LOCUS       NM_001106753            4892 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus cleavage and polyadenylation specific factor 2
            (Cpsf2), mRNA.
ACCESSION   NM_001106753 XM_001066531 XM_216766
VERSION     NM_001106753.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4892)
  AUTHORS   Gruber,A.R., Martin,G., Keller,W. and Zavolan,M.
  TITLE     Means to an end: mechanisms of alternative polyadenylation of
            messenger RNA precursors
  JOURNAL   Wiley Interdiscip Rev RNA 5 (2), 183-196 (2014)
   PUBMED   24243805
  REMARK    Review article
REFERENCE   2  (bases 1 to 4892)
  AUTHORS   Chan,S., Choi,E.A. and Shi,Y.
  TITLE     Pre-mRNA 3'-end processing complex assembly and function
  JOURNAL   Wiley Interdiscip Rev RNA 2 (3), 321-335 (2011)
   PUBMED   21957020
  REMARK    Review article
REFERENCE   3  (bases 1 to 4892)
  AUTHORS   Laishram,R.S. and Anderson,R.A.
  TITLE     The poly A polymerase Star-PAP controls 3'-end cleavage by
            promoting CPSF interaction and specificity toward the pre-mRNA
  JOURNAL   EMBO J 29 (24), 4132-4145 (2010)
   PUBMED   21102410
REFERENCE   4  (bases 1 to 4892)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 4892)
  AUTHORS   Kolev,N.G., Yario,T.A., Benson,E. and Steitz,J.A.
  TITLE     Conserved motifs in both CPSF73 and CPSF100 are required to
            assemble the active endonuclease for histone mRNA 3'-end maturation
  JOURNAL   EMBO Rep 9 (10), 1013-1018 (2008)
   PUBMED   18688255
REFERENCE   6  (bases 1 to 4892)
  AUTHORS   Gonzales,M.L., Mellman,D.L. and Anderson,R.A.
  TITLE     CKIalpha is associated with and phosphorylates star-PAP and is also
            required for expression of select star-PAP target messenger RNAs
  JOURNAL   J Biol Chem 283 (18), 12665-12673 (2008)
   PUBMED   18305108
REFERENCE   7  (bases 1 to 4892)
  AUTHORS   Collart,C., Remacle,J.E., Barabino,S., van Grunsven,L.A.,
            Nelles,L., Schellens,A., Van de Putte,T., Pype,S., Huylebroeck,D.
            and Verschueren,K.
  TITLE     Smicl is a novel Smad interacting protein and cleavage and
            polyadenylation specificity factor associated protein
  JOURNAL   Genes Cells 10 (9), 897-906 (2005)
   PUBMED   16115198
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473982.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_216766.4, XM_001066531.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4892
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..4892
                     /gene="Cpsf2"
                     /note="cleavage and polyadenylation specific factor 2"
                     /db_xref="GeneID:299256"
                     /db_xref="RGD:1309687"
     exon            1..146
                     /gene="Cpsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            147..328
                     /gene="Cpsf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..2528
                     /gene="Cpsf2"
                     /note="cleavage and polyadenylation specific factor 2,
                     100kDa"
                     /codon_start=1
                     /product="cleavage and polyadenylation specificity factor
                     subunit 2"
                     /protein_id="NP_001100223.1"
                     /db_xref="GeneID:299256"
                     /db_xref="RGD:1309687"
                     /translation="MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEHFSVDI
                     IDSLRKHVHQIDAVLLSHPDPLHLGALPFAVGKLGLNCAIYATIPVYKMGQMFMYDLY
                     QSRHNTEDFTLFTLDDVDAAFDKIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIW
                     KIVKDGEEEIVYAVDFNHKREIHLNGCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQ
                     LLTNVLETLRGDGNVLIAVDTAGRVLELAQLLDQIWRTKDAGLGVYSLALLNNVSYNV
                     VEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHGLSDLARVPSPKVVLASQPDLE
                     CGFSRDLFIQWCQDPKNSIILTYRTTPGTLARFLIDNPSEKVTEIELRKRVKLEGKEL
