LOCUS       NM_001106785            7168 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus cleavage and polyadenylation specific factor 6
            (Cpsf6), mRNA.
ACCESSION   NM_001106785 XM_001080973 XM_216893
VERSION     NM_001106785.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7168)
  AUTHORS   Jang,S., Cook,N.J., Pye,V.E., Bedwell,G.J., Dudek,A.M., Singh,P.K.,
            Cherepanov,P. and Engelman,A.N.
  TITLE     Differential role for phosphorylation in alternative
            polyadenylation function versus nuclear import of SR-like protein
            CPSF6
  JOURNAL   Nucleic Acids Res 47 (9), 4663-4683 (2019)
   PUBMED   30916345
REFERENCE   2  (bases 1 to 7168)
  AUTHORS   Zhu,Y., Wang,X., Forouzmand,E., Jeong,J., Qiao,F., Sowd,G.A.,
            Engelman,A.N., Xie,X., Hertel,K.J. and Shi,Y.
  TITLE     Molecular Mechanisms for CFIm-Mediated Regulation of mRNA
            Alternative Polyadenylation
  JOURNAL   Mol Cell 69 (1), 62-74 (2018)
   PUBMED   29276085
REFERENCE   3  (bases 1 to 7168)
  AUTHORS   Gruber,A.R., Martin,G., Keller,W. and Zavolan,M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   4  (bases 1 to 7168)
  AUTHORS   Gruber,A.R., Martin,G., Keller,W. and Zavolan,M.
  TITLE     Cleavage factor Im is a key regulator of 3' UTR length
  JOURNAL   RNA Biol 9 (12), 1405-1412 (2012)
   PUBMED   23187700
REFERENCE   5  (bases 1 to 7168)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 7168)
  AUTHORS   Sartini,B.L., Wang,H., Wang,W., Millette,C.F. and Kilpatrick,D.L.
  TITLE     Pre-messenger RNA cleavage factor I (CFIm): potential role in
            alternative polyadenylation during spermatogenesis
  JOURNAL   Biol Reprod 78 (3), 472-482 (2008)
   PUBMED   18032416
REFERENCE   7  (bases 1 to 7168)
  AUTHORS   Cardinale,S., Cisterna,B., Bonetti,P., Aringhieri,C., Biggiogera,M.
            and Barabino,S.M.
  TITLE     Subnuclear localization and dynamics of the Pre-mRNA 3' end
            processing factor mammalian cleavage factor I 68-kDa subunit
  JOURNAL   Mol Biol Cell 18 (4), 1282-1292 (2007)
   PUBMED   17267687
REFERENCE   8  (bases 1 to 7168)
  AUTHORS   Dettwiler,S., Aringhieri,C., Cardinale,S., Keller,W. and
            Barabino,S.M.
  TITLE     Distinct sequence motifs within the 68-kDa subunit of cleavage
            factor Im mediate RNA binding, protein-protein interactions, and
            subcellular localization
  JOURNAL   J Biol Chem 279 (34), 35788-35797 (2004)
   PUBMED   15169763
REFERENCE   9  (bases 1 to 7168)
  AUTHORS   Brown,K.M. and Gilmartin,G.M.
  TITLE     A mechanism for the regulation of pre-mRNA 3' processing by human
            cleavage factor Im
  JOURNAL   Mol Cell 12 (6), 1467-1476 (2003)
   PUBMED   14690600
REFERENCE   10 (bases 1 to 7168)
  AUTHORS   Ruegsegger,U., Blank,D. and Keller,W.
