgcggt ggaaaaggca gcgttcttcg tgacgttgga cgaatcggag
     1321 cagggataca gagaggagga tcctgaggca tccatcgaca gctacgccaa atccctgctg
     1381 catggaagat gctttgacag gtggtttgac aagtccatca cctttgttgt cttcaaaaac
     1441 agcaagatag gcataaatgc agagcactcc tgggcggacg cgcccgtcgt gggccatttg
     1501 tgggagtatg tcatggccac cgacgtcttc cagctgggtt actcagagga tggacactgt
     1561 aaaggagaca ccaaccccaa catccctaag cccacaaggc tacaatggga cattccagga
     1621 gagtgccagg aggtcataga tgcatccctg agcagcgcca gtcttttggc aaatgatgtg
     1681 gacctgcatt ccttcccatt tgactctttc ggcaaaggct tgatcaagaa gtgccggacg
     1741 agtcccgatg ccttcatcca gctggcgctg cagctcgcac attacaagga catgggcaag
     1801 ttctgcctca catatgaggc ctccatgacc cggctcttcc gagaagggag gacagagact
     1861 gtacgctcct gcactatgga gtcctgcaac tttgtgcagg ccatgatgga ccccaagtca
     1921 acggcagagc agaggctcaa gctgttcaag atagcttgtg agaagcacca gcacctgtac
     1981 cgcctcgcca tgacgggcgc cggcatcgac cgccatctct tctgcctcta tgtggtgtcc
     2041 aagtatcttg cagtcgactc acctttcctg aaggaggtat tgtctgagcc atggaggttg
     2101 tctacgagcc agactcctca gcagcaggtg gagctctttg actttgagaa aaaccctgac
     2161 tatgtgtcct gtggaggggg ctttgggccg gttgccgatg acggctatgg tgtctcctac
     2221 attatagtgg gagagaattt tatccacttc catatttctt ccaagttctc tagccctgag
     2281 acagactcac accgctttgg gaagcacttg agacaagcca tgatggacat tatcaccttg
     2341 tttggcctca ccatcaattc taaaaagtaa acccctgagc cacacggaag gaaaacggac
     2401 cctcgtgata caaaccaaat gaatagatgt tgctcctgac cataggacag gcagaaaatt
     2461 gctcttataa aactcagttt tccttccaga aggtttaccg tcagtctccc tagaacaaca
     2521 gtaggcttca cgtgtgaatt gtgaccctac tacatccaga gatgccttgg ctccaggaat
     2581 attgggcaca gtcccctgat gtcttttgaa tcggctccta ctggataaag ggatttaaat
     2641 gctggtgaat tcctggattc tgggggttgt ttcttcacat gtgttggagg tgacagactt
     2701 cctcagtggt gaccctgtga atacttgggc gtctgactcc acccaggcag tgtgagcatc
     2761 accttgtgga aagagaaagt gtcttcagag ccagcagagg caacagctgt agctaacaca
     2821 tctgtaacac actaatggaa tggttaggcc tggggattaa ggttctgcta tgagtgacag
     2881 ccactgtccc tttggaagtt cacatttcca ggaagcagag taccacctcc ccagtgccac
     2941 cttcctcaca catcttcaaa acccagtgcc ttaaagaagg ggcccattgg caagcgggac
     3001 catagagaag acttagcatc tgtgaagcct ttgggtggat atgtgaggat gctgcttccc
     3061 cttactggtt cctgcataaa gatgtcccta agtaagcact tcccccaccc ctagaaaatg
     3121 aggtccttgg tgaaggcagg gatgctggag tctcattgcc tgccagttcc attaagccac
     3181 aaaatagcag acatgtgtcc acagagggag gggcttggta gtcaaaggct gcatagctgg
     3241 acaacagcgg gagagtgtgg cttgctgtat ttgacagctg ttggcaagag gagtgagacc
     3301 ctggtcacca agtcagacat actgacacag gcagccaaag cctcacggag ccaggagata
     3361 tagatagata ctggcttgta ttctggcaga tacacccctg ggcttatctt ctaatcccac
     3421 ccagtcagat tccaaccaga gtcaaattcc atagaaggct aggtcatttt ggcgacagac
     3481 tcagggatct caagtaatgg gtgcttttac ccacatgcca tccctcagtg ggagtgcctt
     3541 tcttgaaagc atccaatggg ctaaagcagc tctaccaagt ctgtttggta tttaatgtaa
     3601 acatagcata atggagtggt ctctcctacc tgtcaccatc ctgtcctgac aagcttagct
     3661 ctccgaggtt tacatcatgt atttattttc cagtgcccct ttggccttgt ttgattcctg
     3721 cccctgtgcc agaagtggcc cagaagtgag gggtggggtg accagcagtg cagagaggtg
     3781 ctggctgaac agttcatgtg tgtcttatgg gtatacatgt ataaattttg taatgtaaaa
     3841 aaaaaaatca tacctaaaag ggccaaagtt tttttttttt ttttactaaa accaagaaaa
     3901 caaaagacaa cataaagaca taagcagaaa caaactgttg taagtcagag cggcctgact
     3961 ctcgctgctg tgaccactca ccaacctgtg ttactcagag tagcccggct agtgcccgag
     4021 tgggacattc ctctctcagg tttccagtgt ccttgctgct cctgagcagt taccaatgca
     4081 atttcgcatt ccttacaagg cagaagagtg ggctctcact gtatgtgttc aaaggaggag
     4141 gtaagactat tgtgtattta atttaatgtg gaacaaaata tagtcttacc gcagccaagg
     4201 ttcaaatttg gtgttctaat ctgtccattg catgtaaata ccatatgctg tttggatata
     4261 aatcttagaa gtgcatgtgt gagcgaatgt agctggccat taataaaaca ttaatactgt
     4321 ctactacaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