                     EEYVEKEKLKKEAAKKLEQSKEADIDSSDESDVEEDVDQPTAHKTKHDLMMKGEGSRK
                     GSFFKQAKKSYPMFPAPEERIKWDEYGEIIKPEDFLVPELQATEEEKSKLESGLTNGE
                     EPMDQDLSDVPTKCVSATESIEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHG
                     PPEASQDLAECCRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAK
                     DAELAWIDGVLDMRVSKVDTGVILEEGELKDDGEDSEMQVDAPSDSSVIAQQKAMKSL
                     FGDDEKELGEESEVIPTLEPLPPHEVPGHQSVFMNEPRLSDFKQVLLREGIQAEFVGG
                     VLVCNNQVAVRRTETGRIGLEGCLCQDFYRIRDLLYEQYAIV"
     exon            329..488
                     /gene="Cpsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            489..594
                     /gene="Cpsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            595..724
                     /gene="Cpsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            725..840
                     /gene="Cpsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1028
                     /gene="Cpsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1319
                     /gene="Cpsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1420
                     /gene="Cpsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1621
                     /gene="Cpsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1774
                     /gene="Cpsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..2000
                     /gene="Cpsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2300
                     /gene="Cpsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..2435
                     /gene="Cpsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..4892
                     /gene="Cpsf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcccaagat ggcggccacc acacagaggc tcctgccggc tgttctccgc cgctgagcgc
       61 gcgctaggtc tactcgctct ccgacttgcg ttccactagg ggttgggaag ggcagcggtc
      121 ggtaccgggg gagattgacc tggcagcacc ttttagatac tcgttactgg accggaaaga
      181 tgacatctat catcaagtta actaccctct ctggggtcca agaggagtct gctctttgct
      241 atcttctcca ggttgatgag tttagatttt tgttggactg tggctgggat gaacacttct
      301 ctgtggacat tattgattcc ctgaggaagc atgttcacca gatcgatgca gtgctcctgt
      361 ctcaccccga cccactccac ctcggtgccc tcccgttcgc tgtggggaag ctgggtctga
      421 actgtgccat ctatgcaaca attcctgttt ataaaatggg ccagatgttc atgtacgatc
      481 tttatcagtc tcgacacaat acagaagatt ttaccctctt tacattggac gatgtggatg
      541 cagcctttga taaaatacag cagctaaaat tctctcagat cgtgaacctg aaaggcaaag
      601 gacacggttt gtcgatcaca cccctgccag ctggtcatat gataggagga acaatatgga
      661 aaatagtcaa agacggagaa gaagagattg tttatgccgt ggacttcaac cacaagaggg
      721 agattcacct aaatggatgt tccctggaaa tgctaagcag accctctctg cttatcacag
      781 attcatttaa tgctacttat gtgcagccta gaaggaaaca gagagacgag cagctcctga
      841 caaacgtcct ggaaactctt cggggcgatg ggaatgtgct catagccgtg gacacagcag
      901 gcagagttct ggagcttgct caacttcttg atcagatttg gagaactaaa gacgcggggt
      961 tgggcgttta ttcgctggct ctcctgaaca acgtcagtta caacgtggtg gagttctcta
     1021 agtcacaggt agaatggatg agtgataaat tgatgagatg ttttgaagac aagagaaata
     1081 acccatttca gtttcgccat ctctctctgt gccacggtct ttctgacttg gctcgggttc
     1141 caagccccaa agttgtactt gccagtcagc ctgacctgga gtgtggattc tcaagggacc
     1201 tctttattca gtggtgtcag gaccctaaaa actcaatcat cctaacttac aggacaactc
     1261 cgggaacctt agcacgtttc ttaattgata atccttctga gaaagttaca gaaatagagc
     1321 tgaggaaacg cgtgaagctt gaagggaaag aacttgagga atatgtggaa aaagagaaac
     1381 taaagaaaga agctgctaag aaactggagc agtcgaaaga ggcagacatc gactccagtg
     1441 acgagagtga cgtggaggaa gacgtcgacc agccaacagc tcacaaaacg aagcacgacc
     1501 tgatgatgaa gggggaaggc agccgaaaag ggagcttctt caaacaggcc aaaaagtcct
     1561 accccatgtt tcctgcccca gaagaaagga ttaaatggga cgagtatgga gagatcatca
     1621 aaccagaaga tttcttagtg ccagaacttc aggctactga agaagagaaa agcaaattag
     1681 aatccggctt gacaaatgga gaggaaccca tggatcagga cctgtctgat gttcccacca