  TITLE     Human pre-mRNA cleavage factor Im is related to spliceosomal SR
            proteins and can be reconstituted in vitro from recombinant
            subunits
  JOURNAL   Mol Cell 1 (2), 243-253 (1998)
   PUBMED   9659921
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473960.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001080973.1, XM_216893.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..7168
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..7168
                     /gene="Cpsf6"
                     /note="cleavage and polyadenylation specific factor 6"
                     /db_xref="GeneID:299811"
                     /db_xref="RGD:1304640"
     exon            1..98
                     /gene="Cpsf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1694
                     /gene="Cpsf6"
                     /note="cleavage and polyadenylation specific factor 6,
                     68kDa"
                     /codon_start=1
                     /product="cleavage and polyadenylation specificity factor
                     subunit 6"
                     /protein_id="NP_001100255.1"
                     /db_xref="GeneID:299811"
                     /db_xref="RGD:1304640"
                     /translation="MADGVDHIDIYADVGEEFNQEAEYGGHDQIDLYDDVISPSANNG
                     DAPEDRDYMDTLPPTVGDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVH
                     SLGVNDILEIKFFENRANGQSKGFALVGVGSEASSKKLMDLLPKRELHGQNPVVTPCN
                     KQFLSQFEMQSRKTTQSGQMSGEGKAGPPGGGSRAAFPQGGRGRGRFPGAVPGGDRFP
                     GPAGPGGPPPPFPAGQTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPP
                     VLFPGQPFGQPPLGPLPPGPPPPVPGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPP
                     LTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDR
                     GDYGPPGREMDTARTPLSEAEFEEIMNRNRAISSSAISRAVSDASAGDYGSAIETLVT
                     AISLIKQSKVSADDRCKVLISSLQDCLHGIESKSYGSGSRRERSRERDHSRSREKSRR
                     HKSRSRDRHDDYYRERSRERERHRDRDRDRDRERDREREYRHR"
     exon            99..308
                     /gene="Cpsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            309..412
                     /gene="Cpsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            413..558
                     /gene="Cpsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            559..732
                     /gene="Cpsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            733..1237
                     /gene="Cpsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1353
                     /gene="Cpsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1507
                     /gene="Cpsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1697
                     /gene="Cpsf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..7168
                     /gene="Cpsf6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggaggcgg cggcggcggc ggccgaggcc gagggaagat ggcggacggt gtggaccaca
       61 tagacattta cgcggatgtg ggggaagagt tcaaccagga agcggaatat ggtgggcatg
      121 atcagataga tttgtatgat gatgtcatct ctccatctgc aaataatggc gatgccccag
      181 aagaccggga ctacatggat actcttccac caactgttgg tgatgatgtg ggtaaagggg
      241 cagcaccaaa cgttgtctat acttacactg gaaagagaat cgcattgtat attggaaatc
      301 taacatggtg gacaacagat gaggacctaa ctgaagcagt tcattctttg ggagtaaatg
      361 atattttgga gataaaattt tttgaaaatc gggcaaatgg acaatcaaag ggatttgccc
      421 ttgttggtgt tggatctgaa gcatcttcca aaaagttaat ggatcttttg cctaaaagag
      481 aacttcacgg tcagaatcct gttgtaactc catgcaataa acagttcctg agtcagtttg
      541 aaatgcaatc caggaaaact acacaatcag gacaaatgtc tggggaaggt aaagctggtc
      601 ctccaggagg cggttcacgc gcagcatttc cacaaggtgg tagaggacgg ggccgttttc
      661 caggggctgt tcctggtggg gacagatttc ctgggccagc aggaccagga gggccacctc
      721 cacctttccc agctggacag actccaccac gtccacctct aggtccacct ggcccacctg
      781 gccccccagg tcctccacct cccggtcagg ttctgccacc tcctctagca ggacctccta
