LOCUS       NM_001030030            2248 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus cleavage and polyadenylation specific factor 3
            (Cpsf3), mRNA.
ACCESSION   NM_001030030 XM_216667
VERSION     NM_001030030.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2248)
  AUTHORS   Gruber AR, Martin G, Keller W and Zavolan M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   2  (bases 1 to 2248)
  AUTHORS   Chan S, Choi EA and Shi Y.
  TITLE     Pre-mRNA 3'-end processing complex assembly and function
  JOURNAL   Wiley Interdiscip Rev RNA 2 (3), 321-335 (2011)
   PUBMED   21957020
  REMARK    Review article
REFERENCE   3  (bases 1 to 2248)
  AUTHORS   Laishram RS and Anderson RA.
  TITLE     The poly A polymerase Star-PAP controls 3'-end cleavage by
            promoting CPSF interaction and specificity toward the pre-mRNA
  JOURNAL   EMBO J 29 (24), 4132-4145 (2010)
   PUBMED   21102410
REFERENCE   4  (bases 1 to 2248)
  AUTHORS   Yang XC, Sullivan KD, Marzluff WF and Dominski Z.
  TITLE     Studies of the 5' exonuclease and endonuclease activities of
            CPSF-73 in histone pre-mRNA processing
  JOURNAL   Mol Cell Biol 29 (1), 31-42 (2009)
   PUBMED   18955505
REFERENCE   5  (bases 1 to 2248)
  AUTHORS   Kolev NG, Yario TA, Benson E and Steitz JA.
  TITLE     Conserved motifs in both CPSF73 and CPSF100 are required to
            assemble the active endonuclease for histone mRNA 3'-end maturation
  JOURNAL   EMBO Rep 9 (10), 1013-1018 (2008)
   PUBMED   18688255
REFERENCE   6  (bases 1 to 2248)
  AUTHORS   Gonzales ML, Mellman DL and Anderson RA.
  TITLE     CKIalpha is associated with and phosphorylates star-PAP and is also
            required for expression of select star-PAP target messenger RNAs
  JOURNAL   J Biol Chem 283 (18), 12665-12673 (2008)
   PUBMED   18305108
REFERENCE   7  (bases 1 to 2248)
  AUTHORS   Collart C, Remacle JE, Barabino S, van Grunsven LA, Nelles L,
            Schellens A, Van de Putte T, Pype S, Huylebroeck D and Verschueren
            K.
  TITLE     Smicl is a novel Smad interacting protein and cleavage and
            polyadenylation specificity factor associated protein
  JOURNAL   Genes Cells 10 (9), 897-906 (2005)
   PUBMED   16115198
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099817.1.
            
            On Aug 5, 2005 this sequence version replaced XM_216667.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099817.1, SRR8487231.81679.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2248
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..2248
                     /gene="Cpsf3"
                     /note="cleavage and polyadenylation specific factor 3"
                     /db_xref="GeneID:298916"
                     /db_xref="RGD:1305767"
     exon            1..144
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..2152
                     /gene="Cpsf3"
                     /note="cleavage and polyadenylation specificity factor 3;
                     cleavage and polyadenylation specific factor 3, 73kDa"
                     /codon_start=1
                     /product="cleavage and polyadenylation specificity factor
                     subunit 3"
                     /protein_id="NP_001025201.1"
                     /db_xref="GeneID:298916"
                     /db_xref="RGD:1305767"
                     /translation="MSAIPAEESDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIH
                     PGLEGMDALPYIDLIDPAEIDLLLISHFHLDHCGALPWFLQKTSFKGRTFMTHATKAI
                     YRWLLSDYVKVSNISADDMLYTETDLEESMDKIETINFHEVKEVAGIKFWCYHAGHVL
                     GAAMFMIEIAGMKLLYTGDFSRQEDRHLMAAEIPNIKPDILIIESTYGTHIHEKREER
                     EARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYWQNHPELHDIPIYYASSLAK
                     KCMAVYQTYVNAMNDKIRKQININNPFVFKHISNLKSMDHFDDIGPSVVMASPGMIQN
                     GLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIMSEPEEITTMSGQKLPLKMSVDYIS
                     FSAHTDYQQTSEFIRALKPPHVILVHGEQNEMARLKAALIREYEDNDEVHIEVHNPRN
                     TEAVTLNFRGEKLAKVMGFLADKKPEQGQRVSGILVKRNFNYHILSPCDLSNYTDLAM
                     STVKQTQAIPYTGPFYLLYYQLQKLTGDVEELEIQEKPALKVFKSITVVQEPGMVVLE