     1741 agtgtgtttc tgcaacagag tctattgaga taaaagccag agttacttac atagactacg
     1801 aaggacgctc cgatggagac tccattaaaa agatcatcaa tcagatgaaa ccacggcagc
     1861 tgatcattgt ccacggccca ccagaggcca gtcaggatct ggctgagtgc tgccgcgcat
     1921 ttggtgggaa agatatcaaa gtgtacatgc caaagctgca cgagacagtc gatgccacca
     1981 gcgagacaca tatctaccag gtaagattaa aggactcact tgtcagctcg cttcagttct
     2041 gtaaagcgaa agatgctgag ttagcatgga tagacggcgt cttagacatg agagtctcca
     2101 aagtggacac gggagttatt ttagaagaag gagaactcaa ggatgatgga gaagactctg
     2161 aaatgcaagt ggatgctcct tcagattcca gtgtcatagc ccagcagaag gccatgaaaa
     2221 gtctgtttgg agatgatgag aaagagctgg gtgaggagag tgaggtcatc cccacactgg
     2281 agcctttgcc acctcatgag gttcccggac accagtcagt ttttatgaat gaaccgagac
     2341 tgtctgactt caagcaagtt cttttgcggg aagggattca agcggaattt gtagggggcg
     2401 tacttgtctg caacaatcaa gtagcagtcc gcagaacaga aactggacgc atcgggctag
     2461 aaggctgcct ttgtcaagac ttttatagga tacgagacct tttatatgaa cagtatgcca
     2521 ttgtgtaaag gacgtcatgt caagatgtgt ctgcttgacc tttctcagga agaaaggatt
     2581 ctcatctgag gctaaacttt tgctgtcttg ttttgtaaca tacaaaaaga atgtgccaga
     2641 aaacgtgagc atgtgttaga ttttgaaaaa tatgaatcaa gggcctgggg tgtagctcag
     2701 tggtagagct cttgtctagc atgtgcaagg ccctaggttt gattctctgt actgaataaa
     2761 gaaagaaaga aaatgtaaat agaacccatt ttgtaaatgc tcttgcctag ctctgaatgc
     2821 tagaggccca aggaagagac aggcccaggg ctggagggga ttggtttcct ctgcagatcc
     2881 ttgttccaag ggctcattac ttgaagaaga agaaaaagga gaaacagaca gacaaacaaa
     2941 aggaacagtg caacttagca aaccagttca tggccttaca gaaactggtg tgcatgcatt
     3001 tgttcaagca gttttttgtg ttttctggaa tgagaaggga gaaattgtat agagagaata
     3061 tgctatgaaa gataacagaa gctttgtgaa acatttttat tgagaatggg tgtggcggtg
     3121 ctgctcctct tgacctctga tatgcaaccg ctccacacgg agcccccgcc ctctactttc
     3181 agtgcggtgt gaggcagtac acagctagtt tagaaacaaa tttttatttc tcccattcct
     3241 tgtttattaa gattttgttg ttattccatt tgaatttatg acctcatcat ttgaataaat
     3301 gttatctaaa agaaagcctc taagctgagt gtggtacgtg cacttctaat cccggaactc
     3361 aggaggctgg cataggagga ttggaaatta gaggccagcc tgagccgcat ggtgcgagcc
     3421 tgtctcagcc agcaaaagga aagcctggtg tgttaccagt tctgcatata tttcatttag
     3481 actcatctta actattggtc cagtaactgt atttgaaacc atccaatgct ctgttgtttt
     3541 ttgttttgtt tttttttttt aaaaagcaaa tgtggagcct cacattttta taaggtaaca
     3601 gtgtgattta attaaagggt gtaaatgttt tcctttccca gcgtgttttc taagtttatg
     3661 taaacagcgg ttggatttta tgcttgttac tacaaaaaca gtactgaacc cgggtaactg
     3721 ccactcttga tacagcacaa actctgttcg agagtaaaaa ctgaaaatat gtaattctgt
     3781 tgacttgagc tgtgaaccat gttgtcctat tgtatcttgt tggtttaatt ttttagaagg
     3841 tagcttaagc aaggctgtcc ttgatgcctt cttaagcatg gaagcccctt tctctgcact
     3901 tagcatccgg agaagcctca ctcttgctta actttggaac tgtatatttc agcccagtga
     3961 tccgctatcg gtctagaatt agtcttttat gcggtttcat gagctgagag aaccttcagc
     4021 tgtggattgc agcactgaag caaagtttgt agcctttgga tcctgaaaac cagatgtaca
     4081 aaatagcatt gcagagatga gtgtaaaaga acgtattttc cttttagcag tcatgaacca
     4141 ttccacttgc tcctcttgct atatagagga agcctagaat tcaatttcta ttccagggga
     4201 agaaaccctg cagttacatg ctataaagct ctggatatac ctattatgtg gtaataccta
     4261 tatctaaaat tatttcttgc ctaaccttcc tgccgaccta cgagcaggaa ttagatgtta
     4321 aagtacccct tgaagaatgg ctgtcataca gcaatgccac cggagagcag cactgctgcc
     4381 tgtgtctaga tgacatcatc ctaaaccccc tgaaagggag gccttcatta ttgccccagc
     4441 tacttgagaa aaacatgact ttcaaagaca acagtgggat aagtcacgag agcagagagg
     4501 gtctcagatg caagaataaa aaaaaaccac acagcatgtg agacatgagc tgatatctgc
     4561 agatagtttt cttaaaaaga aattgtatct ggtcgcagtg acacataacc tggaatttca
     4621 cctacttcat tcaaacttgg cttaaggcca gtctggacca catacgaccc tgcccaaaag
     4681 agggagaaag gcgttggggc tatagctcag tggaagagtc cttcctactg gcacgtgtga
     4741 ggccctggat ttgacccagg tctggaggcc gagggcctgc ttttactgaa cttgttgcag
     4801 tgtggttata cttgtcaggc gtctttgcac ttatttctat atttttgtga ctcagtaggt
     4861 aacctgagac aatagagaag aaattagttt gt
//