      841 atcgaggaga ccgccctcca ccaccagttc tttttcctgg acaacctttt gggcagcctc
      901 cgctgggtcc acttcctcct gggcctccac ctccagttcc aggctacggc ccccctccag
      961 gtccaccgcc tccacagcag ggaccacctc cacctccagg cccctttcca cctcgaccac
     1021 caggtccact agggcctccc cttacacttg ctcctcctcc acatcttccg ggaccacctc
     1081 caggtgcccc accaccagct ccacatgtga atcctgcttt tttccctcca ccaactaata
     1141 gtggcatgcc aacatcagat agtcgaggtc caccgccaac agacccatat ggccgacctc
     1201 caccatatga taggggtgac tatggtcccc ctgggaggga aatggatact gcaagaacac
     1261 ctctgagtga agctgagttt gaagaaatca tgaatagaaa tcgggcaatc tctagcagtg
     1321 ctatttcaag agctgtatct gatgctagtg ctggtgatta tgggagtgct attgaaacat
     1381 tggtaacagc aatttctcta attaaacaat ccaaagtatc tgccgacgat cgctgcaaag
     1441 ttcttattag ctctttgcaa gactgccttc atggaattga gtccaagtcc tatgggtctg
     1501 gatcaagacg tgaacgatca agagaaaggg accatagtag atcacgggaa aagagtcgac
     1561 gtcataaatc tcggagtaga gatcgccatg atgattatta cagagagaga agcagagagc
     1621 gagagagaca ccgggatcgc gatcgggatc gtgaccggga gcgcgaccga gagcgagaat
     1681 accgtcatcg ttagaagcaa aatctacatc acaaattttg acacattaca gctgaaggaa
     1741 gaggaacacc ttccaagaca aagcagtctt cacggggaaa gtgacgcttg tccagcagtt
     1801 tgcttcttga ttgaactgaa cctgtaagga ttcatggata aactgaacag gaatagatct
     1861 gaataaagca aatctgcata aatggtaacc agtagctcta cttttatttt ttatgttgct
     1921 taactgtttt atttgaagga aactgtgtga tttaaaaagt taatagcttt tgcaacttta
     1981 ttactggtta tatatttggc cattataatg tgcaagcaat tggaaaaagt caagtaaatg
     2041 cttgttttta tagtagtttg ttcttgttaa aatgttcata tgataatgtc tgtaaacagc
     2101 accaatttga ttacaataga tgtagtgttg taataaactg tttaatgggg ctgatgtgta
     2161 aagctgttca agttatttga tgtttacacc tcagggaaag tcttgtgttc agcaatatct
     2221 aaagataatg ttactatgac aacattttta ctgtccttta aaaaagcatt gcaatagcgt
     2281 gtttggatat gcatcaatct aatcttgcgt tcagtgaatt aaacatgact aattaagtgt
     2341 ctattgccct tgattttgat attagaatag gtgattacat gggtatttaa tatttctata
     2401 ttctgctttt ctagctgttt ttacctagtt agcttgtgat tttgctgaat ggtatgtaaa
     2461 cgtgtaaaaa ctgaaatctg acagagcaat ccattcaatg tgttaggggt caaaaaattg
     2521 aaggttgtaa catttttggt aaaaattcat gtatttgcta cagtagtgca gcttaattac
     2581 aacccagata tactgaaatg aaaattgtga actgctagct tttaagatag attttgataa
     2641 ttctgatttc atgcagtaat ttactgtttc atgctgatgg tgccataggc agtgtaatta
     2701 tggccacaca gcaagataaa tgagtaaaga aagccctagt attgtacttg ataaaaattt
     2761 ctgaggggta tgatgtttat taacattggg ttgtattctt cagtgtgaat aatgaaaaat
     2821 tatagttaca ctgtcttcat ggttcgagga attctgtgta tattcctgta actttgttga
     2881 tctatgcttg attagagtta gttatcagtt gttttttttt ttttaatcca gccttaataa
     2941 aaggttgtat taaacacacc tggctagcat gtgttctgca aaattagcag aaacaaactg
     3001 ttaatttgat tgcctatttt tataggaaga taaaaatctg aattcctaaa gaatttttag
     3061 ataaagtcct taagctaatt tgtgttaaat atgttttaaa agatcttaaa gtttacctaa
     3121 atttaagcgc agtgcctaag gcatgtacca taggtcgaga gtgtgcagct tgagacattt
     3181 gtacttttct tcttcagttt catcctttct gcttttaaaa tactcaaaaa tatccatacc
     3241 actgtcagtt cattttaaaa cattttgtga gcagagtatt ttttgcaagg gatcattggt
     3301 gtttacccaa actgttgtta gctctcagaa atgatttttc ttaagtttta atcttgttga
     3361 aatgcaatta ccttttgatt tgagagttgt atcaaaatct attttgtttt gtatataggt
     3421 attgtaagtt tttgtcattt cttagctttt ttaatagttt aattacaata ccctaatgtg
     3481 aagccgtgtg gacatacatg tgtttacaag ggagattaag attagttgat agtgagatta
     3541 aaaggtaagt acaatgccca tagatagaac ttctctgaac atttttaaaa tggaatcaaa
     3601 aatacatata cttgaaatga aactggagat tttgtactaa ttttaatcct ttattacctt
     3661 tttttctttt ttaaaaatga gttggaactc ttattgctct ctgtatgtca ccctcttgcc
     3721 cagcttattc tattacctga ctttggacgc agacagagtg gactagcatt gtttgctgct
     3781 gctagtccat tattttaagt gttgtcagga agaaataaaa taaccttggt ttgtctagtt
     3841 ttacagtgtc tcctccctga taacacatga atgtcagcag taaaagtaaa cattgcaaac
     3901 cttgttttat ttgtcaaagc cttctgttgt tgaggagtca gtttcatttg aaaactggtt
     3961 tttaatgtgt aaaaacaatc caaagagata aaattttaca aagacaccaa aaaaaaaaaa