                     WLANPSNDMYADTVTTVILEVQSNPKIRKGAVQKVSKKLEMHVYSKRLEVMLQDIFGE
                     DCVSVKDDSVLSVTVDGKTANINLETRAVECEEGSEDDESLREMVELAAQRLYEALTP
                     PVH"
     exon            145..208
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            209..306
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            307..435
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            436..613
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            614..703
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            704..854
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1030
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1189
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1336
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1489
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1598
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1697
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1792
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1880
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1950
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2047
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2233
                     /gene="Cpsf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggttttctc ttccttagtt tgctgtggct gtgctttgaa tttagagact gcggcgacgg
       61 gtttgtggtc cacgctgctc cagagactgc caggatgtct gcaattcctg cagaggagag
      121 cgaccagctg ctgatccgac cccttggtgc tggccaagaa gtgggaagat catgtattat
      181 tctggagttc aaaggaagga aaatcatgct agactgtggg atccaccctg gcctggaagg
      241 aatggatgct cttccttaca ttgacctcat cgacccagct gagatcgacc ttctgttgat
      301 cagtcacttc catttggacc actgtggagc cctgccctgg ttccttcaga agacaagttt
      361 caaaggacgg acgtttatga cccacgccac aaaagctatc tatagatggc tcctctcaga
      421 ctatgtcaaa gtcagcaaca tatcagcaga tgacatgctg tacactgaga cagacttgga
      481 agaaagcatg gacaaaatcg aaaccatcaa tttccatgaa gttaaggaag ttgcaggaat
      541 caagttctgg tgttaccatg ccggccacgt cctgggagca gccatgttta tgatagagat
      601 tgctggtatg aagcttttgt atacaggtga tttctcaaga caagaggaca gacatctaat
      661 ggccgctgaa attcctaata ttaagccaga catcctgatc attgaatcta cgtatgggac
      721 ccatatccat gagaagcgtg aagagcgaga agcaagattc tgcaacactg tgcacgacat
      781 tgtcaacaga gggggcagag ggctcattcc tgtctttgct ctcggaagag ctcaggagct
      841 gctcctgatt ctagatgagt actggcagaa ccacccagag ctgcacgaca tccccattta
      901 ctacgcatcg tctctggcca agaagtgcat ggccgtgtac cagacctacg tgaacgccat
      961 gaacgacaag atccggaagc agatcaacat caacaacccc ttcgttttca agcacatcag
     1021 caacctcaag agcatggatc actttgacga cattggcccc agtgttgtaa tggcctcacc
     1081 aggcatgatt caaaatggct tatccagaga gctgtttgaa agctggtgta cagataagag
     1141 gaatggcgtc atcatcgcag ggtactgtgt agaagggaca cttgccaagc acatcatgtc
     1201 tgaacctgaa gaaatcacta ccatgtctgg acagaagttg ccactgaaaa tgtcggttga
     1261 ttacatttct ttctctgctc acacagatta ccagcaaacc agtgaattta ttcgtgctct
     1321 gaagccgcct cacgtgattt tagtccatgg ggaacagaat gaaatggcca gactgaaagc
     1381 agcactgatc cgagaatatg aagataacga tgaagttcac atcgaggttc acaatcctcg
     1441 gaacacagag gccgtgaccc tgaacttcag aggggagaag ctcgccaagg tcatgggctt
     1501 tttagcagac aagaagccag aacagggcca gcgggtctct ggaattcttg ttaaaagaaa
     1561 ctttaattac cacatactct ctccctgtga cctctcgaat tacactgacc tggccatgag
     1621 cactgtgaaa cagacccaag ccatcccata tactgggccc ttttacctgc tctattacca
     1681 gctacagaaa ttgacgggtg atgtagaaga attagaaatt caagaaaagc ctgctttgaa
     1741 ggtattcaaa agcatcaccg tggtgcagga gccgggcatg gtggtcctgg agtggctggc
     1801 gaacccctct aacgacatgt atgcagacac agtgaccacc gtgatattgg aagttcagtc
     1861 gaatccaaaa ataaggaaag gtgcagtgca gaaggtctct aagaagctag agatgcacgt
     1921 ttacagcaag aggcttgagg tcatgctcca ggacatattt ggagaagact gtgtcagtgt
     1981 gaaagatgac tctgtcctca gtgtcacggt ggatggaaaa acagcaaata ttaatttgga
     2041 gactcgggct gtagaatgtg aagaaggaag tgaggatgat gagtccctcc gagaaatggt
     2101 ggaactggcc gcccagagac tgtacgaggc tctgacgccg ccagtgcact gacagccttg
     2161 cctcccagca ctccaccttt tacacttggc attcacttgg gttccttcaa ataaaatacc
     2221 ttagtttctc tggaaaaaaa aaaaaaaa
//