     4021 aaaaaaaagg agagagagag agatagagac aggcagacag acaggcaggc aaatgaacta
     4081 aagagaagaa aaagtcagaa gaaaaaagga actagggaga gtttttaaga aattgtggtt
     4141 catatagtgg cagtgaaagc aagcttgagt ttgtcttgaa tcctagcatt gcctagtgct
     4201 gtgcagtcac attccttgca actagtagtt aaaattccag atgcttggta aagcgcccac
     4261 atggtatttc tcctggagca gcactttgaa ttcaatatac tgctttgagg taaaggaaat
     4321 acatttgtag aaaggattct ttcagtgtac atttacatgt gtgtatgttt tgtcagcttt
     4381 catcagcaag atgagcaaga ttttagtgac ttgctatagc tattgatcat acatgttagg
     4441 ccatttaatg tctccttaac ctataatctt aagcagttaa ctacaatttg gaatttacaa
     4501 atagcatgta gcttaaggta ttattttgat ttgattctcc tatggagact gttgctttag
     4561 tttttactag tttaaagtca gttctaaaaa taaacatgga agttttcatg aacgttgtat
     4621 aatattttat agtaaagggg ggaaattgtt gaaaagggta agactttctc tttccctgtg
     4681 ttgaaatgtg ccaatagcct aagtacattc tgtttcatac aatgagatgc tactgcagga
     4741 ctccgattgg agtgctctta acattttagt tttgctaccc aaatggtcat tgcattgttt
     4801 gtatcttgca aggtggcccc aatattgtgt tttaagcttc agcttaagtt attttaagag
     4861 gaagtttatg ttctgattct ttactgagaa tacagtgttg agattcttgc tattgcacag
     4921 ataaactgat ttttaaattt tattcatgaa cttcatttgc atcccatggg cctctgtaaa
     4981 tgtttcccct ggttgtgtgt tcttactaaa tgcacgcttt ttcattgtac atactagaca
     5041 tttttttgtg ctaaaatata ttaagtaggg tttttgtagc aaagcattct atttttatgt
     5101 tcttatagtg tatgtgttaa cattaatatt cagtttaaac actggtgtat ttatttttag
     5161 caacttgact cctagaagcc ttagactaat ttttaaataa acattcaacc aaaaattatg
     5221 aatttcttga gatgtggcct tatatgtggt gttttctgtg ttcatatcgt gagatttttt
     5281 ttttaattta gattttattt aaatcaagat ttagaattag tttcatttta agtcaaaaca
     5341 gaaagtgtac catgcgtcta ggcttctggg aggaagttct tacactcttc tttcttagca
     5401 ttagaaggaa gcaatatgaa tttatgatat tctcaatatc caggccattg tattatgtcc
     5461 aggttgcttt agcttggttt tagcccaatt taggttggtt ttagcccaat gtttctttaa
     5521 agttccaggt agttggcatt cactgaatat atagctacta cggttttcat atggggcgta
     5581 tgaactcttg gttacatgta ggcagatttt aaaggcttcc tgctacatta attatgttgt
     5641 aacgggagac atctaaaata ttaggtagca ttgaattgaa gtcacacagg tcttgaatgg
     5701 tattcgtgga tagtaaatac tacgagcagt ttccatatca aagtacccta aaactccacc
     5761 atgggagtaa atcacactca cttcatgatt ggatataccc ttcattttag taaaagtact
     5821 tcatttcaaa agtttacact ttactgtgta acacttctca gcatttctgt gtgcaaatta
     5881 ttttaaaatt cagtgataat tcatggtttt ttttttcatt tttttacttt ggaaattgta
     5941 gtactcaggt ggtatttaat gagaaatgat catttgaggt gaatcataat gcattttgag
     6001 gactgcaact ataacattta tgactttagc cttaagaaaa ggtctattat tccttccttg
     6061 catcccatgg tatattagca aatagtttac agcccagcac agccttacaa agttgtttta
     6121 caaattttta tggaaaaccc ttaacaatta aaaaaattgt atcatattac agtacctatg
     6181 agttatgatc cccctctgta aataagttgt ctaataccag aaggccaaag aaagtcttga
     6241 tttagctatt gaatgtggtg acttcataag atttctgtgc aaaaggtaag gtgatattcc
     6301 attcaatagg cattcttttg atgtccatga aaactagact tccatattag cttctttcaa
     6361 aaggctcatt cccattttat taaaatgttt gtacttgcaa atttgtgttt aatgtttact
     6421 ttgtcttttc tttctttagc atttaggtga ctgttcagca gttttctata tggccattgt
     6481 tggccttaaa ctgcgctagt aacaagcatg gtatttatct tgtatggaaa ataaaaaagt
     6541 tttcgtaaga ctttgcagtt tgctcttttt gtttggctta taattttggt aactatttcc
     6601 tttacccttg aataatatct attggggaaa tgcaatatga aagattagac tttcatgtat
     6661 attttgtcta agtcaacact tttgagagtg gctattttct cctggcatat tttaaaagtt
     6721 taaatccatt tcgtatgcat gcatgcatac atacgtgcat gtccagccat ggcccaaatg
     6781 tggaggtgga aggacaactt gcaggggtta ggtggcatca gctttacttg cttagacatc
     6841 tggctaaaat atagttgcct catcttaaga agattatgaa cctcactaat cctttagaat
     6901 taacattttt ggatcatagc aacatacttt accagttaac ttaggaacat tatgggacat
     6961 acttttaaag aacagattag ttcgtcaaat atttgatcca ctggggctgg agatataact
     7021 cagttggtgc agagtacttg catacagcgc tggaagtctg ggtttgatac atggcaccaa
     7081 taagagctga cgcagtaggg cacatctgta atctgagcac ttgggatcag aagtttcctc
     7141 atctgatgag attcaggccg tctttggg
//
